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The Chapman Lab

We are located in the Department of Medicine and the Cardiovascular Research Institute at the University of California San Francisco.

Legend: Six day lung organoid developing under a kidney capsule. Green structures are derived from adult lung stem/progenitor cells whereas the remainder are from embryonic lung cells.

About the Lab

The lab has largely focused on elucidating mechanisms of disease in conditions characterized by extracellular matrix remodeling. The lab has a long history of investigation of proteolytic systems involved in this process, especially the urokinase receptor and endosomal cysteine proteases (cathepsins). Another major interest has been the interaction of the urokinase protease receptor and integrins as this interaction influences epithelial cell migration and tumor cell invasion. In recent years this effort has turned to the influence of matrix proteins on epithelial plasticity. There are currently two major projects in the lab: (1) Elucidation of signaling regulating epithelial to mesenchymal transition (EMT) in the lung and lung tumors, as well as identifying small molecules that could modulate and further define the roles of EMT in in vivo mouse models of fibrosis and cancer. (2) Definition of epithelial pathways of lung regeneration following major injury or during fibrogenesis. This project extends prior work identifying a population of integrin α6β4+ lung stem/progenitor cells located in the parenchyma with regenerative activity ex vivo and in vivo.

 

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