Vincent Auyeung, MD, PhD

Education
Fellowship, 2019 - Pulmonary and Critical Care Medicine, UCSF
Residency, 2016 - Internal Medicine, UCSF
MD, 2014 - Medicine, Harvard Medical School
PhD, 2012 - Molecular Biology, MIT
BS, 2005 - Biology, Caltech
Websites
Publications

  1. Lee JY, Reyes N, Woo SH, Allen NC, Kadota T, Lechner A, Biswas R, Goel S, Stratton F, Kuang C, Tsukui T, Auyeung V, Mansfield AS, LaFave LM, Peng T. Senolytic-sensitive p16Ink4a+ fibroblasts in the tumor stroma rewire lung cancer metabolism and plasticity. Cell stem cell 2025. PMID: 41187746


  2. Auyeung VC, Steinberg TL, Olivier A, Suzuki L, Moreno ME, Khan IS, Downey MS, Thamsen M, Guo L, Maly DJ, Backes BJ, Sheppard D, Papa FR. Pharmacologic inhibition of IRE1a-dependent decay protects alveolar epithelial identity and prevents pulmonary fibrosis in mice. The Journal of clinical investigation 2025. PMID: 41090357


  3. Yadav P, Gómez Ortega J, Dabral P, Tamaki W, Chien C, Chang KC, Biswas N, Pan S, Nilsson J, Yin X, Bhattacharyya A, Boostanpour K, Jujaray T, Wang JT, Tsukui T, Molina CJ, Auyeung VC, Sheppard D, Li B, Maishan M, Taenaka H, Matthay MA, Muramatsu R, Maliskova L, Ghosh A, Eckalbar WL, Molofsky AB, Tamaki SJ, Bivona TG, Abate AR, Wagner A, Pillai SK, Wolters PJ, Tharp KM, Bhattacharya M. Myeloid-mesenchymal crosstalk drives ARG1-dependent profibrotic metabolism via ornithine in lung fibrosis. The Journal of clinical investigation 2025. PMID: 40875483


  4. Khan IS, Molina C, Ren X, Auyeung VC, Cohen M, Tsukui T, Atakilit A, Sheppard D. Impaired myofibroblast proliferation is a central feature of pathologic post-natal alveolar simplification. eLife 2024. PMID: 39660606


  5. Khan IS, Molina C, Ren X, Auyeung VC, Cohen M, Tsukui T, Atakilit A, Sheppard D. Impaired Myofibroblast Proliferation is a Central Feature of Pathologic Post-Natal Alveolar Simplification. bioRxiv : the preprint server for biology 2023. PMID: 38187712


  6. Jourdan Le Saux C, Ho TC, Brumwell AM, Kathiriya JJ, Wei Y, Hughes JB, Garakani K, Atabai K, Auyeung VC, Papa FR, Chapman HA. BCL-2 Modulates IRE1α Activation to Attenuate ER Stress and Pulmonary Fibrosis. American journal of respiratory cell and molecular biology 2023. PMID: 38117250


  7. Auyeung VC, Downey MS, Thamsen M, Wenger TA, Backes BJ, Sheppard D, Papa FR. IRE1α drives lung epithelial progenitor dysfunction to establish a niche for pulmonary fibrosis. 2015 Year Book of Pediatrics. Ed. Cabana MD. (Elsevier; Philadelphia, PA) 2022. PMID: 35170357


  8. Feldman HC, Ghosh R, Auyeung VC, Mueller JL, Kim JH, Potter ZE, Vidadala VN, Perera BGK, Olivier A, Backes BJ, Zikherman J, Papa FR, Maly DJ. ATP-competitive partial antagonists of the IRE1α RNase segregate outputs of the UPR. Nature chemical biology 2021. PMID: 34556859


  9. Auyeung VC, Sheppard D. Stuck in a Moment: Does Abnormal Persistence of Epithelial Progenitors Drive Pulmonary Fibrosis? American journal of respiratory and critical care medicine 2020. PMID: 33226835


  10. Vanderburg S, Alipanah N, Crowder R, Yoon C, Wang R, Thakur N, Slown K, Shete PB, Rofael M, Metcalfe JZ, Merrifield C, Marquez C, Malcolm K, Lipnick M, Jain V, Gomez A, Burns G, Brown LB, Berger C, Auyeung V, Cattamanchi A, Hendrickson CM. Management and Outcomes of Critically-Ill Patients with COVID-19 Pneumonia at a Safety-net Hospital in San Francisco, a Region with Early Public Health Interventions: A Case Series. medRxiv : the preprint server for health sciences 2020. PMID: 32511538


  11. Gonzalez-Teuber V, Albert-Gasco H, Auyeung VC, Papa FR, Mallucci GR, Hetz C. Small Molecules to Improve ER Proteostasis in Disease. 2019. PMID: 31377018


  12. Thamsen M, Ghosh R, Auyeung VC, Brumwell A, Chapman HA, Backes BJ, Perara G, Maly DJ, Sheppard D, Papa FR. Small molecule inhibition of IRE1a kinase/RNase has anti-fibrotic effects in the lung. PloS one 2019. PMID: 30625178


  13. Auyeung VC, Ulitsky I, McGeary SE, Bartel DP. Beyond secondary structure: primary-sequence determinants license pri-miRNA hairpins for processing. Volume 152 of Issue 4. 2013. PMID: 23415231


  14. Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP. Mammalian microRNAs: experimental evaluation of novel and previously annotated genes. Volume 24 of Issue 10. 2010. PMID: 20413612


  15. D'Alise AM, Auyeung V, Feuerer M, Nishio J, Fontenot J, Benoist C, Mathis D. The defect in T-cell regulation in NOD mice is an effect on the T-cell effectors. Volume 105 of Issue 50. Proceedings of the National Academy of Sciences of the United States of America 2008. PMID: 19073938


  16. An DS, Qin FX, Auyeung VC, Mao SH, Kung SK, Baltimore D, Chen IS. Optimization and functional effects of stable short hairpin RNA expression in primary human lymphocytes via lentiviral vectors. Volume 14 of Issue 4. 2006. PMID: 16844419


  17. Dahan DS, Dibas MI, Petersson EJ, Auyeung VC, Chanda B, Bezanilla F, Dougherty DA, Lester HA. A fluorophore attached to nicotinic acetylcholine receptor beta M2 detects productive binding of agonist to the alpha delta site. Volume 101 of Issue 27. Proceedings of the National Academy of Sciences of the United States of America 2004. PMID: 15218096