Michael A. Matthay, MD
Professor in Residence

University of California San Francisco
505 Parnassus Avenue
Box 0624, Rm. M917
San Francisco, California 94143
phone: 415-353-1206
fax: 415-353-1990
email: michael.matthay@ucsf.edu

Michael A. Matthay, MD is a Professor of Medicine and Anesthesia at the University of California at San Francisco and a Senior Associate at the Cardiovascular Research Institute. He is Director of the Critical Care Medicine Training in the Department of Medicine and Associate Director of the Intensive Care Unit. He received his AB from Harvard University in 1969 and his MD from the University of Pennsylvania School of Medicine in 1973. Dr. Matthay received clinical training in Internal Medicine at the University of Colorado from 1973-76 and in Pulmonary and Critical Care Medicine from the University of California at San Francisco from 1977-78. He also received research training from the Cardiovascular Physiology Laboratory, University of Colorado in 1976 and the Cardiovascular Research Institute from 1978-79.
Just recently, Michael Matthay was selected in 2006 by the Academic Senate as the recipient of the Sixth Annual Distinguished Clinical Research Lectureship.

Research Interests

My basic research is focused on active ion and water transport mechanisms that account for the resolution of pulmonary edema as well as mechanisms that account for alveolar epithelial repair after acute lung injury. The studies are carried out in several in vivo and in vitro models. My clinical research is focused on the mechanisms that account for the pathogenesis and resolution of clinical acute lung injury and pulmonary edema. We have a new interest in the role of mesenchymal stem cells for acute lung diseaseMy laboratory has approximately 8-10 fellows with a mixture of PhD and MD fellows with weekly research conferences that include both basic and clinical research topics.

Selected References from Basic Research

1. Pittet JF, Wiener-Kronish JP, McElroy MC, Folkesson HG, Matthay MA: Stimulation of alveolar epithelial liquid clearance by endogenous release of catecholamines in septic shock. Journal of Clinical Investigation 94:663-671, 1994.
2. Matthay MA, Folkesson HG, Clerici C: Lung epithelial fluid transport and the resolution of pulmonary edema. Physiological Reviews 82:569-600, 2002.
3. Matthay MA, Zimmerman GA: Acute lung injury and the acute respiratory distress syndrome: four decades of inquiry into pathogenesis and rational management. American Journal of Respiratory Cell Molecular Biology 33(4):319-27, 2005
4. Lee JW, Fang X, Dolganov G, Fremont RD, Bastarache JA. Ware LB, Matthay MA: Acute lung injury edema fluid decreases net fluid transport across human alveolar epithelial type II cells. Journal of Biological Chemistry 282(33):24109-19, 2007
5. Gupta N, Su X, Popov B, Lee JW, Serikov V, Matthay MA: Intrapulmonary delivery of bone marrow-derived mesenchymal stem cells improves survival and attenuates endotoxin-induced acute lung injury in mice. Journal of Immuonlogy 1:179(3):1855-63, 2007

Selected References from Clinical Research

1. Rubin DB, Wiener-Kronish JP, Murray JF, Turner J, Luce JM, Montgomery AB, Marks JD, Matthay MA: Elevated von-Willebrand factor antigen is an early plasma predictor of impending acute lung injury and death in non-pulmonary sepsis syndrome. Journal of Clinical Investigation 86:474-480, 1990.
2. Folkesson HG, Matthay MA, Hébert C, Broaddus VC: Acid aspiration-induced lung injury in rabbits is mediated by interleukin-8-dependent mechanism. Journal of Clinical Investigation 96:107-116, 1995.
3. Doyle RL, Szaflarski N, Modin GW, Wiener-Kronish JW, Matthay MA: Identification of patients with acute lung injury: predictors of mortality. American Journal of Respiratory and Critical Care Medicine 152:1818-24, 1995.
4. Pittet JF, Mackersie RC, Martin TR, Matthay MA: Biological markers of acute lung injury: prognostic and pathogenetic significance. American Journal of Respiratory and Critical Care Medicine 155:1187-1205, 1997.
5. Pugin J, Verghese G, Widmer M-C, Matthay MA: The alveolar space is the site of intense inflammatory and profibrotic reactions in the early phase of ARDS. Critical Care Medicine 27:304-312, 1999.
6. The Acute Respiratory Distress Syndrome Network. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. New England Journal of Medicine 342:1301-1308, 2000.
7. Ware L.B., Matthay MA. The acute respiratory distress syndrome. New England Journal of Medicine 342:1334-1349, 2000.
8. Matthay MA. Sepsis Syndrome — A new treatment with both anticoagulant and antiinflammatory properties. New England Journal of Medicine 344:759-762, 2001.
9. Ware LB, Matthay MA: Alveolar fluid clearance is impaired in the majority of patients with acute lung injury and the acute respiratory distress syndrome. American Journal of Critical Care Medicine 163:1376-83, 2001.
10. Nuckton TJ, Alonso JA, Kallet RH, Daniel BM, Pittet JF, Eisner MD, Matthay MA: Pulmonary dead-space fraction as a risk factor for death in the acute respiratory distress syndrome. New England Journal of Medicine 346:1281-6, 2002.
11. Matthay MA, Ware LB: Can nicotine treat sepsis? Nature Medicine 10:1161-2, 2004.
12. Curley MA, Hibberd PL, Fineman LD, Wypij D, Shih MC, Thompson JE, Grant MJ, Barr FE, Cvijanovich NZ, Sorce L, Luckett PM, Matthay MA, Arnold JH: Effect of prone positioning on clinical outcomes in children with acute lung injury: a randomized controlled trial. Journal of the American Medical Association 294:229-37, 2005.
13. Ware LB, Matthay MA: Clinical Practice. Acute pulmonary edema. New England Journal of Medicine 29;353(26):2788-96, 2005
14. Matthay MA, Su X: Pulmonary barriers to pneumonia and sepsis. Nature Medicine. 12(7):780-1, 2007

Last Update: 2/21/08->