Kato-Maeda, Midori , MD
Assistant Adjunct Professor

University of California San Francisco
San Francisco General Hospital
Box 0841
San Francisco, California 94143

phone: 415-206-8121
fax: 415-695-1551
email: midori.kato-maeda@ucsf.edu

Dr. Kato-Maeda received her M.D. degree from Universidad La Salle, Mexico City, Mexico, in 1990 and trained in internal medicine and Infectious Diseases at the Instituto Nacional de la Nutrición "Salvador Zubirán", Mexico City, Department of Medicine. She received a master’s degree in Medical  Sciences at the Instituto Nacional de la Nutrición "Salvador Zubirán" and the Universidad Nacional Autónoma de Mexico, Mexico City. She completed a postdoctoral fellowship in molecular epidemiology of tuberculosis at Stanford University with Dr. Peter Small in 2000. From 2002 to 2005, she worked with Dr. Small as senior research assistant in the Stanford Center for Tuberculosis Research. She joined UCSF as a research specialist in 2005 and became Assistant Adjunct Professor in May 2008. She was also Subdirector of the National Tuberculosis Control Program in Mexico from 1997 to 1998.

Research Interests
Dr. Kato-Maeda’s research activities focuses on the epidemiological aspects of tuberculosis. During her postdoctoral fellowship at Stanford University she worked with Dr. Peter Small, a leading expert in the study of the molecular epidemiology of tuberculosis. She participated in several projects with Dr. Small and Dr. Philip Hopewell at UCSF and the San Francisco Department of Public Health Division of Tuberculosis. In February of 2005, Dr. Kato-Maeda together with Dr. Philip Hopewell opened the tuberculosis research laboratory at UCSF, currently located in building 100, room 109 at the SFGH. Her research interests are the molecular epidemiology of tuberculosis and the impact of the genetic polymorphism of Mycobacterium tuberculosis in the clinical presentation and epidemiology of the disease.  She has collaborations with the San Francisco Department of Public Health Division of Tuberculosis, CDC as well as researchers in Panama and Mexico.
Dr. Kato-Maeda participates in teaching activities related to the molecular epidemiology of tuberculosis as well as research management involving laboratory components. She also facilitates laboratory meetings for the tuberculosis research community at SFGH/UCSF. Dr. Kato-Maeda also serves as a consultant for laboratory aspects of the Tuberculosis Control Program, as well as a consultant to numerous research projects related to tuberculosis.

Selected Publications

1. Kato-Maeda M, Sifuentes-Osornio J, Bobadilla-del-Valle M, Ruiz-Palacios GM, Ponce-de- León A. Drug resistance among acid-fast bacilli. Lancet 1999; 353(9165):1709.
2. Kato-Maeda M, Bifani PJ, Kreiswirth BN, Small PM. The nature and consequence of genetic variability within Mycobacterium tuberculosis. J Clin Invest 2001; 107(5):533-7.
3. Kato-Maeda M, Rhee JT, Gingeras TR, Salamon H, Drenkow J, Smittipat N, Small PM. Comparing genomes within the species Mycobacterium tuberculosis. Genome Res 2001; 11(4):547-54.
4. Kato-Maeda M, Gao Q, Small PM. Microarray analysis of pathogens and their interaction with hosts. Cell Microbiol 2001; 3(11):713-9.
5. Bobadilla-del-Valle M, Ponce-de-León A, Arenas-Huertero C, Vargas-Alarcón G, Kuary-Aguilera P, Kato-Maeda M, Small PM, Ruiz-Palacios GM, Sifuentes-Osornio J. Rifampin-resistant Mycobacterium tuberculosis: correlation between minimal inhibitory concentrations and genetic replacement in the rpoB gene. Emerg Infect Dis 2001; 7(6):1010-3.
6. Garcia-García Mde L, Ponce-de-León A, Garcia-Sancho MC, Ferreyra-Reyes L, Palacios-Martinez M, Fuentes J, Kato-Maeda M, Bobadilla-del-Valle M, Small P, Sifuentes-Osornio J. Tuberculosis-related deaths within a well-functioning DOTS control program. Emerg Infect Dis 2002; 8(11):1327-33.
7. Sifuentes-Osornio J, Bobadilla-del-Valle M, Kato-Maeda M, Garcia-García Mde L, Matus-Ruíz MG, Martinez-Gamboa A, Maldonado S, Méndez P, Palacios-Martínez M, Chávez-Mazari B, Small PM, Ponce-de-León A. Epidemiología de la resistencia antimicrobiana en Mycobacterium tuberculosis en México. Gaceta Médica Mexicana 2003; 139:477-80.
8. Bobadilla-del-Valle M, Ponce-de-León A, Kato-Maeda M, Hernández-Cruz A, Calva-Mercado JJ, Chavez-Mazari B, Caballero-Rivera BA, Nolasco-Garcia JC, Sifuentes-Osornio J. Comparison of sodium carbonate, cetyl-pyridinium chloride, and sodium borate for preservation of sputa for culture of Mycobacterium tuberculosis. J Clin Microbiol 2003; 41(9):4487-8.
9. Tsolaki AG, Hirsh AE, DeRiemer K, Encisco JA, Wong MZ, Hannan M, Goguet De La Salmoniere YO, Aman K, Kato-Maeda M, Small PM. Functional and evolutionary genomics of Mycobacterium tuberculosis: Insights from genomic deletions in 100 strains. Proc Natl Acad Sci USA 2004; 101:4721-2.
10. Mostowy S, Onipede A, Gagneux S, Niemann S, Kremer K, Desmond EP, Kato-Maeda M, Behr M. Genomic analysis distinguishes Mycobacterium africanum. J Clin Microbiol 2004; 42:3594-9.
11. Freeman, R., M. Kato-Maeda, K. A. Hauge, K. L. Horan, E. Oren, M. Narita, C. K. Wallis, D. Cave, C. M. Nolan, P. M. Small, and G. A. Cangelosi.. Use of rapid genomic deletion typing to monitor a tuberculosis outbreak within an urban homeless population. J Clin Microbiol 2005 43:5550-4.
12. Gagneux, S., K. Deriemer, T. Van, M. Kato-Maeda, B. C. de Jong, S. Narayanan, M. Nicol, S. Niemann, K. Kremer, M. C. Gutierrez, M. Hilty, P. C. Hopewell, and P. M. Small. Variable host-pathogen compatibility in Mycobacterium tuberculosis. Proc Natl Acad Sci U S A. 2006 103: 2869-73
13. Aga, R. S., E. Fair, N. F. Abernethy, K. Deriemer, E. A. Paz, L. M. Kawamura, P. M. Small, and M. Kato-Maeda. 2006. Microevolution of the direct repeat locus of Mycobacterium tuberculosis in a strain prevalent in San Francisco. J Clin Microbiol 44:1558-60
14.  Wu, B., C. Huang, L. Garcia, A. Ponce de Leon, J. S. Osornio, M. Bobadilla-del-Valle, L. Ferreira, S. Canizales, P. Small, M. Kato-Maeda, A. M. Krensky, and C. Clayberger. 2007. Unique gene expression profiles in infants vaccinated with different strains of Mycobacterium bovis bacille Calmette-Guerin. Infect Immun 75:3658-64..
15. Wu B, Huang C, Kato-Maeda M, Hopewell PC, Daley CL, Krensky AM, Clayberger C. 2007. Messenger RNA Expression of IL-8, FOXP3, and IL-12beta Differentiates Latent Tuberculosis Infection from Disease. J Immunol 178:3688-94.
16. Flores, L., T. Van, S. Narayanan, K. Deriemer, M. Kato-Maeda, and S. Gagneux. 2007. Large Sequence Polymorphisms Classify Mycobacterium tuberculosis with Ancestral Spoligotyping Patterns. J Clin Microbiol. J Clin Microbiol 45: 3393-5.
17. Wu, B., Huang, C., Kato-Maeda, M., Hopewell, P. C., Daley, C. L., Krensky, A. M., and Clayberger, C., 2008. IL-9 is associated with an impaired Th1 immune response in patients with tuberculosis, Clin Immunol 126:202-10
18. Wu B, Huang C,  Kato-Maeda M, Hopewell PC, Daley CL, Krensky AM, Clayberger C. 2008. IL-24 modulates IFN-g expression in patients with tuberculosis. Immunology Lett 117:57-62.