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Dr. Erle received an A.B. degree (Biochemistry) from Harvard College in 1980 and an M.D. degree from UCSF in 1984. He was trained in internal medicine and in pulmonary disease at UCSF. As a CVRI research fellow training at the UCSF Lung Biology Center, he studied leukocyte integrins with Robert Pytela and Dean Sheppard. He joined the Lung Biology Center faculty in 1990. His academic activities include laboratory research and clinical teaching. He is the Director of the Functional Genomics Core Facility, UCSF Sandler Center for Basic Research in Asthma. He is a member of the UCSF Program in Immunology and the Cardiovascular Research Institute. He serves as an Attending Physician in the San Francisco General Hospital Medical ICU and the Pulmonary Consultation Service.
Asthma: role of airway epithelial cells. The airway epithelium is increasingly recognized as a key participant in asthma and other major lung diseases. Our group has developed models to understand how IL-13 and other cytokines produced during airway inflammation act on epithelial cells to produce disease. Ongoing work is investigating how specialized molecules in the endoplasmic reticulum contribute to mucus overproduction in asthma and how micro-RNAs affect airway epithelial cell differentiation and function.
Functional genomics. Powerful genomics tools such as next generation sequencing and microarrays offer new opportunities for understanding lung biology and disease. Members of our group have extensive experience with these technologies. Projects within the lab and collaborative projects with many investigators at UCSF and beyond are using these technologies to investigate pulmonary cell biology, mouse disease models, and samples from humans with asthma and other diseases. We are also pursuing novel genomics approaches, including development of a system for high-throughput analysis of the function of sequences from 3’ untranslated regions of mRNAs.
Kuperman DA, Huang XZ, Koth LL, Zhu Z, Elias JA, Sheppard D, Erle DJ. Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction, two central features of asthma. Nat Med, 8:885-9, 2002.
Kuperman DA, Lewis CC, Woodruff PG, Rodriguez MW, Yang YH, Dolganov GM, Fahy JV, Erle DJ. Dissecting asthma using focused transgenic modeling and functional genomics. J Allergy Clin Immunol 116:305-311, 2005.
Kuperman DA, Huang X, Nguyenvu L, Hölscher C, Brombacher F, Erle DJ. IL-4 receptor signaling in Clara cells is required for allergen-induced mucus production. J Immunol 175:3746-3752, 2005.
Woodruff PG, Koth LL, Yang YH, Rodriguez MW, Favoreto S, Dolganov GM, Paquet AC, Erle DJ. A distinctive alveolar macrophage activation state induced by cigarette smoking. Am J Respir Crit Care Med 172:1383-92, 2005.
Lewis CC, Yang JYH, Huang X, Banerjee SK, Blackburn MR, Baluk P, McDonald DM, Blackwell TS, Nagabhushanam V, Peters W, Voehringer D, Erle DJ. Disease-specific gene expression profiling in multiple models of lung disease. Am J Respir Crit Care Med, 177:376-87, 2008.
Park SW, Verhaeghe C, Nguyenvu LT, Barbeau R, Eisley CJ, Nakagami Y, Huang X, Woodruff PG, Fahy JV, Erle DJ. Distinct roles of FOXA2 and FOXA3 in allergic airway disease and asthma. Am J Respir Crit Care Med 180:603-10, 2009.
Park SW, Zhen G, Verhaeghe C, Nakagami Y, Nguyenvu LT, Barczak AJ, Killeen N, Erle DJ. The protein disulfide isomerase AGR2 is essential for production of intestinal mucus. Proc Natl Acad Sci USA 106:6950-5, 2009.
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