Naveen Gupta, MD is an Assistant Adjunct Professor of Medicine at UCSF, where he attends on the pulmonary consultation service and in the intensive care units. He received his undergraduate degree from Stanford University and his medical degree from the University of Michigan, Ann Arbor. He stayed at Michigan to complete his residency in Internal Medicine and then came to UCSF for his fellowship training in Pulmonary and Critical Care Medicine. After completing his clinical fellowship, Naveen joined Dr. Michael Matthay’s laboratory where he continues to conduct research.
Research Interests
Since joining Dr. Matthay’s laboratory in 2005, my research focus has been on investigating the therapeutic and mechanistic effects of mesenchymal stem cells (MSC) in experimental models of acute lung injury (ALI). My preliminary work has demonstrated that MSC therapy provides a significant protective effect in the mouse model of endotoxin induced ALI. Further work is being done to determine the cellular and molecular mechanisms responsible for this benefit, and to test the effects of MSC in other, clinically relevant models of ALI.
Selected Publications
Gupta N, Su X, Popov B, Serikov V, Matthay MA. Intrapulmonary Delivery of Bone Marrow Derived Mesenchymal Stem Cells Improves Survival and Attenuates Endotoxin-induced Acute Lung Injury in Mice. Journal of Immunology 2007, 179: 1855-63.
Su X, Lee JW, Matthay ZA, Mednick G, Uchida T, Fang X, Gupta N, Matthay MA. Activation of the α7 nAChR Reduces Acid-Induced Acute Lung Injury in Mice and Rats. Am J Respir Cell Mol Biol 2007, 37: 186-192.
Popov B,, Serikov V, Petrov NS, Izusova TV, Gupta N, Matthay MA. Lung Epithelial Cells A549 Induce Endodermal Differentiation in Mouse Mesenchymal BM Stem Cells by a Paracrine Mechanism. Tissue Eng 2007, 13: 2441-2450.
Serikov V, Popov B, Mikhailov VM, Gupta N, Matthay MA. Evidence of Temporary Epithelial Repopulation by BM-Derived Cells in Airways Following Napthalene Injury in Mice. Anat Rec 2007, 290: 1033-45.
Gupta N and Matthay MA. Sepsis and Stretch: Synergistic Effects on Alveolar Epithelial Cell Death? Crit Care Med 2006, 34:1846-7.
