Dr. Chapman received in his M.D. degree from the University of Alabama in 1972.
After internal medicine, pulmonary subspecialty, and research training at the University of Utah, he joined the
faculty of Harvard Medical School at the Brigham and Women's Hospital in 1986. He became Professor and Pulmonary
Division Chief at University of California, San Francisco, in 2000. His academic activities are divided among his
research efforts described below, mentoring clinical and research trainees, and directing the UCSF Pulmonary and Critical
Care Division. He sees patients as a pulmonary consultant in Moffitt-Long Hospital. Research Interests The Chapman lab is focused on basic and biomedical aspects of lung injury and lung tissue remodeling. The lab employs a number of cell and mouse model systems to study underlying mechanisms of this category of disease. In addition, the lab is using blood and tissue samples from patients to test similarities with recent findings in mouse models of disease and to discover biomarkers of disease progression for several important lung diseases: lung cancer, pulmonary fibrosis, and interstitial pneumonias. Current projects in the lab and more detail about the scientific approaches of these efforts can be found at our website (pulmonary.ucsf.edu/chapmanlab) and recent references below.
Recent Publications
Wei Y, Lukasev M, Simon DI, Bodary SC, Rosenburg S, Doyle MV, and HA Chapman. Regulation of integrin function by the urokinase receptor Science 1996;273:1551-1555. (abstract)
Gelb BD, Shi GP. Chapman HA, and RJ Desnick. Pycnodysostosis, a lysosomal disease caused by cathepsin K deficiency. Science 1996;273:1236-1238. (abstract)
Riese R, Wolf P, Bromme D, Natkin L, Villadangos JA, Ploegh H, and HA Chapman. Essential role for cathepsin S in MHC Class II-associated invariant chain processing and antigen presentation. Immunity 1996;4:357-366. (abstract)
Chapman, HA. Endosomal proteolysis and MHC class II function. Current Opinion in Immunology, 1998;10:93-102. (abstract)
Chapman HA and Shi GP. Protease injury in the development of COPD. Chest 2000; 117: 1-4S (abstract)/ (full text)
Zhang F, Tom CC, Kugler MC, Ching TT, Kreidberg JA, Wei Y, Chapman HA. Distinct ligand binding sites in integrin alpha3beta1 regulate matrix adhesion and cell-cell contact. 1: J Cell Biol. 2003 Oct 13;163(1):177-88. (abstract)/(full text)
Chapman HA. Disorders of lung matrix remodeling. J Clin Invest. 2004 Jan;113(2):148-57. (abstract)/(full text)
Y. Wei, R.-P. Czekay, L. Robillard, M.C. Kugler, F. Zhang, K.K. Kim, J.-p. Xiong, M.J. Humphries, and H.A. Chapman. Regulation of a5ß1 integrin conformation and function by urokinase receptor binding. J. Cell Biol. 2005; 168: 501:511.
Tang CH, Lee JW, Galvez MG, Robillard L, Mole SE, Chapman HA. Murine cathepsin F deficiency causes neuronal lipofuscinosis and late-onset neurological disease. Mol Cell Biol 2006 Mar;26(6):2309-16
Kevin K. Kim, Matthias C. Kugler, Paul J. Wolters, Liliane Robillard, Michael G. Galvez, Alexis N. Brumwell, Dean Sheppard and Chapman HA. Alveolar Epithelial Cell Mesenchymal Transition Develops in vivo during Pulmonary Fibrosis and is Regulated by the Extracellular Matrix. Proc Natl Acad Sci 2006 Aug 29;103(35):13180-5.
Ying Wei, Chi-Hui Tang, Feng Zhang, Young Kim, Liliane Robillard, Matthias C. Kugler, Chapman HA. Urokinase Receptors are required for a5b1 integrin-mediated signaling in tumor cells. J of Biol Chem 282(6):3929-39, 2007.
