UCSF home page UCSF home page About UCSF UCSF Medical Center
UCSF navigation bar
photos

Faculty Profiles

Nirav Bhakta, MD
M_MED-PULM-CORE
Assistant Professor

513 Parnassus Avenue
San Francisco, CA 94117

Nirav.Bhakta2@ucsf.edu

After completion of medical school and a PhD at Stanford University School of Medicine, Dr. Bhakta joined the UCSF Internal Medicine Residency program. With an undergraduate background in engineering and graduate work on T cell development, he was drawn to pulmonary and critical care medicine early given the combination of physiology and immunology present in this specialty. He also found the challenges in working with patients and families on critical illness rewarding. After completing fellowship in pulmonary and critical care medicine and a postdoctoral fellowship both at UCSF, Dr. Bhakta joined the faculty in 2013.


Clinical activities:
He attends in the Moffitt-Long Intensive Care Units, sees patients in the Chest Faculty Practice clinic on Parnassus Avenue where he also supervises fellows in their outpatient practice, and interprets pulmonary function tests as an attending in the Adult Pulmonary Function Laboratory.


Research activities:
Research is another important and personally rewarding part of his career. His current research goals are to understand the molecular basis for variations in the presentation of asthma, and to use this knowledge to develop and test targeted treatments. Through his experience in programming and quantitative modeling, he is able to work with common and advanced high-throughput genomic data analysis techniques on human tissues. His research activities not only contribute to the scientific and medical communities, but also synergize with his delivery of evidence-based, patient-centered medicine.


Teaching activities:
He finds that his clinical and research activities enhance his performance as an educator. He is the Director of Education for the UCSF Adult Pulmonary Function Laboratory, where he oversees the education of MD pulmonary and critical care fellows in pulmonary physiology. In addition to this responsibility for the curriculum, he gives lectures and undertakes one-on-one teaching with fellows while interpreting tests. He gives recurring lectures to students, residents, and fellows, and engages in bedside teaching when attending in the Intensive Care Units. To stay current, he participates in invited manuscript reviews for journals, served as an Associate Scientific Advisor for the journal Science Translational Medicine, and has authored book chapters on asthma phenotypes in the 6th edition of Murray and Nadel's Textbook of Respiratory Medicine, and on the management of asthma exacerbations in a European Respiratory Journal monograph on pulmonary emergencies.

Education and Training

Location Degree or Training Specialty Date
University of California, San Francisco Postdoctoral fellowship Asthma Genomics 2013
University of California, San Francisco Fellowship Pulmonary and Critical Care Medicine 2011
University of California, San Francisco Residency School of Medicine - Internal Medicine 2008
Stanford University M.D. School of Medicine 2006
Stanford University Ph.D. School of Medicine, Molecular and Cellular Physiology 2006
Massachusetts Institute of Technology Electrical Engineering and Electrical Science Electrical Engineering 1998

Interests

airway inflammation, asthma, critical care medicine, genomics and bioinformatics, pulmonary physiology

Awards and Honors
2017   Invited Grand Rounds Speaker, University of Vermont, Department of Pathology, 2017
2016   Nina Ireland Program for Lung Health, UCSF, 2016
2011   Podell Hewett Fellowship in Translational Airway Research, UCSF, 2011-2012

Recent Articles (29)

Bhakta NR, Christenson SA, Nerella S, Solberg OD, Nguyen CP, Choy DF, Jung KL, Garudadri S, Bonser LR, Pollack JL, Zlock LT, Erle DJ, Langelier C, Derisi JL, Arron JR, Fahy JV, Woodruff PG. Interferon-stimulated Gene Expression, Type-2 Inflammation and Endoplasmic Reticulum Stress in Asthma. Am J Respir Crit Care Med. 2017 Oct 24.

Lachowicz-Scroggins ME, Finkbeiner WE, Gordon ED, Yuan S, Zlock L, Bhakta NR, Woodruff PG, Fahy JV, Boushey HA. Corticosteroid and long-acting ß-agonist therapy reduces epithelial goblet cell metaplasia. Clin Exp Allergy. 2017 Aug 22.

Phipatanakul W, Mauger DT, Sorkness RL, Gaffin JM, Holguin F, Woodruff PG, Ly NP, Bacharier LB, Bhakta NR, Moore WC, Bleecker ER, Hastie AT, Meyers DA, Castro M, Fahy JV, Fitzpatrick AM, Gaston BM, Jarjour NN, Levy BD, Peters SP, Teague WG, Fajt M, Wenzel SE, Erzurum SC, Israel E. Effects of Age and Disease Severity on Systemic Corticosteroid Responses in Asthma. Am J Respir Crit Care Med. 2017 Jun 01; 195(11):1439-1448.

Bhakta NR. By Expanding the Color Palette, CO-Oximetry Overcomes Some, but Not All, of the Uncommon Limitations of Pulse Oximetry. Ann Am Thorac Soc. 2017 Apr; 14(4):609.

Duvall MG, Barnig C, Cernadas M, Ricklefs I, Krishnamoorthy N, Grossman NL, Bhakta NR, Fahy JV, Bleecker ER, Castro M, Erzurum SC, Gaston BM, Jarjour NN, Mauger DT, Wenzel SE, Comhair SA, Coverstone AM, Fajt ML, Hastie AT, Johansson MW, Peters MC, Phillips BR, Israel E, Levy BD. Natural killer cell-mediated inflammation resolution is disabled in severe asthma. Sci Immunol. 2017 Mar 10; 2(9).

Bhakta NR. Insights from Recognition of a Contradiction in the Equations that Define the Diffusing Capacity of the Lung for Carbon Monoxide. Ann Am Thorac Soc. 2017 Mar; 14(3):473-474.

Denlinger LC, Phillips BR, Ramratnam S, Ross K, Bhakta NR, Cardet JC, Castro M, Peters SP, Phipatanakul W, Aujla S, Bacharier LB, Bleecker ER, Comhair SA, Coverstone A, DeBoer M, Erzurum SC, Fain SB, Fajt M, Fitzpatrick AM, Gaffin J, Gaston B, Hastie AT, Hawkins GA, Holguin F, Irani AM, Israel E, Levy BD, Ly N, Meyers DA, Moore WC, Myers R, Opina MT, Peters MC, Schiebler ML, Sorkness RL, Teague WG, Wenzel SE, Woodruff PG, Mauger DT, Fahy JV, Jarjour NN. Inflammatory and Comorbid Features of Patients with Severe Asthma and Frequent Exacerbations. Am J Respir Crit Care Med. 2017 Feb 01; 195(3):302-313.

Bhakta NR. Grease fires turn up the heat in autoimmune disease. Sci Transl Med. 2017 Jan 25; 9(374).

Bhakta NR. Pitfalls of probiotics. Sci Transl Med. 2016 Dec 07; 8(368):368ec194.

Durack J, Lynch SV, Nariya S, Bhakta NR, Beigelman A, Castro M, Dyer AM, Israel E, Kraft M, Martin RJ, Mauger DT, Rosenberg SR, Sharp-King T, White SR, Woodruff PG, Avila PC, Denlinger LC, Holguin F, Lazarus SC, Lugogo N, Moore WC, Peters SP, Que L, Smith LJ, Sorkness CA, Wechsler ME, Wenzel SE, Boushey HA, Huang YJ. Features of the bronchial bacterial microbiome associated with atopy, asthma, and responsiveness to inhaled corticosteroid treatment. J Allergy Clin Immunol. 2017 Jul; 140(1):63-75.

Ramstein J, Broos CE, Simpson LJ, Ansel KM, Sun SA, Ho ME, Woodruff PG, Bhakta NR, Christian L, Nguyen CP, Antalek BJ, Benn BS, Hendriks RW, van den Blink B, Kool M, Koth LL. IFN-?-Producing T-Helper 17.1 Cells Are Increased in Sarcoidosis and Are More Prevalent than T-Helper Type 1 Cells. Am J Respir Crit Care Med. 2016 Jun 01; 193(11):1281-91.

Hoffman SM, Chapman DG, Lahue KG, Cahoon JM, Rattu GK, Daphtary N, Aliyeva M, Fortner KA, Erzurum SC, Comhair SA, Woodruff PG, Bhakta N, Dixon AE, Irvin CG, Janssen-Heininger YM, Poynter ME, Anathy V. Protein disulfide isomerase-endoplasmic reticulum resident protein 57 regulates allergen-induced airways inflammation, fibrosis, and hyperresponsiveness. J Allergy Clin Immunol. 2016 Mar; 137(3):822-32.e7.

Lawson DA, Bhakta NR, Kessenbrock K, Prummel KD, Yu Y, Takai K, Zhou A, Eyob H, Balakrishnan S, Wang CY, Yaswen P, Goga A, Werb Z. Single-cell analysis reveals a stem-cell program in human metastatic breast cancer cells. Nature. 2015 Oct 01; 526(7571):131-5.

Simpson LJ, Patel S, Bhakta NR, Choy DF, Brightbill HD, Ren X, Wang Y, Pua HH, Baumjohann D, Montoya MM, Panduro M, Remedios KA, Huang X, Fahy JV, Arron JR, Woodruff PG, Ansel KM. A microRNA upregulated in asthma airway T cells promotes TH2 cytokine production. Nat Immunol. 2014 Dec; 15(12):1162-70.

Bhakta NR, Erle DJ. IL-17 and "TH2-high" asthma: Adding fuel to the fire? J Allergy Clin Immunol. 2014 Nov; 134(5):1187-8.

Su R, Li MM, Bhakta NR, Solberg OD, Darnell EP, Ramstein J, Garudadri S, Ho M, Woodruff PG, Koth LL. Longitudinal analysis of sarcoidosis blood transcriptomic signatures and disease outcomes. Eur Respir J. 2014 Oct; 44(4):985-93.

Greer AM, Matthay MA, Kukreja J, Bhakta NR, Nguyen CP, Wolters PJ, Woodruff PG, Fahy JV, Shin JS. Accumulation of BDCA1? dendritic cells in interstitial fibrotic lung diseases and Th2-high asthma. PLoS One. 2014; 9(6):e99084.

Peters MC, Mekonnen ZK, Yuan S, Bhakta NR, Woodruff PG, Fahy JV. Measures of gene expression in sputum cells can identify TH2-high and TH2-low subtypes of asthma. J Allergy Clin Immunol. 2014 Feb; 133(2):388-94.

Bhakta NR, Solberg OD, Nguyen CP, Nguyen CN, Arron JR, Fahy JV, Woodruff PG. A qPCR-based metric of Th2 airway inflammation in asthma. Clin Transl Allergy. 2013 Jul 17; 3(1):24.

Levänen B, Bhakta NR, Torregrosa Paredes P, Barbeau R, Hiltbrunner S, Pollack JL, Sköld CM, Svartengren M, Grunewald J, Gabrielsson S, Eklund A, Larsson BM, Woodruff PG, Erle DJ, Wheelock ÅM. Altered microRNA profiles in bronchoalveolar lavage fluid exosomes in asthmatic patients. J Allergy Clin Immunol. 2013 Mar; 131(3):894-903.

Solberg OD, Ostrin EJ, Love MI, Peng JC, Bhakta NR, Hou L, Nguyen C, Solon M, Nguyen C, Barczak AJ, Zlock LT, Blagev DP, Finkbeiner WE, Ansel KM, Arron JR, Erle DJ, Woodruff PG. Airway epithelial miRNA expression is altered in asthma. Am J Respir Crit Care Med. 2012 Nov 15; 186(10):965-74.

Koth LL, Solberg OD, Peng JC, Bhakta NR, Nguyen CP, Woodruff PG. Sarcoidosis blood transcriptome reflects lung inflammation and overlaps with tuberculosis. Am J Respir Crit Care Med. 2011 Nov 15; 184(10):1153-63.

Bhakta NR, Woodruff PG. Human asthma phenotypes: from the clinic, to cytokines, and back again. Immunol Rev. 2011 Jul; 242(1):220-32.

Bhakta NR, Lewis RS. Real-time measurement of signaling and motility during T cell development in the thymus. Semin Immunol. 2005 Dec; 17(6):411-20.

Bhakta NR, Oh DY, Lewis RS. Calcium oscillations regulate thymocyte motility during positive selection in the three-dimensional thymic environment. Nat Immunol. 2005 Feb; 6(2):143-51.

Bousso P, Bhakta NR, Lewis RS, Robey E. Dynamics of thymocyte-stromal cell interactions visualized by two-photon microscopy. Science. 2002 Jun 07; 296(5574):1876-80.

Bonassar LJ, Grodzinsky AJ, Frank EH, Davila SG, Bhaktav NR, Trippel SB. The effect of dynamic compression on the response of articular cartilage to insulin-like growth factor-I. J Orthop Res. 2001 Jan; 19(1):11-7.

Bhakta NR, Garcia AM, Frank EH, Grodzinsky AJ, Morales TI. The insulin-like growth factors (IGFs) I and II bind to articular cartilage via the IGF-binding proteins. J Biol Chem. 2000 Feb 25; 275(8):5860-6.

  Select data provided by UCSF Profiles, powered by CTSI at UCSF. Learn more about the data source.