Carolyn S. Calfee, MD is Assistant Adjunct Professor of Medicine at UCSF, where she attends in the intensive care units and on the pulmonary consultation service.  She received her undergraduate degree from Yale University and her medical degree from the University of Pennsylvania School of Medicine.  She came to UCSF for residency in Internal Medicine and stayed to complete her chief residency and Pulmonary/Critical Care Medicine fellowship.  After research training with Drs. Michael Matthay and Mark Eisner, she joined the faculty of the division in 2007.

Research Activities

Dr. Calfee’s major academic interests focus on acute lung injury (ALI) and the acute respiratory distress syndrome (ARDS) and include the role of biomarkers in investigating disease pathogenesis, outcomes of ALI/ARDS, and the role of environmental exposures in susceptibility to lung injury.

Recent Publications

Kropski JA, Fremont RD, Calfee CS, Ware LB.  Clara cell protein (CC16), a marker of lung epithelial injury, is decreased in plasma and pulmonary edema fluid from critically ill patients with acute lung injury and the acute respiratory distress syndrome.  Chest, Epub ahead of print.

Levitt JE, Bedi H, Calfee CS, Gould MK, Matthay MA. Identification of Early Acute Lung Injury at Initial Evaluation in an Acute Care Setting Prior to the Onset of Respiratory Failure.  Chest, Epub ahead of print.

Suratt BT, Eisner MD, Calfee CS, Allard JB, Whittaker LA, Engelken DT, Petty JM, Trimarchi T, Gauthier L, Parsons PE.  Plasma G-CSF levels and clinical outcomes in patients with acute lung injury.  Critical Care Medicine, Epub ahead of print. 

Briot R, Frank JA, Uchida T, Lee JW, Calfee CS, Matthay MA.  Elevated levels of RAGE, a marker of alveolar epithelial type I cell injury, predict impaired alveolar fluid clearance in isolated perfused human lungs.  Chest 2009; 135(2): 269-75.

Calfee CS, Eisner MD, Parsons PE, Thompson BT, Matthay MA, Ware LB.   Soluble intercellular adhesion molecule-1 and clinical outcomes in patients with acute lung injury.  Intensive Care Medicine2009; 35(2): 248-57.

Calfee CS, Ware LB, Eisner MD, Parsons PE, Thompson BT, Wickersham N, Matthay MA.  Plasma receptor for advanced glycation end-products and clinical outcomes in acute lung injury.  Thorax 2008; 63(12): 1083-9.

Matthay MA, Calfee CS.  Aerosolized beta-adrenergic agonist therapy reduces pulmonary edema following lung surgery.  Chest 2008; 133:  833-5.

Calfee CS, Ware LB.  Biomarkers of lung injury in primary graft dysfunction following lung transplantation.  Biomarkers in Medicine 2007; 1:  285-91.

Calfee CS, Eisner MD, Ware LB, Thompson BT, Parsons PE, Wheeler AP, Korpak A, Matthay MA. Trauma-associated lung injury differs clinically and biologically from acute lung injury due to other clinical disorders.  Critical Care Medicine 2007; 35(10): 2243-50. (Feature Article)

Calfee CS, Budev MM, Matthay MA, Church G, Brady S, Uchida T, Ishizaka A, Lara A, Ranes J, DeCamp MM, Arroliga AC.  Receptor for advanced glycation endproducts predicts short-term outcomes in lung transplantation.  J Heart Lung Transplantation 2007; 26: 675-80.

Calfee CS, Matthay MA.  Non-ventilatory treatments for acute lung injury and the acute respiratory distress syndrome.  Chest 2007; 131:  913-20.  

Calfee CS, Shah SJ, Wolters PJ, Saint S, King TE Jr.  Anchors away. New England Journal of Medicine 2007, 356: 504-9. 

Calfee CS, Katz PP, Yelin EH, Iribarren C, Eisner MD.  The influence of perceived control of asthma on health outcomes.  Chest 2006; 130(5): 1312-18. Matthay MA, Calfee CS.  Therapeutic value of a lung protective ventilation strategy in acute lung injury.  Chest 2005; 128: 3089-3091.