Bronchiectasis & Pulmonary Nontuberculous Mycobacterium
Bronchiectasis and nontuberculous mycobacterial (NTM) pulmonary infections are chronic conditions. Bronchiectasis is dilation of airways due to an inflammatory process (current or previous), immunologic dysfunction, or a genetic disorder, and is often complicated by chronic or recurrent infections. Often, patients with NTM pulmonary infections have underlying bronchiectasis. We founded the INTEGRATE program as a multidisciplinary approach to diagnosis and treatment of bronchiectasis, primary ciliary dyskinesia, cystic fibrosis related pulmonary disorders, and pulmonary NTM disease. The focus of our program is to provide holistic care for persons with either or both of these conditions. To accomplish this, our team consists of physicians in Pulmonary Medicine, Infectious Diseases, Radiology, Microbiology, as well as providers in physical therapy, respiratory therapy, and pharmacy. Services we provide include consultation for diagnosis and evaluation of bronchiectasis and pulmonary NTM infections, complex disease management, airway clearance, aerosol therapies, multidisciplinary case review, and clinical and translational research programs.
What is Bronchiectasis?
Bronchiectasis is diagnosed when the small airways in the lung are enlarged. This can be due to many causes which will be evaluated by your doctor, but sometimes cannot be identified. When the enlargement occurs, it is difficult for the lungs to clear naturally producing mucus. As a result, mucus will accumulate and can get impacted over time. Bacteria can accumulate in these sites and cause recurrent infections. The central component of therapy is airway clearance and recurrent evaluation of potential bacteria in the lung.
What are Nontuberculous Mycobacterium Pulmonary Infections?
Nontuberculous mycobacterium (NTM) are environmental bacteria. Only a small fraction of NTM that have been identified cause human diseases, most often pulmonary disease. Even more, not all people with a diagnosis of NTM pulmonary disease need to be treated. This decision is based on symptoms, findings on imaging, the type of organism, and most importantly, the individual’s preference after informed discussion. Treatment regimens include airway clearance and multiple antibiotics over an extended period (greater than one year).
New Patient Referral
Please submit new referrals attention to INTEGRATE clinic for bronchiectasis and pulmonary nontuberculous evaluation. Feel free to contact our clinic for any questions at (415) 353-2961.
To provide a thorough evaluation and initial consultation, we require a chest CT within the last 6 months, pulmonary function tests within the last 1 year, and if available, all microbiologic data from respiratory samples. We also require clinical notes from referring physician and pulmonary or infectious diseases specialists.
Resources for Patients
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What is bronchiectasis (American Thoracic Society)
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NTM lung disease (American Thoracic Society)
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Videos on airway clearance
Consultation and Collaboration with:
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Nutrition Counseling
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Gastroenterology
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Thoracic surgery
UCSF Clinics and Sites of Interest:
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Primary Ciliary Dyskinesia
Our Team
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B. Shoshana Zha, MD/PhD Assistant Professor, Pulmonary Medicine Director of Bronchiectasis/ Pulmonary NTM Program |
Catherine DeVoe, MD Assistant Professor, Infectious Diseases, Co-Director of INTEGRATE |
Jonathan Budzik, MD, PhD Assistant Professor, Pulmonary Medicine |
Katerina Byanova, MD Clinical Instructor, Pulmonary Medicine |
Mary Ellen Kleinhenz, MD Professor, Pulmonary Medicine |
Brett Elicker, MD Professor, Radiology Chief of Cardiac & Pulmonary Imaging |
Jeff Tarnow, RCT Respiratory Therapy |
Vicki Jue, PharmD Pharmacy |
Isabella Cheng Clinical Research Coordinator |
Kathy Bonacini, PT, DPT Physical Therapy |
Gail Cunningham AFB Microbiologist |
Sarah Doernberg Associate Professor, Infectious Diseases |
Monica Fung Assistant Professor, Infectious Diseases |
Rachel Bystritsky Assistant Professor, Infectious Diseases |
Brian Schwartz Associate Professor, Infectious Diseases |