Prescott Woodruff, M.D., M.P.H
Assistant Professor in Residence

University of California San Francisco
505 Parnassus Avenue, Room M1093
Box 0111
San Francisco, California 94143
phone: 415-514-2061
fax: 415-476-0752
email: prescott.woodruff@ucsf.edu

lab: http://woodrufflab.ucsf.edu/index.html

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  Dr. Woodruff received his B.A, from Wesleyan University in 1989, received his M.D. degree from the Columbia College of Physicians and Surgeons in 1993, and completed Internal Medicine residency training at the Massachusetts General Hospital. After residency training, he obtained research training as a Research Fellow in the Channing Laboratory, Division of Respiratory Epidemiology, at the Brigham and Women’s Hospital, and pursued graduate studies leading to a Masters in Public Health from the Harvard School of Public Health in 1998. He undertook fellowship training in Pulmonary and Critical Care Medicine here at UCSF beginning in 1998 and joined the UCSF faculty in 2002. He is currently an Assistant Professor of Medicine in the Department of Medicine and is an investigator in the Airway Clinical Research Center as well as the General Clinical Research Center.
  
  Research Interests
  
  My research activity encompasses both clinical and bench research into the mechanisms of diseases of the airways and, consequently, much of it falls under the rubric of "translational research". In these studies, I am interested in understanding the mechanisms of inflammation, airway remodeling, and airway hyperresponsiveness in asthma and chronic obstructive pulmonary disease. These studies are performed in the Airway Clinical Research Center here at UCSF and in the General Clinical Research Unit at the UCSF Parnassus campus where I am an investigator. A major focus of my recent work has been gene expression profiling in tissues obtained at fiberoptic bronchoscopy. Recent applications have included studies of airway smooth muscle structure and phenotype in airway diseases and studies of alveolar macrophage activation in smoking related lung disease. From the purely clinical research perspective, I am a Co-investigator in the NIH/NHLBI COPD Clinical Research Network which is currently designing protocols for multicenter-clinical trials in the therapy of COPD.
  
  Recent Publications
  
• Dolganov GM, Woodruff PG, Novikov AA, Zhang Y, Ferrando RE, Szubin R, Fahy JV A Novel Method of Gene Transcript Profiling in Airway Biopsy Homogenates Reveals Increased Expression of a Na+-K+-Cl Cotransporter (NKCC1) in Asthmatic Subjects. Genome Res 2001; 11:1473-1483.
• Woodruff PG, Khashayar R, Lazarus SC, Janson S, Avila P, Boushey HA, Segal M, Fahy JV. Relationship between airway inflammation, hyperresponsiveness, and obstruction in asthma. J Allergy Clin Immunol.2001;108: 753-8.
• Hays SR, Woodruff PG, Khashayar R, Ferrando RE, Liu J, Fung P, Chang QZ, Wong HH, Fahy JV.  Allergen challenge causes inflammation but not goblet cell degranulation in asthmatic subjects. J Allergy Clin Immunol. 2001;108: 784-90.
• Woodruff PG, Fahy JV.  Asthma: prevalence, pathogenesis, and prospects for novel therapies. JAMA 2001; 286:395-8.
• Woodruff PG, Fahy JV. A role for neutrophils in asthma?  Am J Med. 2002:112(6):498-500
• Weber EJ, Silverman RA, Callaham ML, Pollack CV, Woodruff PG, Clark S, Camargo CA Jr.  A prospective multicenter study of factors associated with hospital admission among adults with acute asthma. Am J Med. 2002 Oct 1;113(5):371-8.
• Silverman RA, Boudreaux ED, Woodruff PG, Clark S, Camargo CA Jr. Cigarette smoking among asthmatic adults presenting to 64 emergency departments. Chest. 2003 May;123(5):1472-9.
• Ferrando RE, Nyengaard JR, Hays SR, Fahy JV, Woodruff PG. Applying stereology to measure thickness of the basement membrane zone in bronchial biopsy specimens. J Allergy Clin Immunol. 2003 Dec;112(6):1243-5.
• Woodruff PG, Dolganov GM, Ferrando RE, Donnelly S, Hays SR, Solberg OD, Carter R, Wong HH, Cadbury PS, Fahy JV. Hyperplasia of smooth muscle in mild to moderate asthma without changes in cell size or gene expression. Am J Respir Crit Care Med. 2004 May 1;169(9):1001-6.
• Kotlikoff MI, Kannan MS, Solway J, Deng KY, Deshpande DA, Dowell M, Feldman M, Green KS, Ji G, Johnston R, Lakser O, Lee J, Lund FE, Milla C, Mitchell RW, Nakai J, Rishniw M, Walseth TF, White TA, Wilson J, Xin HB, Woodruff PG. Methodologic advancements in the study of airway smooth muscle. J Allergy Clin Immunol. 2004 Aug;114(2 Suppl):S18-31.
• Hays SR, Ferrando RE, Carter R, Wong HH, Woodruff PG. Structural Changes to Airway Smooth Muscle in Cystic Fibrosis Thorax. 2005 Mar;60(3):181-2.
• Kuperman DA, Lewis CC, Woodruff PG, Rodriguez MW, Yang YH, Dolganov GM, Fahy JV, Erle DJ. Dissecting asthma using focused transgenic modeling and functional genomics. J Allergy Clin Immunol. 2005 Aug;116(2):305-11.
• Woodruff PG*, Koth LL*, Yang YH, Rodriguez MW, Favoreto S, Dolganov GM, Paquet AC, Erle DJ. A Distinctive alveolar macrophage activation state induced by cigarette smoking. Am J Respir Crit Care Med. 2005 Dec;172(11):1383-92.
• Innes AL*, Woodruff PG*, Ferrando RE, Donnelly S, Dolganov GM, Lazarus SC, Fahy JV. Epithelial mucin stores are increased in the large airways of smokers with airflow obstruction. Chest. 2006 Oct;130(4):1102-8. 13.
• Woodruff PG, Innes AL. Quantitative Morphology using Bronchial Biopsies. European Respir Rev. 2007; 15(101): 157-161.
• Woodruff PG, Boushey HA, Dolganov GM, Barker CS, Yang YH, Donnelly S, Ellwanger A, Sidhu SS, Dao-Pick TP, Pantoja C, Erle DJ, Yamamoto KR, Fahy JV. Genome-Wide Profiling Identifies Epithelial Cell Genes Associated with Asthma and with Treatment Response to Corticosteroids. Proc Natl Acad Sci USA. 2007 Oct 2;104(40):15858-63.
• Panettieri Jr RA, Kotlikoff MI, Gerthoffer WT, Hershenson MB, Woodruff PG, Hall IP, Banks-Schlegel SP. Airway Smooth Muscle in Bronchial Tone, Inflammation and Remodeling: Basic to Clinical Relevance. Am J Respir Crit Care Med. 2008 Feb 1;177(3):248-52.
• Woodruff PG. Gene expression in asthmatic airway smooth muscle Proc Am Thorac Soc. 2008 Jan 1;5(1):113-8.