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Dr. Lazarus is an inbred product of the University of California, having received his A.B. from Berkeley, his M.D. from Irvine, and training in Internal Medicine and Pulmonary & Critical Care Medicine at UCSF. Drafted into military service during the Viet Nam era, he spent 2 years as Chief of Pulmonary Medicine and Co-Director of the ICU at Andrews Air Force Base in Washington, D.C. before returning to UCSF for additional research training in the Cardiovascular Research Institute. Since joining the faculty at UCSF in 1983, Dr. Lazarus has directed basic and clinical research on the mechanisms and treatment of asthma, COPD, and other airway diseases. He is an Attending Physician on the Pulmonary Consult Service, the Adult Pulmonary Function Laboratory, and the Chest Faculty Practice at UCSF-Moffitt-Long Hospital, and has been Director of the Chest Faculty Practice, as well as Director of the Medical Specialty Practices. Currently he is Director of the Training Program in Pulmonary and Critical Care Medicine and Associate Director of the Adult Pulmonary Laboratory.
My research has focused on the role of inflammatory cells and mediators in regulating function of the lung and airways in asthma. I developed continuous mastocytoma cell lines that share many important features of normal human mast cells. These cells have served as a unique model system for mast cell biology as well as a source of mast cell-derived mediators to examine the role of these mediators in important biological processes.
Studies of mast cell mediators, specifically metabolites of arachidonic acid, led to important hypotheses regarding the role of these and other "pro-inflammatory" mediators in human disease. In a series of investigator-initiated clinical research projects I examined the role of leukotrienes in chronic asthma and in mediating the bronchoconstrictor response to inhaled sulfur dioxide and the role of tachykinins in mediating the airway hyperresponsiveness, airway inflammation, and symptoms of chronic asthma. Drs. John Fahy, George Caughey and I collaborated to examine the ability of proteases in sputum from patients with cystic fibrosis to activate eosinophils and mast cells in vitro, and I collaborated with Dr. Jay Nadel to examine the role of the EGF-receptor in mediating eosinophil-induced mucin hypersecretion.
The NHLBI awarded Drs. Homer Boushey, Fahy, and I one of six Asthma Clinical Research Network (ACRN) Centers in the United States. Through this network we have conducted mechanistic studies of asthma therapy, taking advantage of our experience with inflammatory cells and mediators to relate mast cell activation, eosinophil activation, and exhaled nitric oxide to physiological measurements of airway function and clinical outcomes in asthma. Subsequently my successful application for an NHLBI COPD Clinical Research Network (CCRN) site has led to similar studies related to COPD. Based on our expertise at UCSF, Dr. Prescott Woodruff and I are leading the analysis of biomarkers in CCRN studies, as well as a study examining the role of leukotrienes in acute exacerbations of COPD. Finally, I am collaborating with Dr. Susan Janson of the School of Nursing, to test simple interventions to improve adherence in asthma patients in our outpatient clinical programs.
Drazen JM, Israel E, Boushey HA, Chinchilli VM, Fahy JV, Fish JE, Lazarus SC, Lemanske, RF, Martin RJ, Peters SP, Sorkness C, Szefler SJ. Comparison of regularly scheduled with as needed use of albuterol in mild asthma. N. Engl. J. Med 335:841-847, 1996.
Lazarus SC, Wong HH, Watts MJ, Boushey, HA, Lavins BJ, Minkwitz MC. The Leukotriene Receptor Antagonist, Zafirlukast, Inhibits Sulfur Dioxide-Induced Bronchoconstriction in Patients with Asthma, Am J Resp Crit Care Med 156:1725-1730, 1997.
Liu H, Lazarus SC, Caughey GH, Fahy JV. Neutrophil Elastase and Elastase-rich CF Sputum Degranulate Human Eosinophils In Vitro, Am J Physiol: Lung, Cell and Molec Physiol 20:L28-L34, 1999.
Israel E, Drazen JM, Liggett SB, Boushey HA, Cherniack RM, Chinchilli VM, Cooper DM, Fahy JV, Fish JE, Ford JG, Kraft M, Kunselman S, Lazarus SC, Lemanske RF, Martin RJ, McLean DE, Peters SP, Silverman EK, Sorkness CA, Szefler SJ, Weiss ST and Yandava CN. The Effect of Polymorphisms of the ß2-Adrenergic Receptor on the Response to Regular Use of Albuterol in Asthma. Am J Resp Crit Care Med 162:75-80, 2000.
Lazarus SC, Boushey HA, Fahy JV, Chinchilli VM, Lemanske RF, Sorkness C, Kraft M, Fish JE, Peters SP, Craig T, Drazen JM, Ford JG, Israel E, Martin RJ, Mauger EA, Nachman SA, Spahn J, Szefler SJ, for the Asthma Clinical Research Network of the National Heart, Lung, and Blood Instutute. Long Acting ß2-Agonist Monotherapy vs Continued Therapy With Inhaled Corticosteroids in Patients with Persistent Asthma. A Randomized Controlled Trial. JAMA 285: 2583-2593, 2001.
Lemanske RF, Jr., Sorkness CA, Mauger EA, Lazarus SC, Boushey HA, Fahy JV, Drazen JE, Chinchilli VM, Craig T, Fish JE, Ford JG, Israel E, Kraft M, Martin RJ, Nachman S, Peters SP, Spahn JD, Szefler SJ for the Asthma Clinical Research Network of the National Heart, Lung, and Blood Institute. Inhaled Corticosteroid Reduction and Elimination in Patients With Persistent Asthma Receiving Salmeterol. A Randomized Controlled Trial. JAMA 285:2594-2603, 2001.
Fahy JV, Boushey HA, Lazarus SC, Mauger EA, Cherniack RM, Chinchilli VM, Craig TJ, Drazen JM, Ford JG, Fish JE, Israel E, Kraft M, Lemanske RF, Martin RJ, McLean D, Peters SP, Sorkness C, Szefler SJ. Safety and Reproducibility of Sputum Induction in Asthmatic Subjects in a Multicenter Study. Am J Respir Crit Care Med 163(6):1470-1475, 2001.
Burgel P-R, Lazarus SC, Tam DC-W, Ueki IF, Atabai K, Birch M, Nadel JA. Human Eosinophils Induce Mucin Production in Airway Epithelial Cells Via Epidermal Growth Factor Receptor Activation. J Immunol 167:5948-5954, 2001.
Woodruff PG, Khashayar R, Lazarus SC, Janson S, Avila P, Boushey HA, Segal M, Fahy JV. Relationship between airway inflammation, hyperresponsiveness, and obstruction in asthma. J Allergy Clin Immunol 108:753-758, 2001.
Szefler SJ, Martin RJ, King TS, Boushey HA, Cherniack RM, Chinchilli VM, Craig TJ, Dolovich M, Drazen JM, Fagan JK, Fahy JV, Fish JE, Ford JG, Israel E, Kiley J, Kraft M, Lazarus SC, Lemanske RFJr, Mauger E, Peters SP, Sorkness CA. Significant Variability in Response To Inhaled Steroids for Persistent Asthma. J Allergy Clin Immunol 109:410-418, 2002.
Martin RJ, Szefler SJ, Chinchilli VM, Kraft M, Dolovich M, Eng P, Boushey HA, Cherniack RM, Craig TJ, Drazen JM, Fagan JK, Fahy JV, Fish JE, Ford JG, Israel E, Kunselman SJ, Lazarus SC, Lemanske, RF, Peters SP, Sorkness CA. Systemic Effect Comparisons of Six Inhaled Corticosteroid Preparations, Am J Respir Crit Care Med 165:1377-83, 2002.
Kraft M, Martin, RJ, Lazarus SC, Fahy JV, Boushey HA, Lemanske RF, Szefler SJ, et al. Airway Tissue Mast Cells in Persistent Asthma: Predictor of Treatment Failure when Patients Discontinue Inhaled Corticosteroids. Chest. 124:42-50, 2003.
Israel E, Chinchilli VM, Ford JG, Boushey HA, Cherniack R, Craig TJ, Deykin A, Fagan JK, Fahy JV, Fish J, Kraft M, Kunselman SJ, Lazarus SC, Lemanske, RF, Liggett SB, Martin RJ, Mitra N, Peters SP, Silverman E, Sorkness CA, Szefler SJ, Wechsler M, Weiss ST, and Drazen JM. Use of Regularly Scheduled Albuterol Treatment in Asthma: Genotype-Stratified, Randomized, Placebo-Controlled Cross-over Trial Lancet, 364:1505-1512, 2004.
Deykin A, Lazarus SC, Fahy JV, Wechsler M, Boushey HA, Chinchilli VM, Craig T, Dimango E, Kraft M, Leone F, Lemanske RF, Martin RJ, Pesola G, Peters SP, Sorkness CA, Szefler SJ, Israel E: Sputum Eosinophils Predict Asthma Control After Discontinuation of Inhaled Corticosteroids. J Allergy Clin Immunol 115:720-7, 2005.
Boushey HA, Sorkness CA, King TS, Sullivan SD, Fahy JV, Lazarus SC, Chinchilli VM, Craig TJ, DeMango EA, Deykin A, Fagan JK, Fish JE, Ford JG, Kraft M, Lemanske RF, Leone FT, Martin RJ, Mauger EA, Pesola GR, Peters SP, Rollings NJ, Szefler SJ, Wechsler ME, Israel E: Regular Controller Therapy versus Intermittent Inhaled Corticosteroids for Mild Persistent Asthma. N Engl J Med 352:1519-28, 2005.
Wechsler M, Lehman E, Lazarus SC, Lemanske RF, Boushey HA, Deykin A, Fahy JV, Sorkness CA, Chinchilli VM, Craig T, Dimango E, Kraft M, Leone F, Martin RJ, Peters SP, Szefler SJ, Liu W, Israel E. ß-adrenergic Receptor Polymorphisms and Response to Salmeterol. Am J Respir Crit Care Med 173:519-26, 2006.
Innes AL, Woodruff PG, Ferrando RE, Donnelly S, Dolganov GM, Lazarus SC, Fahy JV. Epithelial mucin stores are increased in the large airways of smokers with airflow obstruction. Chest 130:1102-8, 2006.
Martin RJ, Szefler SJ, King TS, Kraft M, Boushey HA, Chinchilli VM, Craig TJ, DiMango EA, Deykin A, Fahy JV, Israel E, Lazarus SC, Lemanske RF, Leone FT, Pesola GR, Peters SP, Sorkness CA, Szwejbka LA, Wechsler ME: Predicting Response to Corticosteroid Efficacy: The Predicting Response to Inhaled Corticosteroid (PRICE) Trial. J Allergy Clin Immunol 119:73-80, 2007.
Lazarus SC, Chinchilli VM, Rollings NJ, Boushey HA, Cherniack R, Craig TJ, Deykin A, DiMango E, Fish JE, Ford JG, Israel E, Kiley J, Kraft M, Lemanske RF, Leone F, Martin RJ, Pesola GR, Peters SP, Sorkness C, Szefler SJ, Wechsler M, Fahy JV: Smoking Affects Response to Inhaled Corticosteroids or Leukotriene Receptor Antagonists in Asthma. Am J Respir Crit Care Med, 175:783-790, 2007.
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