University of California San Francisco
San Francisco General Hospital
Box 0854, Bldg 1-150
San Francisco, California 94143
Laboratory Phone: (415) 206-5902
Clinical Phone: (415) 206-6233
email: dmorris@itsa.ucsf.edu

Dr. Morris received his medical degree with Distinction in Research from the University of Rochester School of Medicine and Dentistry, and completed residency in Internal Medicine at the Massachusetts General Hospital. He came to UCSF in 1996 as a fellow in Pulmonary and Critical Care Medicine and joined the faculty of the division in 2001. He is the Director of the Interstitial Lung Disease Program at the San Francisco General Hospital. His major academic interests are in the areas of lung remodeling.

Research Interests

Remodeling of the adult lung is a complex process that is pivotal in a variety of diseases including pulmonary fibrosis and emphysema. Dr. Morris’ recent work has focused on the role of an epithelial integrin, avb6, in the modulation of alveolar macrophage function. In transgenic and knock-out animals, this interaction regulates the balance between proteolytic and pro-fibrotic processes in the lung. In addition, he is developing a translational research program at San Francisco General Hospital as part of the UCSF Center for Fibrotic Lung Diseases. The focus of work in this area is on dissecting the molecular pathways involved in the initiation, propagation and resolution of lung fibrosis.

Recent Publications

Kaminski, N. , Allard, J., Pittet, J.F., Zuo, F., Griffiths, M. J. D., Morris, D., Huang, X., Sheppard, D.,. Heller, R. A (2000) Global analysis of gene expression in pulmonary fibrosis reveals distinct programs regulating lung inflammation and fibrosis. Proc. Nat. Acad. Sci. 97 (4): 1778-1783.

Morris, D. and B. T. Thompson (1997) Asthma. In Quick Consult Manual of Evidence-Based Medicine, Eds. B. W. Lee, S. I. Hsu and D. S. Stasior. Lippincott-Raven, Philadelphia, PA.

Morris, D. and B. T. Thompson (1997) Chronic Obstructive Pulmonary Disease. In Quick Consult Manual of Evidence-Based Medicine, Eds. B. W. Lee, S. I. Hsu and D. S. Stasior. Lippincott-Raven, Philadelphia, PA.

Ron, D., D. Bottaro, P. Finch, D. Morris, J. Rubin, and S. Aaronson (1993) Expression of Biologically Active Recombinant Keratinocyte Growth Factor, Journal of Biological Chemistry 268 (4), pp. 2984 -2988.