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Faculty Profiles

Mary Ellen Kleinhenz, MD

400 Parnassus Avenue
San Francisco, CA 94117


Dr. Kleinhenz oversees the Ambulatory Practices for the Division of Pulmonary, Critical Care, Allergy-Immunology and Sleep Medicine. She is the Director of the UCSF Adult Cystic Fibrosis Program and Associate Director of the UCSF Cystic Fibrosis Center. Dr. Kleinhenz is also a Transplant Physician of the UCSF Heart Lung Transplant Program.

Dr. Kleinhenz's clinical interests relate to adult cystic fibrosis and lung transplantation. She maintains an active consultative practice in the UCSF Pulmonary Practice at Parnassus. With the implementation of the EPIC electronic health record at UCSF, Dr. Kleinhenz updated workflows and harmonized documentation across the Division's Ambulatory Specialty Practices.

Dr. Kleinhenz has sustained a long-term commitment to adult cystic fibrosis care and management. She is a member of the Center Committee of the Cystic Fibrosis Foundation and participates in the Foundation's Quality Assurance Program. She has championed the training of clinicians in adult cystic fibrosis care; several of her former trainees now staff and direct Adult Cystic Fibrosis Programs across the Nation. Dr. Kleinhenz has directed several trials of potential therapies for cystic fibrosis at UCSF.

Education and Training

Location Degree or Training Specialty Date
University of Pennsylvania M.D. School of Medicine 1975

Related Web Sites

Recent Articles (14)

Kerkhoff AD, Patrick L, Cornett P, Kleinhenz ME, Brondfield S. Severe piperacillin-tazobactam-induced hemolysis in a cystic fibrosis patient. Clin Case Rep. 2017 Dec; 5(12):2059-2061.

Singer JP, Katz PP, Soong A, Shrestha P, Huang D, Ho J, Mindo M, Greenland JR, Hays SR, Golden J, Kukreja J, Kleinhenz ME, Shah RJ, Blanc PD. Effect of Lung Transplantation on Health-Related Quality of Life in the Era of the Lung Allocation Score: A U.S. Prospective Cohort Study. Am J Transplant. 2017 May; 17(5):1334-1345.

Okumura MJ, Kleinhenz ME. Cystic Fibrosis Transitions of Care: Lessons Learned and Future Directions for Cystic Fibrosis. Clin Chest Med. 2016 Mar; 37(1):119-26.

Tokman S, Hays SR, Leard LE, Bush EL, Kukreja J, Kleinhenz ME, Golden JA, Singer JP. Prolonged Barium-Impaction Ileus in Two Lung Transplant Recipients With Systemic Sclerosis: Case Report. Transplant Proc. 2015 Dec; 47(10):2965-7.

Kern RM, Seethamraju H, Blanc PD, Sinha N, Loebe M, Golden J, Kukreja J, Scheinin S, Hays S, Kleinhenz ME, Leard L, Hoopes C, Singer JP. The feasibility of lung transplantation in HIV-seropositive patients. Ann Am Thorac Soc. 2014 Jul; 11(6):882-9.

Okumura MJ, Ong T, Dawson D, Nielson D, Lewis N, Richards M, Brindis CD, Kleinhenz ME. Improving transition from paediatric to adult cystic fibrosis care: programme implementation and evaluation. BMJ Qual Saf. 2014 Apr; 23 Suppl 1:i64-i72.

Cox MJ, Allgaier M, Taylor B, Baek MS, Huang YJ, Daly RA, Karaoz U, Andersen GL, Brown R, Fujimura KE, Wu B, Tran D, Koff J, Kleinhenz ME, Nielson D, Brodie EL, Lynch SV. Airway microbiota and pathogen abundance in age-stratified cystic fibrosis patients. PLoS One. 2010 Jun 23; 5(6):e11044.

Webb EM, Kleinhenz ME, Coakley FV, Chang CI, Westphalen AC, Yeh BM. Colonic wall redundancy at CT in patients with cystic fibrosis. Radiology. 2008 Sep; 248(3):869-75.

Gasper WJ, Sweet MP, Golden JA, Hoopes C, Leard LE, Kleinhenz ME, Hays SR, Patti MG. Lung transplantation in patients with connective tissue disorders and esophageal dysmotility. Dis Esophagus. 2008; 21(7):650-5.

Gasper WJ, Sweet MP, Hoopes C, Leard LE, Kleinhenz ME, Hays SR, Golden JA, Patti MG. Antireflux surgery for patients with end-stage lung disease before and after lung transplantation. Surg Endosc. 2008 Feb; 22(2):495-500.

Espiritu JD, Ruppel G, Shrestha Y, Kleinhenz ME. The diffusing capacity in adult cystic fibrosis. Respir Med. 2003 Jun; 97(6):606-11.

Kleinhenz ME, Lewis CY. Chronic ventilator dependence in elderly patients. Clin Geriatr Med. 2000 Nov; 16(4):735-56.

Espiritu JD, Kleinhenz ME. Paradoxical embolization in an adult patient with cystic fibrosis. Mayo Clin Proc. 2000 Oct; 75(10):1100-2.

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