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Dr. Woodruff received his B.A, from Wesleyan University in 1989,
received his M.D. degree from the Columbia College of Physicians
and Surgeons in 1993, and completed Internal Medicine residency
training at the Massachusetts General Hospital. After residency
training, he obtained research training as a Research Fellow in
the Channing Laboratory, Division of Respiratory Epidemiology,
at the Brigham and Women’s Hospital, and pursued graduate
studies leading to a Masters in Public Health from the Harvard
School of Public Health in 1998. He undertook fellowship training
in Pulmonary and Critical Care Medicine here at UCSF beginning
in 1998 and joined the UCSF faculty in 2002. He is currently an
Assistant Professor of Medicine in the Department of Medicine
and is an investigator in the Airway Clinical Research Center
as well as the General Clinical Research Center.
My research activity encompasses both clinical and bench research into the
mechanisms of diseases of the airways and, consequently, much of it falls
under the rubric of "translational research". In these studies, I am interested
in understanding the mechanisms of inflammation, airway remodeling, and airway
hyperresponsiveness in asthma and chronic obstructive pulmonary disease. These
studies are performed in the Airway Clinical Research Center here at UCSF and
in the General Clinical Research Unit at the UCSF Parnassus campus where I am
an investigator. A major focus of my recent work has been gene expression
profiling in tissues obtained at fiberoptic bronchoscopy. Recent applications
have included studies of airway smooth muscle structure and phenotype in
airway diseases and studies of alveolar macrophage activation in smoking
related lung disease. From the purely clinical research perspective, I am a
Co-investigator in the NIH/NHLBI COPD Clinical Research Network which is
currently designing protocols for multicenter-clinical trials in the therapy
of COPD.
Dolganov GM, Woodruff PG, Novikov AA, Zhang Y, Ferrando RE, Szubin R, Fahy JV. A Novel Method of Gene Transcript Profiling in Airway Biopsy Homogenates Reveals Increased Expression of a Na+-K+-Cl Cotransporter (NKCC1) in Asthmatic Subjects. Genome Res 2001; 11:1473-1483.
Woodruff PG, Fahy JV. Asthma: prevalence, pathogenesis, and prospects for novel therapies. JAMA 2001; 286:395-8.
Woodruff PG, Khashayar R, Lazarus SC, Janson S, Avila P, Boushey HA, Segal M, Fahy JV. Relationship between airway inflammation, hyperresponsiveness, and obstruction in asthma. J Allergy Clin Immunol. 2001;108: 753-8.
Hays SR, Woodruff PG, Khashayar R, Ferrando RE, Liu J, Fung P, Chang QZ, Wong HH, Fahy JV. Allergen challenge causes inflammation but not goblet cell degranulation in asthmatic subjects. J Allergy Clin Immunol. 2001;108: 784-90.
Woodruff PG, Fahy JV. A role for neutrophils in asthma? Am J Med. 2002;112:498-500.
Woodruff PG, Fahy JV. Airway remodeling in asthma. Semin Resp Crit Care Med. 2002; 361-368.
Ferris TG, Blumenthal D, Woodruff PG, Clark S, Camargo CA. Insurance and quality of care for adults with acute asthma. J Gen Intern Med. 2002;17:905-13.
Silverman RA, Boudreaux ED, Woodruff PG, Clark S, Camargo CA Jr. Cigarette smoking among asthmatic adults presenting to 64 emergency departments. Chest. 2003;23:1472-9.
Ferrando RE, Nyengaard JR, Hays SR, Fahy JV, Woodruff PG. Applying stereology to measure thickness of the basement membrane zone in bronchial biopsies. J Allergy Clin Immunology 2003; 122, 1241-2.
Kalayci O, Sonna LA, Woodruff PG, Camargo CA Jr, Luster AD, Lilly CM. Monocyte chemotactic protein-4 (MCP-4; CCL-13): a biomarker of asthma. J Asthma. 2004 Feb;41(1):27-33.
Woodruff PG, Dolganov GM, Ferrando RE, Donnelly S, Hays SR, Solberg OD, Carter R, Wong HH, Cadbury PS, Fahy JV. Hyperplasia of smooth muscle in mild/moderate asthma without changes in cell size or gene expression. Am J Respir Crit Care Med. 2004 May 1;169(9):1001-6.
Kotlikoff MI, Kannan MS, Solway J, Deng KY, Deshpande DA, Dowell M, Feldman M, Green KS, Ji G, Johnston R, Lakser O, Lee J, Lund FE, Milla C, Mitchell RW, Nakai J, Rishniw M, Walseth TF, White TA, Wilson J, Xin HB, Woodruff PG. Methodologic advancements in the study of airway smooth muscle. J Allergy Clin Immunol. 2004 Aug;114 (2 Pt 2):S18-S31.
Hays SR, Ferrando RE, Carter R, Wong HH, Woodruff PG. Structural Changes to Airway Smooth Muscle in Cystic Fibrosis Thorax. 2005 Mar;60(3):181-2.
Woodruff PG, Koth LL, Yang YH, Rodriguez MW, Favoreto S, Dolganov GM, Paquet A, Erle DJ. A Distinctive Alveolar Macrophage Activation State Induced by Cigarette Smoking. Am J Respir Crit Care Med; 2005 [in Press].
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