Dean Sheppard, MD

Professor

Dean Sheppard is a Professor of Medicine. His research focuses on the molecular mechanisms underlying pulmonary (and other organ) fibrosis, asthma and acute lung injury. One aim of the research is to identify new therapeutic targets to ultimately improve the treatment of each of these common diseases. The work began with basic investigation of how cells use members of the integrin family to detect, modify and respond to spatially restricted extracellular clues and how these responses contribute to the development of common lung diseases. Utilizing mice with global or conditional knockouts of the epithelial-restricted integrin, avß6, and the widely expressed integrins, a5ß1, a9ß1, avß5 and avß8, the lab has identified important roles for these integrins in models of each common lung disease and key steps upstream and downstream of the integrins that provide potential therapeutic targets. His lab identified the unique roles that 3 integrins, avß1, avß6 and avß8 play in activation of the growth factor, latent transforming growth factor beta (TGFß) and has identified critical roles for this process in acute lung injury, pulmonary fibrosis, post-natal brain development and immunosuppression in the setting of cancer. Current work is using single cell RNA sequencing to understand the heterogeneity of cells that contribute to tissue fibrosis and using these results to generate novel murine lines to establish the lineage, fate and functional importance of each of the new cell states identified. The lab is also collaborating with Wendell Lim to engineer cells that delivery genetically encoded therapeutics at sites of fibrosis and acute lung injury and exploring the roles of distinct mesenchymal subsets in models of bronchopulmonary dysplasia.
Education
2018 - Diversity, Equity, and Inclusion Champion Training, University of California
M.D., 1975 - School of Medicine, SUNY, Stony Brook
Residency, - School of Medicine, University of California, San Francisco
Honors and Awards
  • Elected Fellow, American Association for the Advancement of Science, American Association for the Advancement of Science, 2022
  • Lifetime Achievement in Mentoring Award, UCSF, 2021
  • Elected Member, American Academy of Arts and Sciences, AAAS, 2018
  • UCSF Faculty Research Lecture in Translational Science, UCSF, 2016
  • Top 20 Translational Scientists, Nature Biotechnology, 2013
  • Amberson Lecturer, American Thoracic Society, 2010
  • NIH Merit Award, NIH, 2004-2014
  • Scientific Achievement Award, American Thoracic Society, 1998
  • Elected Member, Association of American Physicians, AAP, 1995
  • Clean Air Award, California Lung Association, 1995
  • Elected Member, American Society for Clinical Investigation, ASCI, 1992
Publications

  1. Lee JY, Reyes NS, Ravishankar S, Zhou M, Krasilnikov M, Ringler C, Pohan G, Wilson C, Ang KK, Wolters PJ, Tsukui T, Sheppard D, Arkin MR, Peng T. An in vivo screening platform identifies senolytic compounds that target p16INK4a+ fibroblasts in lung fibrosis. The Journal of clinical investigation 2024. PMID: 38451724


  2. De Giovanni M, Vykunta VS, Biram A, Chen KY, Taglinao H, An J, Sheppard D, Paidassi H, Cyster JG. Mast cells help organize the Peyer's patch niche for induction of IgA responses. Science immunology 2024. PMID: 38427721


  3. Vukmirovic M, Benam KH, Rose JJ, Turner S, Magin CM, Lagares D, Cohen AH, Kaminski N, Hirota JA, Maher TM, Königshoff M, Mallampalli RK, Sheppard D, Tarran R, Gomer RH, Kenyon NJ, Morris D, Hobbie S, Raju SV, Petrache I, Watkins T, Kumar R, Lam WA, Sherer T, Hecker L. Challenges and Opportunities for Commercializing Technologies in the Pulmonary Arena: An Official American Thoracic Society Report. Annals of the American Thoracic Society 2023. PMID: 37903340


  4. Khan IS, Molina C, Ren X, Auyeung VC, Cohen M, Tsukui T, Atakilit A, Sheppard D. Impaired Myofibroblast Proliferation is a Central Feature of Pathologic Post-Natal Alveolar Simplification. bioRxiv : the preprint server for biology 2023. PMID: 38187712


  5. Yin Z, Rosenzweig N, Kleemann KL, Zhang X, Brandão W, Margeta MA, Schroeder C, Sivanathan KN, Silveira S, Gauthier C, Mallah D, Pitts KM, Durao A, Herron S, Shorey H, Cheng Y, Barry JL, Krishnan RK, Wakelin S, Rhee J, Yung A, Aronchik M, Wang C, Jain N, Bao X, Gerrits E, Brouwer N, Deik A, Tenen DG, Ikezu T, Santander NG, McKinsey GL, Baufeld C, Sheppard D, Krasemann S, Nowarski R, Eggen BJL, Clish C, Tanzi RE, Madore C, Arnold TD, Holtzman DM, Butovsky O. APOE4 impairs the microglial response in Alzheimer's disease by inducing TGFβ-mediated checkpoints. Nature immunology 2023. PMID: 37749326


  6. McKinsey GL, Santander N, Zhang X, Kleemann K, Tran L, Katewa A, Conant K, Barraza M, Waddell K, Lizama C, La Russa M, Koo HJ, Lee H, Mukherjee D, Paidassi H, Anton ES, Atabai K, Sheppard D, Butovsky O, Arnold TD. Radial glia promote microglial development through integrin α V β 8 -TGFβ1 signaling. bioRxiv : the preprint server for biology 2023. PMID: 37790363


  7. Massagué J, Sheppard D. TGF-β signaling in health and disease. Cell 2023. PMID: 37714133


  8. Zhang J, Tsukui T, Wu X, Brito A, Trumble JM, Caraballo JC, Allen GM, Zavala-Solorio J, Zhang C, Paw J, Lim WA, Geng J, Kutskova Y, Freund A, Kolumam G, Sheppard D, Cohen RL. An immune-based tool platform for in vivo cell clearance. Life science alliance 2023. PMID: 37311583


  9. Sikkema L, Ramírez-Suástegui C, Strobl DC, Gillett TE, Zappia L, Madissoon E, Markov NS, Zaragosi LE, Ji Y, Ansari M, Arguel MJ, Apperloo L, Banchero M, Bécavin C, Berg M, Chichelnitskiy E, Chung MI, Collin A, Gay ACA, Gote-Schniering J, Hooshiar Kashani B, Inecik K, Jain M, Kapellos TS, Kole TM, Leroy S, Mayr CH, Oliver AJ, von Papen M, Peter L, Taylor CJ, Walzthoeni T, Xu C, Bui LT, De Donno C, Dony L, Faiz A, Guo M, Gutierrez AJ, Heumos L, Huang N, Ibarra IL, Jackson ND, Kadur Lakshminarasimha Murthy P, Lotfollahi M, Tabib T, Talavera-López C, Travaglini KJ, Wilbrey-Clark A, Worlock KB, Yoshida M, Lung Biological Network Consortium, van den Berge M, Bossé Y, Desai TJ, Eickelberg O, Kaminski N, Krasnow MA, Lafyatis R, Nikolic MZ, Powell JE, Rajagopal J, Rojas M, Rozenblatt-Rosen O, Seibold MA, Sheppard D, Shepherd DP, Sin DD, Timens W, Tsankov AM, Whitsett J, Xu Y, Banovich NE, Barbry P, Duong TE, Falk CS, Meyer KB, Kropski JA, Pe'er D, Schiller HB, Tata PR, Schultze JL, Teichmann SA, Misharin AV, Nawijn MC, Luecken MD, Theis FJ. An integrated cell atlas of the lung in health and disease. Nature medicine 2023. PMID: 37291214


  10. Livanos AE, Dunn A, Fischer J, Ungaro RC, Turpin W, Lee SH, Rui S, Del Valle DM, Jougon JJ, Martinez-Delgado G, Riddle MS, Murray JA, Laird RM, Torres J, Agrawal M, Magee JS, Dervieux T, Gnjatic S, Sheppard D, Sands BE, Porter CK, Croitoru K, Petralia F, CCC-GEM Project Research Consortium, OSCCAR Consortium, Colombel JF, Mehandru S. Anti-Integrin av�6 Autoantibodies Are a Novel Biomarker That Antedate Ulcerative Colitis. Gastroenterology 2023. PMID: 36634824


  11. Monieri M, Rainone P, Sacchi A, Gori A, Gasparri AM, Coliva A, Citro A, Ferrara B, Policardi M, Valtorta S, Pocaterra A, Alfano M, Sheppard D, Piemonti L, Moresco RM, Corti A, Curnis F. A stapled chromogranin A-derived peptide homes in on tumors that express av�6 or av�8 integrins. International journal of biological sciences 2023. PMID: 36594095


  12. Reyes NS, Krasilnikov M, Allen NC, Lee JY, Hyams B, Zhou M, Ravishankar S, Cassandras M, Wang C, Khan I, Matatia P, Johmura Y, Molofsky A, Matthay M, Nakanishi M, Sheppard D, Campisi J, Peng T. Sentinel p16INK4a+ cells in the basement membrane form a reparative niche in the lung. Science (New York, N.Y.) 2022. PMID: 36227993


  13. Bhattacharyya A, Torre P, Yadav P, Boostanpour K, Chen TY, Tsukui T, Sheppard D, Muramatsu R, Seed RI, Nishimura SL, Jung JB, Tang XZ, Allen CDC, Bhattacharya M. Macrophage Cx43 Is Necessary for Fibroblast Cytosolic Calcium and Lung Fibrosis After Injury. 2015 Year Book of Pediatrics. Ed. Cabana MD. (Elsevier; Philadelphia, PA) 2022. PMID: 35634278


  14. Bapat SP, Whitty C, Mowery CT, Liang Y, Yoo A, Jiang Z, Peters MC, Zhang LJ, Vogel I, Zhou C, Nguyen VQ, Li Z, Chang C, Zhu WS, Hastie AT, He H, Ren X, Qiu W, Gayer SG, Liu C, Choi EJ, Fassett M, Cohen JN, Sturgill JL, Crotty Alexander LE, Suh JM, Liddle C, Atkins AR, Yu RT, Downes M, Liu S, Nikolajczyk BS, Lee IK, Guttman-Yassky E, Ansel KM, Woodruff PG, Fahy JV, Sheppard D, Gallo RL, Ye CJ, Evans RM, Zheng Y, Marson A. Obesity alters pathology and treatment response in inflammatory disease. 2015 Year Book of Pediatrics. Ed. Cabana MD. (Elsevier; Philadelphia, PA) 2022. PMID: 35355021


  15. Auyeung VC, Downey MS, Thamsen M, Wenger TA, Backes BJ, Sheppard D, Papa FR. IRE1α drives lung epithelial progenitor dysfunction to establish a niche for pulmonary fibrosis. 2015 Year Book of Pediatrics. Ed. Cabana MD. (Elsevier; Philadelphia, PA) 2022. PMID: 35170357


  16. Shihan MH, Novo SG, Wang Y, Sheppard D, Atakilit A, Arnold TD, Rossi NM, Faranda AP, Duncan MK. αVβ8 integrin targeting to prevent posterior capsular opacification (PCO). JCI insight 2021. PMID: 34554928


  17. Lainé A, Labiad O, Hernandez-Vargas H, This S, Sanlaville A, Léon S, Dalle S, Sheppard D, Travis MA, Paidassi H, Marie JC. Regulatory T cells promote cancer immune-escape through integrin αvβ8-mediated TGF-β activation. 2015 Year Book of Pediatrics. Ed. Cabana MD. (Elsevier; Philadelphia, PA) 2021. PMID: 34711823


  18. Dodagatta-Marri E, Ma HY, Liang B, Li J, Meyer DS, Chen SY, Sun KH, Ren X, Zivak B, Rosenblum MD, Headley MB, Pinzas L, Reed NI, Del Cid JS, Hann BC, Yang S, Giddabasappa A, Noorbehesht K, Yang B, Dal Porto J, Tsukui T, Niessen K, Atakilit A, Akhurst RJ, Sheppard D. Integrin αvβ8 on T cells suppresses anti-tumor immunity in multiple models and is a promising target for tumor immunotherapy. Cell reports 2021. PMID: 34233193


  19. Liu S, Ngo U, Tang XZ, Ren X, Qiu W, Huang X, DeGrado W, Allen CD, Jo H, Sheppard D, Sundaram AB. Integrin α2β1 regulates collagen I tethering to modulate hyperresponsiveness in reactive airway disease models. The Journal of clinical investigation 2021. PMID: 33956668


  20. Auyeung VC, Sheppard D. Stuck in a Moment: Does Abnormal Persistence of Epithelial Progenitors Drive Pulmonary Fibrosis? American journal of respiratory and critical care medicine 2020. PMID: 33226835


  21. Nishimichi N, Tsujino K, Kanno K, Sentani K, Kobayashi T, Chayama K, Sheppard D, Yokosaki Y. Induced hepatic stellate cell integrin, a8ß1, enhances cellular contractility and TGFß activity in liver fibrosis. The Journal of pathology 2021. PMID: 33433924


  22. Wong JC, Perez-Mancera PA, Huang TQ, Kim J, Grego-Bessa J, Alzamora MDP, Kogan SC, Sharir A, Keefe SH, Morales CE, Schanze D, Castel P, Hirose K, Huang GN, Zenker M, Sheppard D, Klein O, Tuveson D, Braun BS, Shannon K. KrasP34R and KrasT58I mutations induce distinct RASopathy phenotypes in mice. JCI insight 2020. PMID: 32990679


  23. Cassandras M, Wang C, Kathiriya J, Tsukui T, Matatia P, Matthay M, Wolters P, Molofsky A, Sheppard D, Chapman H, Peng T. Gli1+ mesenchymal stromal cells form a pathological niche to promote airway progenitor metaplasia in the fibrotic lung. Nature cell biology 2020. PMID: 33046884


  24. Sundaram A, Chen C, Isik Reed N, Liu S, Ki Yeon S, McIntosh J, Tang YZ, Yang H, Adler M, Beresis R, Seiple IB, Sheppard D, DeGrado WF, Jo H. Dual antagonists of a5ß1/ avß1 integrin for airway hyperresponsiveness. Bioorganic & medicinal chemistry letters 2020. PMID: 33007395


  25. Alsamman S, Christenson SA, Yu A, Ayad NME, Mooring MS, Segal JM, Hu JK, Schaub JR, Ho SS, Rao V, Marlow MM, Turner SM, Sedki M, Pantano L, Ghoshal S, Ferreira DDS, Ma HY, Duwaerts CC, Espanol-Suner R, Wei L, Newcomb B, Mileva I, Canals D, Hannun YA, Chung RT, Mattis AN, Fuchs BC, Tager AM, Yimlamai D, Weaver VM, Mullen AC, Sheppard D, Chen JY. Targeting acid ceramidase inhibits YAP/TAZ signaling to reduce fibrosis in mice. Science translational medicine 2020. PMID: 32817366


  26. Santander N, Lizama CO, Meky E, McKinsey GL, Jung B, Sheppard D, Betsholtz C, Arnold TD. Lack of Flvcr2 impairs brain angiogenesis without affecting the blood-brain barrier. The Journal of clinical investigation 2020. PMID: 32369453


  27. Tsukui T, Sun KH, Wetter JB, Wilson-Kanamori JR, Hazelwood LA, Henderson NC, Adams TS, Schupp JC, Poli SD, Rosas IO, Kaminski N, Matthay MA, Wolters PJ, Sheppard D. Collagen-producing lung cell atlas identifies multiple subsets with distinct localization and relevance to fibrosis. Nature communications 2020. PMID: 32317643


  28. Zhang Z, Bai M, Barbosa GO, Chen A, Wei Y, Luo S, Wang X, Wang B, Tsukui T, Li H, Sheppard D, Kornberg TB, Ma DK. Broadly conserved roles of TMEM131 family proteins in intracellular collagen assembly and secretory cargo trafficking. Science advances 2020. PMID: 32095531


  29. Del Cid JS, Isik Reed N, Molnar K, Liu S, Dang B, Jensen SA, DeGrado W, Handford PA, Sheppard D, Sundaram AB. A disease associated mutation in fibrillin-1 differentially regulates integrin mediated cell adhesion. The Journal of biological chemistry 2019. PMID: 31640988


  30. Arnold TD, Lizama CO, Cautivo KM, Santander N, Lin L, Qiu H, Huang EJ, Liu C, Mukouyama YS, Reichardt LF, Zovein AC, Sheppard D. Impaired aVß8 and TGFß signaling lead to microglial dysmaturation and neuromotor dysfunction. The Journal of experimental medicine 2019. PMID: 30846482


  31. Bengs S, Becker E, Busenhart P, Spalinger MR, Raselli T, Kasper S, Lang S, Atrott K, Mamie C, Vavricka SR, von Boehmer L, Knuth A, Tuomisto A, Mäkinen MJ, Hruz P, Turina M, Rickenbacher A, Petrowsky H, Weber A, Frei P, Halama M, Jenkins G, Sheppard D, Croner RS, Christoph J, Britzen-Laurent N, Naschberger E, Schellerer V, Stürzl M, Fried M, Rogler G, Scharl M. ß6 -Integrin serves as a novel serum tumor marker for colorectal carcinoma. International journal of cancer 2019. PMID: 30653264


  32. Bulek K, Chen X, Parron V, Sundaram A, Herjan T, Ouyang S, Liu C, Majors A, Zepp J, Gao J, Dongre A, Bodaszewska-Lubas M, Echard A, Aronica M, Carman J, Garantziotis S, Sheppard D, Li X. IL-17A Recruits Rab35 to IL-17R to Mediate PKCa-Dependent Stress Fiber Formation and Airway Smooth Muscle Contractility. Journal of immunology (Baltimore, Md. : 1950) 2019. PMID: 30683702


  33. Thamsen M, Ghosh R, Auyeung VC, Brumwell A, Chapman HA, Backes BJ, Perara G, Maly DJ, Sheppard D, Papa FR. Small molecule inhibition of IRE1a kinase/RNase has anti-fibrotic effects in the lung. PloS one 2019. PMID: 30625178


  34. Greenhalgh SN, Matchett KP, Taylor RS, Huang K, Li JT, Saeteurn K, Donnelly MC, Simpson EE, Pollack JL, Atakilit A, Simpson KJ, Maher JJ, Iredale JP, Sheppard D, Henderson NC. Loss of integrin avß8 in murine hepatocytes accelerates liver regeneration. The American journal of pathology 2018. PMID: 30448409


  35. Fong V, Hsu A, Wu E, Looney AP, Ganesan P, Ren X, Sheppard D, Wicher SA, Thompson MA, Britt RD, Prakash YS, Bhattacharya M. Arhgef12 drives IL17A-induced airway contractility and airway hyperresponsiveness in mice. JCI insight 2018. PMID: 30385725


  36. Podolsky MJ, Gupta D, Ha A, Ta R, Khalifeh-Soltani A, McKleroy W, Datta R, Sheppard D, Atabai K. Cell Division Cycle 7-Kinase is a negative regulator of cell-mediated collagen degradation. American journal of physiology. Lung cellular and molecular physiology 2018. PMID: 29792348


  37. Kim KK, Sheppard D, Chapman HA. TGF-ß1 Signaling and Tissue Fibrosis. Volume 10 of Issue 4. 2018. PMID: 28432134


  38. Stockis J, Liénart S, Colau D, Collignon A, Nishimura SL, Sheppard D, Coulie PG, Lucas S. Blocking immunosuppression by human Tregs in vivo with antibodies targeting integrin aVß8. Volume 114 of Issue 47. Proceedings of the National Academy of Sciences of the United States of America 2017. PMID: 29109269


  39. Tsujino K, Li JT, Tsukui T, Ren X, Bakiri L, Wagner E, Sheppard D. Fra-2 negatively regulates postnatal alveolar septation by modulating myofibroblast function. Volume 313 of Issue 5. American journal of physiology. Lung cellular and molecular physiology 2017. PMID: 28818870


  40. Jenkins RG, Moore BB, Chambers RC, Eickelberg O, Königshoff M, Kolb M, Laurent GJ, Nanthakumar CB, Olman MA, Pardo A, Selman M, Sheppard D, Sime PJ, Tager AM, Tatler AL, Thannickal VJ, White ES. An Official American Thoracic Society Workshop Report: Use of Animal Models for the Preclinical Assessment of Potential Therapies for Pulmonary Fibrosis. Volume 56 of Issue 5. 2017. PMID: 28459387


  41. Chang Y, Lau WL, Jo H, Tsujino K, Gewin L, Reed NI, Atakilit A, Nunes ACF, DeGrado WF, Sheppard D. Pharmacologic Blockade of avß1 Integrin Ameliorates Renal Failure and Fibrosis In Vivo. Journal of the American Society of Nephrology : JASN 2017. PMID: 28220032


  42. Sundaram A, Chen C, Khalifeh-Soltani A, Atakilit A, Ren X, Qiu W, Jo H, DeGrado W, Huang X, Sheppard D. Targeting integrin a5ß1 ameliorates severe airway hyperresponsiveness in experimental asthma. Volume 127 of Issue 1. The Journal of clinical investigation 2016. PMID: 27918306


  43. Tsujino K, Reed NI, Atakilit A, Ren X, Sheppard D. Transforming growth factor-ß plays divergent roles in modulating vascular remodeling, inflammation, and pulmonary fibrosis in a murine model of scleroderma. Volume 312 of Issue 1. American journal of physiology. Lung cellular and molecular physiology 2016. PMID: 27864286


  44. Reed NI, Tang YZ, McIntosh J, Wu Y, Molnar KS, Civitavecchia A, Sheppard D, DeGrado WF, Jo H. Exploring N-Arylsulfonyl-l-proline Scaffold as a Platform for Potent and Selective avß1 Integrin Inhibitors. Volume 7 of Issue 10. 2016. PMID: 27774126


  45. Meliopoulos VA, Van de Velde LA, Van de Velde NC, Karlsson EA, Neale G, Vogel P, Guy C, Sharma S, Duan S, Surman SL, Jones BG, Johnson MD, Bosio C, Jolly L, Jenkins RG, Hurwitz JL, Rosch JW, Sheppard D, Thomas PG, Murray PJ, Schultz-Cherry S. An Epithelial Integrin Regulates the Amplitude of Protective Lung Interferon Responses against Multiple Respiratory Pathogens. Volume 12 of Issue 8. PLoS pathogens 2016. PMID: 27505057


  46. McAleer JP, Nguyen NL, Chen K, Kumar P, Ricks DM, Binnie M, Armentrout RA, Pociask DA, Hein A, Yu A, Vikram A, Bibby K, Umesaki Y, Rivera A, Sheppard D, Ouyang W, Hooper LV, Kolls JK. Pulmonary Th17 Antifungal Immunity Is Regulated by the Gut Microbiome. Volume 197 of Issue 1. Journal of immunology (Baltimore, Md. : 1950) 2016. PMID: 27217583


  47. Reboldi A, Arnon TI, Rodda LB, Atakilit A, Sheppard D, Cyster JG. IgA production requires B cell interaction with subepithelial dendritic cells in Peyer's patches. Volume 352 of Issue 6287. 2016. PMID: 27174992


  48. Sun KH, Chang Y, Reed NI, Sheppard D. a-Smooth muscle actin is an inconsistent marker of fibroblasts responsible for force-dependent TGFß activation or collagen production across multiple models of organ fibrosis. Volume 310 of Issue 9. American journal of physiology. Lung cellular and molecular physiology 2016. PMID: 26944089


  49. Mohammed J, Beura LK, Bobr A, Astry B, Chicoine B, Kashem SW, Welty NE, Igyártó BZ, Wijeyesinghe S, Thompson EA, Matte C, Bartholin L, Kaplan A, Sheppard D, Bridges AG, Shlomchik WD, Masopust D, Kaplan DH. Stromal cells control the epithelial residence of DCs and memory T cells by regulated activation of TGF-ß. Volume 17 of Issue 4. 2016. PMID: 26901152


  50. Tsujino K, Sheppard D. Critical Appraisal of the Utility and Limitations of Animal Models of Scleroderma. Volume 18 of Issue 1. 2016. PMID: 26711695


  51. Peng ZW, Ikenaga N, Liu SB, Sverdlov DY, Vaid KA, Dixit R, Weinreb PH, Violette S, Sheppard D, Schuppan D, Popov Y. Integrin avß6 critically regulates hepatic progenitor cell function and promotes ductular reaction, fibrosis, and tumorigenesis. Volume 63 of Issue 1. 2015. PMID: 26448099


  52. Plaks V, Boldajipour B, Linnemann JR, Nguyen NH, Kersten K, Wolf Y, Casbon AJ, Kong N, van den Bijgaart RJ, Sheppard D, Melton AC, Krummel MF, Werb Z. Adaptive Immune Regulation of Mammary Postnatal Organogenesis. Volume 34 of Issue 5. 2015. PMID: 26321127


  53. Li JT, Melton AC, Su G, Hamm DE, LaFemina M, Howard J, Fang X, Bhat S, Huynh KM, O'Kane CM, Ingram RJ, Muir RR, McAuley DF, Matthay MA, Sheppard D. Unexpected Role for Adaptive aßTh17 Cells in Acute Respiratory Distress Syndrome. Volume 195 of Issue 1. Journal of immunology (Baltimore, Md. : 1950) 2015. PMID: 26002979


  54. Reed NI, Jo H, Chen C, Tsujino K, Arnold TD, DeGrado WF, Sheppard D. The avß1 integrin plays a critical in vivo role in tissue fibrosis. Volume 7 of Issue 288. Science translational medicine 2015. PMID: 25995225


  56. Xu P, Bailey-Bucktrout S, Xi Y, Xu D, Du D, Zhang Q, Xiang W, Liu J, Melton A, Sheppard D, Chapman HA, Bluestone JA, Derynck R. Innate antiviral host defense attenuates TGF-ß function through IRF3-mediated suppression of Smad signaling. Volume 56 of Issue 6. 2014. PMID: 25526531


  57. Arnold TD, Niaudet C, Pang MF, Siegenthaler J, Gaengel K, Jung B, Ferrero GM, Mukouyama YS, Fuxe J, Akhurst R, Betsholtz C, Sheppard D, Reichardt LF. Excessive vascular sprouting underlies cerebral hemorrhage in mice lacking aVß8-TGFß signaling in the brain. Volume 141 of Issue 23. 2014. PMID: 25406396


  58. Bhattacharya M, Sundaram A, Kudo M, Farmer J, Ganesan P, Khalifeh-Soltani A, Arjomandi M, Atabai K, Huang X, Sheppard D. IQGAP1-dependent scaffold suppresses RhoA and inhibits airway smooth muscle contraction. Volume 124 of Issue 11. The Journal of clinical investigation 2014. PMID: 25271629


  59. Erle DJ, Sheppard D. The cell biology of asthma. Volume 205 of Issue 5. 2014. PMID: 24914235


  60. Ito K, Morimoto J, Kihara A, Matsui Y, Kurotaki D, Kanayama M, Simmons S, Ishii M, Sheppard D, Takaoka A, Uede T. Integrin a9 on lymphatic endothelial cells regulates lymphocyte egress. Volume 111 of Issue 8. Proceedings of the National Academy of Sciences of the United States of America 2014. PMID: 24516133


  61. Madala SK, Korfhagen TR, Schmidt S, Davidson C, Edukulla R, Ikegami M, Violette SM, Weinreb PH, Sheppard D, Hardie WD. Inhibition of the avß6 integrin leads to limited alteration of TGF-a-induced pulmonary fibrosis. Volume 306 of Issue 8. American journal of physiology. Lung cellular and molecular physiology 2014. PMID: 24508732


  62. Blackwell TS, Tager AM, Borok Z, Moore BB, Schwartz DA, Anstrom KJ, Bar-Joseph Z, Bitterman P, Blackburn MR, Bradford W, Brown KK, Chapman HA, Collard HR, Cosgrove GP, Deterding R, Doyle R, Flaherty KR, Garcia CK, Hagood JS, Henke CA, Herzog E, Hogaboam CM, Horowitz JC, King TE, Loyd JE, Lawson WE, Marsh CB, Noble PW, Noth I, Sheppard D, Olsson J, Ortiz LA, O'Riordan TG, Oury TD, Raghu G, Roman J, Sime PJ, Sisson TH, Tschumperlin D, Violette SM, Weaver TE, Wells RG, White ES, Kaminski N, Martinez FJ, Wynn TA, Thannickal VJ, Eu JP. Future directions in idiopathic pulmonary fibrosis research. An NHLBI workshop report. Volume 189 of Issue 2. American journal of respiratory and critical care medicine 2014. PMID: 24160862


  63. Travis MA, Sheppard D. TGF-ß activation and function in immunity. Volume 32. 2013. PMID: 24313777


  64. Henderson NC, Arnold TD, Katamura Y, Giacomini MM, Rodriguez JD, McCarty JH, Pellicoro A, Raschperger E, Betsholtz C, Ruminski PG, Griggs DW, Prinsen MJ, Maher JJ, Iredale JP, Lacy-Hulbert A, Adams RH, Sheppard D. Targeting of av integrin identifies a core molecular pathway that regulates fibrosis in several organs. Volume 19 of Issue 12. Nature medicine 2013. PMID: 24216753


  65. Goh YP, Henderson NC, Heredia JE, Red Eagle A, Odegaard JI, Lehwald N, Nguyen KD, Sheppard D, Mukundan L, Locksley RM, Chawla A. Eosinophils secrete IL-4 to facilitate liver regeneration. Volume 110 of Issue 24. Proceedings of the National Academy of Sciences of the United States of America 2013. PMID: 23716700


  66. Katsumoto TR, Kudo M, Chen C, Sundaram A, Callahan EC, Zhu JW, Lin J, Rosen CE, Manz BN, Lee JW, Matthay MA, Huang X, Sheppard D, Weiss A. The phosphatase CD148 promotes airway hyperresponsiveness through SRC family kinases. Volume 123 of Issue 5. The Journal of clinical investigation 2013. PMID: 23543053


  67. Sheppard D. ROCKing pulmonary fibrosis. Volume 123 of Issue 3. The Journal of clinical investigation 2013. PMID: 23434586


  68. Su G, Atakilit A, Li JT, Wu N, Luong J, Chen R, Bhattacharya M, Sheppard D. Effective treatment of mouse sepsis with an inhibitory antibody targeting integrin avß5. Volume 41 of Issue 2. Critical care medicine 2013. PMID: 23263571


  69. Friedman SL, Sheppard D, Duffield JS, Violette S. Therapy for fibrotic diseases: nearing the starting line. Volume 5 of Issue 167. Science translational medicine 2013. PMID: 23303606


  70. Freimuth J, Clermont FF, Huang X, DeSapio A, Tokuyasu TA, Sheppard D, Akhurst RJ. Epistatic interactions between Tgfb1 and genetic loci, Tgfbm2 and Tgfbm3, determine susceptibility to an asthmatic stimulus. Volume 109 of Issue 44. Proceedings of the National Academy of Sciences of the United States of America 2012. PMID: 23064636


  71. Henderson NC, Sheppard D. Integrin-mediated regulation of TGFß in fibrosis. Volume 1832 of Issue 7. Biochimica et biophysica acta 2012. PMID: 23046811


  72. Huang F, Zhang H, Wu M, Yang H, Kudo M, Peters CJ, Woodruff PG, Solberg OD, Donne ML, Huang X, Sheppard D, Fahy JV, Wolters PJ, Hogan BL, Finkbeiner WE, Li M, Jan YN, Jan LY, Rock JR. Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction. Volume 109 of Issue 40. Proceedings of the National Academy of Sciences of the United States of America 2012. PMID: 22988107


  73. Chen C, Kudo M, Rutaganira F, Takano H, Lee C, Atakilit A, Robinett KS, Uede T, Wolters PJ, Shokat KM, Huang X, Sheppard D. Integrin a9ß1 in airway smooth muscle suppresses exaggerated airway narrowing. Volume 122 of Issue 8. The Journal of clinical investigation 2012. PMID: 22772469


  74. Sheppard D. Modulation of acute lung injury by integrins. Volume 9 of Issue 3. 2012. PMID: 22802286


  75. Thornton EE, Looney MR, Bose O, Sen D, Sheppard D, Locksley R, Huang X, Krummel MF. Spatiotemporally separated antigen uptake by alveolar dendritic cells and airway presentation to T cells in the lung. Volume 209 of Issue 6. 2012. PMID: 22585735


  76. Bhattacharya M, Su G, Su X, Oses-Prieto JA, Li JT, Huang X, Hernandez H, Atakilit A, Burlingame AL, Matthay MA, Sheppard D. IQGAP1 is necessary for pulmonary vascular barrier protection in murine acute lung injury and pneumonia. Volume 303 of Issue 1. American journal of physiology. Lung cellular and molecular physiology 2012. PMID: 22561460


  77. Kudo M, Melton AC, Chen C, Engler MB, Huang KE, Ren X, Wang Y, Bernstein X, Li JT, Atabai K, Huang X, Sheppard D. IL-17A produced by aß T cells drives airway hyper-responsiveness in mice and enhances mouse and human airway smooth muscle contraction. Volume 18 of Issue 4. Nature medicine 2012. PMID: 22388091


  78. Doherty TA, Khorram N, Sugimoto K, Sheppard D, Rosenthal P, Cho JY, Pham A, Miller M, Croft M, Broide DH. Alternaria induces STAT6-dependent acute airway eosinophilia and epithelial FIZZ1 expression that promotes airway fibrosis and epithelial thickness. Volume 188 of Issue 6. Journal of immunology (Baltimore, Md. : 1950) 2012. PMID: 22327070


  79. Giacomini MM, Travis MA, Kudo M, Sheppard D. Epithelial cells utilize cortical actin/myosin to activate latent TGF-ß through integrin a(v)ß(6)-dependent physical force. Volume 318 of Issue 6. 2012. PMID: 22309779


  80. Sugimoto K, Kudo M, Sundaram A, Ren X, Huang K, Bernstein X, Wang Y, Raymond WW, Erle DJ, Abrink M, Caughey GH, Huang X, Sheppard D. The avß6 integrin modulates airway hyperresponsiveness in mice by regulating intraepithelial mast cells. Volume 122 of Issue 2. The Journal of clinical investigation 2012. PMID: 22232213


  81. Su G, Atakilit A, Li JT, Wu N, Bhattacharya M, Zhu J, Shieh JE, Li E, Chen R, Sun S, Su CP, Sheppard D. Absence of integrin avß3 enhances vascular leak in mice by inhibiting endothelial cortical actin formation. Volume 185 of Issue 1. American journal of respiratory and critical care medicine 2012. PMID: 21980034


  82. Munger JS, Sheppard D. Cross talk among TGF-ß signaling pathways, integrins, and the extracellular matrix. Volume 3 of Issue 11. 2011. PMID: 21900405


  83. Tatler AL, John AE, Jolly L, Habgood A, Porte J, Brightling C, Knox AJ, Pang L, Sheppard D, Huang X, Jenkins G. Integrin avß5-mediated TGF-ß activation by airway smooth muscle cells in asthma. Volume 187 of Issue 11. Journal of immunology (Baltimore, Md. : 1950) 2011. PMID: 22025551


  85. Bombieri C, Claustres M, De Boeck K, Derichs N, Dodge J, Girodon E, Sermet I, Schwarz M, Tzetis M, Wilschanski M, Bareil C, Bilton D, Castellani C, Cuppens H, Cutting GR, Drevínek P, Farrell P, Elborn JS, Jarvi K, Kerem B, Kerem E, Knowles M, Macek M, Munck A, Radojkovic D, Seia M, Sheppard DN, Southern KW, Stuhrmann M, Tullis E, Zielenski J, Pignatti PF, Ferec C. Recommendations for the classification of diseases as CFTR-related disorders. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society 2011. PMID: 21658649


  88. Nishimichi N, Hayashita-Kinoh H, Chen C, Matsuda H, Sheppard D, Yokosaki Y. Osteopontin undergoes polymerization in vivo and gains chemotactic activity for neutrophils mediated by integrin alpha9beta1. Volume 286 of Issue 13. The Journal of biological chemistry 2011. PMID: 21321126


  89. Spassov DS, Wong CH, Sergina N, Ahuja D, Fried M, Sheppard D, Moasser MM. Phosphorylation of Trask by Src kinases inhibits integrin clustering and functions in exclusion with focal adhesion signaling. Volume 31 of Issue 4. 2010. PMID: 21189288


  90. Melton AC, Bailey-Bucktrout SL, Travis MA, Fife BT, Bluestone JA, Sheppard D. Expression of avß8 integrin on dendritic cells regulates Th17 cell development and experimental autoimmune encephalomyelitis in mice. Volume 120 of Issue 12. The Journal of clinical investigation 2010. PMID: 21099117


  91. Atabai K, Jame S, Azhar N, Kuo A, Lam M, McKleroy W, Dehart G, Rahman S, Xia DD, Melton AC, Wolters P, Emson CL, Turner SM, Werb Z, Sheppard D. Mfge8 diminishes the severity of tissue fibrosis in mice by binding and targeting collagen for uptake by macrophages. Volume 119 of Issue 12. The Journal of clinical investigation 2009. PMID: 19884654


  92. Hogmalm A, Sheppard D, Lappalainen U, Bry K. beta6 Integrin subunit deficiency alleviates lung injury in a mouse model of bronchopulmonary dysplasia. Volume 43 of Issue 1. 2009. PMID: 19717813


  93. Bazigou E, Xie S, Chen C, Weston A, Miura N, Sorokin L, Adams R, Muro AF, Sheppard D, Makinen T. Integrin-alpha9 is required for fibronectin matrix assembly during lymphatic valve morphogenesis. Volume 17 of Issue 2. 2009. PMID: 19686679


  94. Seibold MA, Reese TA, Choudhry S, Salam MT, Beckman K, Eng C, Atakilit A, Meade K, Lenoir M, Watson HG, Thyne S, Kumar R, Weiss KB, Grammer LC, Avila P, Schleimer RP, Fahy JV, Rodriguez-Santana J, Rodriguez-Cintron W, Boot RG, Sheppard D, Gilliland FD, Locksley RM, Burchard EG. Differential enzymatic activity of common haplotypic versions of the human acidic Mammalian chitinase protein. Volume 284 of Issue 29. The Journal of biological chemistry 2009. PMID: 19435888


  95. Grassinger J, Haylock DN, Storan MJ, Haines GO, Williams B, Whitty GA, Vinson AR, Be CL, Li S, Sørensen ES, Tam PP, Denhardt DT, Sheppard D, Choong PF, Nilsson SK. Thrombin-cleaved osteopontin regulates hemopoietic stem and progenitor cell functions through interactions with alpha9beta1 and alpha4beta1 integrins. Volume 114 of Issue 1. Blood 2009. PMID: 19417209


  96. Xu MY, Porte J, Knox AJ, Weinreb PH, Maher TM, Violette SM, McAnulty RJ, Sheppard D, Jenkins G. Lysophosphatidic acid induces alphavbeta6 integrin-mediated TGF-beta activation via the LPA2 receptor and the small G protein G alpha(q). Volume 174 of Issue 4. 2009. PMID: 19147812


  97. Singh P, Chen C, Pal-Ghosh S, Stepp MA, Sheppard D, Van De Water L. Loss of integrin alpha9beta1 results in defects in proliferation, causing poor re-epithelialization during cutaneous wound healing. Volume 129 of Issue 1. 2008. PMID: 18633440


  98. deHart GW, Jin T, McCloskey DE, Pegg AE, Sheppard D. The alpha9beta1 integrin enhances cell migration by polyamine-mediated modulation of an inward-rectifier potassium channel. Volume 105 of Issue 20. Proceedings of the National Academy of Sciences of the United States of America 2008. PMID: 18480266


  99. Sheppard D. Dust mites' dirty dealings with dendritic cells. Volume 14 of Issue 5. Nature medicine 2008. PMID: 18463654


  100. Tabata T, Kawakatsu H, Maidji E, Sakai T, Sakai K, Fang-Hoover J, Aiba M, Sheppard D, Pereira L. Induction of an epithelial integrin alphavbeta6 in human cytomegalovirus-infected endothelial cells leads to activation of transforming growth factor-beta1 and increased collagen production. Volume 172 of Issue 4. 2008. PMID: 18349127


  101. Ganter MT, Roux J, Miyazawa B, Howard M, Frank JA, Su G, Sheppard D, Violette SM, Weinreb PH, Horan GS, Matthay MA, Pittet JF. Interleukin-1beta causes acute lung injury via alphavbeta5 and alphavbeta6 integrin-dependent mechanisms. Volume 102 of Issue 7. 2008. PMID: 18276918


  102. Muro AF, Moretti FA, Moore BB, Yan M, Atrasz RG, Wilke CA, Flaherty KR, Martinez FJ, Tsui JL, Sheppard D, Baralle FE, Toews GB, White ES. An essential role for fibronectin extra type III domain A in pulmonary fibrosis. Volume 177 of Issue 6. American journal of respiratory and critical care medicine 2007. PMID: 18096707


  103. Araya J, Cambier S, Markovics JA, Wolters P, Jablons D, Hill A, Finkbeiner W, Jones K, Broaddus VC, Sheppard D, Barzcak A, Xiao Y, Erle DJ, Nishimura SL. Squamous metaplasia amplifies pathologic epithelial-mesenchymal interactions in COPD patients. Volume 117 of Issue 11. The Journal of clinical investigation 2007. PMID: 17965775


  104. Horan GS, Wood S, Ona V, Li DJ, Lukashev ME, Weinreb PH, Simon KJ, Hahm K, Allaire NE, Rinaldi NJ, Goyal J, Feghali-Bostwick CA, Matteson EL, O'Hara C, Lafyatis R, Davis GS, Huang X, Sheppard D, Violette SM. Partial inhibition of integrin alpha(v)beta6 prevents pulmonary fibrosis without exacerbating inflammation. Volume 177 of Issue 1. American journal of respiratory and critical care medicine 2007. PMID: 17916809


  105. Travis MA, Reizis B, Melton AC, Masteller E, Tang Q, Proctor JM, Wang Y, Bernstein X, Huang X, Reichardt LF, Bluestone JA, Sheppard D. Loss of integrin alpha(v)beta8 on dendritic cells causes autoimmunity and colitis in mice. Volume 449 of Issue 7160. 2007. PMID: 17694047


  106. Koth LL, Alex B, Hawgood S, Nead MA, Sheppard D, Erle DJ, Morris DG. Integrin beta6 mediates phospholipid and collectin homeostasis by activation of latent TGF-beta1. Volume 37 of Issue 6. 2007. PMID: 17641300


  107. Nandrot EF, Anand M, Almeida D, Atabai K, Sheppard D, Finnemann SC. Essential role for MFG-E8 as ligand for alphavbeta5 integrin in diurnal retinal phagocytosis. Volume 104 of Issue 29. Proceedings of the National Academy of Sciences of the United States of America 2007. PMID: 17620600


  108. Raj JU, Aliferis C, Caprioli RM, Cowley AW, Davies PF, Duncan MW, Erle DJ, Erzurum SC, Finn PW, Ischiropoulos H, Kaminski N, Kleeberger SR, Leikauf GD, Loyd JE, Martin TR, Matalon S, Moore JH, Quackenbush J, Sabo-Attwood T, Shapiro SD, Schnitzer JE, Schwartz DA, Schwiebert LM, Sheppard D, Ware LB, Weiss ST, Whitsett JA, Wurfel MM, Matthay MA. Genomics and proteomics of lung disease: conference summary. Volume 293 of Issue 1. American journal of physiology. Lung cellular and molecular physiology 2007. PMID: 17468134


  109. Vlahakis NE, Young BA, Atakilit A, Hawkridge AE, Issaka RB, Boudreau N, Sheppard D. Integrin alpha9beta1 directly binds to vascular endothelial growth factor (VEGF)-A and contributes to VEGF-A-induced angiogenesis. Volume 282 of Issue 20. The Journal of biological chemistry 2007. PMID: 17363377


  110. Atabai K, Sheppard D, Werb Z. Roles of the innate immune system in mammary gland remodeling during involution. Volume 12 of Issue 1. 2007. PMID: 17286210


  111. Hahm K, Lukashev ME, Luo Y, Yang WJ, Dolinski BM, Weinreb PH, Simon KJ, Chun Wang L, Leone DR, Lobb RR, McCrann DJ, Allaire NE, Horan GS, Fogo A, Kalluri R, Shield CF, Sheppard D, Gardner HA, Violette SM. Alphav beta6 integrin regulates renal fibrosis and inflammation in Alport mouse. Volume 170 of Issue 1. 2007. PMID: 17200187


  113. Morris DG, Sheppard D. Pulmonary emphysema: when more is less. Volume 21. 2006. PMID: 17119152


  114. Chen C, Huang X, Atakilit A, Zhu QS, Corey SJ, Sheppard D. The Integrin alpha9beta1 contributes to granulopoiesis by enhancing granulocyte colony-stimulating factor receptor signaling. Volume 25 of Issue 6. 2006. PMID: 17137800


  115. Su G, Hodnett M, Wu N, Atakilit A, Kosinski C, Godzich M, Huang XZ, Kim JK, Frank JA, Matthay MA, Sheppard D, Pittet JF. Integrin alphavbeta5 regulates lung vascular permeability and pulmonary endothelial barrier function. Volume 36 of Issue 3. 2006. PMID: 17079779


  116. Rao H, Lu G, Kajiya H, Garcia-Palacios V, Kurihara N, Anderson J, Patrene K, Sheppard D, Blair HC, Windle JJ, Choi SJ, Roodman GD. Alpha9beta1: a novel osteoclast integrin that regulates osteoclast formation and function. Volume 21 of Issue 10. 2006. PMID: 16995821


  117. Chen C, Huang X, Sheppard D. ADAM33 is not essential for growth and development and does not modulate allergic asthma in mice. Volume 26 of Issue 18. 2006. PMID: 16943435


  118. Kim KK, Kugler MC, Wolters PJ, Robillard L, Galvez MG, Brumwell AN, Sheppard D, Chapman HA. Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix. Volume 103 of Issue 35. Proceedings of the National Academy of Sciences of the United States of America 2006. PMID: 16924102


  120. Jenkins RG, Su X, Su G, Scotton CJ, Camerer E, Laurent GJ, Davis GE, Chambers RC, Matthay MA, Sheppard D. Ligation of protease-activated receptor 1 enhances alpha(v)beta6 integrin-dependent TGF-beta activation and promotes acute lung injury. Volume 116 of Issue 6. The Journal of clinical investigation 2006. PMID: 16710477


  121. Neurohr C, Nishimura SL, Sheppard D. Activation of transforming growth factor-beta by the integrin alphavbeta8 delays epithelial wound closure. Volume 35 of Issue 2. 2006. PMID: 16574941


  122. Choudhry S, Coyle NE, Tang H, Salari K, Lind D, Clark SL, Tsai HJ, Naqvi M, Phong A, Ung N, Matallana H, Avila PC, Casal J, Torres A, Nazario S, Castro R, Battle NC, Perez-Stable EJ, Kwok PY, Sheppard D, Shriver MD, Rodriguez-Cintron W, Risch N, Ziv E, Burchard EG. Population stratification confounds genetic association studies among Latinos. Volume 118 of Issue 5. 2005. PMID: 16283388


  123. Atabai K, Fernandez R, Huang X, Ueki I, Kline A, Li Y, Sadatmansoori S, Smith-Steinhart C, Zhu W, Pytela R, Werb Z, Sheppard D. Mfge8 is critical for mammary gland remodeling during involution. Volume 16 of Issue 12. 2005. PMID: 16195353


  124. Sheppard D. Integrin-mediated activation of latent transforming growth factor beta. Volume 24 of Issue 3. 2005. PMID: 16258727


  125. Salari K, Choudhry S, Tang H, Naqvi M, Lind D, Avila PC, Coyle NE, Ung N, Nazario S, Casal J, Torres-Palacios A, Clark S, Phong A, Gomez I, Matallana H, Pérez-Stable EJ, Shriver MD, Kwok PY, Sheppard D, Rodriguez-Cintron W, Risch NJ, Burchard EG, Ziv E. Genetic admixture and asthma-related phenotypes in Mexican American and Puerto Rican asthmatics. Volume 29 of Issue 1. 2005. PMID: 15918156


  126. Bridges LC, Sheppard D, Bowditch RD. ADAM disintegrin-like domain recognition by the lymphocyte integrins alpha4beta1 and alpha4beta7. Volume 387 of Issue Pt 1. 2005. PMID: 15504110


  127. Ludlow A, Yee KO, Lipman R, Bronson R, Weinreb P, Huang X, Sheppard D, Lawler J. Characterization of integrin beta6 and thrombospondin-1 double-null mice. Volume 9 of Issue 2. 2005. PMID: 15963261


  128. Roux J, Kawakatsu H, Gartland B, Pespeni M, Sheppard D, Matthay MA, Canessa CM, Pittet JF. Interleukin-1beta decreases expression of the epithelial sodium channel alpha-subunit in alveolar epithelial cells via a p38 MAPK-dependent signaling pathway. Volume 280 of Issue 19. The Journal of biological chemistry 2005. PMID: 15755725


  129. Bates RC, Bellovin DI, Brown C, Maynard E, Wu B, Kawakatsu H, Sheppard D, Oettgen P, Mercurio AM. Transcriptional activation of integrin beta6 during the epithelial-mesenchymal transition defines a novel prognostic indicator of aggressive colon carcinoma. Volume 115 of Issue 2. The Journal of clinical investigation 2005. PMID: 15668738


  130. Nandrot EF, Kim Y, Brodie SE, Huang X, Sheppard D, Finnemann SC. Loss of synchronized retinal phagocytosis and age-related blindness in mice lacking alphavbeta5 integrin. Volume 200 of Issue 12. 2004. PMID: 15596525


  131. Vlahakis NE, Young BA, Atakilit A, Sheppard D. The lymphangiogenic vascular endothelial growth factors VEGF-C and -D are ligands for the integrin alpha9beta1. Volume 280 of Issue 6. The Journal of biological chemistry 2004. PMID: 15590642


  132. Choudhry S, Ung N, Avila PC, Ziv E, Nazario S, Casal J, Torres A, Gorman JD, Salari K, Rodriguez-Santana JR, Toscano M, Sylvia JS, Alioto M, Castro RA, Salazar M, Gomez I, Fagan JK, Salas J, Clark S, Lilly C, Matallana H, Selman M, Chapela R, Sheppard D, Weiss ST, Ford JG, Boushey HA, Drazen JM, Rodriguez-Cintron W, Silverman EK, Burchard EG. Pharmacogenetic differences in response to albuterol between Puerto Ricans and Mexicans with asthma. American journal of respiratory and critical care medicine 2004. PMID: 15557128


  133. Lane NE, Yao W, Nakamura MC, Humphrey MB, Kimmel D, Huang X, Sheppard D, Ross FP, Teitelbaum SL. Mice lacking the integrin beta5 subunit have accelerated osteoclast maturation and increased activity in the estrogen-deficient state. Volume 20 of Issue 1. 2004. PMID: 15619670


  134. Sheppard D. Fishing in the bloodstream: insights into the mechanisms of pulmonary hypertension? Volume 170 of Issue 8. American journal of respiratory and critical care medicine 2004. PMID: 15475403


  135. Chen C, Young BA, Coleman CS, Pegg AE, Sheppard D. Spermidine/spermine N1-acetyltransferase specifically binds to the integrin alpha9 subunit cytoplasmic domain and enhances cell migration. Volume 167 of Issue 1. 2004. PMID: 15479742


  136. Sheppard D. Roles of alphav integrins in vascular biology and pulmonary pathology. Volume 16 of Issue 5. 2004. PMID: 15363806


  137. Williams CH, Kajander T, Hyypiä T, Jackson T, Sheppard D, Stanway G. Integrin alpha v beta 6 is an RGD-dependent receptor for coxsackievirus A9. Volume 78 of Issue 13. Journal of virology 2004. PMID: 15194773


  138. Bazan-Socha S, Kisiel DG, Young B, Theakston RD, Calvete JJ, Sheppard D, Marcinkiewicz C. Structural requirements of MLD-containing disintegrins for functional interaction with alpha 4 beta 1 and alpha 9 beta1 integrins. Volume 43 of Issue 6. 2004. PMID: 14769041


  139. Weinreb PH, Simon KJ, Rayhorn P, Yang WJ, Leone DR, Dolinski BM, Pearse BR, Yokota Y, Kawakatsu H, Atakilit A, Sheppard D, Violette SM. Function-blocking integrin alphavbeta6 monoclonal antibodies: distinct ligand-mimetic and nonligand-mimetic classes. Volume 279 of Issue 17. The Journal of biological chemistry 2004. PMID: 14960589


  140. Burchard EG, Avila PC, Nazario S, Casal J, Torres A, Rodriguez-Santana JR, Toscano M, Sylvia JS, Alioto M, Salazar M, Gomez I, Fagan JK, Salas J, Lilly C, Matallana H, Ziv E, Castro R, Selman M, Chapela R, Sheppard D, Weiss ST, Ford JG, Boushey HA, Rodriguez-Cintron W, Drazen JM, Silverman EK. Lower bronchodilator responsiveness in Puerto Rican than in Mexican subjects with asthma. American journal of respiratory and critical care medicine 2003. PMID: 14617512


  141. Tomczuk M, Takahashi Y, Huang J, Murase S, Mistretta M, Klaffky E, Sutherland A, Bolling L, Coonrod S, Marcinkiewicz C, Sheppard D, Stepp MA, White JM. Role of multiple beta1 integrins in cell adhesion to the disintegrin domains of ADAMs 2 and 3. Volume 290 of Issue 1. 2003. PMID: 14516789


  142. Ma LJ, Yang H, Gaspert A, Carlesso G, Barty MM, Davidson JM, Sheppard D, Fogo AB. Transforming growth factor-beta-dependent and -independent pathways of induction of tubulointerstitial fibrosis in beta6(-/-) mice. Volume 163 of Issue 4. 2003. PMID: 14507636


  143. Wu W, Samet JM, Silbajoris R, Dailey LA, Sheppard D, Bromberg PA, Graves LM. Heparin-binding epidermal growth factor cleavage mediates zinc-induced epidermal growth factor receptor phosphorylation. Volume 30 of Issue 4. 2003. PMID: 12972402


  144. Lind DL, Choudhry S, Ung N, Ziv E, Avila PC, Salari K, Ha C, Lovins EG, Coyle NE, Nazario S, Casal J, Torres A, Rodriguez-Santana JR, Matallana H, Lilly CM, Salas J, Selman M, Boushey HA, Weiss ST, Chapela R, Ford JG, Rodriguez-Cintron W, Silverman EK, Sheppard D, Kwok PY, González Burchard E. ADAM33 is not associated with asthma in Puerto Rican or Mexican populations. American journal of respiratory and critical care medicine 2003. PMID: 12958057


  145. Frank J, Roux J, Kawakatsu H, Su G, Dagenais A, Berthiaume Y, Howard M, Canessa CM, Fang X, Sheppard D, Matthay MA, Pittet JF. Transforming growth factor-beta1 decreases expression of the epithelial sodium channel alphaENaC and alveolar epithelial vectorial sodium and fluid transport via an ERK1/2-dependent mechanism. Volume 278 of Issue 45. The Journal of biological chemistry 2003. PMID: 12930837


  146. Sheppard D. Functions of pulmonary epithelial integrins: from development to disease. Volume 83 of Issue 3. 2003. PMID: 12843406


  147. Burchard EG, Ziv E, Coyle N, Gomez SL, Tang H, Karter AJ, Mountain JL, Pérez-Stable EJ, Sheppard D, Risch N. The importance of race and ethnic background in biomedical research and clinical practice. Volume 348 of Issue 12. The New England journal of medicine 2003. PMID: 12646676


  148. Morris DG, Huang X, Kaminski N, Wang Y, Shapiro SD, Dolganov G, Glick A, Sheppard D. Loss of integrin alpha(v)beta6-mediated TGF-beta activation causes Mmp12-dependent emphysema. Volume 422 of Issue 6928. 2003. PMID: 12634787


  149. Sheppard D. Endothelial integrins and angiogenesis: not so simple anymore. Volume 110 of Issue 7. The Journal of clinical investigation 2002. PMID: 12370267


  151. Crystal RG, Bitterman PB, Mossman B, Schwarz MI, Sheppard D, Almasy L, Chapman HA, Friedman SL, King TE, Leinwand LA, Liotta L, Martin GR, Schwartz DA, Schultz GS, Wagner CR, Musson RA. Future research directions in idiopathic pulmonary fibrosis: summary of a National Heart, Lung, and Blood Institute working group. Volume 166 of Issue 2. American journal of respiratory and critical care medicine 2002. PMID: 12119236


  152. Kuperman DA, Huang X, Koth LL, Chang GH, Dolganov GM, Zhu Z, Elias JA, Sheppard D, Erle DJ. Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma. Volume 8 of Issue 8. Nature medicine 2002. PMID: 12091879


  153. Zuo F, Kaminski N, Eugui E, Allard J, Yakhini Z, Ben-Dor A, Lollini L, Morris D, Kim Y, DeLustro B, Sheppard D, Pardo A, Selman M, Heller RA. Gene expression analysis reveals matrilysin as a key regulator of pulmonary fibrosis in mice and humans. Volume 99 of Issue 9. Proceedings of the National Academy of Sciences of the United States of America 2002. PMID: 11983918


  154. Mu D, Cambier S, Fjellbirkeland L, Baron JL, Munger JS, Kawakatsu H, Sheppard D, Broaddus VC, Nishimura SL. The integrin alpha(v)beta8 mediates epithelial homeostasis through MT1-MMP-dependent activation of TGF-beta1. Volume 157 of Issue 3. 2002. PMID: 11970960


  155. Sheppard D. Killed by leukocytes that don't know when to leave. Volume 3 of Issue 4. 2002. PMID: 11919573


  156. Eliceiri BP, Puente XS, Hood JD, Stupack DG, Schlaepfer DD, Huang XZ, Sheppard D, Cheresh DA. Src-mediated coupling of focal adhesion kinase to integrin alpha(v)beta5 in vascular endothelial growth factor signaling. Volume 157 of Issue 1. 2002. PMID: 11927607


  157. Eto K, Huet C, Tarui T, Kupriyanov S, Liu HZ, Puzon-McLaughlin W, Zhang XP, Sheppard D, Engvall E, Takada Y. Functional classification of ADAMs based on a conserved motif for binding to integrin alpha 9beta 1: implications for sperm-egg binding and other cell interactions. Volume 277 of Issue 20. The Journal of biological chemistry 2002. PMID: 11882657


  159. Kaminski N, Zuo F, Cojocaro G, Yakhini Z, Ben-Dor A, Morris D, Sheppard D, Pardo A, Selman M, Heller RA. Use of oligonucleotide microarrays to analyze gene expression patterns in pulmonary fibrosis reveals distinct patterns of gene expression in mice and humans. Volume 121 of Issue 3 Suppl. Chest 2002. PMID: 11893671


  160. Liao YF, Gotwals PJ, Koteliansky VE, Sheppard D, Van De Water L. The EIIIA segment of fibronectin is a ligand for integrins alpha 9beta 1 and alpha 4beta 1 providing a novel mechanism for regulating cell adhesion by alternative splicing. Volume 277 of Issue 17. The Journal of biological chemistry 2002. PMID: 11839764


  161. Jackson T, Mould AP, Sheppard D, King AM. Integrin alphavbeta1 is a receptor for foot-and-mouth disease virus. Volume 76 of Issue 3. Journal of virology 2002. PMID: 11773368


  162. Reynolds LE, Wyder L, Lively JC, Taverna D, Robinson SD, Huang X, Sheppard D, Hynes RO, Hodivala-Dilke KM. Enhanced pathological angiogenesis in mice lacking beta3 integrin or beta3 and beta5 integrins. Volume 8 of Issue 1. Nature medicine 2002. PMID: 11786903


  163. Ljubimov AV, Saghizadeh M, Pytela R, Sheppard D, Kenney MC. Increased expression of tenascin-C-binding epithelial integrins in human bullous keratopathy corneas. Volume 49 of Issue 11. 2001. PMID: 11668187


  164. Lee JH, Kaminski N, Dolganov G, Grunig G, Koth L, Solomon C, Erle DJ, Sheppard D. Interleukin-13 induces dramatically different transcriptional programs in three human airway cell types. Volume 25 of Issue 4. 2001. PMID: 11694453


  166. Thomas GJ, Lewis MP, Whawell SA, Russell A, Sheppard D, Hart IR, Speight PM, Marshall JF. Expression of the alphavbeta6 integrin promotes migration and invasion in squamous carcinoma cells. Volume 117 of Issue 1. 2001. PMID: 11442751


  167. Sheppard D. Integrin-mediated activation of transforming growth factor-beta(1) in pulmonary fibrosis. Volume 120 of Issue 1 Suppl. Chest 2001. PMID: 11451914


  168. Sheppard D. Pulmonary fibrosis: a cellular overreaction or a failure of communication? Volume 107 of Issue 12. The Journal of clinical investigation 2001. PMID: 11413155


  169. Pittet JF, Griffiths MJ, Geiser T, Kaminski N, Dalton SL, Huang X, Brown LA, Gotwals PJ, Koteliansky VE, Matthay MA, Sheppard D. TGF-beta is a critical mediator of acute lung injury. Volume 107 of Issue 12. The Journal of clinical investigation 2001. PMID: 11413161


  170. Miller LC, Blakemore W, Sheppard D, Atakilit A, King AM, Jackson T. Role of the cytoplasmic domain of the beta-subunit of integrin alpha(v)beta6 in infection by foot-and-mouth disease virus. Volume 75 of Issue 9. Journal of virology 2001. PMID: 11287565


  171. Miller LA, Barnett NL, Sheppard D, Hyde DM. Expression of the beta6 integrin subunit is associated with sites of neutrophil influx in lung epithelium. Volume 49 of Issue 1. 2001. PMID: 11118477


  172. Eto K, Puzon-McLaughlin W, Sheppard D, Sehara-Fujisawa A, Zhang XP, Takada Y. RGD-independent binding of integrin alpha9beta1 to the ADAM-12 and -15 disintegrin domains mediates cell-cell interaction. Volume 275 of Issue 45. The Journal of biological chemistry 2000. PMID: 10944520


  173. Marcinkiewicz C, Taooka Y, Yokosaki Y, Calvete JJ, Marcinkiewicz MM, Lobb RR, Niewiarowski S, Sheppard D. Inhibitory effects of MLDG-containing heterodimeric disintegrins reveal distinct structural requirements for interaction of the integrin alpha 9beta 1 with VCAM-1, tenascin-C, and osteopontin. Volume 275 of Issue 41. The Journal of biological chemistry 2000. PMID: 10926928


  174. Davidson DJ, Kilanowski FM, Randell SH, Sheppard DN, Dorin JR. A primary culture model of differentiated murine tracheal epithelium. Volume 279 of Issue 4. American journal of physiology. Lung cellular and molecular physiology 2000. PMID: 11000138


  175. Albelda SM, Sheppard D. Functional genomics and expression profiling: be there or be square. Volume 23 of Issue 3. 2000. PMID: 10970813


  176. Takahashi H, Isobe T, Horibe S, Takagi J, Yokosaki Y, Sheppard D, Saito Y. Tissue transglutaminase, coagulation factor XIII, and the pro-polypeptide of von Willebrand factor are all ligands for the integrins alpha 9beta 1 and alpha 4beta 1. Volume 275 of Issue 31. The Journal of biological chemistry 2000. PMID: 10816592


  177. Huang XZ, Wu JF, Ferrando R, Lee JH, Wang YL, Farese RV, Sheppard D. Fatal bilateral chylothorax in mice lacking the integrin alpha9beta1. Volume 20 of Issue 14. 2000. PMID: 10866676


  178. Sheppard D. In vivo functions of integrins: lessons from null mutations in mice. Volume 19 of Issue 3. 2000. PMID: 10936445


  179. Jackson T, Sheppard D, Denyer M, Blakemore W, King AM. The epithelial integrin alphavbeta6 is a receptor for foot-and-mouth disease virus. Volume 74 of Issue 11. Journal of virology 2000. PMID: 10799568


  182. Kaminski N, Allard JD, Pittet JF, Zuo F, Griffiths MJ, Morris D, Huang X, Sheppard D, Heller RA. Global analysis of gene expression in pulmonary fibrosis reveals distinct programs regulating lung inflammation and fibrosis. Volume 97 of Issue 4. Proceedings of the National Academy of Sciences of the United States of America 2000. PMID: 10677534


  183. Huang X, Griffiths M, Wu J, Farese RV, Sheppard D. Normal development, wound healing, and adenovirus susceptibility in beta5-deficient mice. Volume 20 of Issue 3. 2000. PMID: 10629031


  184. Yokosaki Y, Matsuura N, Sasaki T, Murakami I, Schneider H, Higashiyama S, Saitoh Y, Yamakido M, Taooka Y, Sheppard D. The integrin alpha(9)beta(1) binds to a novel recognition sequence (SVVYGLR) in the thrombin-cleaved amino-terminal fragment of osteopontin. Volume 274 of Issue 51. The Journal of biological chemistry 1999. PMID: 10593924


  185. Spirin KS, Ljubimov AV, Castellon R, Wiedoeft O, Marano M, Sheppard D, Kenney MC, Brown DJ. Analysis of gene expression in human bullous keratopathy corneas containing limiting amounts of RNA. Volume 40 of Issue 13. 1999. PMID: 10586931


  186. Milner R, Huang X, Wu J, Nishimura S, Pytela R, Sheppard D, ffrench-Constant C. Distinct roles for astrocyte alphavbeta5 and alphavbeta8 integrins in adhesion and migration. Volume 112 ( Pt 23). 1999. PMID: 10564645


  187. Busse W, Elias J, Sheppard D, Banks-Schlegel S. Airway remodeling and repair. Volume 160 of Issue 3. American journal of respiratory and critical care medicine 1999. PMID: 10471638


  189. Roger P, Puchelle E, Bajolet-Laudinat O, Tournier JM, Debordeaux C, Plotkowski MC, Cohen JH, Sheppard D, de Bentzmann S. Fibronectin and alpha5beta1 integrin mediate binding of Pseudomonas aeruginosa to repairing airway epithelium. Volume 13 of Issue 6. The European respiratory journal 1999. PMID: 10445605


  191. Munger JS, Huang X, Kawakatsu H, Griffiths MJ, Dalton SL, Wu J, Pittet JF, Kaminski N, Garat C, Matthay MA, Rifkin DB, Sheppard D. The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis. Volume 96 of Issue 3. 1999. PMID: 10025398


  192. Grünig G, Warnock M, Wakil AE, Venkayya R, Brombacher F, Rennick DM, Sheppard D, Mohrs M, Donaldson DD, Locksley RM, Corry DB. Requirement for IL-13 independently of IL-4 in experimental asthma. Volume 282 of Issue 5397. 1998. PMID: 9856950


  193. Desloges N, Basora N, Perreault N, Bouatrouss Y, Sheppard D, Beaulieu JF. Regulated expression of the integrin alpha9beta1 in the epithelium of the developing human gut and in intestinal cell lines: relation with cell proliferation. Volume 71 of Issue 4. 1998. PMID: 9827699


  195. Sheppard D. Airway epithelial integrins: why so many? Volume 19 of Issue 3. 1998. PMID: 9730861


  197. Schneider H, Harbottle RP, Yokosaki Y, Kunde J, Sheppard D, Coutelle C. A novel peptide, PLAEIDGIELTY, for the targeting of alpha9beta1-integrins. Volume 429 of Issue 3. 1998. PMID: 9662430


  198. Yokosaki Y, Matsuura N, Higashiyama S, Murakami I, Obara M, Yamakido M, Shigeto N, Chen J, Sheppard D. Identification of the ligand binding site for the integrin alpha9 beta1 in the third fibronectin type III repeat of tenascin-C. Volume 273 of Issue 19. The Journal of biological chemistry 1998. PMID: 9565552


  199. Corry DB, Grünig G, Hadeiba H, Kurup VP, Warnock ML, Sheppard D, Rennick DM, Locksley RM. Requirements for allergen-induced airway hyperreactivity in T and B cell-deficient mice. Volume 4 of Issue 5. 1998. PMID: 9642684


  200. Lansdell KA, Delaney SJ, Lunn DP, Thomson SA, Sheppard DN, Wainwright BJ. Comparison of the gating behaviour of human and murine cystic fibrosis transmembrane conductance regulator Cl- channels expressed in mammalian cells. The Journal of physiology 1998. PMID: 9508803


  201. Basora N, Desloges N, Chang Q, Bouatrouss Y, Gosselin J, Poisson J, Sheppard D, Beaulieu JF. Expression of the alpha9beta1 integrin in human colonic epithelial cells: resurgence of the fetal phenotype in a subset of colon cancers and adenocarcinoma cell lines. Volume 75 of Issue 5. 1998. PMID: 9495242


  202. Cass DL, Bullard KM, Sylvester KG, Yang EY, Sheppard D, Herlyn M, Adzick NS. Epidermal integrin expression is upregulated rapidly in human fetal wound repair. Volume 33 of Issue 2. 1998. PMID: 9498408


  203. Agrez MV, Shafren DR, Gu X, Cox K, Sheppard D, Barry RD. Integrin alpha v beta 6 enhances coxsackievirus B1 lytic infection of human colon cancer cells. Volume 239 of Issue 1. 1997. PMID: 9426447


  204. Ramos DM, Chen BL, Boylen K, Stern M, Kramer RH, Sheppard D, Nishimura SL, Greenspan D, Zardi L, Pytela R. Stromal fibroblasts influence oral squamous-cell carcinoma cell interactions with tenascin-C. Volume 72 of Issue 2. 1997. PMID: 9219848


  205. Smith LL, Cheung HK, Ling LE, Chen J, Sheppard D, Pytela R, Giachelli CM. Osteopontin N-terminal domain contains a cryptic adhesive sequence recognized by alpha9beta1 integrin. Volume 271 of Issue 45. The Journal of biological chemistry 1996. PMID: 8910476


  206. Wang A, Yokosaki Y, Ferrando R, Balmes J, Sheppard D. Differential regulation of airway epithelial integrins by growth factors. Volume 15 of Issue 5. 1996. PMID: 8918373


  208. Hérard AL, Pierrot D, Hinnrasky J, Kaplan H, Sheppard D, Puchelle E, Zahm JM. Fibronectin and its alpha 5 beta 1-integrin receptor are involved in the wound-repair process of airway epithelium. Volume 271 of Issue 5 Pt 1. 1996. PMID: 8944715


  211. Sheppard D. Epithelial integrins. Volume 18 of Issue 8. 1996. PMID: 8760339


  212. Huang XZ, Wu JF, Cass D, Erle DJ, Corry D, Young SG, Farese RV, Sheppard D. Inactivation of the integrin beta 6 subunit gene reveals a role of epithelial integrins in regulating inflammation in the lung and skin. Volume 133 of Issue 4. 1996. PMID: 8666675


  213. Agrez MV, Bates RC, Mitchell D, Wilson N, Ferguson N, Anseline P, Sheppard D. Multiplicity of fibronectin-binding alpha V integrin receptors in colorectal cancer. Volume 73 of Issue 7. 1996. PMID: 8611401


  214. Kumar NM, Sigurdson SL, Sheppard D, Lwebuga-Mukasa JS. Differential modulation of integrin receptors and extracellular matrix laminin by transforming growth factor-beta 1 in rat alveolar epithelial cells. Volume 221 of Issue 2. 1995. PMID: 7493638


  215. Wang A, Patrone L, McDonald JA, Sheppard D. Expression of the integrin subunit alpha 9 in the murine embryo. Volume 204 of Issue 4. Developmental dynamics : an official publication of the American Association of Anatomists 1995. PMID: 8601035


  216. Boylan AM, Sanan DA, Sheppard D, Broaddus VC. Vitronectin enhances internalization of crocidolite asbestos by rabbit pleural mesothelial cells via the integrin alpha v beta 5. Volume 96 of Issue 4. The Journal of clinical investigation 1995. PMID: 7560092


  217. Schnapp LM, Hatch N, Ramos DM, Klimanskaya IV, Sheppard D, Pytela R. The human integrin alpha 8 beta 1 functions as a receptor for tenascin, fibronectin, and vitronectin. Volume 270 of Issue 39. The Journal of biological chemistry 1995. PMID: 7559467


  219. Weinacker A, Ferrando R, Elliott M, Hogg J, Balmes J, Sheppard D. Distribution of integrins alpha v beta 6 and alpha 9 beta 1 and their known ligands, fibronectin and tenascin, in human airways. Volume 12 of Issue 5. 1995. PMID: 7537970


  221. Schnapp LM, Breuss JM, Ramos DM, Sheppard D, Pytela R. Sequence and tissue distribution of the human integrin alpha 8 subunit: a beta 1-associated alpha subunit expressed in smooth muscle cells. Volume 108 ( Pt 2). 1995. PMID: 7768999


  222. Nikkari L, Haapasalmi K, Aho H, Torvinen A, Sheppard D, Larjava H, Heino J. Localization of the alpha v subfamily of integrins and their putative ligands in synovial lining cell layer. Volume 22 of Issue 1. 1995. PMID: 7535359


  223. Massion PP, Hébert CA, Leong S, Chan B, Inoue H, Grattan K, Sheppard D, Nadel JA. Staphylococcus aureus stimulates neutrophil recruitment by stimulating interleukin-8 production in dog trachea. Volume 268 of Issue 1 Pt 1. 1995. PMID: 7840233


  224. Nishimura SL, Sheppard D, Pytela R. Integrin alpha v beta 8. Interaction with vitronectin and functional divergence of the beta 8 cytoplasmic domain. Volume 269 of Issue 46. The Journal of biological chemistry 1994. PMID: 7525578


  225. Yokosaki Y, Palmer EL, Prieto AL, Crossin KL, Bourdon MA, Pytela R, Sheppard D. The integrin alpha 9 beta 1 mediates cell attachment to a non-RGD site in the third fibronectin type III repeat of tenascin. Volume 269 of Issue 43. The Journal of biological chemistry 1994. PMID: 7523411


  226. Agrez M, Chen A, Cone RI, Pytela R, Sheppard D. The alpha v beta 6 integrin promotes proliferation of colon carcinoma cells through a unique region of the beta 6 cytoplasmic domain. Volume 127 of Issue 2. 1994. PMID: 7929593


  227. Lukashev ME, Sheppard D, Pytela R. Disruption of integrin function and induction of tyrosine phosphorylation by the autonomously expressed beta 1 integrin cytoplasmic domain. Volume 269 of Issue 28. The Journal of biological chemistry 1994. PMID: 7518428


  229. Cone RI, Weinacker A, Chen A, Sheppard D. Effects of beta subunit cytoplasmic domain deletions on the recruitment of the integrin alpha v beta 6 to focal contacts. Volume 2 of Issue 2. 1994. PMID: 8081887


  230. Weinacker A, Chen A, Agrez M, Cone RI, Nishimura S, Wayner E, Pytela R, Sheppard D. Role of the integrin alpha v beta 6 in cell attachment to fibronectin. Heterologous expression of intact and secreted forms of the receptor. Volume 269 of Issue 9. The Journal of biological chemistry 1994. PMID: 8120056


  231. Pytela R, Suzuki S, Breuss J, Erle DJ, Sheppard D. Polymerase chain reaction cloning with degenerate primers: homology-based identification of adhesion molecules. Volume 245. 1994. PMID: 7760745


  232. Sheppard D. Identification and characterization of novel airway epithelial integrins. Volume 148 of Issue 6 Pt 2. The American review of respiratory disease 1993. PMID: 8256923


  233. Palmer EL, Rüegg C, Ferrando R, Pytela R, Sheppard D. Sequence and tissue distribution of the integrin alpha 9 subunit, a novel partner of beta 1 that is widely distributed in epithelia and muscle. Volume 123 of Issue 5. 1993. PMID: 8245132


  234. Breuss JM, Gillett N, Lu L, Sheppard D, Pytela R. Restricted distribution of integrin beta 6 mRNA in primate epithelial tissues. Volume 41 of Issue 10. 1993. PMID: 8245410


  235. Royce S, Wald P, Sheppard D, Balmes J. Occupational asthma in a pesticides manufacturing worker. Volume 103 of Issue 1. Chest 1993. PMID: 8417906


  236. Sheppard D, Cohen DS, Wang A, Busk M. Transforming growth factor beta differentially regulates expression of integrin subunits in guinea pig airway epithelial cells. Volume 267 of Issue 24. The Journal of biological chemistry 1992. PMID: 1512272


  237. Busk M, Pytela R, Sheppard D. Characterization of the integrin alpha v beta 6 as a fibronectin-binding protein. Volume 267 of Issue 9. The Journal of biological chemistry 1992. PMID: 1532572


  238. Sheppard D, Erle D, Busk M, Pytela R. Identification of novel airway epithelial integrins using the homology-based polymerase chain reaction. Volume 101 of Issue 3 Suppl. Chest 1992. PMID: 1541204


  239. Gordon T, Balmes J, Fine J, Sheppard D. Airway oedema and obstruction in guinea pigs exposed to inhaled endotoxin. Volume 48 of Issue 9. 1991. PMID: 1911406


  240. Wang A, Cohen DS, Palmer E, Sheppard D. Polarized regulation of fibronectin secretion and alternative splicing by transforming growth factor. Volume 266 of Issue 24. The Journal of biological chemistry 1991. PMID: 1874718


  241. Erle DJ, Sheppard D, Breuss J, Rüegg C, Pytela R. Novel integrin alpha and beta subunit cDNAs identified in airway epithelial cells and lung leukocytes using the polymerase chain reaction. Volume 5 of Issue 2. 1991. PMID: 1892648


  242. Cohen DS, Palmer E, Welch WJ, Sheppard D. The response of guinea pig airway epithelial cells and alveolar macrophages to environmental stress. Volume 5 of Issue 2. 1991. PMID: 1892643


  243. Erle DJ, Rüegg C, Sheppard D, Pytela R. Complete amino acid sequence of an integrin beta subunit (beta 7) identified in leukocytes. Volume 266 of Issue 17. The Journal of biological chemistry 1991. PMID: 2040616


  244. Aris R, Christian D, Sheppard D, Balmes JR. Lack of bronchoconstrictor response to sulfuric acid aerosols and fogs. Volume 143 of Issue 4 Pt 1. The American review of respiratory disease 1991. PMID: 2008986


  245. Aris R, Christian D, Sheppard D, Balmes JR. The effects of sequential exposure to acidic fog and ozone on pulmonary function in exercising subjects. Volume 143 of Issue 1. The American review of respiratory disease 1991. PMID: 1846067


  246. Sheppard D, Rozzo C, Starr L, Quaranta V, Erle DJ, Pytela R. Complete amino acid sequence of a novel integrin beta subunit (beta 6) identified in epithelial cells using the polymerase chain reaction. Volume 265 of Issue 20. The Journal of biological chemistry 1990. PMID: 2365683


  247. Aris R, Christian D, Sheppard D, Balmes JR. Acid fog-induced bronchoconstriction. The role of hydroxymethanesulfonic acid. Volume 141 of Issue 3. The American review of respiratory disease 1990. PMID: 2155554


  248. Balmes JR, Fine JM, Gordon T, Sheppard D. Potential bronchoconstrictor stimuli in acid fog. Volume 79. 1989. PMID: 2539989


  249. Fine JM, Gordon T, Sheppard D. Epithelium removal alters responsiveness of guinea pig trachea to substance P. Volume 66 of Issue 1. 1989. PMID: 2465289


  250. Sheppard D. Sulfur dioxide and asthma--a double-edged sword? Volume 82 of Issue 6. 1988. PMID: 3060513


  251. Sheppard D, Scypinski L. A tachykinin receptor antagonist inhibits and an inhibitor of tachykinin metabolism potentiates toluene diisocyanate-induced airway hyperresponsiveness in guinea pigs. Volume 138 of Issue 3. The American review of respiratory disease 1988. PMID: 2462379


  252. Balmes JR, Fine JM, Christian D, Gordon T, Sheppard D. Acidity potentiates bronchoconstriction induced by hypoosmolar aerosols. Volume 138 of Issue 1. The American review of respiratory disease 1988. PMID: 2849338


  253. Gordon T, Thompson JE, Sheppard D. Arachidonic acid metabolites do not mediate toluene diisocyanate-induced airway hyperresponsiveness in guinea pigs. Volume 35 of Issue 5. 1988. PMID: 2840688


  254. Sheppard D, Thompson JE, Scypinski L, Dusser D, Nadel JA, Borson DB. Toluene diisocyanate increases airway responsiveness to substance P and decreases airway neutral endopeptidase. Volume 81 of Issue 4. The Journal of clinical investigation 1988. PMID: 2450892


  255. Gordon T, Sheppard D. Tumor necrosis factor inhibits a polymorphonuclear leukocyte-dependent airway edema in guinea pigs. Volume 64 of Issue 4. 1988. PMID: 2837454


  256. Turner JR, Corkery KJ, Eckman D, Gelb AM, Lipavsky A, Sheppard D. Equivalence of continuous flow nebulizer and metered-dose inhaler with reservoir bag for treatment of acute airflow obstruction. Volume 93 of Issue 3. Chest 1988. PMID: 3342656


  257. Shipley JM, Sheppard DM, Sheer D. Karyotypic analysis of the human monoblastic cell line U937. Cancer genetics and cytogenetics 1988. PMID: 3422581


  258. Thompson JE, Sheppard D. Phosphoramidon potentiates the increase in lung resistance mediated by tachykinins in guinea pigs. Volume 137 of Issue 2. The American review of respiratory disease 1988. PMID: 2449105


  260. Balmes JR, Fine JM, Sheppard D. Symptomatic bronchoconstriction after short-term inhalation of sulfur dioxide. Volume 136 of Issue 5. The American review of respiratory disease 1987. PMID: 3674573


  261. Fine JM, Gordon T, Sheppard D. The roles of pH and ionic species in sulfur dioxide- and sulfite-induced bronchoconstriction. Volume 136 of Issue 5. The American review of respiratory disease 1987. PMID: 3674574


  262. Sheppard D. What does exercise have to do with "exercise-induced" asthma? Volume 136 of Issue 3. The American review of respiratory disease 1987. PMID: 3631726


  263. Thompson JE, Scypinski LA, Gordon T, Sheppard D. Tachykinins mediate the acute increase in airway responsiveness caused by toluene diisocyanate in guinea pigs. Volume 136 of Issue 1. The American review of respiratory disease 1987. PMID: 2440357


  264. Gordon T, Milligan SA, Levin J, Thompson JE, Fine JM, Sheppard D. Apparent effect of catalase on airway edema in guinea pigs. Role of endotoxin contamination. Volume 135 of Issue 4. The American review of respiratory disease 1987. PMID: 3032030


  265. Fine JM, Gordon T, Thompson JE, Sheppard D. The role of titratable acidity in acid aerosol-induced bronchoconstriction. Volume 135 of Issue 4. The American review of respiratory disease 1987. PMID: 3551704


  266. Sheppard D. Physiology of the parasympathetic nervous system of the lung. Volume 63 Suppl 1. Postgraduate medical journal 1987. PMID: 3321011


  267. Thompson JE, Scypinski LA, Gordon T, Sheppard D. Hydroxyurea inhibits airway hyperresponsiveness in guinea pigs by a granulocyte-independent mechanism. Volume 134 of Issue 6. The American review of respiratory disease 1986. PMID: 3024538


  268. Sheppard D. Mechanisms of bronchoconstriction from nonimmunologic environmental stimuli. Volume 90 of Issue 4. Chest 1986. PMID: 3757569


  269. Myers DJ, Bigby BG, Calvayrac P, Sheppard D, Boushey HA. Interaction of cromolyn and a muscarinic antagonist in inhibiting bronchial reactivity to sulfur dioxide and to eucapnic hyperpnea alone. Volume 133 of Issue 6. The American review of respiratory disease 1986. PMID: 2940953


  270. Sheppard D, Scypinski L, Horn J, Gordon T, Thompson JE. Granulocyte-mediated airway edema in guinea pigs. Volume 60 of Issue 4. 1986. PMID: 3009387


  271. Bigby TD, Margolskee D, Curtis JL, Michael PF, Sheppard D, Hadley WK, Hopewell PC. The usefulness of induced sputum in the diagnosis of Pneumocystis carinii pneumonia in patients with the acquired immunodeficiency syndrome. Volume 133 of Issue 4. The American review of respiratory disease 1986. PMID: 3485945


  272. Sheppard D, DiStefano S, Byrd RC, Eschenbacher WL, Bell V, Steck J, Laddu A. Effects of esmolol on airway function in patients with asthma. Volume 26 of Issue 3. 1986. PMID: 2870080


  273. Sheppard D, Distefano S, Morse L, Becker C. Acute effects of routine firefighting on lung function. Volume 9 of Issue 4. 1986. PMID: 3518426


  274. Gordon T, Sheppard D, McDonald DM, Distefano S, Scypinski L. Airway hyperresponsiveness and inflammation induced by toluene diisocyanate in guinea pigs. Volume 132 of Issue 5. The American review of respiratory disease 1985. PMID: 2998244


  275. Tam EK, Geffroy BA, Myers DJ, Seltzer J, Sheppard D, Boushey HA. Effect of eucapnic hypoxia on bronchomotor tone and on the bronchomotor response to dry air in asthmatic subjects. Volume 132 of Issue 3. The American review of respiratory disease 1985. PMID: 3929659


  276. Siegel D, Sheppard D, Gelb A, Weinberg PF. Aminophylline increases the toxicity but not the efficacy of an inhaled beta-adrenergic agonist in the treatment of acute exacerbations of asthma. Volume 132 of Issue 2. The American review of respiratory disease 1985. PMID: 2862819


  277. Eschenbacher WL, Sheppard D. Respiratory heat loss is not the sole stimulus for bronchoconstriction induced by isocapnic hyperpnea with dry air. Volume 131 of Issue 6. The American review of respiratory disease 1985. PMID: 3923883


  278. Sheppard D. Pharmacotherapy of asthma. Volume 142 of Issue 5. The Western journal of medicine 1985. PMID: 2861694


  279. Bethel RA, Sheppard D, Geffroy B, Tam E, Nadel JA, Boushey HA. Effect of 0.25 ppm sulfur dioxide on airway resistance in freely breathing, heavily exercising, asthmatic subjects. Volume 131 of Issue 4. The American review of respiratory disease 1985. PMID: 3994163


  280. Sheppard D, Eschenbacher WL, Epstein J. Lack of bronchomotor response to up to 3 ppm formaldehyde in subjects with asthma. Volume 35 of Issue 1. 1984. PMID: 6489284


  281. Eschenbacher WL, Bethel RA, Boushey HA, Sheppard D. Morphine sulfate inhibits bronchoconstriction in subjects with mild asthma whose responses are inhibited by atropine. Volume 130 of Issue 3. The American review of respiratory disease 1984. PMID: 6476586


  282. Bethel RA, Sheppard D, Epstein J, Tam E, Nadel JA, Boushey HA. Interaction of sulfur dioxide and dry cold air in causing bronchoconstriction in asthmatic subjects. Volume 57 of Issue 2. 1984. PMID: 6469811


  283. Sheppard D, Eschenbacher WL, Boushey HA, Bethel RA. Magnitude of the interaction between the bronchomotor effects of sulfur dioxide and those of dry (cold) air. Volume 130 of Issue 1. The American review of respiratory disease 1984. PMID: 6742611


  284. Sheppard D, Eschenbacher WL. Respiratory water loss as a stimulus to exercise-induced bronchoconstriction. Volume 73 of Issue 5 Pt 2. 1984. PMID: 6715729


  285. Eschenbacher WL, Boushey HA, Sheppard D. Alteration in osmolarity of inhaled aerosols cause bronchoconstriction and cough, but absence of a permeant anion causes cough alone. Volume 129 of Issue 2. The American review of respiratory disease 1984. PMID: 6696320


  286. Sheppard D, Epstein J, Skoogh BE, Bethel RA, Nadel JA, Boushey HA. Variable inhibition of histamine-induced bronchoconstriction by atropine in subjects with asthma. Volume 73 of Issue 1 Pt 1. 1984. PMID: 6363488


  287. Bethel RA, Epstein J, Sheppard D, Nadel JA, Boushey HA. Sulfur dioxide-induced bronchoconstriction in freely breathing, exercising, asthmatic subjects. Volume 128 of Issue 6. The American review of respiratory disease 1983. PMID: 6650990


  288. Skoogh BE, Nadel JA, Fabbri LM, Sheppard D, Holtzman MJ. Antihistaminic versus anticholinergic effects of atropine on canine trachealis muscle. Volume 128 of Issue 4. The American review of respiratory disease 1983. PMID: 6137986


  289. Bethel RA, Erle DJ, Epstein J, Sheppard D, Nadel JA, Boushey HA. Effect of exercise rate and route of inhalation on sulfur-dioxide-induced bronchoconstriction in asthmatic subjects. Volume 128 of Issue 4. The American review of respiratory disease 1983. PMID: 6354021


  291. Woo OF, Healey KM, Sheppard D, Tong TG. Chest pain and hypoxemia from inhalation of a trichloroethane aerosol product. Volume 20 of Issue 4. 1983. PMID: 6689182


  292. Sheppard D, Rizk NW, Boushey HA, Bethel RA. Mechanism of cough and bronchoconstriction induced by distilled water aerosol. Volume 127 of Issue 6. The American review of respiratory disease 1983. PMID: 6407371


  293. Sheppard D, Epstein J, Bethel RA, Nadel JA, Boushey HA. Tolerance to sulfur dioxide-induced bronchoconstriction in subjects with asthma. Volume 30 of Issue 2. 1983. PMID: 6832125


  294. Sheppard D, Epstein J, Holtzman MJ, Nadel JA, Boushey HA. Effect of route of atropine delivery on bronchospasm from cold air and methacholine. Volume 54 of Issue 1. 1983. PMID: 6337982


  295. Holtzman MJ, McNamara MP, Sheppard D, Fabbri LM, Hahn HL, Graf PD, Nadel JA. Intravenous versus inhaled atropine for inhibiting bronchoconstrictor responses in dogs. Volume 54 of Issue 1. 1983. PMID: 6826397


  296. Sheppard D. Occupational asthma. Volume 137 of Issue 6. The Western journal of medicine 1982. PMID: 7164429


  297. Kirkpatrick MB, Sheppard D, Nadel JA, Boushey HA. Effect of the oronasal breathing route on sulfur dioxide-induced bronchoconstriction in exercising asthmatic subjects. Volume 125 of Issue 6. The American review of respiratory disease 1982. PMID: 7091868


  298. Sheppard D, Nadel JA, Boushey HA. Inhibition of sulfur dioxide-induced bronchoconstriction by disodium cromoglycate in asthmatic subjects. Volume 124 of Issue 3. The American review of respiratory disease 1981. PMID: 6792956


  299. Sheppard D, Saisho A, Nadel JA, Boushey HA. Exercise increases sulfur dioxide-induced bronchoconstriction in asthmatic subjects. Volume 123 of Issue 5. The American review of respiratory disease 1981. PMID: 7235370


  300. Sheppard D, Wong WS, Uehara CF, Nadel JA, Boushey HA. Lower threshold and greater bronchomotor responsiveness of asthmatic subjects to sulfur dioxide. Volume 122 of Issue 6. The American review of respiratory disease 1980. PMID: 7458061