|
Dr. Wei received in her
M.D. degree from Shanghai Medical University, Shanghai, People’s
Republic of China, in 1991. After research training at Shanghai
Institute of Cell Biology, Academic sinica, she joined Dr. Chapman’s
Lab of Harvard Medical School at the Brigham and Women’s
Hospital in 1993 and was appointed Instructor of Medicine in 1997.
She became a faculty member of the Pulmonary and Critical Care
Division at University of California at San Francisco in 2001.
Her major academic interests are in the areas of adhesion receptors
and tissue remodeling.
The main interest is focused on the glycolipid-anchored urokinase
receptor (uPAR) and its associated proteins in lung inflammation
and cancer metastasis. uPAR, a multifunctional protein, is believed
to associate with the integrin adhesion receptor superfamily,
coordinating signaling for cell adhesion, migration and growth,
therefore, influencing cellular behavior in angiogenesis, inflammation,
wound repair and tumor progression. Another focus is to define
the physical interaction site on uPAR with b1-integrins and look
for approaches that have uPAR-based therapeutic potential in cancers.
Wei Y, Lukasev M, Simon DI, Bodary SC, Rosenburg S, Doyle MV,
and Chapman HA. Regulation of integrin function by the urokinase
receptor. Science 1996; 273:1551-1555.
Simon DI, Rao NK, Xu H, Wei Y, Majdic O, Ronne E, Kobzik L, and
Chapman HA. Mac-1 (CD11b/CD18) and the urokinase receptor (CD87)
form a functional unit on monocytic cells. Blood 1996; 88:3185-3194.
Waltz DA, Natkin LR, Fujita RM, Wei Y, and Chapman HA. Plasmin
and plasminogen activator inhibitor type I promote cellular motility
by regulating the interaction between the urokinase receptor and
vitronectin. J Clin Invest 1997; 100:58-67.
Wei Y, Yang XW, Liu QM, Wilkins JA, and Chapman HA. Role for caveolin
in b1 integrin and urokinase receptor-mediated cell adhesion.
J Cell Biol 1999; 144:1285-1294.
Chapman HA, Wei Y, Simon DI, and Waltz DA. Role of urokinase receptor
and caveolin in regulation of integrin signaling. Review. Thromb
Haemost 1999; 82: 291-7.
Simon DI, Wei Y, Chen Z, Rao NK, Rosenberg S, and Chapman HA.
Identification of a urokinase receptor-integrin interaction site:
promiscuous regulator of integrin function. J Biol Chem 2000;
275: 10228-10234.
Chapman HA and Wei Y. Protease crosstalk with integrins: the urokinase
receptor paradigm. Review. Thromb Haemost 2001; 86:124-129.
Wei Y, Eble JA, Wang ZM, Kreidberg JA, and Chapman HA. Urokinase
receptors promote beta1 integrin function through interactions
with the integrin alpha3beta1. Mol Biol Cell 2001; 12: 2975-2986.
Feng Z, Tom CC, Kugler MC, Ching TT, Kreidberg JA, Wei Y, and
Chapman HA. Distinct ligand binding sites in integrin alpha3beta1
regulate matrix adhesion and cell-cell contact. J Cell Biol 2003;
163: 177-188
Wei, Y; Czekay, RP; Robillard, L; Kugler, MC; Zhang, F; Kim, KK; Xiong, JP; Humphries, MJ; Chapman, HA. Regulation of Alpha5_eta1 Integrin Conformation and Function by Urokinase Receptor Binding. J. Cell Biol. 2005; 168: 501-511 (Co-correspondence Author)
Ghosh S; Johnson JJ, Sen R; Mukhopadhyay S; Liu YY; Zhang, F; Wei, Y; Chapman, HA and Stack, MS. Functional Relevance of Urinary-type Plasminogen Activator Receptor (uPAR)-a3b1 Integrin Association in Proteinase Regulatory Pathways. J. Biol. Chem. 2006; 281: 13021-9
Wei, Y; Tang, CH; Kim, Y; Robillard, L; Zhang F; Kugler MC; and Chapman, HA. Urokinase Receptors Are Required for Alpha5beta1 Integrin-mediated Signaling in Tumor Cells. J. Biol. Chem. 2007; 282: 3929-39 (Co-correspondence Author) |
