In addition to asthma-specific research presented on the Asthma webpage, UCSF has significant basic research into the pathogenesis of allergic inflammation more generally. This basic research is carried out within the Division of Pulmonary, Critical Care, Allergy and Sleep Medicine and is also undertaken in collaborating laboratories in other Divisions and Schools at UCSF. Some of these collaborators are organized under the umbrella of the Sandler Asthma Basic Research Program. Below are examples of projects related to ongoing basic research on Allergy at UCSF.

  • The role of known and novel mast cell proteases in regulation of allergic inflammation. Caughey Lab
  • Regulation of lung inflammation by integrins. Sheppard Lab
  • The application of function-tracking mice to report the activation of cytokines and enzymes important in allergic inflammation. Locksley Lab
  • The study of enzymatic deactivation of NO bioactivity and its role in allergic disease. Liu Lab
  • The role of FceRI (high affinity IgE receptor) expression on dendritic cells in asthma. Shin Lab
  • The role of MicroRNAs, transcription factors, and epigenetic regulation in control lymphocyte development, differentiation, and function. Ansel Lab
  • The use of in cutting-edge microscopy to visualize interactions among cells in the lungs and lymphoid organs that ‘prime’ cells for immune responses. Allen Lab
  • Application of real-time 3D imaging to study the spatio-temporal characteristics of the cellular immune response in the sensitization and effector phases of allergy. Krummel Lab