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Faculty Profiles

Jay Nadel, MD
M_MED-PULM-CORE
Professor Emeritus




A. Background
• 1968 appointed the first Chief of the Division of Pulmonary Diseases in the Department of Medicine, UCSF
• Lobbied Congress to rename the National Heart Institute to the National Heart and Lung Institute
• Co-Editor of the Murray/Nadel Textbook of Respiratory Medicine


B. Early Areas of Studies
• Chronic airway diseases, including asthma, COPD, and CF
• Air pollutants (sulfur dioxide and ozone)
• Airway epithelium
• Viruses, bacteria, air pollutants, allergens, cigarette smoke
• Na+, Cl¯ exchange mechanism in the airway epithelium


C. Later Areas of Study
• Cell and molecular biology
• Antimuscarinic Therapy of Bronchospasm
• Signaling pathways for mucin production


D. Recent Areas of Study
• EGFR Signaling Pathways
• Modulation of proinflammatory responses
• Viral infections
• CFTR and its role in inflammatory airway diseases
• Bronchiolitis Obliterans Syndrome following lung transplantation

Education and Training

Location Degree or Training Specialty Date
Cardiovascular Research Institute Fellowship University of California, San Francisco 1960
Philadelphia General Hospital Internship Philadelphia General Hospital, Philadelphia, PA 1954
Jefferson MD Jefferson Medical College, Philadelphia, PA 1953

Awards and Honors

2016   Distinguished Scientist Honor Lecture in Cardiopulmonary Physiology and Distinguished Service Award, CHEST, Los Angeles, CA, 2016
2016   Honorary Lecture, 65th Annual Meeting of Japanese Society of Allergology (JSA), Japanese Society of Allergology (JSA), Tokyo, Japan, 2016
2015   The Nadel Honorary Pulmonary Symposium, University of California San Francisco School of Medicine, 2015
2014   Honorary Fellow, European Respiratory Society, 2014
2013   Honorary Lecture in Lung Research, Karolinska Institute, Stockholm, 2013
2012   Invited Lecture, XIII National Conference of the Italian Union of Pneumology, Catania, Italy, 2012
2012   Invited Lecture, 7th International Symposium on Cough, National Heart and Lung Institute, Imperial College, London, UK, 2012
2012   John Widdicombe Memorial Lecture, 7th International Symposium on Cough, National Heart and Lung Institute, Imperial College, London, UK, 2012
2011   Honorary Lecturer, Japanese Respiratory Society, Tokyo, 2011
2011   Special Lecturer, Chest Meeting, Airways Network, Hawaii, 2011
2010   Honorary Lecturer, Transatlantic Airway Conference 25th Anniversary, Lucerne, 2010
2008   René Descartes Medal, University of Paris, 2008
2005   Honorary Jerome I. Kleinerman Annual Lecture, Case Western Reserve University School of Medicine, Cleveland, 2005
2002   Festschrift Honoring Prof. Gert Kunkel, Free University of Berlin, 2002
2002   Honorary Member Associazione Nicolo Copernico Alumni Dell Ateneo Estense, University of Ferrara, Italy, 2002
2002   First Annual Honorary Joseph R. Rodarte Lectureship in Pulmonary Medicine, Baylor College of Medicine, 2002
1999   Best Doctors of San Francisco Bay Area Nomination, 1999
1998   Alumni Achievement Award, JH Coley Lectureship, Jefferson Medical College, Philadelphia, 1998
1998   Best Doctors of America Nomination, 1998
1997   Honorary Degree in Law, Dickinson Law School, Carlisle, PA, 1997
1997   Trudeau Medal, American Thoracic Society, 1997
1996   Honorary Doctorate of Medicine, University of Lund, Sweden, 1996
1994   Honorary Membership, Society for Lung and Airway Research, German Society of Pulmonology, 1994
1994   Honorary Membership, Finnish Association of Pulmonary Physicians, 1994
1994   Medal of the University, University of Helsinki, 1994
1993   Amberson Lecturer, American Thoracic Society, San Francisco, 1993
1992   Distinguished Achievement Award, Ben Gurion University, 1992
1992   Sam J. Sills Honorary Lectureship, University of Southern California, 1992
1992   Crocker Clean Air Award (for outstanding research in Air Pollution), American Lung Association, 1992
1991   Giles S. Filley Lecture, Aspen Lung Conferences, 1991
1991   Honorary Doctorate of Medicine, University of Ferrara, Ferrara, Italy, 1991
1990   Pfizer Visiting Professor, Royal Society of Medicine Foundation, 1990
1990   Kass Lectureship and Medalist, University of Nebraska School of Medicine, 1990
1989   Distinguished Lecturer, The Ninth William P. Buffum Oration, Brown University School of Medicine, 1989
1987   Distinguished Lecturer in Physiology, American College of Chest Physicians, 1987
1984   California Medal, American Lung Association of California, 1984
1984   Clean Air Award, American Lung Association of California, 1984
1984   Honorary Membership, California Thoracic Society, 1984
1973   Visiting Scientist, Hammersmith Hospital, London, England, 1973
1962   Visiting Scientist, University Laboratory of Physiology, University of Oxford, Oxford, England, 1962
1960   Giannini Research Fellow, Cardiovascular Research Institute, University of California, San Francisco, 1960-1961
1955   Blockley Award for Outstanding Publication, Philadelphia General Hospital, 1955
1953   Medical Practice Prize, Jefferson Medical College, 1953

Related Web Sites

Recent Articles (67)

Gelb AF, Nadel JA. Affirmation of the adoration of the vagi and role of tiotropium in asthmatic patients. J Allergy Clin Immunol. 2016 Oct; 138(4):1011-1013.

Gelb AF, Christenson SA, Nadel JA. Understanding the pathophysiology of the asthma-chronic obstructive pulmonary disease overlap syndrome. Curr Opin Pulm Med. 2016 Mar; 22(2):100-5.

Gelb AF, Nadel JA. Understanding the pathophysiology of the asthma-chronic obstructive pulmonary disease overlap syndrome. J Allergy Clin Immunol. 2015 Sep; 136(3):553-5.

Gelb AF, Yamamoto A, Verbeken EK, Nadel JA. Unraveling the Pathophysiology of the Asthma-COPD Overlap Syndrome: Unsuspected Mild Centrilobular Emphysema Is Responsible for Loss of Lung Elastic Recoil in Never Smokers With Asthma With Persistent Expiratory Airflow Limitation. Chest. 2015 Aug; 148(2):313-20.

Kalinowski A, Ueki I, Min-Oo G, Ballon-Landa E, Knoff D, Galen B, Lanier LL, Nadel JA, Koff JL. EGFR activation suppresses respiratory virus-induced IRF1-dependent CXCL10 production. Am J Physiol Lung Cell Mol Physiol. 2014 Jul 15; 307(2):L186-96.

Nadel JA. The CFTR and EGFR relationship in airway vascular growth, and its importance in cystic fibrosis. Eur Respir J. 2013 Dec; 42(6):1438-40.

Gelb AF, Yamamoto A, Mauad T, Kollin J, Schein MJ, Nadel JA. Unsuspected mild emphysema in nonsmoking patients with chronic asthma with persistent airway obstruction. J Allergy Clin Immunol. 2014 Jan; 133(1):263-5.e1-3.

Ueki IF, Min-Oo G, Kalinowski A, Ballon-Landa E, Lanier LL, Nadel JA, Koff JL. Respiratory virus-induced EGFR activation suppresses IRF1-dependent interferon ? and antiviral defense in airway epithelium. J Exp Med. 2013 Sep 23; 210(10):1929-36.

Kim S, Beyer BA, Lewis C, Nadel JA. Normal CFTR inhibits epidermal growth factor receptor-dependent pro-inflammatory chemokine production in human airway epithelial cells. PLoS One. 2013; 8(8):e72981.

Chung KF, Nadel JA, Fontana G. John Widdicombe's contribution to respiratory physiology and cough: reminiscences. Cough. 2013; 9(1):6.

Nadel JA. Mucous hypersecretion and relationship to cough. Pulm Pharmacol Ther. 2013 Oct; 26(5):510-3.

Kim S, Lewis C, Nadel JA. Epidermal growth factor receptor reactivation induced by E-prostanoid-3 receptor- and tumor necrosis factor-alpha-converting enzyme-dependent feedback exaggerates interleukin-8 production in airway cancer (NCI-H292) cells. Exp Cell Res. 2011 Nov 1; 317(18):2650-60.

Kim S, Lewis C, Nadel JA. CCL20/CCR6 feedback exaggerates epidermal growth factor receptor-dependent MUC5AC mucin production in human airway epithelial (NCI-H292) cells. J Immunol. 2011 Mar 15; 186(6):3392-400.

Burgel PR, Nadel JA. Epidermal growth factor receptor-mediated innate immune responses and their roles in airway diseases. Eur Respir J. 2008 Oct; 32(4):1068-81.

Koff JL, Shao MX, Ueki IF, Nadel JA. Multiple TLRs activate EGFR via a signaling cascade to produce innate immune responses in airway epithelium. Am J Physiol Lung Cell Mol Physiol. 2008 Jun; 294(6):L1068-75.

Nadel JA. Innate immune mucin production via epithelial cell surface signaling: relationship to allergic disease. Curr Opin Allergy Clin Immunol. 2007 Feb; 7(1):57-62.

Koff JL, Shao MX, Kim S, Ueki IF, Nadel JA. Pseudomonas lipopolysaccharide accelerates wound repair via activation of a novel epithelial cell signaling cascade. J Immunol. 2006 Dec 15; 177(12):8693-700.

Shao MX, Nadel JA. Neutrophil elastase induces MUC5AC mucin production in human airway epithelial cells via a cascade involving protein kinase C, reactive oxygen species, and TNF-alpha-converting enzyme. J Immunol. 2005 Sep 15; 175(6):4009-16.

Shao MX, Nadel JA. Dual oxidase 1-dependent MUC5AC mucin expression in cultured human airway epithelial cells. Proc Natl Acad Sci U S A. 2005 Jan 18; 102(3):767-72.

Nadel JA. COPD. Role of the Airway Epithelium in Defense Against Inhaled Invaders. 2005; 3:285-287.

Shao MX, Nakanaga T, Nadel JA. Cigarette smoke induces MUC5AC mucin overproduction via tumor necrosis factor-alpha-converting enzyme in human airway epithelial (NCI-H292) cells. Am J Physiol Lung Cell Mol Physiol. 2004 Aug; 287(2):L420-7.

Shao MX, Ueki IF, Nadel JA. Tumor necrosis factor alpha-converting enzyme mediates MUC5AC mucin expression in cultured human airway epithelial cells. Proc Natl Acad Sci U S A. 2003 Sep 30; 100(20):11618-23.

Takeyama K, Dabbagh K, Jeong Shim J, Dao-Pick T, Ueki IF, Nadel JA. Oxidative stress causes mucin synthesis via transactivation of epidermal growth factor receptor: role of neutrophils. J Immunol. 2000 Feb 1; 164(3):1546-52.

Takeyama K, Dabbagh K, Lee HM, Agustí C, Lausier JA, Ueki IF, Grattan KM, Nadel JA. Epidermal growth factor system regulates mucin production in airways. Proc Natl Acad Sci U S A. 1999 Mar 16; 96(6):3081-6.

Li JD, Dohrman AF, Gallup M, Miyata S, Gum JR, Kim YS, Nadel JA, Prince A, Basbaum CB. Transcriptional activation of mucin by Pseudomonas aeruginosa lipopolysaccharide in the pathogenesis of cystic fibrosis lung disease. Proc Natl Acad Sci U S A. 1997 Feb 4; 94(3):967-72.

Rosenecker J, Zhang W, Hong K, Lausier J, Geppetti P, Yoshihara S, Papahadjopoulos D, Nadel JA. Increased liposome extravasation in selected tissues: effect of substance P. Proc Natl Acad Sci U S A. 1996 Jul 9; 93(14):7236-41.

Inoue H, Massion PP, Ueki IF, Grattan KM, Hara M, Dohrman AF, Chan B, Lausier JA, Golden JA, Nadel JA. Pseudomonas stimulates interleukin-8 mRNA expression selectively in airway epithelium, in gland ducts, and in recruited neutrophils. Am J Respir Cell Mol Biol. 1994 Dec; 11(6):651-63.

Richman-Eisenstat JB, Jorens PG, Hébert CA, Ueki I, Nadel JA. Interleukin-8: an important chemoattractant in sputum of patients with chronic inflammatory airway diseases. Am J Physiol. 1993 Apr; 264(4 Pt 1):L413-8.

Jorens PG, Graf PD, Ueki IF, Olesch J, Nadel JA. Interleukin-8 induces neutrophil accumulation in the trachea of allergic dogs. Trans Assoc Am Physicians. 1992; 105:190-6.

Nadel JA, Conrad DJ, Ueki IF, Schuster A, Sigal E. Immunocytochemical localization of arachidonate 15-lipoxygenase in erythrocytes, leukocytes, and airway cells. J Clin Invest. 1991 Apr; 87(4):1139-45.

Rubinstein I, Nadel JA, Graf PD, Caughey GH. Mast cell chymase potentiates histamine-induced wheal formation in the skin of ragweed-allergic dogs. J Clin Invest. 1990 Aug; 86(2):555-9.

Jacoby DB, Nadel JA. Parainfluenza virus infection of cultured airway epithelial cells. J Virol Methods. 1989 Nov; 26(2):199-208.

Vanderslice P, Craik CS, Nadel JA, Caughey GH. Molecular cloning of dog mast cell tryptase and a related protease: structural evidence of a unique mode of serine protease activation. Biochemistry. 1989 May 16; 28(10):4148-55.

Sommerhoff CP, Caughey GH, Finkbeiner WE, Lazarus SC, Basbaum CB, Nadel JA. Mast cell chymase. A potent secretagogue for airway gland serous cells. J Immunol. 1989 Apr 1; 142(7):2450-6.

Sigal E, Grunberger D, Craik CS, Caughey GH, Nadel JA. Arachidonate 15-lipoxygenase from human leukocytes: purification and structural homology to other mammalian lipoxygenases. Adv Prostaglandin Thromboxane Leukot Res. 1989; 19:156-9.

Sigal E, Craik CS, Highland E, Grunberger D, Costello LL, Dixon RA, Nadel JA. Molecular cloning and primary structure of human 15-lipoxygenase. Biochem Biophys Res Commun. 1988 Dec 15; 157(2):457-64.

Gruenert DC, Basbaum CB, Welsh MJ, Li M, Finkbeiner WE, Nadel JA. Characterization of human tracheal epithelial cells transformed by an origin-defective simian virus 40. Proc Natl Acad Sci U S A. 1988 Aug; 85(16):5951-5.

Jacoby DB, Tamaoki J, Borson DB, Nadel JA. Influenza infection causes airway hyperresponsiveness by decreasing enkephalinase. J Appl Physiol (1985). 1988 Jun; 64(6):2653-8.

Caughey GH, Viro NF, Lazarus SC, Nadel JA. Purification and characterization of dog mastocytoma chymase: identification of an octapeptide conserved in chymotryptic leukocyte proteinases. Biochim Biophys Acta. 1988 Jan 29; 952(2):142-9.

Caughey GH, Viro NF, Ramachandran J, Lazarus SC, Borson DB, Nadel JA. Dog mastocytoma tryptase: affinity purification, characterization, and amino-terminal sequence. Arch Biochem Biophys. 1987 Nov 1; 258(2):555-63.

Hunter JA, Finkbeiner WE, Nadel JA, Goetzl EJ, Holtzman MJ. Predominant generation of 15-lipoxygenase metabolites of arachidonic acid by epithelial cells from human trachea. Proc Natl Acad Sci U S A. 1985 Jul; 82(14):4633-7.

Leikauf GD, Ueki IF, Nadel JA. Autonomic regulation of viscoelasticity of cat tracheal gland secretions. J Appl Physiol Respir Environ Exerc Physiol. 1984 Feb; 56(2):426-30.

Barnes PJ, Skoogh BE, Nadel JA, Roberts JM. Postsynaptic alpha 2-adrenoceptors predominate over alpha 1-adrenoceptors in canine tracheal smooth muscle and mediate neuronal and hormonal alpha-adrenergic contraction. Mol Pharmacol. 1983 May; 23(3):570-5.

Sheppard D, Epstein J, Holtzman MJ, Nadel JA, Boushey HA. Effect of route of atropine delivery on bronchospasm from cold air and methacholine. J Appl Physiol Respir Environ Exerc Physiol. 1983 Jan; 54(1):130-3.

Sheppard D, Epstein J, Holtzman MJ, Nadel JA, Boushey HA. Dose-dependent inhibition of cold air-induced bronchoconstriction by atropine. J Appl Physiol Respir Environ Exerc Physiol. 1982 Jul; 53(1):169-74.

Sheppard D, Saisho A, Nadel JA, Boushey HA. Exercise increases sulfur dioxide-induced bronchoconstriction in asthmatic subjects. Am Rev Respir Dis. 1981 May; 123(5):486-91.

German VF, Ueki IF, Nadel JA. Micropipette measurement of airway submucosal gland secretion: laryngeal reflex. Am Rev Respir Dis. 1980 Sep; 122(3):413-6.

Ueki I, German VF, Nadel JA. Micropipette measurement of airway submucosal gland secretion. Autonomic effects. Am Rev Respir Dis. 1980 Feb; 121(2):351-7.

Golden JA, Nadel JA, Boushey HA. Bronchial hyperirritability in healthy subjects after exposure to ozone. Am Rev Respir Dis. 1978 Aug; 118(2):287-94.

Newth CJ, Cotton DJ, Nadel JA. Pulmonary diffusing capacity measured at multiple intervals during a single exhalation in man. J Appl Physiol Respir Environ Exerc Physiol. 1977 Oct; 43(4):617-25.

Olver RE, Davis B, Marin MG, Nadel JA. Active transport of Na+ and Cl- across the canine tracheal epithelium in vitro. Am Rev Respir Dis. 1975 Dec; 112(6):811-5.

Jones JG, Fraser RB, Nadel JA. Prediction of maximum expiratory flow rate from area-transmural pressure curve of compressed airway. J Appl Physiol. 1975 Jun; 38(6):1002-11.

Gamsu G, Nadel JA. New technique for roentgenographic study of airways and lungs using powdered tantalum. Cancer. 1972 Nov; 30(5):1353-7.

Fallat RJ, Powell MR, Youker JE, Nadel JA. Pulmonary deposition and clearance of 131-I-labeled oil after lymphography in man. Correlation with lung function. Radiology. 1970 Dec; 97(3):511-20.

Hinchcliffe WA, Zamel N, Fishman NH, Dedo HH, Greenspan RH, Nadel J. Roentgenographic study of the human trachea with powdered tantalum. Radiology. 1970 Nov; 97(2):327-30.

Nadel JA, Clarke SW. A new technique for studying airway deposition, morphology and mechanisms using powdered tantalum. Inhaled Part. 1970; 1:43-7.

Lawson TL, Margulis AR, Nadel JA, Rambo ON, Wolfe WG. Intraperitoneal introduction of tantalum powder. A roentgenographic and pathologic study. Invest Radiol. 1969 Sep-Oct; 4(5):293-300.

Goldsmith JR, Nadel JA. Experimental exposure of human subjects to ozone. J Air Pollut Control Assoc. 1969 May; 19(5):329-30.

Nadel JA, Wolfe WG, Graf PD. Powdered tantalum as a medium for bronchography in canine and human lungs. Invest Radiol. 1968 Jul-Aug; 3(4):229-38.

Simonsson BG, Jacobs FM, Nadel JA. Role of autonomic nervous system and the cough reflex in the increased responsiveness of airways in patients with obstructive airway disease. J Clin Invest. 1967 Nov; 46(11):1812-8.

Gold WM, Kaufman HS, Nadel JA. Elastic recoil of the lungs in chronic asthmatic patients before and after therapy. J Appl Physiol. 1967 Oct; 23(4):433-8.

TOKIWA Y, TAMPLIN BR, NADEL JA. MONITORING HUMAN EXPOSURES TO SULFUR DIOXIDE IN A BODY PLETHYSMOGRAPH. J Air Pollut Control Assoc. 1965 Mar; 15:96-8.

TOOLEY WH, DEMUTH G, NADEL JA. THE REVERSIBILITY OF OBSTRUCTIVE CHANGES IN SEVERE CHILDHOOD ASTHMA. J Pediatr. 1965 Mar; 66:517-24.

NADEL JA, SALEM H, TAMPLIN B, TOKIWA Y. MECHANISM OF BRONCHOCONSTRICTION DURING INHALATION OF SULFUR DIOXIDE. J Appl Physiol. 1965 Jan; 20:164-7.

WIDDICOMBE JG, KENT DC, NADEL JA. Mechanism of bronchoconstriction during inhalation of dust. J Appl Physiol. 1962 Jul; 17:613-6.

NADEL JA, COMROE JH. Acute effects of inhalation of cigarette smoke on airway conductance. J Appl Physiol. 1961 Jul; 16:713-6.

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