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Dr. Frank received his medical doctorate degree from the University of Colorado and went on to residency and fellowship training at the University of California, San Francisco. Dr. Frank joined the Department of Medicine faculty in 2002. Dr. Frank’s primary focus is critical care medicine and he has a special interest in advancing treatment for patients with acute lung injury and the acute respiratory distress syndrome (ARDS). He is currently an attending physician in the intensive care unit at the San Francisco VA Medical Center.
American Board of Internal Medicine
- Internal Medicine
- Pulmonary Disease
Acute lung injury, including ARDS, is a common clinical problem in the intensive care unit contributing to 75,000 deaths per year in the U.S. There are currently no effective pharmacologic therapies for acute lung injury. Acute lung injury is characterized by uncontrolled inflammation and the breakdown of the alveolar barrier in the airspaces of the lung. The loss of alveolar barrier function allows fluid to fill the airspaces compromising oxygen uptake. Preserved alveolar barrier function is associated with lower mortality in patients with acute lung injury; however, the mechanisms for alveolar barrier regulation are incompletely understood. The Frank lab investigates how the cells that line the airspaces of the lung repair injury to the alveolar barrier, including how they form the tight junctions that limit edema formation. The overall objective of Dr. Frank’s research program is to understand the regulation of alveolar barrier function so that new treatments for acute lung injury may be developed.
Frank JA, Wang Y, Osorio O, Matthay MA. ß-adrenergic agonist therapy accelerates the resolution of hydrostatic pulmonary edema in sheep and rats. J Appl Physiol. 89:1255-1265, 2000.
Frank JA, Gutierrez J, Jones K, Allen L, Dobbs L, Matthay M. Low tidal volume reduces epithelial and endothelial injury in acid-injured rat lungs. Am J Resp Crit Care Med. 165:242-249, 2002.
Frank JA, Pittet JF, Lee, H, Matthay, MA. High tidal volume ventilation induces NOS2 and impairs cAMP-dependent airspace fluid clearance. Am J Physiol, 284: L791-98, 2003.
Frank JA, Matthay, MA. Mechanisms of Ventilator-Induced Lung Injury. Critical Care, 7:233-41, 2003.
Frank J, Roux J, Kawakatsu H, Su G, Dagenais A, Berthiaume Y, Howard M, Canessa C, Fang XH, Sheppard D, Matthay MA, Pittet JF. TGF-ß1 reduces alveolar epithelial sodium and fluid transport via an ERK 1/2-dependent mechanism. J Biol Chem. 2003 Nov 7;278(45):43939-50.
Frank JA, McAuley DF, Fang XH, Matthay MA. Clinically relevant concentrations of beta2-adrenergic agonists stimulate maximal cyclic adenosine monophosphate-dependent airspace fluid clearance and decrease pulmonary edema in experimental acid-induced lung injury. Crit Care Med. 2004 Jul;32(7):1470-6.
Frank JA, McAuley D, Gutierrez J, Daniel B, Dobbs L, Matthay MA. Differential effects of sustained inflation recruitment maneuvers on alveolar epithelial and lung endothelial injury. Crit Care Med. 2005 Jan;33(1):181-8.
Dotson RH, Daniel BM, and Frank JA. General Principles of Managing the Patient with Respiratory Failure in Chest Medicine – Essentials of Pulmonary and Critical Care Medicine. Fifth edition. R.B. George, R.W. Light, M.A. Matthay, R.A. Matthay eds. 2005. Baltimore, Maryland, Williams and Wilkins, pp 517-534.
Frank JA, Matthay MA. Leukotrienes in acute lung injury: A potential therapeutic target. Am J Respir Crit Care Med. 172(3):261-2, 2005.
Godzich M, Hodnett M, Frank J, Su G, Pespeni M, Angel A, Howard M, Matthay M, Pittet JF. Activation of the stress protein response prevents the development of pulmonary edema by inhibiting VEGF cell signaling in a model of lung ischemia-reperfusion injury in rats. The FASEB Journal. 2006;20:1519-152.
Frank JA and Matthay MA. “Ventilator-induced alveolar epithelial injury” in Ventilator-Induced Lung Injury. Dreyfus D, Saumone G, Hubmayr R eds. Vol 215 in the series Lung Biology in Health and Disease. Taylor and Francis, New York, pp377-401, 2006.
Frank JA, Parsons P, Matthay M. Pathogenetic significance of biological markers of ventilator-associated lung injury in experimental and clinical studies. Chest 130:1906-1914, 2006.
Frank J, Wray C, McAuley D, Schwendener R, Matthay, M. Alveolar macrophages contribute to alveolar epithelial barrier dysfunction in ventilator-induced lung injury. Am J Physiol LCMP, 2006; 291:1191-1198.
Su G, Hodnett M, Wu N, Frank JA, Kosinski C, Godzich M, Atakilit A, Matthay M, Sheppard D, and Pittet JF. Integrin αvβ5 regulates pulmonary endothelial permeability and acute lung injury. Am J Respir Cell Mol Biol. 2007; 36(3):377-86.
Hirsch J, Hansen K, Frank JA, Chalkley R, Fang X, Trinidad J, Baker P, Burlingame AL, Matthay M. Impact of low and high tidal volume on the rat alveolar epithelial type II cell proteome. Am J Respir Crit Care Med. 2007; 175(10):1006-13.
Frank JA, Briot R, Lee JW, Ishizaka A, Uchida T, Matthay M. Physiological and biochemical studies of lung fluid balance in human lungs rejected for transplantation. Am J Physiol LCMP 2007 Mar 9. PMID: 17351061
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