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Dr. Nadel received his MD degree from Jefferson Medical College in 1953. After internal medical training and research training with Julius Comroe at the University of California, San Francisco (UCSF) he joined the faculty at the University of California and became Chief of the Section of Pulmonary Diseases in 1968 and Professor of Medicine and Physiology. His major academic activities include laboratory research, directorship of the UCSF NIH Multidisciplinary Pulmonary Research Training Program, Co-editor of the Textbook of Respiratory Medicine, and various advisory and editorial committees.
In 2008 Dr. Nadel was awarded the President’s Medal, European Respiratory Society (ERS), by Dr. Leo Fabbri, President of the ERS.
Dr. Nadel has been appointed as Assistant Health Minister of Health of Kosovo. In this position, he will help to design programs for battling infectious diseases of the newborn and to help organize community clinics in this new country.
The René Descartes award was presented to Professor Nadel in 2007, by the President of the University of Paris, Jean-Francois Dhainaut. The award is made for outstanding contributions to the University of Paris. Professor Nadel has mentored many academicians in Paris, and he is an active collaborator with researchers in Paris.
In addition to his continuing contributions to basic research and its utilization in clinical medicine, Prof. Nadel has been devoted to teaching and mentoring young academicians. He has supervised approximately 150 young academicians in his laboratory and mentors many young professors throughout the world. His devotion to mentoring and research collaboration played important roles in his receiving he René Descartes Medal.
“Invaders” from the environment (eg, viruses, bacteria, cigarette smoke, allergens, occupational irritants) invade the host after deposition on the airway epithelial surface. The epithelium responds to these invaders by intercepting the signals and developing a series of defensive responses that include leukocyte mobilization, the production of antibacterial peptides, mucin production (to aid in trapping and clearing of foreign particulates). These so-called “innate immune responses” also include healing of wounded epithelium via epithelial proliferation and production of new blood vessels (angiogenesis). Normally, these host responses prevent invasion with few symptoms. However, occasionally overexuberant inflammatory responses occur, leading to chronic inflammatory diseases [eg, asthma, chronic obstructive pulmonary diseases (COPD), cystic fibrosis] or overexuberant proliferative responses (cancer).
Over the past several years, my laboratory has discovered a series of signaling pathways responsible for multiple epithelial defensive responses. We have developed therapies for blocking the exuberant responses, which we believe to be important in the pathogenesis of chronic airway diseases.
Takeyama K, Dabbagh K, Lee H-M, Agustí C, Lausier JA, Ueki IF, Grattan KM, Nadel JA. Epidermal growth factor system regulates mucus production in airways. Proc Nat Acad Sci, 96:3081-3086, 1999.
Takeyama K, Dabbagh K, Shim JJ, Dao-Pick T, Ueki IF, Nadel JA. Oxidative stress causes mucin synthesis via transactivation of epidermal growth factor receptor: role of neutrophils. J Immunol, 164:1546-1552, 2000.
Shim JJ, Dabbagh K, Ueki IF, Dao-Pick T, Burgel P-R, Takeyama K, Tam D C-W, Nadel JA. Interleukin-13 induces mucin production by stimulating epidermal growth factor receptors and by activating neutrophils. Am J Physiol: Lung Cell Mol Physiol, 280:L134-L140, 2001.
Shao MXG, Ueki IF, Nadel JA. Tumor necrosis factor-alpha converting enzyme (TACE) mediates MUC5AC expression in cultured airway epithelial cells. Proc Nat Acad Sci, 100:11618-11623, 2003.
Shao MXG, Nakanaga T, Nadel JA. Cigarette smoke induces MUC5AC mucin overproduction via tumor necrosis factor-a converting enzyme in human airway epithelial cells. Am J Physiol: Lung Cell Mol Physiol, 287:L420-L427, 2004.
Kim S, Schein AJ, Nadel JA. E-cadherin promotes EGFR-mediated cell differentiation and MUC5AC mucin expression in cultured human airway epithelial cells. Am J Physiol: Lung Cell Mol Physiol, 289:1049-1060, 2005.
Shao MXG, Nadel JA. Dual oxidase 1-dependent MUC5AC mucin expression in cultured human airway epithelial cells. Proc Nat Acad Sci, 102:767-772, 2005.
Shao MXG, Nadel JA. Neutrophil elastase induces MUC5AC mucin production in human airway epithelial cells via a cascade involving protein kinase C, reactive oxygen species, and tumor necrosis factor-alpha-converting enzyme. J Immunol, 175:4009-4016, 2005.
Finzi L, Barbu V, Burgel P-R, Mergey M, Kirkwood K S, Wick EC, Scoazec J-V, Peschaud F, Paye F, Nadel JA, Housset C. MUC5AC, a gel-forming mucin accumulating in gallstone disease, is overproduced via an EGF-R pathway in the human gallbladder. Am J Path, 169:2031-2041, 2006.
Koff JL, Shao MXG, Kim S, Ueki IF, Nadel JA. Pseudomonas Lipopolysaccharide accelerates wound repair via activation of a novel epithelial cell signaling cascade. J Immunol, 177:8693-8700, 2006.
Burgel P-R, Montani D, Danel C, Dusser DJ, Nadel JA. A morphometric study of mucins and small airway plugging in cystic fibrosis. Thorax, 62:153-161, 2007.
Nakanaga T, Nadel JA, Ueki IF, Koff JL, Shao MXG. Regulation of interleukin-8 via an airway epithelial signaling cascade. Am J Physiol: Lung Cell Mol Physiol, 292:L1289-1296, 2007.
DeshmukhH, ShaverC, CaseL, DietschM, WesselkamperS, HardieW, KorfhagenT, CorradiM, NadelJ, BorchersM, Leikauf G. Acrolein-activated matrix metalloproteinase 9 contributes to persistent mucin production. AJRCMB, 38:446-454, 2008.
Koff JL, Shao XG, Ueki IF, Nadel JA. Multiple TLRs activate EGFR via a signaling cascade to produce innate immune responses in airway epithelium. Am J Physiol Lung Cell Mol Physiol, 294:L1068-1075, 2008.
Finzi L, Shao M, Paye F, Housset C, Nadel JA. LPS initiates a positive feedback loop between the EGF-R and the COX-2/PGE2 signaling pathways in biliary carcinoma cells. J Immunol, 182:2269-2276 2009.
Burgel P, Nadel JA. Roles of epidermal growth factor receptor activation in epithelial cell repair and mucin production in airway epithelium. In: Thorax 59:992-996, 2004,
Kim S, Nadel JA. Role of neutrophils in mucus hypersecretion in COPD and implications for therapy. In: Treatments in Respiratory Medicine 3:147-159, 2004.
Nadel JA, Introduction. In: Asthma in the Workplace, Bernstein L, Chan-Yeung M, Malo J-L, Bernstein DI, eds., Marcel Dekker, New York, 3rd Edition, 2005
Murray JF, Nadel JA, eds. Textbook of Respiratory Medicine Elsevier Saunders Co., Philadelphia, 4th Edition, 2005
Kim S, Shao MXG, Nadel JA. Mucus Production, Secretion, and Clearance. In: Textbook of Respiratory Medicine, Medicine Elsevier Saunders Co., Philadelphia, 4th Edition, 2005.
Nadel JA. Role of epidermal growth factor receptor cascade in airway epithelial regulation of mucus secretion. In: Allergy Frontiers: Epigenetics to Future Perspectives. Volume 2. Pawankar R, Holgate S, Rosenwasser R, eds., Springer, Tokyo (in press 2007).
Burgel, P-R, Nadel, JA. Epidermal growth factor receptor-mediated innate immune responses and their roles in airway diseases. Eur Respir J, 32:1068-1081, 2008.
Nadel JA. Epidermal Growth Factor Receptor Cascade is Responsible for Airway Mucin Production: Signalling pathway and Clinical implications. In: Structure/Function of Mucins: Roles in Cancer and Inflammatory Diseases. Van Seuningen I, ed., Signposts, Kerala, pp. 157-168, 2008. |
