James Frank, MD


James Frank, MD, MA is a clinician-educator and Professor of Medicine at the University of California San Francisco where he focuses on medical education across undergraduate and graduate learners. He is a medical student coach in the UCSF Bridges Curriculum and directs the medical student critical care immersion experience at the San Francisco VA. He is the program director for the UCSF Pulmonary and Critical Care Fellowship Program. His clinical work includes critical care medicine, co-leading the pulmonary embolism response team, thoracentesis service and Neuromuscular/Amyotrophic Lateral Sclerosis respiratory clinic at the SFVA. Dr. Frank formerly ran a biomedical research program and has experience in training and mentoring physician-scientists. His current academic interests include education leadership, teaching quality improvement and communication skills, professional coaching, and curriculum development and implementation.
2020 - Medical Education Research Certificate, American Association of Medical Colleges (AAMC)
2017 - Diversity, Equity, and Inclusion Champion Training, University of California, San Francisco
- Internal Medicine Residency, University of California, San Francisco
- Pulmonary & Critical Care Medicine Fellowship, University of California, San Francisco
- M.D., University of Colorado School of Medicine
Honors and Awards
  • Osler Distinguished Teacher Award, UCSF School of Medicine, 2023
  • Outstanding Educator Award, Association of Pulmonary and Critical Care Program Directors, APCCMPD, 2022
  • Haile T. Debas Academy of Medical Educators Service Award, UCSF, 2022
  • Excellence and Innovation in Graduate Medical Education Award, UCSF, 2020
  • Induction - Haile T. Debas Academy of Medical Educators, UCSF, 2020
  • Outstanding Coach, Bridges Curriculum Foundations 1 and 2 Teaching Award, UCSF School of Medicine, 2020
  • Michael S. Stulbarg Outstanding Teaching Award, UCSF, 2015
  • Haile T. Debas Academy of Medical Educators Excellence in Teaching Award, UCSF, 2014
  1. Ju M, Bochatay N, Robertson K, Frank J, O'Brien B, van Schaik S. From ideal to real: a qualitative study of the implementation of in situ interprofessional simulation-based education. 2015 Year Book of Pediatrics. Ed. Cabana MD. (Elsevier; Philadelphia, PA) 2022. PMID: 35449012

  2. Baugh A, Frank J. Account for Identity in URM Mentorship. 2015 Year Book of Pediatrics. Ed. Cabana MD. (Elsevier; Philadelphia, PA) 2022. PMID: 35013930

  3. Huppert LA, Hsu G, Elnachef N, Flint L, Frank JA, Gensler LS, Hsiao EC, Khanna RR, Qasim A, Schwartz BS, Widera E, Zapata C, Babik JM. A single center evaluation of applicant experiences in virtual interviews across eight internal medicine subspecialty fellowship programs. Medical education online 2021. PMID: 34187346

  4. Huppert LA, Hsiao EC, Cho KC, Marquez C, Chaudhry RI, Frank J, Goglin SE, Hsu G, Kathpalia P, Khanna R, Kompala T, Rao MN, Bower BA, Trafas V, Santhosh L, Schwartz BS, Babik JM. Virtual Interviews at Graduate Medical Education Training Programs: Determining Evidence-Based Best Practices. Academic medicine : journal of the Association of American Medical Colleges 2020. PMID: 33298691

  5. Widera E, Anderson WG, Santhosh L, McKee KY, Smith AK, Frank J. Family Meetings on Behalf of Patients with Serious Illness. The New England journal of medicine 2020. PMID: 32905678

  6. Isikbay M, Henry TS, Frank JA, Hope MD. When to Rule Out COVID-19: How Many Negative RT-PCR Tests Are Needed? Respiratory medicine case reports 2020. PMID: 32837902

  7. Ghasemiesfe M, Ravi D, Vali M, Korenstein D, Arjomandi M, Frank J, Austin PC, Keyhani S. Marijuana Use, Respiratory Symptoms, and Pulmonary Function: A Systematic Review and Meta-analysis. Annals of internal medicine 2018. PMID: 29971337

  8. Elicker BM, Jones KT, Naeger DM, Frank JA. Imaging of Acute Lung Injury. Volume 54 of Issue 6. Radiologic clinics of North America 2016. PMID: 27719979

  9. Sweerus K, Lachowicz-Scroggins M, Gordon E, LaFemina M, Huang X, Parikh M, Kanegai C, Fahy JV, Frank JA. Claudin-18 deficiency is associated with airway epithelial barrier dysfunction and asthma. Volume 139 of Issue 1. 2016. PMID: 27215490

  10. Brune K, Frank J, Schwingshackl A, Finigan J, Sidhaye VK. Pulmonary epithelial barrier function: some new players and mechanisms. Volume 308 of Issue 8. American journal of physiology. Lung cellular and molecular physiology 2015. PMID: 25637609

  11. LaFemina MJ, Sutherland KM, Bentley T, Gonzales LW, Allen L, Chapin CJ, Rokkam D, Sweerus KA, Dobbs LG, Ballard PL, Frank JA. Claudin-18 deficiency results in alveolar barrier dysfunction and impaired alveologenesis in mice. Volume 51 of Issue 4. 2014. PMID: 24787463

  12. Hirsch J, Chalkley RJ, Bentley T, Burlingame AL, Frank JA. Double impact of cigarette smoke and mechanical ventilation on the alveolar epithelial type II cell. Volume 18 of Issue 2. 2014. PMID: 24666941

  13. Frank JA, Matthay MA. TGF-ß and lung fluid balance in ARDS. Volume 111 of Issue 3. Proceedings of the National Academy of Sciences of the United States of America 2014. PMID: 24449829

  14. Yang J, Wheeler SE, Velikoff M, Kleaveland KR, LaFemina MJ, Frank JA, Chapman HA, Christensen PJ, Kim KK. Activated alveolar epithelial cells initiate fibrosis through secretion of mesenchymal proteins. Volume 183 of Issue 5. 2013. PMID: 24012677

  15. Katherine Sutherland, Trevor Bentley, Michael LaFemina, James Frank. Claudin-4 promotes epithelial repair and restoration of barrier function via interactions with the small GTPase Rap1. The FASEB Journal 2013. PMID:

  16. Frank JA. Claudins and alveolar epithelial barrier function in the lung. Volume 1257. 2012. PMID: 22671604

  17. Katherine Marie Sutherland, Trevor Bentley, Michael LaFemina, Gwen Ho, Jan Hirsch, James Frank. Claudin-4 interacts with the small GTPase Rap1 and accelerates epithelial repair. The FASEB Journal 2012. PMID:

  18. Rokkam D, Lafemina MJ, Lee JW, Matthay MA, Frank JA. Claudin-4 levels are associated with intact alveolar fluid clearance in human lungs. Volume 179 of Issue 3. 2011. PMID: 21741940

  19. Deepti Rokkam, Jan Hirsch, Gwen Ho, Chris Griffin, Michael J LaFemina, James A Frank. Claudin-4 promotes repair and barrier function in lung epithelia. The FASEB Journal 2011. PMID:

  20. LaFemina MJ, Rokkam D, Chandrasena A, Pan J, Bajaj A, Johnson M, Frank JA. Keratinocyte growth factor enhances barrier function without altering claudin expression in primary alveolar epithelial cells. Volume 299 of Issue 6. American journal of physiology. Lung cellular and molecular physiology 2010. PMID: 20833776

  21. Deepti Rokkam, Gwendolyn Ho, James A. Frank. Claudin-4 is required for EGFR-mediated alveolar epithelial migration. The FASEB Journal 2010. PMID:

  22. Wolters PJ, Wray C, Sutherland RE, Kim SS, Koff J, Mao Y, Frank JA. Neutrophil-derived IL-6 limits alveolar barrier disruption in experimental ventilator-induced lung injury. Volume 182 of Issue 12. Journal of immunology (Baltimore, Md. : 1950) 2009. PMID: 19494331

  23. Wray C, Mao Y, Pan J, Chandrasena A, Piasta F, Frank JA. Claudin-4 augments alveolar epithelial barrier function and is induced in acute lung injury. Volume 297 of Issue 2. American journal of physiology. Lung cellular and molecular physiology 2009. PMID: 19447895

  24. Jae Woo Lee, Naveen Gupta, Xiaohui Fang, James A. Frank, Raphael Briot, Michael A. Matthay. Allogeneic human mesenchymal stem cells for treatment of E. Coli endotoxin-induced acute lung injury in an ex vivo perfused human lung. The FASEB Journal 2009. PMID:

  25. Horak FB, Wrisley DM, Frank J. The Balance Evaluation Systems Test (BESTest) to differentiate balance deficits. Physical Therapy 2009. PMID: 19329772

  26. Zier LS, Burack JH, Micco G, Chipman AK, Frank JA, White DB. Surrogate decision makers' responses to physicians' predictions of medical futility. Volume 136 of Issue 1. Chest 2009. PMID: 19318665

  27. Kim KK, Wei Y, Szekeres C, Kugler MC, Wolters PJ, Hill ML, Frank JA, Brumwell AN, Wheeler SE, Kreidberg JA, Chapman HA. Epithelial cell alpha3beta1 integrin links beta-catenin and Smad signaling to promote myofibroblast formation and pulmonary fibrosis. Volume 119 of Issue 1. The Journal of clinical investigation 2008. PMID: 19104148

  28. Zier LS, Burack JH, Micco G, Chipman AK, Frank JA, Luce JM, White DB. Doubt and belief in physicians' ability to prognosticate during critical illness: the perspective of surrogate decision makers. Volume 36 of Issue 8. Critical care medicine 2008. PMID: 18596630

  29. Hirsch J, Niemann CU, Hansen KC, Choi S, Su X, Frank JA, Fang X, Hirose R, Theodore P, Sapru A, Burlingame AL, Matthay MA. Alterations in the proteome of pulmonary alveolar type II cells in the rat after hepatic ischemia-reperfusion. Volume 36 of Issue 6. Critical care medicine 2008. PMID: 18496381

  30. Ganter MT, Roux J, Miyazawa B, Howard M, Frank JA, Su G, Sheppard D, Violette SM, Weinreb PH, Horan GS, Matthay MA, Pittet JF. Interleukin-1beta causes acute lung injury via alphavbeta5 and alphavbeta6 integrin-dependent mechanisms. Volume 102 of Issue 7. 2008. PMID: 18276918

  31. Frank JA, Pittet JF, Wray C, Matthay MA. Protection from experimental ventilator-induced acute lung injury by IL-1 receptor blockade. Volume 63 of Issue 2. 2007. PMID: 17901159

  32. Frank JA, Erle DJ. Progress toward a systems biology approach to acute lung injury. Volume 293 of Issue 2. American journal of physiology. Lung cellular and molecular physiology 2007. PMID: 17575007

  33. Hirsch J, Hansen KC, Sapru A, Frank JA, Chalkley RJ, Fang X, Trinidad JC, Baker P, Burlingame AL, Matthay MA. Impact of low and high tidal volumes on the rat alveolar epithelial type II cell proteome. Volume 175 of Issue 10. American journal of respiratory and critical care medicine 2007. PMID: 17363773

  34. Frank JA, Briot R, Lee JW, Ishizaka A, Uchida T, Matthay MA. Physiological and biochemical markers of alveolar epithelial barrier dysfunction in perfused human lungs. Volume 293 of Issue 1. American journal of physiology. Lung cellular and molecular physiology 2007. PMID: 17351061

  35. Frank JA, Parsons PE, Matthay MA. Pathogenetic significance of biological markers of ventilator-associated lung injury in experimental and clinical studies. Volume 130 of Issue 6. Chest 2006. PMID: 17167015

  36. Su G, Hodnett M, Wu N, Atakilit A, Kosinski C, Godzich M, Huang XZ, Kim JK, Frank JA, Matthay MA, Sheppard D, Pittet JF. Integrin alphavbeta5 regulates lung vascular permeability and pulmonary endothelial barrier function. Volume 36 of Issue 3. 2006. PMID: 17079779

  37. Frank JA, Wray CM, McAuley DF, Schwendener R, Matthay MA. Alveolar macrophages contribute to alveolar barrier dysfunction in ventilator-induced lung injury. Volume 291 of Issue 6. American journal of physiology. Lung cellular and molecular physiology 2006. PMID: 16877636

  38. Godzich M, Hodnett M, Frank JA, Su G, Pespeni M, Angel A, Howard MB, Matthay MA, Pittet JF. Activation of the stress protein response prevents the development of pulmonary edema by inhibiting VEGF cell signaling in a model of lung ischemia-reperfusion injury in rats. Volume 20 of Issue 9. 2006. PMID: 16793871

  39. Frank JA, Matthay MA. Leukotrienes in acute lung injury: a potential therapeutic target? Volume 172 of Issue 3. American journal of respiratory and critical care medicine 2005. PMID: 16040787

  40. L Robriquet, Y Song, H Folkesson, J Frank, A Verkman, M Matthay. Effect of pharmacological inhibition of chloride transport on lung fluid balance in acute Escherichia coli pneumonia in mice. Critical Care 2005. PMID:

  41. Frank JA, McAuley DF, Gutierrez JA, Daniel BM, Dobbs L, Matthay MA. Differential effects of sustained inflation recruitment maneuvers on alveolar epithelial and lung endothelial injury. Volume 33 of Issue 1. Critical care medicine 2005. PMID: 15644667

  42. J Hirsch, K Hansen, J Frank, R Chalkley, X Fang, A Burlingame, M Matthay. Altered proteomic patterns in rat alveolar epithelial type II cells after ventilation with high and low tidal volumes. Critical Care 2004. PMID:

  43. G Perkins, D McAuley, J Frank, D Thickett, X Fang, M Matthay. Clinically relevant concentrations of beta agonists may stimulate alveolar fluid clearance in acute respiratory distress syndrome. Critical Care 2004. PMID:

  44. Frank J, Roux J, Kawakatsu H, Su G, Dagenais A, Berthiaume Y, Howard M, Canessa CM, Fang X, Sheppard D, Matthay MA, Pittet JF. Transforming growth factor-beta1 decreases expression of the epithelial sodium channel alphaENaC and alveolar epithelial vectorial sodium and fluid transport via an ERK1/2-dependent mechanism. Volume 278 of Issue 45. The Journal of biological chemistry 2003. PMID: 12930837

  45. Frank JA, Pittet JF, Lee H, Godzich M, Matthay MA. High tidal volume ventilation induces NOS2 and impairs cAMP- dependent air space fluid clearance. Volume 284 of Issue 5. American journal of physiology. Lung cellular and molecular physiology 2003. PMID: 12562562

  46. Frank JA, Matthay MA. Science review: mechanisms of ventilator-induced injury. Volume 7 of Issue 3. 2002. PMID: 12793874

  47. Frank JA, Gutierrez JA, Jones KD, Allen L, Dobbs L, Matthay MA. Low tidal volume reduces epithelial and endothelial injury in acid-injured rat lungs. Volume 165 of Issue 2. American journal of respiratory and critical care medicine 2002. PMID: 11790662

  48. M. A. Matthay, L. B. Ware, J. A. Frank. Pulmonary Epithelial Injury: Clinical and Experimental Evidence for a Major Role in Acute Lung Injury and Multiple Organ Dysfunction. Mechanisms of Organ Dysfunction in Critical Illness 2002. PMID:

  49. Frank JA, Wang Y, Osorio O, Matthay MA. Beta-adrenergic agonist therapy accelerates the resolution of hydrostatic pulmonary edema in sheep and rats. Volume 89 of Issue 4. 2000. PMID: 11007557

  50. Matthay MA, Fukuda N, Frank J, Kallet R, Daniel B, Sakuma T. Alveolar epithelial barrier. Role in lung fluid balance in clinical lung injury. Volume 21 of Issue 3. Clinics in chest medicine 2000. PMID: 11019721

  51. Frank JA, Nuckton TJ, Matthay MA. Diabetes mellitus: a negative predictor for the development of acute respiratory distress syndrome from septic shock. Volume 28 of Issue 7. Critical care medicine 2000. PMID: 10921610

  52. Stulbarg MS, Frank JA. Obstructive pulmonary disease. The clinician's perspective. Volume 36 of Issue 1. Radiologic clinics of North America 1998. PMID: 9465865