Faculty ProfilesMehrdad Arjomandi, MD
4150 Clement Street
San Francisco, CA 94121
Dr. Arjomandi is Associate Professor of Medicine in the Division of Pulmonary, Critical Care, Allergy, Immunology, and Sleep Medicine at UCSF with a joint appointment at San Francisco Veterans Affairs Medical Center. He is Associate Director of the UCSF Human Exposure Laboratory at San Francisco General Hospital, and an investigator at the UCSF Center for Tobacco Control Research and Education.
Dr. Arjomandi received his bachelor degree in molecular biology from University of California San Diego in 1991, and his MD degree from Stanford University School of Medicine in 1996. He completed his residency in Internal Medicine at UCLA Medical Center (1999) and his fellowship in Pulmonary and Critical Care Medicine at UCSF (2003). Dr. Arjomandi's current funding include NIH/NHLBI Mentored Patient- oriented Career Development Award (K23), the UCSF Flight Attendants Medical Research Institute (FAMRI) Center of Excellence Research Award, and the Health Effect Institute (HEI).
The lung is constantly exposed to various environmental pollutants, allergens, and toxins, which interact with airways and alveoli and result in inflammation, injury, and disease. Exposure-related pulmonary diseases are increasingly recognized as a growing global problem. Although exposures to various environmental agents cause a range of airway and lung diseases, evidence exists to suggest that many of these agents share common pathways of inflammation and injury. Oxidative stress has been recognized as such a common underlying mechanism that contributes to pathophysiology of many exposure-related lung diseases.
My laboratory primary research interest is to study the role of oxidative stress in pathogenesis of lung diseases. We have focused our effort on studying the physiology as well as inflammatory mechanisms through which exposure to pollutants and oxidative stress contributes to lung diseases:
1- Oxidative Stress and Innate Immunity: We study how oxidative stress modulates innate immune responses in various exposure-response models such as ozone-induced, allergen-induced, and wood or tobacco smoke-induced oxidative stress and airway inflammation. We study these effects through controlled human exposure studies, and evaluation of in vivo and ex vivo responses of airway inflammatory cells (alveolar macrophages) and bronchial epithelial cells.
2- Early Physiologic, anatomic, and inflammatory changes in COPD: We study the physiologic, anatomic, and inflammatory changes in a well-characterized cohort of subjects with long and remote history of intense exposure to secondhand tobacco smoke who have evidence of mild COPD. We characterize our cohort by exercise physiology, quantitative radiographic imaging of lungs, and assessment of airway inflammation and lung tissue matrix degradation.
Related Web Sites
- Lung Biology Center
- Human Exposure Laboratory
- Breathe California Clean Air Award 2015
- UCSF Faculty Profile
Recent Articles (27)
Schneiderman AI, Dougherty DD, Fonseca VP, Wolters CL, Bossarte RM, Arjomandi M. Diagnosing Chronic Obstructive Pulmonary Disease Among Afghanistan and Iraq Veterans: Veterans Affair's Concordance With Clinical Guidelines for Spirometry Administration. Mil Med. 2017 Sep; 182(9):e1993-e2000.
Tham A, Lullo D, Dalton S, Zeng S, van Koeverden I, Arjomandi M. Modeling vascular inflammation and atherogenicity after inhalation of ambient levels of ozone: exploratory lessons from transcriptomics. Inhal Toxicol. 2017 Feb; 29(3):96-105.
Leroy P, Tham A, Wong H, Tenney R, Chen C, Stiner R, Balmes JR, Paquet AC, Arjomandi M. Inflammatory and repair pathways induced in human bronchoalveolar lavage cells with ozone inhalation. PLoS One. 2015; 10(6):e0127283.
Mortazavi SM, Rahimi S, Mosleh-Shirazi MA, Arjomandi M, Soleimani A, Koohi Hossein-Abadi O, Haghani M, Alavi M. A Comparative Study on the Life-Saving Radioprotective Effects of Vitamins A, E, C and Over-the-Counter Multivitamins. J Biomed Phys Eng. 2015 Jun; 5(2):59-66.
Arjomandi M, Wong H, Donde A, Frelinger J, Dalton S, Ching W, Power K, Balmes JR. Exposure to medium and high ambient levels of ozone causes adverse systemic inflammatory and cardiac autonomic effects. Am J Physiol Heart Circ Physiol. 2015 Jun 15; 308(12):H1499-509.
Holland N, Davé V, Venkat S, Wong H, Donde A, Balmes JR, Arjomandi M. Ozone inhalation leads to a dose-dependent increase of cytogenetic damage in human lymphocytes. Environ Mol Mutagen. 2015 May; 56(4):378-87.
Bhattacharya M, Sundaram A, Kudo M, Farmer J, Ganesan P, Khalifeh-Soltani A, Arjomandi M, Atabai K, Huang X, Sheppard D. IQGAP1-dependent scaffold suppresses RhoA and inhibits airway smooth muscle contraction. J Clin Invest. 2014 Nov; 124(11):4895-8.
Mehrdad Arjomandi. Proceedings of the American Association for the Advancement of Science: Proceedings of the U.S.-Iran Symposium on Air Pollution in Megacities; September 2013 (http://www.aaas.org/report/Iran-airpollution). Hidden Costs of Climate Change: Contribution of Ozone to Human Diseases. 2013.
Kudo M, Khalifeh Soltani SM, Sakuma SA, McKleroy W, Lee TH, Woodruff PG, Lee JW, Huang K, Chen C, Arjomandi M, Huang X, Atabai K. Mfge8 suppresses airway hyperresponsiveness in asthma by regulating smooth muscle contraction. Proc Natl Acad Sci U S A. 2013 Jan 8; 110(2):660-5.
Donde A, Wong H, Frelinger J, Power K, Balmes JR, Arjomandi M. Effects of exercise on systemic inflammatory, coagulatory, and cardiac autonomic parameters in an inhalational exposure study. J Occup Environ Med. 2012 Apr; 54(4):466-70.
Arjomandi M, Galanter JM, Choudhry S, Eng C, Hu D, Beckman K, Chapela R, Rodríguez-Santana JR, Rodríguez-Cintrón W, Ford J, Avila PC, Burchard EG. Polymorphism in Osteopontin Gene (SPP1) Is Associated with Asthma and Related Phenotypes in a Puerto Rican Population. Pediatr Allergy Immunol Pulmonol. 2011 Dec; 24(4):207-214.
Arjomandi M, Frelinger J, Donde A, Wong H, Yellamilli A, Raymond W. Secreted osteopontin is highly polymerized in human airways and fragmented in asthmatic airway secretions. PLoS One. 2011; 6(10):e25678.
Goolaerts A, Lafargue M, Song Y, Miyazawa B, Arjomandi M, Carlès M, Roux J, Howard M, Parks DA, Iles KE, Pittet JF. PAI-1 is an essential component of the pulmonary host response during Pseudomonas aeruginosa pneumonia in mice. Thorax. 2011 Sep; 66(9):788-96.
Arjomandi M, Seward J, Gotway MB, Nishimura S, Fulton GP, Thundiyil J, King TE, Harber P, Balmes JR. Low prevalence of chronic beryllium disease among workers at a nuclear weapons research and development facility. J Occup Environ Med. 2010 Jun; 52(6):647-52.
Arjomandi M, Haight T, Redberg R, Gold WM. Pulmonary function abnormalities in never-smoking flight attendants exposed to secondhand tobacco smoke in the aircraft cabin. J Occup Environ Med. 2009 Jun; 51(6):639-46.
Arjomandi M, Tager IB, Bastaki M, Chen C, Holland N, Balmes JR. Is there an association between lifetime cumulative exposure and acute pulmonary responses to ozone? J Occup Environ Med. 2008 Mar; 50(3):341-9.
Chen C, Arjomandi M, Balmes J, Tager I, Holland N. Effects of chronic and acute ozone exposure on lipid peroxidation and antioxidant capacity in healthy young adults. Environ Health Perspect. 2007 Dec; 115(12):1732-7.
Chen C, Arjomandi M, Qin H, Balmes J, Tager I, Holland N. Cytogenetic damage in buccal epithelia and peripheral lymphocytes of young healthy individuals exposed to ozone. Mutagenesis. 2006 Mar; 21(2):131-7.
Witten A, Solomon C, Abbritti E, Arjomandi M, Zhai W, Kleinman M, Balmes J. Effects of nitrogen dioxide on allergic airway responses in subjects with asthma. J Occup Environ Med. 2005 Dec; 47(12):1250-9.
Arjomandi M, Witten A, Abbritti E, Reintjes K, Schmidlin I, Zhai W, Solomon C, Balmes J. Repeated exposure to ozone increases alveolar macrophage recruitment into asthmatic airways. Am J Respir Crit Care Med. 2005 Aug 15; 172(4):427-32.
Wang BY, Candipan RC, Arjomandi M, Hsiun PT, Tsao PS, Cooke JP. Arginine restores nitric oxide activity and inhibits monocyte accumulation after vascular injury in hypercholesterolemic rabbits. J Am Coll Cardiol. 1996 Nov 15; 28(6):1573-9.
Renoir JM, Le Bihan S, Mercier-Bodard C, Gold A, Arjomandi M, Radanyi C, Baulieu EE. Effects of immunosuppressants FK506 and rapamycin on the heterooligomeric form of the progesterone receptor. J Steroid Biochem Mol Biol. 1994 Jan; 48(1):101-10.