Interstitial Lung Diseases

UCSF has an active research program conducting both clinical and basic research in the pathogenesis of lung fibrosis. Through the generosity of our patients, who collaborate with our world-class physician scientists, we have developed a better understanding of the fundamental, cellular and molecular mechanisms of interstitial lung disease. The clinical research involves both observational studies and clinical trials that use the knowledge gained in basic research to study the benefits of novel treatments in patients with lung fibrosis. Click the link for a list of publications related to clinical and translational research achievements from our program in which our patients have participated.

Below are examples of projects related to ongoing research on interstitial lung diseases at UCSF. See Publications.

Clinical Research

  • NIH and industry sponsored clinical trials investigating novel therapies for treatment of idiopathic pulmonary fibrosis.
  • NIH sponsored clinical trials investigating therapies for treatment of scleroderma associated interstitial lung disease.
  • Clinical research focusing on biologic and clinical predictors of the pathogenesis and progression of interstitial lung diseases.

Discovery Research

  • Translational research investigating the molecular mechanisms of lung fibrosis.
  • Basic research on the role of avb6 mediated TGF-b activation in pulmonary fibrosis.
  • NIH sponsored program project grant that is developing novel therapies targeting the alveolar epithelial cell for the treatment of idiopathic pulmonary fibrosis.
  • Basic investigation of the molecular mechanisms of the unfolded protein response to the pathogenesis of pulmonary fibrosis.
  • Basic and translation studies of the mechanisms of autoimmune-mediated lung disease.
  • Basic and translational research on the contribution of epithelial to mesenchymal transition plays in the pathogenesis of pulmonary fibrosis.
  • Basic research directed at understanding the pathways that regulate collagen turnover in relation to fibrotic disease.
  • Translational research investigating molecular mechanisms of sarcoidosis.
  • Investigations into the genetic causes of lung fibrosis

Clinical Trials

See our Clinical Trials page for more information.

Faculty