Anthony Shum, MD

Education
2018 - Diversity, Equity, and Inclusion Champion Training, University of California
M.D., - Pritzker School of Medicine, University of Chicago
Honors and Awards
  • Elected Member, American Society for Clinical Investigation, 2022
  • Lee Howley Sr. Prize for Arthritis Scientific Research, Arthritis Foundation, 2015
  • Innovative Research Grant, Rheumatology Research Foundation, 2015
  • Robert L. Kroc Chair in Rheumatic and Connective Tissue Diseases II, UCSF, 2015
  • Young Physician-Scientist Award, American Society for Clinical Investigation, 2014
  • American Thoracic Society Career Development Award, American Thoracic Society, 2007
  • Will Rogers Institute Fellowship, Will Rogers Institute, 2005
Websites
Publications

  1. Fagundes MDC, Bianco T, Nunes DP, Ostroski TKD, Bridi GDP, Kawassaki AM, Barbas CSV, Mendonça LO, Barros SF, Kalil J, Shum AK, Escuissato DL. Twenty-year-old patient with polyarthritis since childhood showing cysts and ground glass attenuation on HRCT. Thorax 2024. PMID: 38195643


  2. Deng Z, Law CS, Kurra S, Simchoni N, Shum AK. Activated STING in the thymus alters T cell development and selection leading to autoimmunity. bioRxiv : the preprint server for biology 2024. PMID: 38464209


  3. Anna Pavlova, Sasthi C. Mandal, Noa Simchoni, Christopher S. Law, Atanu Acharya, Anthony K. Shum, James C. Gumbart. Pathogenic COPA mutations decrease binding of dilysine motifs through allosteric effects. Biophysical journal 2024. PMID:


  4. Simchoni N, Vogel TP, Shum AK. COPA Syndrome from Diagnosis to Treatment: A Clinician's Guide. Rheumatic diseases clinics of North America 2023. PMID: 37821196


  5. Yoon YM, Velez TE, Upadhyay V, Vazquez SE, Lee CT, Selvan KC, Law CS, Blaine KM, Hollinger MK, Decker DC, Clark MR, Strek ME, Guzy RD, Adegunsoye A, Noth I, Wolters PJ, Anderson M, DeRisi JL, Shum AK, Sperling AI. Antigenic responses are hallmarks of fibrotic interstitial lung diseases independent of underlying etiologies. medRxiv : the preprint server for health sciences 2023. PMID: 37214861


  6. Upadhyay V, Yoon YM, Vazquez SE, Velez TE, Jones KD, Lee CT, Law CS, Wolters PJ, Lee S, Yang MM, Farrand E, Noth I, Strek ME, Anderson M, DeRisi J, Sperling AI, Shum AK. PhIP-Seq uncovers novel autoantibodies and unique endotypes in interstitial lung disease. bioRxiv : the preprint server for biology 2023. PMID: 37163026


  7. Young me Yoon, Tania Velez, Vaibhav Upadhyay, Sara Vazquez, Cathryn T Lee, Kelly Blaine, Donna Decker, Robert Guzy, Ayodeji Adegunsoye, Mary Strek, Imre Noth, Mark S Anderson, Joseph DeRisi, Anthony Shum, Anne I Sperling. Interstitial lung disease patients exhibit augmented germinal center responses in lung lymph nodes and increased serum reactivities to novel autoantigens. The Journal of Immunology 2022. PMID:


  8. Psarianos P, Kwan JYY, Dell S, Wee WB, Rey-McIntyre K, Chen H, Dissanayake D, Laxer RM, Shum A, Liu FF, Yip KW. COPA Syndrome (Ala239Pro) Presenting with Isolated Follicular Bronchiolitis in Early Childhood: Case Report. Journal of clinical immunology 2021. PMID: 34115278


  9. Kojiro Mukai, Anthony Shum, Tomohiko Taguchi. Homeostatic regulation of STING by retrograde membrane traffic to the ER. The FASEB Journal 2021. PMID:


  10. Mukai K, Ogawa E, Uematsu R, Kuchitsu Y, Kiku F, Uemura T, Waguri S, Suzuki T, Dohmae N, Arai H, Shum AK, Taguchi T. Homeostatic regulation of STING by retrograde membrane traffic to the ER. Nature communications 2021. PMID: 33397928


  11. Deng Z, Chong Z, Law CS, Mukai K, Ho FO, Martinu T, Backes BJ, Eckalbar WL, Taguchi T, Shum AK. A defect in COPI-mediated transport of STING causes immune dysregulation in COPA syndrome. The Journal of experimental medicine 2020. PMID: 32725126


  12. Deng Z, Law CS, Ho FO, Wang KM, Jones KD, Shin JS, Shum AK. A Defect in Thymic Tolerance Causes T Cell-Mediated Autoimmunity in a Murine Model of COPA Syndrome. Journal of immunology (Baltimore, Md. : 1950) 2020. PMID: 32198142


  13. Lalaoui N, Boyden SE, Oda H, Wood GM, Stone DL, Chau D, Liu L, Stoffels M, Kratina T, Lawlor KE, Zaal KJM, Hoffmann PM, Etemadi N, Shield-Artin K, Biben C, Tsai WL, Blake MD, Kuehn HS, Yang D, Anderton H, Silke N, Wachsmuth L, Zheng L, Moura NS, Beck DB, Gutierrez-Cruz G, Ombrello AK, Pinto-Patarroyo GP, Kueh AJ, Herold MJ, Hall C, Wang H, Chae JJ, Dmitrieva NI, McKenzie M, Light A, Barham BK, Jones A, Romeo TM, Zhou Q, Aksentijevich I, Mullikin JC, Gross AJ, Shum AK, Hawkins ED, Masters SL, Lenardo MJ, Boehm M, Rosenzweig SD, Pasparakis M, Voss AK, Gadina M, Kastner DL, Silke J. Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease. Nature 2019. PMID: 31827281


  14. Tsui JL, Estrada OA, Deng Z, Wang KM, Law CS, Elicker BM, Jones KD, Dell SD, Gudmundsson G, Hansdottir S, Helfgott SM, Volpi S, Gattorno M, Waterfield MR, Chan AY, Chung SA, Ley B, Shum AK. Analysis of pulmonary features and treatment approaches in the COPA syndrome. 2018. PMID: 29977900


  15. Volpi S, Tsui J, Mariani M, Pastorino C, Caorsi R, Sacco O, Ravelli A, Shum AK, Gattorno M, Picco P. Type I interferon pathway activation in COPA syndrome. Volume 187. 2017. PMID: 29030294


  16. Chung SA, Shum AK. Rare variants, autoimmune disease, and arthritis. Volume 28 of Issue 4. 2016. PMID: 27224741


  17. Shum AK. T cell types that take your breath away. Volume 7 of Issue 301. Science translational medicine 2015. PMID: 26290409


  18. Assayag D, Kim EJ, Elicker BM, Jones KD, Golden JA, King TE, Koth LL, Shum AK, Wolters PJ, Collard HR, Lee JS. Survival in interstitial pneumonia with features of autoimmune disease: a comparison of proposed criteria. Volume 109 of Issue 10. Respiratory medicine 2015. PMID: 26303338


  19. Assayag D, Vittinghoff E, Ryerson CJ, Cocconcelli E, Tonelli R, Hu X, Elicker BM, Golden JA, Jones KD, King TE, Koth LL, Lee JS, Ley B, Shum AK, Wolters PJ, Ryu JH, Collard HR. The effect of bronchodilators on forced vital capacity measurement in patients with idiopathic pulmonary fibrosis. Volume 109 of Issue 8. Respiratory medicine 2015. PMID: 26140806


  20. Landegren N, Sharon D, Shum AK, Khan IS, Fasano KJ, Hallgren Å, Kampf C, Freyhult E, Ardesjö-Lundgren B, Alimohammadi M, Rathsman S, Ludvigsson JF, Lundh D, Motrich R, Rivero V, Fong L, Giwercman A, Gustafsson J, Perheentupa J, Husebye ES, Anderson MS, Snyder M, Kämpe O. Transglutaminase 4 as a prostate autoantigen in male subfertility. Volume 7 of Issue 292. Science translational medicine 2015. PMID: 26084804


  21. Watkin LB, Jessen B, Wiszniewski W, Vece TJ, Jan M, Sha Y, Thamsen M, Santos-Cortez RL, Lee K, Gambin T, Forbes LR, Law CS, Stray-Pedersen A, Cheng MH, Mace EM, Anderson MS, Liu D, Tang LF, Nicholas SK, Nahmod K, Makedonas G, Canter DL, Kwok PY, Hicks J, Jones KD, Penney S, Jhangiani SN, Rosenblum MD, Dell SD, Waterfield MR, Papa FR, Muzny DM, Zaitlen N, Leal SM, Gonzaga-Jauregui C. COPA mutations impair ER-Golgi transport and cause hereditary autoimmune-mediated lung disease and arthritis. Volume 47 of Issue 6. 2015. PMID: 25894502


  22. Price JV, Haddon DJ, Kemmer D, Delepine G, Mandelbaum G, Jarrell JA, Gupta R, Balboni I, Chakravarty EF, Sokolove J, Shum AK, Anderson MS, Cheng MH, Robinson WH, Browne SK, Holland SM, Baechler EC, Utz PJ. Protein microarray analysis reveals BAFF-binding autoantibodies in systemic lupus erythematosus. Volume 123 of Issue 12. The Journal of clinical investigation 2013. PMID: 24270423


  23. Shum AK, Alimohammadi M, Tan CL, Cheng MH, Metzger TC, Law CS, Lwin W, Perheentupa J, Bour-Jordan H, Carel JC, Husebye ES, De Luca F, Janson C, Sargur R, Dubois N, Kajosaari M, Wolters PJ, Chapman HA, Kämpe O, Anderson MS. BPIFB1 is a lung-specific autoantigen associated with interstitial lung disease. Volume 5 of Issue 206. Science translational medicine 2013. PMID: 24107778


  24. Lee JS, Kim EJ, Lynch KL, Elicker B, Ryerson CJ, Katsumoto TR, Shum AK, Wolters PJ, Cerri S, Richeldi L, Jones KD, King TE, Collard HR. Prevalence and clinical significance of circulating autoantibodies in idiopathic pulmonary fibrosis. Volume 107 of Issue 2. Respiratory medicine 2012. PMID: 23186614


  25. Jordan Price, Dodge Kemmer, Imelda Balboni, David Haddon, Gil Mandelbaum, Guillaume Delepine, Jeremy Sokolove, Anthony Shum, Sarah Browne, Paul Utz. Protein microarray analysis of serum factor-reactive autoantibodies reveals BAFF-binding autoantibodies in systemic lupus erythematosus (58.22). The Journal of Immunology 2012. PMID:


  26. Su MA, Davini D, Cheng P, Giang K, Fan U, DeVoss JJ, Johannes KP, Taylor L, Shum AK, Valenzise M, Meloni A, Bour-Jordan H, Anderson MS. Defective autoimmune regulator-dependent central tolerance to myelin protein zero is linked to autoimmune peripheral neuropathy. Volume 188 of Issue 10. Journal of immunology (Baltimore, Md. : 1950) 2012. PMID: 22490868


  27. Anthony K. Shum. IgM Antibodies to the Rescue!. 2015 Year Book of Pediatrics. Ed. Cabana MD. (Elsevier; Philadelphia, PA) 2012. PMID:


  28. Anthony K. Shum. Smoking Out a New Therapy for Lung Disease. 2015 Year Book of Pediatrics. Ed. Cabana MD. (Elsevier; Philadelphia, PA) 2012. PMID:


  29. Anthony K. Shum. A New Twist in a Fibrous Condition. 2015 Year Book of Pediatrics. Ed. Cabana MD. (Elsevier; Philadelphia, PA) 2011. PMID:


  30. Anthony K. Shum. A Joint Venture Between Complement and Chondrocytes. 2015 Year Book of Pediatrics. Ed. Cabana MD. (Elsevier; Philadelphia, PA) 2011. PMID:


  31. Anthony K. Shum. Refreshing Your Memory. 2015 Year Book of Pediatrics. Ed. Cabana MD. (Elsevier; Philadelphia, PA) 2011. PMID:


  32. Anthony K. Shum. Digesting the Unexpected Side Effects of Chronic Antibiotic Use. 2015 Year Book of Pediatrics. Ed. Cabana MD. (Elsevier; Philadelphia, PA) 2011. PMID:


  33. Anthony K. Shum. A Gut Check for Asthma. 2015 Year Book of Pediatrics. Ed. Cabana MD. (Elsevier; Philadelphia, PA) 2011. PMID:


  34. Anthony K. Shum. The "Eyes" Have It. 2015 Year Book of Pediatrics. Ed. Cabana MD. (Elsevier; Philadelphia, PA) 2011. PMID:


  35. Anthony K. Shum. A Mimic for Lupus Treatment. 2015 Year Book of Pediatrics. Ed. Cabana MD. (Elsevier; Philadelphia, PA) 2011. PMID:


  36. Anthony K. Shum. Pearls of Wisdom for Pulmonary Fibrosis. 2015 Year Book of Pediatrics. Ed. Cabana MD. (Elsevier; Philadelphia, PA) 2011. PMID:


  37. Anthony K. Shum. OutFOXing Tolerance in Multiple Sclerosis. 2015 Year Book of Pediatrics. Ed. Cabana MD. (Elsevier; Philadelphia, PA) 2011. PMID:


  38. Anthony K. Shum. A Little Tolerance Can Prevent a Broken Heart. 2015 Year Book of Pediatrics. Ed. Cabana MD. (Elsevier; Philadelphia, PA) 2011. PMID:


  39. Shum AK, DeVoss J, Tan CL, Hou Y, Johannes K, O'Gorman CS, Jones KD, Sochett EB, Fong L, Anderson MS. Identification of an autoantigen demonstrates a link between interstitial lung disease and a defect in central tolerance. Volume 1 of Issue 9. Science translational medicine 2009. PMID: 20368189


  40. Devoss JJ, Shum AK, Johannes KP, Lu W, Krawisz AK, Wang P, Yang T, Leclair NP, Austin C, Strauss EC, Anderson MS. Effector mechanisms of the autoimmune syndrome in the murine model of autoimmune polyglandular syndrome type 1. Volume 181 of Issue 6. Journal of immunology (Baltimore, Md. : 1950) 2008. PMID: 18768863


  41. Zhang L, Barker JM, Babu S, Su M, Stenerson M, Cheng M, Shum A, Zamir E, Badolato R, Law A, Eisenbarth GS, Anderson MS. A robust immunoassay for anti-interferon autoantibodies that is highly specific for patients with autoimmune polyglandular syndrome type 1. Volume 125 of Issue 2. 2007. PMID: 17825626


  42. Cheng MH, Shum AK, Anderson MS. What's new in the Aire? Volume 28 of Issue 7. 2007. PMID: 17556019


  43. Davis JL, Shum AK, Huang L. A 36-year-old man with AIDS and relapsing, nonproductive cough. Volume 131 of Issue 6. Chest 2007. PMID: 17565026


  44. Anthony Shum, Jason DeVoss, Mark Anderson. Aire Deficient Mice—A Model for Autoimmune Lung Disease. Clinical Immunology 2007. PMID:


  45. Choo SJ, Duran CM. A surgical method for selecting appropriate size of graft in aortic root remodeling. The Annals of thoracic surgery 1999. PMID: 10197719


  46. Sperling AI, Decker DC, DiPaolo RJ, Stern DA, Shum A, Bluestone JA. Selective expansion of Vgamma2-Vdelta7 TCR gammadelta cells in C57BL/6 mice is postnatal and extrathymic. Volume 159 of Issue 1. Journal of immunology (Baltimore, Md. : 1950) 1997. PMID: 9200442