Mark R. Looney, MD is Assistant Adjunct Professor of Medicine and Attending Physician on the Pulmonary Consultation Service and the Intensive Care Units at UCSF. He received his undergraduate degree from Lipscomb University in Nashville, Tennessee and his medical degree from the University of Tennessee, Memphis. He then came to UCSF where he completed his residency in Internal Medicine and a fellowship in Pulmonary and Critical Care Medicine. Since 2003, he has conducted research in the Cardiovascular Research Institute in the laboratory of his mentor, Michael A. Matthay, MD.
Research Interests
I have directed my clinical interest in acute lung injury into a research program investigating the mechanisms responsible for pulmonary insufficiency secondary to hemotherapy. I have developed a mouse model of transfusion-related acute lung injury (TRALI), replicating many features of the human condition, which I am using to dissect the cellular and molecular pathways that lead to lung injury. Clinically, I am prospectively enrolling patients in an observational cohort study of TRALI in conjunction with the UCSF TRALI SCCOR grant.
Recent publications
Looney MR, Matthay MA. The role of protein C in sepsis. Curr Infect Dis Rep 3(5):413-418, 2001.
Su X, Looney M, Robriquet L, Fang X, Matthay MA. Direct visual instillation as a method for efficient delivery of fluid into the distal airspaces of anesthetized mice. Exp Lung Res30:479-493, 2004.
Looney MR, Sartori C, Chakraborty S, James PF, Lingrel JB, Matthay MA. Decreased expression of both the alpha1- and alpha2-subunits of the Na-K-ATPase reduces maximal alveolar epithelial fluid clearance. Am J Physiol Lung Cell Mol Physiol 289:L104-10, 2005.
Looney MR and Matthay MA. Animal models of transfusion-related acute lung injury. Crit Care Med (in press).
Church GD, Price C, Sanchez R, Looney MR. Transfusion-related acute lung injury in the pediatric patient: two case reports and a review of the literature. Transfus Med (in press).
Looney MR, Su X, Van Ziffle JA, Lowell CA, Matthay MA.† Neutrophils and their Fcg receptors are essential in a mouse model of transfusion-related acute lung injury. J Clin Invest 116(6):1615-1623, 2006.
Looney MR.† Newly recognized causes of acute lung injury: transfusion of blood products, severe acute respiratory syndrome, and avian influenza.† Clin Chest Med 27(4):591-600, 2006.
Looney MR and Matthay MA.† The role of activated protein C in maintaining endothelial tight junction function and its relationship to organ injury.† Crit Care 10(6):239-244, 2006.
