Interstitial Lung Disease


FigureUCSF has an active research program conducting both clinical and basic research in the pathogenesis of lung fibrosis. Through the generosity of our patients, who collaborate with our world-class physician scientists, we have developed a better understanding of the fundamental, cellular and molecular mechanisms of interstitial lung disease. The clinical research involves both observational studies and clinical trials that use the knowledge gained in basic research to study the benefits of novel treatments in patients with lung fibrosis. Click the link for a list of publications related to clinical and translational research achievements from our program in which our patients have participated.

Below are examples of projects related to ongoing research on interstitial lung diseases at UCSF.

Clinical Research
  • NIH and industry sponsored clinical trials investigating novel therapies for treatment of idiopathic pulmonary fibrosis. (Golden Lab)

  • NIH sponsored clinical trials investigating therapies for treatment of scleroderma associated interstitial lung disease. (Golden Lab)

  • Clinical research focusing on biologic and clinical predictors of the pathogenesis and progression of interstitial lung diseases. (Collard and Farrand Labs)

Basic Research
  • Translational research investigating the molecular mechanisms of lung fibrosis. 

  • Basic research on the role of avb6 mediated TGF-b activation in pulmonary fibrosis. (Sheppard Lab)

  • Development of novel therapies for the treatment of idiopathic pulmonary fibrosis. (Chapman and Sheppard Lab)

  • Basic investigation of the molecular mechanisms of the unfolded protein response to the pathogenesis of pulmonary fibrosis. (Papa Lab)

  • Basic and translation studies of the mechanisms of autoimmune-mediated lung disease. (Shum Lab)

  • Basic and translational research on the contribution of epithelial to mesenchymal transition plays in the pathogenesis of pulmonary fibrosis. (Wolters and Chapman Lab)

  • Basic research directed at understanding the pathways that regulate collagen turnover in relation to fibrotic disease. Atabai Lab)

  • Translational research investigating molecular mechanisms of sarcoidosis. (Koth Lab)

  • Investigations into the genetic causes of lung fibrosis (Collard and Wolters Labs)

  • Basic and translational research on the contribution of macrophages to pulmonary fibrosis. (Bhattacharya and Atabai Lab)

  • Basic and translational research investigating the consequences of telomere dysfunction to pulmonary fibrosis. (Wolters Lab)


Clinical Trials

See our Clinical Trials page for more information.

Faculty ​​​​​​