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Faculty Profiles

Tien Peng, MD
M_MED-PULM-CORE
Assistant Professor

513 Parnassus Ave
San Francisco, CA 94143
415-502-4852
Tien.Peng@ucsf.edu

Our laboratory is interested in studying how key developmental pathways continue to persist in adulthood to maintain normal homeostatic organ function. We are particularly focused on the mesenchymal cell types (e.g. fibroblasts, pericytes, and etc.) that are poorly understood and lack precise anatomical definition, but are integral to the structural integrity and function of adult organs such as the lung. Previous work focused on how the Hedgehog pathway directed mesenchymal progenitor differentiation during embryonic development, and much to our surprise, how Hedgehog continues to maintain normal mesenchymal homeostasis during adulthood. We found that cellular quiescence in the adult lung is not a default state, but rather actively maintained by epithelial-mesenchymal crosstalk coordinated by Hedgehog. This suggests that cellular quiescence is tightly regulated by the state of Hedgehog activation within the mesenchyme to regulate cellular turnover during homeostasis and injury, and that dysregulated Hedgehog signaling could lead to maladaptive remodeling and lung diseases. Our projects utilizes sophisticated murine genetic models to manipulate and characterize cellular populations in a temporally/spatially specific manner, dissecting the role of key developmental pathways in regulating adult organ structural integrity, immune homeostasis, and aging.

Education and Training

Location Degree or Training Specialty Date
University of Pennsylvania Pulmonary Critical Care/Postdoctoral Research Fellowship Medicine/Cell and Developmental Biology 2015
Columbia University Medical Center Internal Medicine Residency 2009
Johns Hopkins University M.D. School of Medicine 2006
University of Virginia B.A. 2000

Awards and Honors

2016   Young Physician Scientist Award, American Society for Clinical Investigation, 2016
2016   NIH New Innovator Award, National Institutes of Health, 2016-2021
2014   Jo Rae Wright Award, Federation of American Societies for Experimental Biology, 2014

Related Web Sites

In the News

Awarded Grants

Project Title Project Number Fiscal Year
Defining the resident mesenchymal stem cell niche and function in vivo DP2AG056034 2021
The roles of Hedgehog signaling in pulmonary vascular development and remodeling K08HL121146 2019
Recent Articles (12)

Frank DB, Peng T, Zepp JA, Snitow M, Vincent TL, Penkala IJ, Cui Z, Herriges MJ, Morley MP, Zhou S, Lu MM, Morrisey EE. Emergence of a Wave of Wnt Signaling that Regulates Lung Alveologenesis by Controlling Epithelial Self-Renewal and Differentiation. Cell Rep. 2016 Nov 22; 17(9):2312-2325.

Peng T, Frank DB, Kadzik RS, Morley MP, Rathi KS, Wang T, Zhou S, Cheng L, Lu MM, Morrisey EE. Hedgehog actively maintains adult lung quiescence and regulates repair and regeneration. Nature. 2015 Oct 22; 526(7574):578-82.

Herriges MJ, Swarr DT, Morley MP, Rathi KS, Peng T, Stewart KM, Morrisey EE. Long noncoding RNAs are spatially correlated with transcription factors and regulate lung development. Genes Dev. 2014 Jun 15; 28(12):1363-79.

Choi YS, Zhang Y, Xu M, Yang Y, Ito M, Peng T, Cui Z, Nagy A, Hadjantonakis AK, Lang RA, Cotsarelis G, Andl T, Morrisey EE, Millar SE. Distinct functions for Wnt/ß-catenin in hair follicle stem cell proliferation and survival and interfollicular epidermal homeostasis. Cell Stem Cell. 2013 Dec 5; 13(6):720-33.

Peng T, Tian Y, Boogerd CJ, Lu MM, Kadzik RS, Stewart KM, Evans SM, Morrisey EE. Coordination of heart and lung co-development by a multipotent cardiopulmonary progenitor. Nature. 2013 Aug 29; 500(7464):589-92.

Peng T, Morrisey EE. Development of the pulmonary vasculature: Current understanding and concepts for the future. Pulm Circ. 2013 Jan; 3(1):176-8.

Peng T, Zamanian R, Krowka MJ, Benza RL, Roberts KE, Taichman DB, Rybak D, Trotter JF, Brown RS, Fallon MB, Kawut SM. Plasma levels of S100A4 in portopulmonary hypertension. Biomarkers. 2009 May; 14(3):156-60.

Peng T, Blakeley J, Cingolani E, Griffiths E, Grossman SA. Herpes simplex encephalitis in a patient with recurrent pituitary adenoma receiving radiation therapy. Am J Clin Oncol. 2007 Dec; 30(6):664-5.

Ngo TT, Peng T, Liang XJ, Akeju O, Pastorino S, Zhang W, Kotliarov Y, Zenklusen JC, Fine HA, Maric D, Wen PY, De Girolami U, Black PM, Wu WW, Shen RF, Jeffries NO, Kang DW, Park JK. The 1p-encoded protein stathmin and resistance of malignant gliomas to nitrosoureas. J Natl Cancer Inst. 2007 Apr 18; 99(8):639-52.

Akeju O, Peng T, Park JK. Short hairpin RNA loop design for the facilitation of sequence verification. Biotechniques. 2006 Feb; 40(2):154, 156, 158.

Yu X, Zhan X, D'Costa J, Tanavde VM, Ye Z, Peng T, Malehorn MT, Yang X, Civin CI, Cheng L. Lentiviral vectors with two independent internal promoters transfer high-level expression of multiple transgenes to human hematopoietic stem-progenitor cells. Mol Ther. 2003 Jun; 7(6):827-38.

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