Dr. Nahid is Assistant Professor of Medicine in the Division of Pulmonary and Critical Care Medicine at UCSF, Director of the Chest and High Risk Asthma Clinic and Attending Physician on the Pulmonary Consultation Service and the Intensive Care Units at San Francisco General Hospital. Dr. Nahid received his undergraduate degree and medical degree from University of California, Irvine. He completed residency and chief residency in Internal Medicine at Scripps Clinic and Research Foundation in San Diego, and his fellowship in Pulmonary and Critical Care Medicine at UCSF. Since 2002, he has conducted clinical research in tuberculosis under the tutelage of his mentor, Philip C. Hopewell.
Research Interests
Although the past decade has seen substantial progress in the development and implementation of the strategies necessary for effective global tuberculosis control, the disease remains an enormous and growing global health problem, killing nearly 2 million people each year. The parallel pandemic of HIV infection has contributed to a resurgence of tuberculosis in many areas of the world. Moreover, in some areas, levels of multidrug drug resistant (MDR) tuberculosis have reached alarming levels. The emergence of extensively drug-resistant (XDR) tuberculosis, or MDR tuberculosis that is also resistant to a fluoroquinolone and at least one of three injectable second-line drugs, has brought about additional challenges in the pursuit of controlling and ultimately eliminating tuberculosis. To gain true control of tuberculosis and to meet the target established by the WHO to reduce the global incidence of tuberculosis to less than 1 per million by the year 2050, new tools – drugs, diagnostic tests, and an effective vaccine – will be necessary.
Dr. Nahid’s research interests are multifaceted in that they include clinical, translational and public health components. As the San Francisco site director of the multicenter Tuberculosis Trials Consortium (TBTC), Dr. Nahid is actively involved in clinical studies of new treatment regimens. This consortium is funded by the Centers for Disease Control and Prevention and is currently involved in several randomized clinical trials of new regimens for active tuberculosis, pharmacokinetic studies of new drugs, and a new rifapentine-based regimen for treatment of latent infection.
Dr. Nahid is also involved in translational research that seeks to establish the existence of differential susceptibility to M. tuberculosis. The intent of his research is to explore the interactions between strains of M. tuberculosis and hosts of differing ethnicities –specifically to determine whether the genetically diverse strains of M. tuberculosis induce different innate and adaptive immune responses amongst and between select ethnicities. The discovery of potential ethnic-specific susceptibility and resistance for particular strains of M. tuberculosis has significant public health implications as it may pave the way for tailoring vaccines to specific populations.
Select Publications
Jasmer RM, Nahid P, Hopewell PC. Clinical practice. Latent tuberculosis infection. N Engl J Med 2002; 347:1860-6.
Nahid P, Pai M, Hopewell PC: Advances in the diagnosis and treatment of tuberculosis. Proc Am Thorac Soc 3:103-10, 2006.
Nahid P, Daley CL: Prevention of tuberculosis in HIV-infected patients. Curr Opin Infect Dis 19:189-193, 2006.
Nyamathi A, Christiani A, Nahid P, Gregerson P, Leake B. A randomized controlled trial of two treatment programs for homeless adults with latent tuberculosis infection. Int J Tuberc Lung Dis. 2006 Jul;10(7):775-82.
Nahid P, Gonzalez LC, Rudoy I, de Jong B, Unger A, Kawamura LM, Daley CL. Treatment Outcomes of Patients with Tuberculosis and HIV. Am J Respir Crit Care Med. Jun 1;175(11):1199-206 2007
Walter ND, Jasmer RM, Grinsdale J, Kawamura LM, Hopewell PC, Nahid P. Reaching the limits of tuberculosis prevention among foreign-born individuals: a tuberculosis-control program perspective. Clin Infect Dis. 2008 Jan 1;46(1):103-6.
Cattamanchi A, Nahid P, Marras TK, Gotway MB, Lee TJ, Gonzalez LC, Morris A, Webb WR, Osmond DH, Daley CL. Detailed analysis of the radiographic presentation of Mycobacterium kansasii lung disease in patients with HIV infection. Chest. 2008 Apr;133(4):875-80.
