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Dr. Huang graduated from Johns Hopkins University and received his M.D. degree from Columbia University, College of Physicians and Surgeons. He completed a categorical Internal Medicine residency at Columbia Presbyterian Medical Center (New York) and his Pulmonary and Critical Care Medicine fellowship at University of California, San Francisco. Dr. Huang joined the faculty at University of California, San Francisco in 1995, where he is an attending physician in the Department of Medicine at San Francisco General Hospital with dual appointments in the Division of Pulmonary and Critical Care Medicine and the HIV/AIDS Division. Currently, he is the Chief of the San Francisco General Hospital HIV/AIDS Chest Clinic and an Assistant Director of the UCSF Clinical and Translational Science Institute (CTSI) Mentor Development Program.
Dr. Huang's main clinical and clinical research interests are in HIV-associated pulmonary diseases, including Pneumocystis pneumonia (PCP), tuberculosis (TB), bacterial pneumonia, HIV-associated chronic obstructive lung diseases, HIV-associated pulmonary arterial hypertension, and critical care of HIV-infected persons. He is Principal Investigator of the NIH-funded International HIV-associated Opportunistic Pneumonias (IHOP) Study and is Co-Principal Investigator of the NIH-funded Lung Microbiome in Cohorts of HIV-Infected Persons (Lung MicroCHIP) Study. Dr. Huang has clinical and translational research collaborations with co-investigators at the National Institutes of Health, the University of Cincinnati, the University of North Carolina, the University of Pittsburgh, the University of Washington, the University of Colorado, and Makerere University Kampala, Uganda as well as at San Francisco General Hospital and University of California, San Francisco. In addition, Dr. Huang has independent studies on PCP and ICU outcomes among HIV-infected patients at San Francisco General Hospital. These collaborative studies are supported through an NIH K24 Mid-career Investigator Award in Patient-Oriented Research Award, 4 NIH R01 Awards, and 3 NIH U01 Awards. Current research studies include: (1) An International (San Francisco, Kampala) cohort study of HIV-associated opportunistic pneumonias; (2) Development and validation of several new molecular applications to study PCP epidemiology, diagnosis, drug-resistance, and host immune response; (3) Development and validation of several new molecular applications to study TB and bacterial pneumonia epidemiology and diagnosis; (4) Comprehensive molecular-epidemiology study that addresses whether PCP results from person-to-person transmission (as has been convincingly demonstrated from animal-to-animal laboratory studies) and whether disease results from reactivation of latent infection or from recent exposure and infection; (5) Exploration of the lung microbiome in persons with and without underlying HIV infection and in periods of health and disease (pneumonia).
Boehme, CC, Nicol, MP, Nabeta, P, Michael, JS, Gotuzzo, E, Tahirli, R, Gler, MT, Blakemore, R, Worodria, W, Gray, C, Huang, L, Caceres, T, Mehdiyev, R, Raymond, L, Whitelaw, A, Sagadevan, K, Alexander, H, Albert, H, Cobelens, F, Cox, H, Alland, D, and Perkins, MD. Feasibility, diagnostic accuracy, and effectiveness of decentralised use of the Xpert MTB/RIF test for diagnosis of tuberculosis and multidrug resistance: a multicentre implementation study. Lancet 2011;377(9776):1495-1505.
Dhanireddy, S, Harrington, RD, Crane, HM, Gingo, MR, Morris, A, Huang, L, and Crothers, K. Pandemic (H1N1) 2009 and HIV Infection. Emerging Infectious Diseases 2011;17(6):1140-1143.
Crothers, K, Thompson, BW, Burkhardt, K, Morris, A, Flores, SC, Diaz, PT, Chaisson, RE, Kirk, GD, Rom, WN, and Huang, L for the Lung HIV Study. HIV-associated lung infections and complications in the era of combination antiretroviral therapy. Proceedings of the American Thoracic Society 2011;8(3):275-281.
Huang, L, Cattamanchi, A, Davis, JL, den Boon, S, Kovacs, J, Meshnick, S, Miller, RF, Walzer, PD, Worodria, W, and Masur, H on behalf of the International HIV- associated Opportunistic Pneumonias (IHOP) Study and the Lung HIV Study. HIV-associated Pneumocystis pneumonia. Proceedings of the American Thoracic Society 2011;8(3):294-300.
Akgun, KM, Huang, L, Morris, A, Justice, AC, Pisani, M, and Crothers, K. Critical illness in HIV-infected patients in the era of combination antiretroviral therapy. Proceedings of the American Thoracic Society 2011;8(3):301-307.
Almodovar, S, Hsue, PY, Morelli, J, Huang, L, and Flores, SC. Pathogenesis of HIV-associated pulmonary hypertension: Potential role of HIV-1 nef. Proceedings of the American Thoracic Society 2011;8(3):308-312.
Morris, A, George, MP, Crothers, K, Huang, L, Lucht, L, Kessinger, C, and Kleerup, EC on behalf of the Lung HIV Group. HIV and chronic obstructive pulmonary disease: Is it worse and why? Proceedings of the American Thoracic Society 2011;8(3):320-325.
Yoo, SD, Cattamanchi, A, den Boon, S, Worodria, W, Kisembo, H, Huang, L, and Davis, JL. Clinical significance of normal chest radiographs among HIV-seropositive patients with suspected tuberculosis in Uganda. Respirology 2011;16(5):836-841.
Davis, J, Katamba, A, Vasquez, J, Crawford, E, Sserwanga, A, Kakeeto, S, Kizito, F, Dorsey, G, den Boon, S, Vittinghoff, E, Huang, L, Adatu, F, Kamya, MR, Hopewell, PC, and Cattamanchi, A. Evaluating tuberculosis case detection via real-time monitoring of tuberculosis diagnostic services. American Journal of Respiratory and Critical Care Medicine 2011;184(3):362-367.
Metcalfe, JZ, Everett, CK, Steingart, KR, Cattamanchi, A, Huang, L, Hopewell, PC, and Pai, M. Interferon-gamma release assays for active pulmonary tuberculosis diagnosis in adults in low- and middle-income countries: Systematic review and meta-analysis. Journal of Infectious Diseases2011;204 Suppl 4:S1120-1129.
Worodria, W, Anderson, J, Cattamanchi, A, Davis, JL, den Boon, S, Andama, A, Yoo, SD, Joloba, M, Huang, L, and Kato-Maeda, M. The role of speciation in positive Lowenstein-Jensen culture isolates from a high tuberculosis burden country. PLoS ONE 2011;6(11):e27017.
Taylor, SM, Meshnick, SR, Worodria, W, Andama, A, Davis, JL, Cattamanchi, A, den Boon, S, Yoo, SD, Goodman, CD, and Huang, L. Low prevalence of Pneumocystis jirovecii lung colonization in Ugandan HIV-infected patients hospitalized with non-Pneumocystis pneumonia. Diagnostic Microbiology and Infectious Diseases 2012;72(2):139-143.
Kisembo, HN, den Boon, S, Davis, JL, Okello, R, Worodria, W, Cattamanchi, A, Huang, L, and Kawooya, MG. Chest radiographic abnormalities in hospitalized patients with cough in a population highly endemic for HIV and tuberculosis. The British Journal of Radiology 2012. In Press.
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