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Dr. Innes received her M.D. from the Medical College of Georgia in 1998 and then completed her residency and chief residency in Internal Medicine at Temple University Hospital in Philadelphia. She came to UCSF for fellowship training in Pulmonary/Critical Care Medicine and was a research fellow working with John Fahy in the Cardiovascular Research Institute. Dr. Innes joined the faculty in 2007, and she now serves as an attending physician in the intensive care units, pulmonary consultation service, and the Adult Cystic Fibrosis Clinic. She is currently funded by a NIH/NHLBI sponsored K23 award to study mechanisms of mucus plugging in acute severe asthma.
Dr. Innes’ primary research interest is to develop innovative mechanisms to degrade airway mucus, with the goal of identifying novel mucolytics for acute severe asthma and other airway diseases with mucus plugging. She has pursued methodological training in rheology, the study of flow of unusual fluids, to characterize the physical and chemical properties of airway mucus. Plugging of the airways with mucus is a major cause of morbidity and mortality in acute exacerbations of asthma, yet there are currently no available therapies to effectively degrade these plugs and improve airflow obstruction. Dr. Innes has also collaborated with Professor Susan Muller in the Department of Chemical Engineering at UC Berkeley over the past three years to develop expert skills in rheology, which has enabled the development of a unique niche since there are very few clinical investigators with expertise in this area. She is also becoming expert in the biochemical study of mucin glycoproteins, plasma proteins, and proteases found in airway mucus in order to better understand the complex interactions in the acute asthmatic airway which lead to mucus plugging and its pathologic consequences.
A.L. Innes,S.R. Marder, L.L. Chen, D.G. Morris, M.B. Gotway. Endobronchial Foreign Body Aspiration with Fiberoptic Bronchoscopic Retrieval. Clinical Pulmonary Medicine 2003;10(3):190-193.A.L. Innes, S. Nishimura, L. Huang. Resolution of Lymphocytic Interstitial Pneumonitis in an HIV-infected Adult After Treatment with Highly Active Antiretroviral Therapy. Sex Transm Infect. 2004 Oct;80(5):417-8.
A.L. Innes and J.V. Fahy. Mechanisms of Asthma Exacerbation. In Exacerbations of Asthma. Johnston SL and O’Byrne P, eds. Informa Healthcare, 2006; 129-142.
A.L. Innes, J.A.Katz, J.P.Wiener-Kronish. Chronic Pulmonary Disease. In Basics of Anesthesia, Fifth edition. Stoelting RK, Miller RD, eds. Elsevier, 2006; 406-424.
A.L. Innes, P.G. Woodruff, R. Ferrando, S. Donnelly, G. Dolganov, S.C. Lazarus, and J.V. Fahy. Epithelial Mucins are Increased in the Large Airways of Smokers with Airflow Obstruction. Chest 2006; 130: 1102-1108.
P.G. Woodruff, A.L. Innes. Quantitative Morphology Using Bronchial Biopsies. European Respiratory Review 2006; 15: 157-161.
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