John Fahy, MD

Publications

  1. Liegeois MA, Braunreuther M, Charbit AR, Raymond WW, Tang M, Woodruff PG, Christenson SA, Castro M, Erzurum SC, Israel E, Jarjour NN, Levy BD, Moore WC, Wenzel SE, Fuller GG, Fahy JV. Peroxidase-mediated mucin cross-linking drives pathologic mucus gel formation in IL-13-stimulated airway epithelial cells. JCI insight 2024. PMID: 38889046


  2. Leung C, Fain SB, Hoffman EA, Fahy JV. Reply to Mozaffaripour et al.: Dose Modulation, Body Mass Index, and Computed Tomography Air Trapping. American journal of respiratory and critical care medicine 2024. PMID: 38574365


  3. Leung C, Tang M, Huang BK, Fain SB, Hoffman EA, Choi J, Dunican EM, Mauger DT, Denlinger LC, Jarjour NN, Israel E, Levy BD, Wenzel SE, Sumino K, Hastie AT, Schirm J, McCulloch CE, Peters MC, Woodruff PG, Sorkness RL, Castro M, Fahy JV, NHLBI Severe Asthma Research Program (SARP). A Novel Air Trapping Segment Score Identifies Opposing Effects of Obesity and Eosinophilia on Air Trapping in Asthma. American journal of respiratory and critical care medicine 2023. PMID: 38113166


  4. Everman JL, Sajuthi SP, Liegeois MA, Jackson ND, Collet EH, Peters MC, Chioccioli M, Moore CM, Patel BB, Dyjack N, Powell R, Rios C, Montgomery MT, Eng C, Elhawary JR, Mak ACY, Hu D, Huntsman S, Salazar S, Feriani L, Fairbanks-Mahnke A, Zinnen GL, Michel CR, Gomez J, Zhang X, Medina V, Chu HW, Cicuta P, Gordon ED, Zeitlin P, Ortega VE, Reisdorph N, Dunican EM, Tang M, Elicker BM, Henry TS, Bleecker ER, Castro M, Erzurum SC, Israel E, Levy BD, Mauger DT, Meyers DA, Sumino K, Gierada DS, Hastie AT, Moore WC, Denlinger LC, Jarjour NN, Schiebler ML, Wenzel SE, Woodruff PG, Rodriguez-Santana J, Pearson CG, Burchard EG, Fahy JV, Seibold MA. A common polymorphism in the Intelectin-1 gene influences mucus plugging in severe asthma. Nature communications 2024. PMID: 38724552


  5. Charbit AR, Liegeois MA, Raymond WW, Comhair SAA, Johansson MW, Hastie AT, Bleecker ER, Fajt M, Castro M, Sumino K, Erzurum SC, Israel E, Jarjour NN, Mauger DT, Moore WC, Wenzel SE, Woodruff PG, Levy BD, Tang MC, Fahy JV. A novel DNase assay reveals low DNase activity in severe asthma. American journal of physiology. Lung cellular and molecular physiology 2024. PMID: 38651338


  6. Tang M, Charbit AR, Johansson MW, Jarjour NN, Denlinger LC, Raymond WW, Peters MC, Dunican EM, Castro M, Sumino K, Erzurum SC, Comhair SA, Moore WC, Levy BD, Israel E, Phipatanakul W, Phillips BR, Mauger DT, Bleecker ER, Wenzel SE, Fajt ML, Woodruff PG, Hastie AT, Fahy JV, National Heart Lung and Blood Institute Severe Asthma Research Program. Utility of eosinophil peroxidase as a biomarker of eosinophilic inflammation in asthma. The Journal of allergy and clinical immunology 2024. PMID: 38663815


  7. Khoche S, Ellis S, Kellogg L, Fahy J, Her B, Maus TM. The Year in Perioperative Echocardiography: Selected Highlights from 2023. Journal of cardiothoracic and vascular anesthesia 2024. PMID: 38890085


  8. Huang BK, Elicker BM, Henry TS, Kallianos KG, Hahn LD, Tang M, Heng F, McCulloch CE, Bhakta NR, Majumdar S, Choi J, Denlinger LC, Fain SB, Hastie AT, Hoffman EA, Israel E, Jarjour NN, Levy BD, Mauger DT, Sumino K, Wenzel SE, Castro M, Woodruff PG, Fahy JV. Persistent mucus plugs in proximal airways are consequential for airflow limitation in asthma. JCI insight 2023. PMID: 38127464


  9. Hastie AT, Bishop AC, Khan MS, Bleecker ER, Castro M, Denlinger LC, Erzurum SC, Fahy JV, Israel E, Levy BD, Mauger DT, Meyers DA, Moore WC, Ortega VE, Peters SP, Wenzel SE, Steele CH. Protein-Protein interactive networks identified in bronchoalveolar lavage of severe compared to nonsevere asthma. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2024. PMID: 38253462


  10. Xu W, Hong YS, Hu B, Comhair SAA, Janocha AJ, Zein JG, Chen R, Meyers DA, Mauger DT, Ortega VE, Bleecker ER, Castro M, Denlinger LC, Fahy JV, Israel E, Levy BD, Jarjour NN, Moore WC, Wenzel SE, Gaston B, Liu C, Arking DE, Erzurum SC, National Heart, Lung, and Blood Institute (NHLBI) Severe Asthma Research Program (SARP) and TOPMed m. Mitochondrial DNA Copy Number Variation in Asthma Risk, Severity, and Exacerbations. medRxiv : the preprint server for health sciences 2023. PMID: 38106101


  11. Fahy JV, Locksley RM. Immune treatment tackles chronic obstructive pulmonary disease. Nature 2023. PMID: 37587279


  12. Addante A, Raymond W, Gitlin I, Charbit A, Orain X, Wolfe Scheffler A, Kuppe A, Duerr J, Daniltchenko M, Drescher M, Graeber SY, Healy AM, Oscarson S, Fahy JV, Mall MA. A novel thiol-saccharide mucolytic for the treatment of muco-obstructive lung diseases. The European respiratory journal 2023. PMID: 37080569


  13. Li X, Li H, Christenson SA, Castro M, Denlinger LC, Erzurum SC, Fahy JV, Gaston BM, Israel E, Jarjour NN, Levy BD, Mauger DT, Moore WC, Zein J, Kaminski N, Wenzel SE, Woodruff PG, Bleecker ER, Meyers DA, NHLBI Severe Asthma Research Program (SARP). Genetic analyses of chr11p15.5 region identify MUC5AC-MUC5B associated with asthma-related phenotypes. The Journal of asthma : official journal of the Association for the Care of Asthma 2023. PMID: 36946148


  14. Li H, Castro M, Denlinger LC, Erzurum SC, Fahy JV, Gaston B, Israel E, Jarjour NN, Levy BD, Mauger DT, Moore WC, Wenzel SE, Zein J, Bleecker ER, Meyers DA, Chen Y, Li X, NHLBI Severe Asthma Research Program (SARP). Investigations of a combination of atopic status and age of asthma onset identify asthma subphenotypes. The Journal of asthma : official journal of the Association for the Care of Asthma 2023. PMID: 36940238


  15. Gauthier M, Kale SL, Oriss TB, Gorry M, Ramonell RP, Dalton K, Ray P, Fahy JV, Seibold MA, Castro M, Jarjour N, Gaston B, Bleecker ER, Meyers DA, Moore W, Hastie AT, Israel E, Levy BD, Mauger D, Erzurum S, Comhair SA, Wenzel SE, Ray A. CCL5 is a Potential Bridge Between Type-1 and Type-2 Inflammation in Asthma. The Journal of allergy and clinical immunology 2023. PMID: 36893862


  16. Li X, Guerra S, Ledford JG, Kraft M, Li H, Hastie AT, Castro M, Denlinger LC, Erzurum SC, Fahy JV, Gaston B, Israel E, Jarjour NN, Levy BD, Mauger DT, Moore WC, Zein J, Kaminski N, Wenzel SE, Woodruff PG, Meyers DA, Bleecker ER, NHLBI Severe Asthma Research Program (SARP). Low CC16 mRNA Expression Levels in Bronchial Epithelial Cells Are Associated with Asthma Severity. American journal of respiratory and critical care medicine 2022. PMID: 36066606


  17. Tattersall MC, Lee KE, Tsuchiya N, Osman F, Korcarz CE, Hansen KM, Peters MC, Fahy JV, Longhurst CA, Dunican E, Wentzel SE, Leader JK, Israel E, Levy BD, Castro M, Erzurum SC, Lempel J, Moore W, Bleecker E, Phillips BR, Mauger DT, Hoffman EA, Fain SB, Reeder SB, Sorkness RL, Jarjour NN, Denlinger LC, Schiebler ML. Skeletal Muscle Adiposity and Lung Function Trajectory in the Severe Asthma Research Program (SARP). American journal of respiratory and critical care medicine 2022. PMID: 36194556


  18. Peters MC, Schiebler ML, Mauger DT, Fahy JV. Reply to Nie et al. and Bhammar et�al. American journal of respiratory and critical care medicine 2023. PMID: 36029296


  19. Tang M, Mauger DT, Fahy JV, Dunican EM. Reply to: Statistical Concern Regarding the Relationship of Change in Mucus Plug Score with Airflow Over Time. American journal of respiratory and critical care medicine 2022. PMID: 35876128


  20. Peters MC, Schiebler M, Cardet JC, Johansson MW, Sorkness R, DeBoer MD, Bleecker ER, Meyers DA, Castro M, Sumino K, Erzurum SC, Tattersall MC, Zein JG, Hastie AT, Moore W, Levy BD, Israel E, Duvall M, Phillips BR, Mauger DT, Wenzel SE, Fajt ML, Koliwad SK, Denlinger LC, Woodruff PG, Jarjour NN, Fahy JV, National Heart Lung and Blood Institute Severe Asthma Research Program-3. The Impact of Insulin Resistance on Loss of Lung Function and Response to Treatment in Asthma. 2015 Year Book of Pediatrics. Ed. Cabana MD. (Elsevier; Philadelphia, PA) 2022. PMID: 35687105


  21. Wang Z, Xu W, Comhair SAA, Fu X, Shao Z, Bearden R, Zein JG, Bleecker ER, Castro M, Denlinger LC, Fahy JV, Israel E, Levy BD, Jarjour NN, Moore WC, Wenzel SE, Mauger DT, Gaston B, Hazen SL, Erzurum SC. Urinary total conjugated 3-bromotyrosine, asthma severity, and exacerbation risk. American journal of physiology. Lung cellular and molecular physiology 2022. PMID: 36126269


  22. Khanna K, Raymond W, Jin J, Charbit AR, Gitlin I, Tang M, Werts AD, Barrett EG, Cox JM, Birch SM, Martinelli R, Sperber HS, Franz S, Duff T, Hoffmann M, Healy AM, Oscarson S, Pöhlmann S, Pillai SK, Simmons G, Fahy JV. Exploring antiviral and anti-inflammatory effects of thiol drugs in COVID-19. American journal of physiology. Lung cellular and molecular physiology 2022. PMID: 35762590


  23. Izquierdo ME, Marion CR, Moore WC, Raraigh KS, Taylor-Cousar JL, Cutting GR, Ampleford E, Hawkins GA, Zein J, Castro M, Denlinger LC, Erzurum SC, Fahy JV, Israel E, Jarjour NN, Mauger D, Levy BD, Wenzel SE, Woodruff P, Bleecker ER, Meyers DA, Ortega VE. DNA sequencing analysis of cystic fibrosis transmembrane conductance regulator gene identifies cystic fibrosis-associated variants in the Severe Asthma Research Program. 2015 Year Book of Pediatrics. Ed. Cabana MD. (Elsevier; Philadelphia, PA) 2022. PMID: 35451201


  24. Tang M, Elicker BM, Henry T, Gierada DS, Schiebler ML, Huang BK, Peters MC, Castro M, Hoffman EA, Fain SB, Ash SY, Choi J, Hall C, Phillips BR, Mauger DT, Denlinger LC, Jarjour NN, Israel E, Phipatanakul W, Levy BD, Wenzel SE, Bleecker ER, Woodruff PG, Fahy JV, Dunican EM, National Heart Lung and Blood Institute (NHLBI) Severe Asthma Research Program-3 (SARP-3).. Mucus Plugs Persist in Asthma and Changes in Mucus Plugs Associate with Changes in Airflow Over Time. 2015 Year Book of Pediatrics. Ed. Cabana MD. (Elsevier; Philadelphia, PA) 2022. PMID: 35104436


  25. Trivedi AP, Hall C, Goss CW, Lew D, Krings JG, McGregor MC, Samant M, Sieren JP, Li H, Schechtman KB, Schirm J, McEleney S, Peterson S, Moore WC, Bleecker ER, Meyers DA, Israel E, Washko GR, Levy BD, Leader JK, Wenzel SE, Fahy JV, Schiebler ML, Fain SB, Jarjour NN, Mauger DT, Reinhardt JM, Newell JD, Hoffman EA, Castro M, Sheshadri A, NHLBI Severe Asthma Research Program (SARP). Quantitative CT Characteristics of Cluster Phenotypes in the Severe Asthma Research Program Cohorts. 2015 Year Book of Pediatrics. Ed. Cabana MD. (Elsevier; Philadelphia, PA) 2022. PMID: 35471111


  26. Liegeois MA, Fahy JV. The Mucin Gene MUC5B is Required for Normal Lung Function. 2015 Year Book of Pediatrics. Ed. Cabana MD. (Elsevier; Philadelphia, PA) 2022. PMID: 35148488


  27. Bapat SP, Whitty C, Mowery CT, Liang Y, Yoo A, Jiang Z, Peters MC, Zhang LJ, Vogel I, Zhou C, Nguyen VQ, Li Z, Chang C, Zhu WS, Hastie AT, He H, Ren X, Qiu W, Gayer SG, Liu C, Choi EJ, Fassett M, Cohen JN, Sturgill JL, Crotty Alexander LE, Suh JM, Liddle C, Atkins AR, Yu RT, Downes M, Liu S, Nikolajczyk BS, Lee IK, Guttman-Yassky E, Ansel KM, Woodruff PG, Fahy JV, Sheppard D, Gallo RL, Ye CJ, Evans RM, Zheng Y, Marson A. Obesity alters pathology and treatment response in inflammatory disease. 2015 Year Book of Pediatrics. Ed. Cabana MD. (Elsevier; Philadelphia, PA) 2022. PMID: 35355021


  28. Gitlin I, Fahy JV. Mucus secretion blocked at its source in the lungs. 2015 Year Book of Pediatrics. Ed. Cabana MD. (Elsevier; Philadelphia, PA) 2022. PMID: 35322214


  29. Nagasaki T, Schuyler AJ, Zhao J, Samovich SN, Yamada K, Deng Y, Ginebaugh SP, Christenson SA, Woodruff PG, Fahy JV, Trudeau JB, Stoyanovsky D, Ray A, Tyurina YY, Kagan VE, Wenzel SE. 15LO1 dictates glutathione redox changes in asthmatic airway epithelium to worsen type-2 inflammation. 2015 Year Book of Pediatrics. Ed. Cabana MD. (Elsevier; Philadelphia, PA) 2021. PMID: 34762602


  30. Mummy DG, Dunican EM, Carey KJ, Evans MD, Elicker BM, Newell JD, Gierada DS, Nagle SK, Schiebler ML, Sorkness RL, Jarjour NN, Denlinger LC, Fahy JV, Fain SB. Mucus Plugs in Asthma at CT Associated with Regional Ventilation Defects at Helium 3 MRI. 2015 Year Book of Pediatrics. Ed. Cabana MD. (Elsevier; Philadelphia, PA) 2021. PMID: 34931858


  31. Georas SN, Wright RJ, Ivanova A, Israel E, LaVange LM, Akuthota P, Carr TF, Denlinger LC, Fajt ML, Kumar R, O'Neal WK, Phipatanakul W, Szefler SJ, Aronica MA, Bacharier LB, Burbank AJ, Castro M, Alexander LC, Bamdad J, Cardet JC, Comhair SAA, Covar RA, DiMango EA, Erwin K, Erzurum SC, Fahy JV, Gaffin JM, Gaston B, Gerald LB, Hoffman EA, Holguin F, Jackson DJ, James J, Jarjour NN, Kenyon NJ, Khatri S, Kirwan JP, Kraft M, Krishnan JA, Liu AH, Liu MC, Marquis MA, Martinez F, Mey J, Moore WC, Moy JN, Ortega VE, Peden DB, Pennington E, Peters MC, Ross K, Sanchez M, Smith LJ, Sorkness RL, Wechsler ME, Wenzel SE, White SR, Zein J, Zeki AA, Noel P, PrecISE Study Team. The Precision Interventions for Severe and/or Exacerbation-Prone (PrecISE) Asthma Network: an overview of Network organization, procedures and interventions. 2015 Year Book of Pediatrics. Ed. Cabana MD. (Elsevier; Philadelphia, PA) 2021. PMID: 34848210


  32. Khanna K, Raymond W, Charbit AR, Jin J, Gitlin I, Tang M, Sperber HS, Franz S, Pillai S, Simmons G, Fahy JV. Binding of SARS-CoV-2 spike protein to ACE2 is disabled by thiol-based drugs; evidence from in vitro SARS-CoV-2 infection studies. bioRxiv : the preprint server for biology 2020. PMID: 33330868


  33. Zein JG, McManus JM, Sharifi N, Erzurum SC, Marozkina N, Lahm T, Giddings O, Davis MD, DeBoer MD, Comhair SA, Bazeley P, Kim HJ, Busse W, Calhoun W, Castro M, Chung KF, Fahy JV, Israel E, Jarjour NN, Levy BD, Mauger DT, Moore WC, Ortega VE, Peters M, Bleecker ER, Meyers DA, Zhao Y, Wenzel SE, Gaston B. Benefits of Airway Androgen Receptor Expression in Human Asthma. American journal of respiratory and critical care medicine 2021. PMID: 33779531


  35. Dunican EM, Elicker BM, Henry T, Gierada DS, Schiebler ML, Anderson W, Barjaktarevic I, Barr RG, Bleecker ER, Boucher RC, Bowler RP, Christenson SA, Comellas A, Cooper CB, Couper D, Criner GJ, Dransfield M, Doerschuk CM, Drummond MB, Hansel NN, Han MK, Hastie AT, Hoffman EA, Krishnan JA, Lazarus SC, Martinez FJ, McCulloch CE, O'Neal WK, Ortega VE, Paine R, Peters S, Schroeder JD, Woodruff PG, Fahy JV. Mucus Plugs and Emphysema in the Pathophysiology of Airflow Obstruction and Hypoxemia in Smokers. American journal of respiratory and critical care medicine 2020. PMID: 33180550


  36. Hastie AT, Mauger DT, Denlinger LC, Coverstone A, Castro M, Erzurum S, Jarjour N, Levy BD, Meyers DA, Moore WC, Phillips BR, Wenzel SE, Fahy JV, Israel E, Bleecker ER. Mixed Sputum Granulocyte Longitudinal Impact on Lung Function in the Severe Asthma Research Program. American journal of respiratory and critical care medicine 2021. PMID: 33545021


  37. Denlinger LC, Phillips BR, Sorkness RL, Bleecker ER, Castro M, DeBoer MD, Fitzpatrick AM, Hastie AT, Gaffin JM, Moore WC, Peters MC, Peters SP, Phipatanakul W, Cardet JC, Erzurum SC, Fahy JV, Fajt ML, Gaston B, Levy BD, Meyers DA, Ross K, Teague WG, Wenzel SE, Woodruff PG, Zein J, Jarjour NN, Mauger DT, Israel E. Responsiveness to Parenteral Corticosteroids and Lung Function Trajectory in Adults with Moderate to Severe Asthma. American journal of respiratory and critical care medicine 2020. PMID: 33290668


  38. Israel E, Denlinger LC, Bacharier LB, LaVange LM, Moore WC, Peters MC, Georas SN, Wright RJ, Mauger DT, Noel P, Akuthota P, Bach J, Bleecker ER, Cardet JC, Carr TF, Castro M, Cinelli A, Comhair SAA, Covar RA, Alexander LC, DiMango EA, Erzurum SC, Fahy JV, Fajt ML, Gaston BM, Hoffman EA, Holguin F, Jackson DJ, Jain S, Jarjour NN, Ji Y, Kenyon NJ, Kosorok MR, Kraft M, Krishnan JA, Kumar R, Liu AH, Liu MC, Ly NP, Marquis MA, Martinez FD, Moy JN, O'Neal WK, Ortega VE, Peden DB, Phipatanakul W, Ross K, Smith LJ, Szefler SJ, Teague WG, Tulchinsky AF, Vijayanand P, Wechsler ME, Wenzel SE, White SR, Zeki AA, Ivanova A. PrecISE: Precision Medicine in Severe Asthma An Adaptive Platform Trial with Biomarker Ascertainment. The Journal of allergy and clinical immunology 2021. PMID: 33667479


  40. Peters MC, Fahy JV. Erratum: COVID-19-related Genes in Sputum Cells in Asthma: Relationship to Demographic Features and Corticosteroids. American journal of respiratory and critical care medicine 2020. PMID: 33320072


  42. Peters MC, Fahy JV, Denlinger LC. Reply to Nannini and Lipworth et al. American journal of respiratory and critical care medicine 2020. PMID: 32687407


  43. Peters MC, Mauger D, Ross KR, Phillips B, Gaston B, Cardet JC, Israel E, Levy BD, Phipatanakul W, Jarjour NN, Castro M, Wenzel SE, Hastie A, Moore W, Bleecker E, Fahy JV, Denlinger LC. Evidence for Exacerbation-Prone Asthma and Predictive Biomarkers of Exacerbation Frequency. American journal of respiratory and critical care medicine 2020. PMID: 32479111


  44. Ivanova A, Israel E, LaVange LM, Peters MC, Denlinger LC, Moore WC, Bacharier LB, Marquis MA, Gotman NM, Kosorok MR, Tomlinson C, Mauger DT, Georas SN, Wright RJ, Noel P, Rosner GL, Akuthota P, Billheimer D, Bleecker ER, Cardet JC, Castro M, DiMango EA, Erzurum SC, Fahy JV, Fajt ML, Gaston BM, Holguin F, Jain S, Kenyon NJ, Krishnan JA, Kraft M, Kumar R, Liu MC, Ly NP, Moy JN, Phipatanakul W, Ross K, Smith LJ, Szefler SJ, Teague WG, Wechsler ME, Wenzel SE, White SR. The precision interventions for severe and/or exacerbation-prone asthma (PrecISE) adaptive platform trial: statistical considerations. Journal of biopharmaceutical statistics 2020. PMID: 32941098


  45. Li X, Christenson SA, Modena B, Li H, Busse WW, Castro M, Denlinger LC, Erzurum SC, Fahy JV, Gaston B, Hastie AT, Israel E, Jarjour NN, Levy BD, Moore WC, Woodruff PG, Kaminski N, Wenzel SE, Bleecker ER, Meyers DA. Genetic analyses identify GSDMB associated with asthma severity, exacerbations, and antiviral pathways. The Journal of allergy and clinical immunology 2020. PMID: 32795586


  46. Kerr SC, Gonzalez JR, Schanin J, Peters MC, Lambrecht BN, Brock EC, Charbit A, Ansel KM, Youngblood BA, Fahy JV. An Anti-Siglec-8 Antibody Depletes Sputum Eosinophils from Asthmatic Subjects and Inhibits Lung Mast Cells. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2020. PMID: 32542913


  47. Peters MC, Sajuthi S, Deford P, Christenson S, Rios CL, Montgomery MT, Woodruff PG, Mauger DT, Erzurum SC, Johansson MW, Denlinger LC, Jarjour NN, Castro M, Hastie AT, Moore W, Ortega VE, Bleecker ER, Wenzel SE, Israel E, Levy BD, Seibold MA, Fahy JV. COVID-19 Related Genes in Sputum Cells in Asthma: Relationship to Demographic Features and Corticosteroids. American journal of respiratory and critical care medicine 2020. PMID: 32348692


  48. Hastie AT, Mauger DT, Denlinger LC, Coverstone A, Castro M, Erzurum S, Jarjour N, Levy BD, Meyers DA, Moore WC, Phillips B, Wenzel SE, Fahy JV, Israel E, Bleecker ER. Baseline sputum eosinophil+neutrophil subgroups' clinical characteristics and longitudinal trajectories for NHLBI Severe Asthma Research Program (SARP 3) Cohort. The Journal of allergy and clinical immunology 2020. PMID: 32032631


  49. Maun HR, Jackman JK, Choy DF, Loyet KM, Staton TL, Jia G, Dressen A, Hackney JA, Bremer M, Walters BT, Vij R, Chen X, Trivedi NN, Morando A, Lipari MT, Franke Y, Wu X, Zhang J, Liu J, Wu P, Chang D, Orozco LD, Christensen E, Wong M, Corpuz R, Hang JQ, Lutman J, Sukumaran S, Wu Y, Ubhayakar S, Liang X, Schwartz LB, Babina M, Woodruff PG, Fahy JV, Ahuja R, Caughey GH, Kusi A, Dennis MS, Eigenbrot C, Kirchhofer D, Austin CD, Wu LC, Koerber JT, Lee WP, Yaspan BL, Alatsis KR, Arron JR, Lazarus RA, Yi T. An Allosteric Anti-tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma. Cell 2020. PMID: 31978350


  50. Zein J, Gaston B, Bazeley P, DeBoer MD, Igo RP, Bleecker ER, Meyers D, Comhair S, Marozkina NV, Cotton C, Patel M, Alyamani M, Xu W, Busse WW, Calhoun WJ, Ortega V, Hawkins GA, Castro M, Chung KF, Fahy JV, Fitzpatrick AM, Israel E, Jarjour NN, Levy B, Mauger DT, Moore WC, Noel P, Peters SP, Teague WG, Wenzel SE, Erzurum SC, Sharifi N. HSD3B1 genotype identifies glucocorticoid responsiveness in severe asthma. Proceedings of the National Academy of Sciences of the United States of America 2020. PMID: 31932420


  51. Ross KR, Gupta R, DeBoer MD, Zein J, Phillips BR, Mauger DT, Li C, Myers RE, Phipatanakul W, Fitzpatrick AM, Ly NP, Bacharier LB, Jackson DJ, Celedón JC, Larkin A, Israel E, Levy B, Fahy JV, Castro M, Bleecker ER, Meyers D, Moore WC, Wenzel SE, Jarjour NN, Erzurum SC, Teague WG, Gaston B. Severe asthma during childhood and adolescence: A longitudinal study. The Journal of allergy and clinical immunology 2019. PMID: 31622688


  52. Fitzpatrick AM, Szefler SJ, Mauger DT, Phillips BR, Denlinger LC, Moore WC, Sorkness RL, Wenzel SE, Gergen PJ, Bleecker ER, Castro M, Erzurum SC, Fahy JV, Gaston BM, Israel E, Levy BD, Meyers DA, Teague WG, Bacharier LB, Ly NP, Phipatanakul W, Ross KR, Zein J, Jarjour NN. Development and Initial Validation of the Asthma Severity Scoring System (ASSESS). The Journal of allergy and clinical immunology 2019. PMID: 31604088


  53. Maun HR, Jackman JK, Choy DF, Loyet KM, Staton TL, Jia G, Dressen A, Hackney JA, Bremer M, Walters BT, Vij R, Chen X, Trivedi NN, Morando A, Lipari MT, Franke Y, Wu X, Zhang J, Liu J, Wu P, Chang D, Orozco LD, Christensen E, Wong M, Corpuz R, Hang JQ, Lutman J, Sukumaran S, Wu Y, Ubhayakar S, Liang X, Schwartz LB, Babina M, Woodruff PG, Fahy JV, Ahuja R, Caughey GH, Kusi A, Dennis MS, Eigenbrot C, Kirchhofer D, Austin CD, Wu LC, Koerber JT, Lee WP, Yaspan BL, Alatsis KR, Arron JR, Lazarus RA, Yi T. An Allosteric Anti-tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma. Cell 2019. PMID: 31585081


  54. Mah PT, O'Connell P, Focaroli S, Lundy R, O'Mahony TF, Hastedt JE, Gitlin I, Oscarson S, Fahy JV, Marie Healy A. The use of hydrophobic amino acids in protecting spray dried trehalose formulations against moisture-induced changes. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 2019. PMID: 31536784


  55. Ash SY, Vegas Sanchez-Ferrero G, Schiebler ML, Rahaghi FN, Rai A, Come CE, Ross JC, Colon AG, Cardet JC, Bleecker ER, Castro M, Fahy JV, Fain SB, Gaston BM, Hoffman EA, Jarjour NN, Lempel JK, Mauger DT, Tattersall MC, Wenzel SE, Levy BD, Washko GR, Israel E, San Jose Estepar R. Estimated Ventricular Size, Asthma Severity and Exacerbations: The SARP III Cohort. Chest 2019. PMID: 31521672


  56. Li X, Hastie AT, Peters MC, Hawkins GA, Phipatanakul W, Li H, Moore WC, Busse WW, Castro M, Erzurum SC, Gaston B, Israel E, Jarjour NN, Levy BD, Wenzel SE, Meyers DA, Fahy JV, Bleecker ER. Investigation of the relationship between IL-6 and type 2 biomarkers in severe asthma. The Journal of allergy and clinical immunology 2019. PMID: 31513878


  57. Fahy JV, Locksley RM. Making Asthma Crystal Clear. The New England journal of medicine 2019. PMID: 31461600


  58. Coverstone AM, Bacharier LB, Wilson BS, Fitzpatrick AM, Teague WG, Phipatanakul W, Wenzel SE, Gaston BM, Bleecker ER, Moore WC, Ramratnam S, Jarjour NN, Ly NP, Fahy JV, Mauger DT, Schechtman KB, Yin-DeClue H, Boomer JS, Castro M. Clinical significance of the bronchodilator response in children with severe asthma. Pediatric pulmonology 2019. PMID: 31424170


  59. Wu W, Bang S, Bleecker ER, Castro M, Denlinger L, Erzurum SC, Fahy JV, Fitzpatrick AM, Gaston BM, Hastie AT, Israel E, Jarjour NN, Levy BD, Mauger DT, Meyers DA, Moore WC, Peters M, Phillips BR, Phipatanakul W, Sorkness RL, Wenzel SE. Multiview Cluster Analysis Identifies Variable Corticosteroid Response Phenotypes in Severe Asthma. American journal of respiratory and critical care medicine 2019. PMID: 30682261


  60. Lazarus SC, Krishnan JA, King TS, Lang JE, Blake KV, Covar R, Lugogo N, Wenzel S, Chinchilli VM, Mauger DT, Dyer AM, Boushey HA, Fahy JV, Woodruff PG, Bacharier LB, Cabana MD, Cardet JC, Castro M, Chmiel J, Denlinger L, DiMango E, Fitzpatrick AM, Gentile D, Hastie A, Holguin F, Israel E, Jackson D, Kraft M, LaForce C, Lemanske RF, Martinez FD, Moore W, Morgan WJ, Moy JN, Myers R, Peters SP, Phipatanakul W, Pongracic JA, Que L, Ross K, Smith L, Szefler SJ, Wechsler ME, Sorkness CA. Mometasone or Tiotropium in Mild Asthma with a Low Sputum Eosinophil Level. The New England journal of medicine 2019. PMID: 31112384


  61. Lachowicz-Scroggins ME, Dunican EM, Charbit AR, Raymond W, Looney MR, Peters MC, Gordon ED, Woodruff PG, Lefrançais E, Phillips BR, Mauger DT, Comhair SA, Erzurum SC, Johansson MW, Jarjour NN, Coverstone AM, Castro M, Hastie AT, Bleecker ER, Fajt ML, Wenzel SE, Israel E, Levy BD, Fahy JV. Extracellular DNA, Neutrophil Extracellular Traps, and Inflammasome Activation in Severe Asthma. American journal of respiratory and critical care medicine 2019. PMID: 30888839


  62. Schaefer N, Li X, Seibold MA, Jarjour NN, Denlinger LC, Castro M, Coverstone AM, Teague WG, Boomer J, Bleecker ER, Meyers DA, Moore WC, Hawkins GA, Fahy J, Phillips BR, Mauger DT, Dakhama A, Gellatly S, Pavelka N, Berman R, Di YP, Wenzel SE, Chu HW. The effect of BPIFA1/SPLUNC1 genetic variation on its expression and function in asthmatic airway epithelium. JCI insight 2019. PMID: 30996135


  63. Lambrecht BN, Hammad H, Fahy JV. The Cytokines of Asthma. Immunity 2019. PMID: 30995510


  64. Focaroli S, Mah PT, Hastedt JE, Gitlin I, Oscarson S, Fahy JV, Healy AM. A Design of Experiment (DoE) approach to optimise spray drying process conditions for the production of trehalose/leucine formulations with application in pulmonary delivery. International journal of pharmaceutics 2019. PMID: 30849470


  65. Peters MC, Ringel L, Dyjack N, Herrin R, Woodruff PG, Rios C, O'Connor B, Fahy JV, Seibold MA. A Transcriptomic Method to Determine Airway Immune Dysfunction in T2-High and T2-Low Asthma. American journal of respiratory and critical care medicine 2018. PMID: 30371106


  66. Fitzpatrick AM, Gillespie SE, Mauger DT, Phillips BR, Bleecker ER, Israel E, Meyers DA, Moore WC, Sorkness RL, Wenzel SE, Bacharier LB, Castro M, Denlinger LC, Erzurum SC, Fahy JV, Gaston BM, Jarjour NN, Larkin A, Levy BD, Ly NP, Ortega VE, Peters SP, Phipatanakul W, Ramratnam S, Teague WG. Racial disparities in asthma-related health care use in the National Heart, Lung, and Blood Institute's Severe Asthma Research Program. The Journal of allergy and clinical immunology 2019. PMID: 30635198


  67. Dunican EM, Watchorn DC, Fahy JV. Autopsy and Imaging Studies of Mucus in Asthma. Lessons Learned about Disease Mechanisms and the Role of Mucus in Airflow Obstruction. Annals of the American Thoracic Society 2018. PMID: 30431352


  68. MacNee W, Fahy JV, Nicod LP, Kolls J. Purpose of the Conference: The 2018 Transatlantic Conference on Lung Diseases. Annals of the American Thoracic Society 2018. PMID: 30431342


  69. Krishnamoorthy N, Douda DN, Brüggemann TR, Ricklefs I, Duvall MG, Abdulnour RE, Martinod K, Tavares L, Wang X, Cernadas M, Israel E, Mauger DT, Bleecker ER, Castro M, Erzurum SC, Gaston BM, Jarjour NN, Wenzel S, Dunican E, Fahy JV, Irimia D, Wagner DD, Levy BD. Neutrophil cytoplasts induce TH17 differentiation and skew inflammation toward neutrophilia in severe asthma. Science immunology 2018. PMID: 30076281


  70. Ash SY, Rahaghi FN, Come CE, Ross JC, Colon AG, Cardet-Guisasola JC, Dunican EM, Bleecker ER, Castro M, Fahy JV, Fain SB, Gaston BM, Hoffman EA, Jarjour NN, Mauger DT, Wenzel SE, Levy BD, San Jose Estepar R, Israel E, Washko GR. Pruning of the Pulmonary Vasculature in Asthma. The Severe Asthma Research Program (SARP) Cohort. American journal of respiratory and critical care medicine 2018. PMID: 29672122


  71. DeBoer MD, Phillips BR, Mauger DT, Zein J, Erzurum SC, Fitzpatrick AM, Gaston BM, Myers R, Ross KR, Chmiel J, Lee MJ, Fahy JV, Peters M, Ly NP, Wenzel SE, Fajt ML, Holguin F, Moore WC, Peters SP, Meyers D, Bleecker ER, Castro M, Coverstone AM, Bacharier LB, Jarjour NN, Sorkness RL, Ramratnam S, Irani AM, Israel E, Levy B, Phipatanakul W, Gaffin JM, Gerald Teague W. Effects of endogenous sex hormones on lung function and symptom control in adolescents with asthma. BMC pulmonary medicine 2018. PMID: 29631584


  72. Ricklefs I, Barkas I, Duvall MG, Cernadas M, Grossman NL, Israel E, Bleecker ER, Castro M, Erzurum SC, Fahy JV, Gaston BM, Denlinger LC, Mauger DT, Wenzel SE, Comhair SA, Coverstone AM, Fajt ML, Hastie AT, Johansson MW, Peters MC, Phillips BR, Levy BD. ALX receptor ligands define a biochemical endotype for severe asthma. JCI insight 2018. PMID: 29563345


  73. Peters MC, Kerr S, Dunican EM, Woodruff PG, Fajt ML, Levy BD, Israel E, Phillips BR, Mauger DT, Comhair SA, Erzurum SC, Johansson MW, Jarjour NN, Coverstone AM, Castro M, Hastie AT, Bleecker ER, Wenzel SE, Fahy JV. Refractory airway type 2 inflammation in a large subgroup of asthmatic patients treated with inhaled corticosteroids. The Journal of allergy and clinical immunology 2018. PMID: 29524537


  74. Lachowicz-Scroggins ME, Gordon ED, Wesolowska-Andersen A, Jackson ND, MacLeod HJ, Sharp LZ, Sun M, Seibold MA, Fahy JV. Cadherin-26 (CDH26) regulates airway epithelial cell cytoskeletal structure and polarity. Cell discovery 2018. PMID: 29449961


  75. Dunican EM, Elicker BM, Gierada DS, Nagle SK, Schiebler ML, Newell JD, Raymond WW, Lachowicz-Scroggins ME, Di Maio S, Hoffman EA, Castro M, Fain SB, Jarjour NN, Israel E, Levy BD, Erzurum SC, Wenzel SE, Meyers DA, Bleecker ER, Phillips BR, Mauger DT, Gordon ED, Woodruff PG, Peters MC, Fahy JV. Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction. The Journal of clinical investigation 2018. PMID: 29400693


  76. Bhakta NR, Christenson SA, Nerella S, Solberg OD, Nguyen CP, Choy DF, Jung KL, Garudadri S, Bonser LR, Pollack JL, Zlock LT, Erle DJ, Langelier C, Derisi JL, Arron JR, Fahy JV, Woodruff PG. IFN-stimulated Gene Expression, Type 2 Inflammation, and Endoplasmic Reticulum Stress in Asthma. Volume 197 of Issue 3. American journal of respiratory and critical care medicine 2018. PMID: 29064281


  77. MacNee W, Fahy JV, Nicod LP, Kolls J. Purpose of the Conference: The 2017 Transatlantic Conference on Lung Diseases. Annals of the American Thoracic Society 2017. PMID: 29161085


  78. Wong-McGrath K, Denlinger LC, Bleecker ER, Castro M, Gaston B, Israel E, Jarjour NN, Mauger DT, Peters S, Phillips BR, Wenzel SE, Fahy JV, Peters MC. Internet-Based Monitoring in the Severe Asthma Research Program Identifies a Subgroup of Patients With Labile Asthma Control. Chest 2017. PMID: 29080709


  79. Lachowicz-Scroggins ME, Finkbeiner WE, Gordon ED, Yuan S, Zlock L, Bhakta NR, Woodruff PG, Fahy JV, Boushey HA. Corticosteroid and long-acting ß-agonist therapy reduces epithelial goblet cell metaplasia. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2017. PMID: 28833774


  80. Pavord ID, Beasley R, Agusti A, Anderson GP, Bel E, Brusselle G, Cullinan P, Custovic A, Ducharme FM, Fahy JV, Frey U, Gibson P, Heaney LG, Holt PG, Humbert M, Lloyd CM, Marks G, Martinez FD, Sly PD, von Mutius E, Wenzel S, Zar HJ, Bush A. After asthma: redefining airways diseases. Lancet (London, England) 2017. PMID: 28911920


  81. Teague WG, Phillips BR, Fahy JV, Wenzel SE, Fitzpatrick AM, Moore WC, Hastie AT, Bleecker ER, Meyers DA, Peters SP, Castro M, Coverstone AM, Bacharier LB, Ly NP, Peters MC, Denlinger LC, Ramratnam S, Sorkness RL, Gaston BM, Erzurum SC, Comhair SAA, Myers RE, Zein J, DeBoer MD, Irani AM, Israel E, Levy B, Cardet JC, Phipatanakul W, Gaffin JM, Holguin F, Fajt ML, Aujla SJ, Mauger DT, Jarjour NN. Baseline Features of the Severe Asthma Research Program (SARP III) Cohort: Differences with Age. The journal of allergy and clinical immunology. In practice 2017. PMID: 28866107


  82. Ricklefs I, Barkas I, Duvall MG, Cernadas M, Grossman NL, Israel E, Bleecker ER, Castro M, Erzurum SC, Fahy JV, Gaston BM, Denlinger LC, Mauger DT, Wenzel SE, Comhair SA, Coverstone AM, Fajt ML, Hastie AT, Johansson MW, Peters MC, Phillips BR, Levy BD. ALX receptor ligands define a biochemical endotype for severe asthma. JCI insight 2017. PMID: 28724795


  83. Dunican EM, Fahy JV. Asthma and corticosteroids: time for a more precise approach to treatment. The European respiratory journal 2017. PMID: 28663322


  84. Phipatanakul W, Mauger DT, Sorkness RL, Gaffin JM, Holguin F, Woodruff PG, Ly NP, Bacharier LB, Bhakta NR, Moore WC, Bleecker ER, Hastie AT, Meyers DA, Castro M, Fahy JV, Fitzpatrick AM, Gaston BM, Jarjour NN, Levy BD, Peters SP, Teague WG, Fajt M, Wenzel SE, Erzurum SC, Israel E. Effects of Age and Disease Severity on Systemic Corticosteroid Responses in Asthma. American journal of respiratory and critical care medicine 2017. PMID: 27967215


  85. Duvall MG, Barnig C, Cernadas M, Ricklefs I, Krishnamoorthy N, Grossman NL, Bhakta NR, Fahy JV, Bleecker ER, Castro M, Erzurum SC, Gaston BM, Jarjour NN, Mauger DT, Wenzel SE, Comhair SA, Coverstone AM, Fajt ML, Hastie AT, Johansson MW, Peters MC, Phillips BR, Israel E, Levy BD. Natural killer cell-mediated inflammation resolution is disabled in severe asthma. Science immunology 2017. PMID: 28783702


  86. Denlinger LC, Phillips BR, Ramratnam S, Ross K, Bhakta NR, Cardet JC, Castro M, Peters SP, Phipatanakul W, Aujla S, Bacharier LB, Bleecker ER, Comhair SA, Coverstone A, DeBoer M, Erzurum SC, Fain SB, Fajt M, Fitzpatrick AM, Gaffin J, Gaston B, Hastie AT, Hawkins GA, Holguin F, Irani AM, Israel E, Levy BD, Ly N, Meyers DA, Moore WC, Myers R, Opina MT, Peters MC, Schiebler ML, Sorkness RL, Teague WG, Wenzel SE, Woodruff PG, Mauger DT, Fahy JV, Jarjour NN. Inflammatory and Comorbid Features of Patients with Severe Asthma and Frequent Exacerbations. American journal of respiratory and critical care medicine 2017. PMID: 27556234


  87. MacNee W, Fahy JV, Nicod LP, Kolls JK. Purpose of the Conference: 2016 Transatlantic Airway Conference. Annals of the American Thoracic Society 2016. PMID: 28005426


  88. Lachowicz-Scroggins ME, Yuan S, Kerr SC, Dunican EM, Yu M, Carrington SD, Fahy JV. Abnormalities in MUC5AC and MUC5B Protein in Airway Mucus in Asthma. American journal of respiratory and critical care medicine 2016. PMID: 27845589


  89. Dickey BF, Fahy JV, Kesimer M, Boucher RC, Evans CM, Thornton D. Measuring Airway Mucin 2 in Patients with Severe Chronic Obstructive Pulmonary Disease with Bacterial Colonization. Annals of the American Thoracic Society 2016. PMID: 27831803


  90. Luyster FS, Strollo PJ, Holguin F, Castro M, Dunican EM, Fahy J, Gaston B, Israel E, Jarjour NN, Mauger DT, Moore WC, Wenzel SE. Association Between Insomnia and Asthma Burden in the Severe Asthma Research Program (SARP) III. Chest 2016. PMID: 27720882


  91. Gordon ED, Palandra J, Wesolowska-Andersen A, Ringel L, Rios CL, Lachowicz-Scroggins ME, Sharp LZ, Everman JL, MacLeod HJ, Lee JW, Mason RJ, Matthay MA, Sheldon RT, Peters MC, Nocka KH, Fahy JV, Seibold MA. IL1RL1 asthma risk variants regulate airway type 2 inflammation. JCI insight 2016. PMID: 27699235


  92. Peters MC, Fahy JV. Metabolic consequences of obesity as an "outside in" mechanism of disease severity in asthma. The European respiratory journal 2016. PMID: 27478182


  93. Gordon ED, Simpson LJ, Rios CL, Ringel L, Lachowicz-Scroggins ME, Peters MC, Wesolowska-Andersen A, Gonzalez JR, MacLeod HJ, Christian LS, Yuan S, Barry L, Woodruff PG, Ansel KM, Nocka K, Seibold MA, Fahy JV. Alternative splicing of interleukin-33 and type 2 inflammation in asthma. Proceedings of the National Academy of Sciences of the United States of America 2016. PMID: 27432971


  94. Peters MC, McGrath KW, Hawkins GA, Hastie AT, Levy BD, Israel E, Phillips BR, Mauger DT, Comhair SA, Erzurum SC, Johansson MW, Jarjour NN, Coverstone AM, Castro M, Holguin F, Wenzel SE, Woodruff PG, Bleecker ER, Fahy JV. Plasma interleukin-6 concentrations, metabolic dysfunction, and asthma severity: a cross-sectional analysis of two cohorts. The Lancet. Respiratory medicine 2016. PMID: 27283230


  95. Gordon ED, Locksley RM, Fahy JV. Cross-Talk between Epithelial Cells and Type 2 Immune Signaling. The Role of IL-25. American journal of respiratory and critical care medicine 2016. PMID: 27128698


  96. Sweerus K, Lachowicz-Scroggins M, Gordon E, LaFemina M, Huang X, Parikh M, Kanegai C, Fahy JV, Frank JA. Claudin-18 deficiency is associated with airway epithelial barrier dysfunction and asthma. Volume 139 of Issue 1. 2016. PMID: 27215490


  97. Kerr SC, Fischer GJ, Sinha M, McCabe O, Palmer JM, Choera T, Lim FY, Wimmerova M, Carrington SD, Yuan S, Lowell CA, Oscarson S, Keller NP, Fahy JV. FleA Expression in Aspergillus fumigatus Is Recognized by Fucosylated Structures on Mucins and Macrophages to Prevent Lung Infection. PLoS pathogens 2016. PMID: 27058347


  98. Reber LL, Fahy JV. Mast cells in asthma: biomarker and therapeutic target. The European respiratory journal 2016. PMID: 27037311


  99. Fahy JV. Asthma Was Talking, But We Weren't Listening. Missed or Ignored Signals That Have Slowed Treatment Progress. Annals of the American Thoracic Society 2016. PMID: 27027957


  100. Levy BD, Noel PJ, Freemer MM, Cloutier MM, Georas SN, Jarjour NN, Ober C, Woodruff PG, Barnes KC, Bender BG, Camargo CA, Chupp GL, Denlinger LC, Fahy JV, Fitzpatrick AM, Fuhlbrigge A, Gaston BM, Hartert TV, Kolls JK, Lynch SV, Moore WC, Morgan WJ, Nadeau KC, Ownby DR, Solway J, Szefler SJ, Wenzel SE, Wright RJ, Smith RA, Erzurum SC. Future Research Directions in Asthma. An NHLBI Working Group Report. American journal of respiratory and critical care medicine 2015. PMID: 26305520


  101. MacNee W, Fahy J, Nicod L, Kolls J. Purpose of the Conference: 2015 Transatlantic Airway Conference. Annals of the American Thoracic Society 2015. PMID: 26595725


  102. Dunican EM, Fahy JV. The Role of Type 2 Inflammation in the Pathogenesis of Asthma Exacerbations. Annals of the American Thoracic Society 2015. PMID: 26595730


  103. Yuan S, Hollinger M, Lachowicz-Scroggins ME, Kerr SC, Dunican EM, Daniel BM, Ghosh S, Erzurum SC, Willard B, Hazen SL, Huang X, Carrington SD, Oscarson S, Fahy JV. Oxidation increases mucin polymer cross-links to stiffen airway mucus gels. Science translational medicine 2015. PMID: 25717100


  104. Fahy JV. Type 2 inflammation in asthma--present in most, absent in many. Nature reviews. Immunology 2015. PMID: 25534623


  105. MacNee W, Fahy J, Nicod L, Kolls J. Twenty-Ninth Transatlantic Airway Conference. Innate and adaptive immune responses in airway disease. Purpose of the conference. Annals of the American Thoracic Society 2014. PMID: 25525724


  106. Simpson LJ, Patel S, Bhakta NR, Choy DF, Brightbill HD, Ren X, Wang Y, Pua HH, Baumjohann D, Montoya MM, Panduro M, Remedios KA, Huang X, Fahy JV, Arron JR, Woodruff PG, Ansel KM. A microRNA upregulated in asthma airway T cells promotes TH2 cytokine production. Nature immunology 2014. PMID: 25362490


  107. Greer AM, Matthay MA, Kukreja J, Bhakta NR, Nguyen CP, Wolters PJ, Woodruff PG, Fahy JV, Shin JS. Accumulation of BDCA1? dendritic cells in interstitial fibrotic lung diseases and Th2-high asthma. PloS one 2014. PMID: 24915147


  108. Kerr SC, Carrington SD, Oscarson S, Gallagher ME, Solon M, Yuan S, Ahn JN, Dougherty RH, Finkbeiner WE, Peters MC, Fahy JV. Intelectin-1 is a prominent protein constituent of pathologic mucus associated with eosinophilic airway inflammation in asthma. American journal of respiratory and critical care medicine 2014. PMID: 24735037


  109. Locksley RM, Fahy JV. Asthma and the flu: a tricky two-step. Immunology and cell biology 2014. PMID: 24687019


  110. Jackson DJ, Hartert TV, Martinez FD, Weiss ST, Fahy JV. Asthma: NHLBI Workshop on the Primary Prevention of Chronic Lung Diseases. Annals of the American Thoracic Society 2014. PMID: 24754822


  111. Houser J, Komarek J, Kostlanova N, Cioci G, Varrot A, Kerr SC, Lahmann M, Balloy V, Fahy JV, Chignard M, Imberty A, Wimmerova M. A soluble fucose-specific lectin from Aspergillus fumigatus conidia--structure, specificity and possible role in fungal pathogenicity. PloS one 2013. PMID: 24340081


  113. MacNee W, Fahy J, Nicod L, Wanner A. Purpose of the conference. Annals of the American Thoracic Society 2013. PMID: 24313758


  114. Peters MC, Mekonnen ZK, Yuan S, Bhakta NR, Woodruff PG, Fahy JV. Measures of gene expression in sputum cells can identify TH2-high and TH2-low subtypes of asthma. The Journal of allergy and clinical immunology 2013. PMID: 24075231


  115. Peters MC, Fahy JV. Type 2 immune responses in obese individuals with asthma. American journal of respiratory and critical care medicine 2013. PMID: 24032378


  116. Bhakta NR, Solberg OD, Nguyen CP, Nguyen CN, Arron JR, Fahy JV, Woodruff PG. A qPCR-based metric of Th2 airway inflammation in asthma. Clinical and translational allergy 2013. PMID: 23866775


  117. Seumois G, Vijayanand P, Eisley CJ, Omran N, Kalinke L, North M, Ganesan AP, Simpson LJ, Hunkapiller N, Moltzahn F, Woodruff PG, Fahy JV, Erle DJ, Djukanovic R, Blelloch R, Ansel KM. An integrated nano-scale approach to profile miRNAs in limited clinical samples. Volume 1 of Issue 2. 2012. PMID: 23304658


  118. Denlinger LC, Manthei DM, Seibold MA, Ahn K, Bleecker E, Boushey HA, Calhoun WJ, Castro M, Chinchili VM, Fahy JV, Hawkins GA, Icitovic N, Israel E, Jarjour NN, King T, Kraft M, Lazarus SC, Lehman E, Martin RJ, Meyers DA, Peters SP, Sheerar D, Shi L, Sutherland ER, Szefler SJ, Wechsler ME, Sorkness CA, Lemanske RF. P2X7-regulated protection from exacerbations and loss of control is independent of asthma maintenance therapy. American journal of respiratory and critical care medicine 2012. PMID: 23144325


  119. Huang F, Zhang H, Wu M, Yang H, Kudo M, Peters CJ, Woodruff PG, Solberg OD, Donne ML, Huang X, Sheppard D, Fahy JV, Wolters PJ, Hogan BL, Finkbeiner WE, Li M, Jan YN, Jan LY, Rock JR. Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction. Volume 109 of Issue 40. Proceedings of the National Academy of Sciences of the United States of America 2012. PMID: 22988107


  120. Calhoun WJ, Ameredes BT, King TS, Icitovic N, Bleecker ER, Castro M, Cherniack RM, Chinchilli VM, Craig T, Denlinger L, DiMango EA, Engle LL, Fahy JV, Grant JA, Israel E, Jarjour N, Kazani SD, Kraft M, Kunselman SJ, Lazarus SC, Lemanske RF, Lugogo N, Martin RJ, Meyers DA, Moore WC, Pascual R, Peters SP, Ramsdell J, Sorkness CA, Sutherland ER, Szefler SJ, Wasserman SI, Walter MJ, Wechsler ME, Boushey HA. Comparison of physician-, biomarker-, and symptom-based strategies for adjustment of inhaled corticosteroid therapy in adults with asthma: the BASALT randomized controlled trial. JAMA 2012. PMID: 22968888


  121. Jia G, Erickson RW, Choy DF, Mosesova S, Wu LC, Solberg OD, Shikotra A, Carter R, Audusseau S, Hamid Q, Bradding P, Fahy JV, Woodruff PG, Harris JM, Arron JR. Periostin is a systemic biomarker of eosinophilic airway inflammation in asthmatic patients. The Journal of allergy and clinical immunology 2012. PMID: 22857879


  122. Diez D, Goto S, Fahy JV, Erle DJ, Woodruff PG, Wheelock ÅM, Wheelock CE. Network analysis identifies a putative role for the PPAR and type 1 interferon pathways in glucocorticoid actions in asthmatics. Volume 5. 2012. PMID: 22713245


  123. Sutherland ER, Goleva E, King TS, Lehman E, Stevens AD, Jackson LP, Stream AR, Fahy JV, Leung DY. Cluster analysis of obesity and asthma phenotypes. PloS one 2012. PMID: 22606276


  124. Szefler SJ, Wenzel S, Brown R, Erzurum SC, Fahy JV, Hamilton RG, Hunt JF, Kita H, Liu AH, Panettieri RA, Schleimer RP, Minnicozzi M. Asthma outcomes: biomarkers. The Journal of allergy and clinical immunology 2012. PMID: 22386512


  125. McGrath KW, Icitovic N, Boushey HA, Lazarus SC, Sutherland ER, Chinchilli VM, Fahy JV. A large subgroup of mild-to-moderate asthma is persistently noneosinophilic. American journal of respiratory and critical care medicine 2012. PMID: 22268133


  126. Aminuddin F, Akhabir L, Stefanowicz D, Paré PD, Connett JE, Anthonisen NR, Fahy JV, Seibold MA, Burchard EG, Eng C, Gulsvik A, Bakke P, Cho MH, Litonjua A, Lomas DA, Anderson WH, Beaty TH, Crapo JD, Silverman EK, Sandford AJ. Genetic association between human chitinases and lung function in COPD. Volume 131 of Issue 7. 2011. PMID: 22200767


  127. Gordon ED, Sidhu SS, Wang ZE, Woodruff PG, Yuan S, Solon MC, Conway SJ, Huang X, Locksley RM, Fahy JV. A protective role for periostin and TGF-ß in IgE-mediated allergy and airway hyperresponsiveness. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2011. PMID: 22093101


  128. Fahy JV, Locksley RM. The airway epithelium as a regulator of Th2 responses in asthma. American journal of respiratory and critical care medicine 2011. PMID: 21844510


  129. Commins SP, James HR, Kelly LA, Pochan SL, Workman LJ, Perzanowski MS, Kocan KM, Fahy JV, Nganga LW, Ronmark E, Cooper PJ, Platts-Mills TA. The relevance of tick bites to the production of IgE antibodies to the mammalian oligosaccharide galactose-a-1,3-galactose. The Journal of allergy and clinical immunology 2011. PMID: 21453959


  130. Chabre YM, Brisebois PP, Abbassi L, Kerr SC, Fahy JV, Marcotte I, Roy R. Hexaphenylbenzene as a rigid template for the straightforward syntheses of "star-shaped" glycodendrimers. The Journal of organic chemistry 2010. PMID: 21190367


  131. Choy DF, Modrek B, Abbas AR, Kummerfeld S, Clark HF, Wu LC, Fedorowicz G, Modrusan Z, Fahy JV, Woodruff PG, Arron JR. Gene expression patterns of Th2 inflammation and intercellular communication in asthmatic airways. Journal of immunology (Baltimore, Md. : 1950) 2010. PMID: 21187436


  132. Fahy JV, Dickey BF. Airway mucus function and dysfunction. The New England journal of medicine 2010. PMID: 21121836


  133. McGrath KW, Fahy JV. Negative methacholine challenge tests in subjects who report physician-diagnosed asthma. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2010. PMID: 21105916


  134. Sutherland ER, King TS, Icitovic N, Ameredes BT, Bleecker E, Boushey HA, Calhoun WJ, Castro M, Cherniack RM, Chinchilli VM, Craig TJ, Denlinger L, DiMango EA, Fahy JV, Israel E, Jarjour N, Kraft M, Lazarus SC, Lemanske RF, Peters SP, Ramsdell J, Sorkness CA, Szefler SJ, Walter MJ, Wasserman SI, Wechsler ME, Chu HW, Martin RJ. A trial of clarithromycin for the treatment of suboptimally controlled asthma. The Journal of allergy and clinical immunology 2010. PMID: 20920764


  135. Peters SP, Kunselman SJ, Icitovic N, Moore WC, Pascual R, Ameredes BT, Boushey HA, Calhoun WJ, Castro M, Cherniack RM, Craig T, Denlinger L, Engle LL, DiMango EA, Fahy JV, Israel E, Jarjour N, Kazani SD, Kraft M, Lazarus SC, Lemanske RF, Lugogo N, Martin RJ, Meyers DA, Ramsdell J, Sorkness CA, Sutherland ER, Szefler SJ, Wasserman SI, Walter MJ, Wechsler ME, Chinchilli VM, Bleecker ER. Tiotropium bromide step-up therapy for adults with uncontrolled asthma. The New England journal of medicine 2010. PMID: 20979471


  136. Innes AL, McGrath KW, Dougherty RH, McCulloch CE, Woodruff PG, Seibold MA, Okamoto KS, Ingmundson KJ, Solon MC, Carrington SD, Fahy JV. The H antigen at epithelial surfaces is associated with susceptibility to asthma exacerbation. American journal of respiratory and critical care medicine 2010. PMID: 20732988


  137. Sidhu SS, Yuan S, Innes AL, Kerr S, Woodruff PG, Hou L, Muller SJ, Fahy JV. Roles of epithelial cell-derived periostin in TGF-beta activation, collagen production, and collagen gel elasticity in asthma. Proceedings of the National Academy of Sciences of the United States of America 2010. PMID: 20660732


  138. Dougherty RH, Sidhu SS, Raman K, Solon M, Solberg OD, Caughey GH, Woodruff PG, Fahy JV. Accumulation of intraepithelial mast cells with a unique protease phenotype in T(H)2-high asthma. Volume 125 of Issue 5. 2010. PMID: 20451039


  139. Fahy JV. Identifying clinical phenotypes of asthma: steps in the right direction. American journal of respiratory and critical care medicine 2010. PMID: 20130143


  140. Woodruff PG, Wolff M, Hohlfeld JM, Krug N, Dransfield MT, Sutherland ER, Criner GJ, Kim V, Prasse A, Nivens MC, Tetzlaff K, Heilker R, Fahy JV. Safety and efficacy of an inhaled epidermal growth factor receptor inhibitor (BIBW 2948 BS) in chronic obstructive pulmonary disease. American journal of respiratory and critical care medicine 2009. PMID: 20007923


  141. Wechsler ME, Kunselman SJ, Chinchilli VM, Bleecker E, Boushey HA, Calhoun WJ, Ameredes BT, Castro M, Craig TJ, Denlinger L, Fahy JV, Jarjour N, Kazani S, Kim S, Kraft M, Lazarus SC, Lemanske RF, Markezich A, Martin RJ, Permaul P, Peters SP, Ramsdell J, Sorkness CA, Sutherland ER, Szefler SJ, Walter MJ, Wasserman SI, Israel E. Effect of beta2-adrenergic receptor polymorphism on response to longacting beta2 agonist in asthma (LARGE trial): a genotype-stratified, randomised, placebo-controlled, crossover trial. Lancet (London, England) 2009. PMID: 19932356


  142. Park SW, Verhaeghe C, Nguyenvu LT, Barbeau R, Eisley CJ, Nakagami Y, Huang X, Woodruff PG, Fahy JV, Erle DJ. Distinct roles of FOXA2 and FOXA3 in allergic airway disease and asthma. Volume 180 of Issue 7. American journal of respiratory and critical care medicine 2009. PMID: 19628779


  143. Woodruff PG, Modrek B, Choy DF, Jia G, Abbas AR, Ellwanger A, Koth LL, Arron JR, Fahy JV. T-helper type 2-driven inflammation defines major subphenotypes of asthma. American journal of respiratory and critical care medicine 2009. PMID: 19483109


  144. Seibold MA, Reese TA, Choudhry S, Salam MT, Beckman K, Eng C, Atakilit A, Meade K, Lenoir M, Watson HG, Thyne S, Kumar R, Weiss KB, Grammer LC, Avila P, Schleimer RP, Fahy JV, Rodriguez-Santana J, Rodriguez-Cintron W, Boot RG, Sheppard D, Gilliland FD, Locksley RM, Burchard EG. Differential enzymatic activity of common haplotypic versions of the human acidic Mammalian chitinase protein. Volume 284 of Issue 29. The Journal of biological chemistry 2009. PMID: 19435888


  145. Innes AL, Carrington SD, Thornton DJ, Kirkham S, Rousseau K, Dougherty RH, Raymond WW, Caughey GH, Muller SJ, Fahy JV. Ex vivo sputum analysis reveals impairment of protease-dependent mucus degradation by plasma proteins in acute asthma. Volume 180 of Issue 3. American journal of respiratory and critical care medicine 2009. PMID: 19423716


  146. Fahy JV. Eosinophilic and neutrophilic inflammation in asthma: insights from clinical studies. Proceedings of the American Thoracic Society 2009. PMID: 19387026


  147. Dougherty RH, Fahy JV. Acute exacerbations of asthma: epidemiology, biology and the exacerbation-prone phenotype. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2009. PMID: 19187331


  148. Seibold MA, Donnelly S, Solon M, Innes A, Woodruff PG, Boot RG, Burchard EG, Fahy JV. Chitotriosidase is the primary active chitinase in the human lung and is modulated by genotype and smoking habit. Volume 122 of Issue 5. 2008. PMID: 18845328


  149. Walter MJ, Castro M, Kunselman SJ, Chinchilli VM, Reno M, Ramkumar TP, Avila PC, Boushey HA, Ameredes BT, Bleecker ER, Calhoun WJ, Cherniack RM, Craig TJ, Denlinger LC, Israel E, Fahy JV, Jarjour NN, Kraft M, Lazarus SC, Lemanske RF, Martin RJ, Peters SP, Ramsdell JW, Sorkness CA, Sutherland ER, Szefler SJ, Wasserman SI, Wechsler ME. Predicting worsening asthma control following the common cold. The European respiratory journal 2008. PMID: 18768579


  150. Woodruff PG, Boushey HA, Dolganov GM, Barker CS, Yang YH, Donnelly S, Ellwanger A, Sidhu SS, Dao-Pick TP, Pantoja C, Erle DJ, Yamamoto KR, Fahy JV. Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids. Proceedings of the National Academy of Sciences of the United States of America 2007. PMID: 17898169


  151. Lazarus SC, Chinchilli VM, Rollings NJ, Boushey HA, Cherniack R, Craig TJ, Deykin A, DiMango E, Fish JE, Ford JG, Israel E, Kiley J, Kraft M, Lemanske RF, Leone FT, Martin RJ, Pesola GR, Peters SP, Sorkness CA, Szefler SJ, Wechsler ME, Fahy JV. Smoking affects response to inhaled corticosteroids or leukotriene receptor antagonists in asthma. American journal of respiratory and critical care medicine 2007. PMID: 17204725


  152. Martin RJ, Szefler SJ, King TS, Kraft M, Boushey HA, Chinchilli VM, Craig TJ, Dimango EA, Deykin A, Fahy JV, Israel E, Lazarus SC, Lemanske RF, Leone FT, Pesola GR, Peters SP, Sorkness CA, Szwejbka LA, Wechsler ME. The Predicting Response to Inhaled Corticosteroid Efficacy (PRICE) trial. The Journal of allergy and clinical immunology 2007. PMID: 17208587


  153. Innes AL, Woodruff PG, Ferrando RE, Donnelly S, Dolganov GM, Lazarus SC, Fahy JV. Epithelial mucin stores are increased in the large airways of smokers with airflow obstruction. Chest 2006. PMID: 17035444


  154. Deykin A, Wechsler ME, Boushey HA, Chinchilli VM, Kunselman SJ, Craig TJ, DiMango E, Fahy JV, Kraft M, Leone F, Lazarus SC, Lemanske RF, Martin RJ, Pesola GR, Peters SP, Sorkness CA, Szefler SJ, Israel E. Combination therapy with a long-acting beta-agonist and a leukotriene antagonist in moderate asthma. American journal of respiratory and critical care medicine 2006. PMID: 16973987


  155. Hays SR, Fahy JV. Characterizing mucous cell remodeling in cystic fibrosis: relationship to neutrophils. American journal of respiratory and critical care medicine 2006. PMID: 16917116


  156. Fahy JV. Anti-IgE: lessons learned from effects on airway inflammation and asthma exacerbation. The Journal of allergy and clinical immunology 2006. PMID: 16750979


  157. Ratto J, Wong H, Liu J, Fahy J, Boushey H, Solomon C, Balmes J. Effects of multiday exposure to ozone on airway inflammation as determined using sputum induction. Environmental health perspectives 2006. PMID: 16451856


  158. Wechsler ME, Lehman E, Lazarus SC, Lemanske RF, Boushey HA, Deykin A, Fahy JV, Sorkness CA, Chinchilli VM, Craig TJ, DiMango E, Kraft M, Leone F, Martin RJ, Peters SP, Szefler SJ, Liu W, Israel E. beta-Adrenergic receptor polymorphisms and response to salmeterol. American journal of respiratory and critical care medicine 2005. PMID: 16322642


  159. Kuperman DA, Lewis CC, Woodruff PG, Rodriguez MW, Yang YH, Dolganov GM, Fahy JV, Erle DJ. Dissecting asthma using focused transgenic modeling and functional genomics. Volume 116 of Issue 2. 2005. PMID: 16083784


  160. Akpinar-Elci M, Stemple KJ, Enright PL, Fahy JV, Bledsoe TA, Kreiss K, Weissman DN. Induced sputum evaluation in microwave popcorn production workers. Chest 2005. PMID: 16100197


  161. Boushey HA, Sorkness CA, King TS, Sullivan SD, Fahy JV, Lazarus SC, Chinchilli VM, Craig TJ, Dimango EA, Deykin A, Fagan JK, Fish JE, Ford JG, Kraft M, Lemanske RF, Leone FT, Martin RJ, Mauger EA, Pesola GR, Peters SP, Rollings NJ, Szefler SJ, Wechsler ME, Israel E. Daily versus as-needed corticosteroids for mild persistent asthma. The New England journal of medicine 2005. PMID: 15829533


  162. Deykin A, Lazarus SC, Fahy JV, Wechsler ME, Boushey HA, Chinchilli VM, Craig TJ, Dimango E, Kraft M, Leone F, Lemanske RF, Martin RJ, Pesola GR, Peters SP, Sorkness CA, Szefler SJ, Israel E. Sputum eosinophil counts predict asthma control after discontinuation of inhaled corticosteroids. The Journal of allergy and clinical immunology 2005. PMID: 15805990


  163. Israel E, Chinchilli VM, Ford JG, Boushey HA, Cherniack R, Craig TJ, Deykin A, Fagan JK, Fahy JV, Fish J, Kraft M, Kunselman SJ, Lazarus SC, Lemanske RF, Liggett SB, Martin RJ, Mitra N, Peters SP, Silverman E, Sorkness CA, Szefler SJ, Wechsler ME, Weiss ST, Drazen JM. Use of regularly scheduled albuterol treatment in asthma: genotype-stratified, randomised, placebo-controlled cross-over trial. Lancet (London, England) 2004. PMID: 15500895


  164. McNamara N, Gallup M, Khong A, Sucher A, Maltseva I, Fahy J, Basbaum C. Adenosine up-regulation of the mucin gene, MUC2, in asthma. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004. PMID: 15345696


  165. Djukanovic R, Wilson SJ, Kraft M, Jarjour NN, Steel M, Chung KF, Bao W, Fowler-Taylor A, Matthews J, Busse WW, Holgate ST, Fahy JV. Effects of treatment with anti-immunoglobulin E antibody omalizumab on airway inflammation in allergic asthma. American journal of respiratory and critical care medicine 2004. PMID: 15172898


  166. Woodruff PG, Dolganov GM, Ferrando RE, Donnelly S, Hays SR, Solberg OD, Carter R, Wong HH, Cadbury PS, Fahy JV. Hyperplasia of smooth muscle in mild to moderate asthma without changes in cell size or gene expression. American journal of respiratory and critical care medicine 2004. PMID: 14726423


  167. Avila PC, Boushey HA, Wong H, Grundland H, Liu J, Fahy JV. Effect of a single dose of the selectin inhibitor TBC1269 on early and late asthmatic responses. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2004. PMID: 14720266


  168. Ferrando RE, Nyengaard JR, Hays SR, Fahy JV, Woodruff PG. Applying stereology to measure thickness of the basement membrane zone in bronchial biopsy specimens. The Journal of allergy and clinical immunology 2003. PMID: 14657892


  169. Janson SL, Fahy JV, Covington JK, Paul SM, Gold WM, Boushey HA. Effects of individual self-management education on clinical, biological, and adherence outcomes in asthma. The American journal of medicine 2003. PMID: 14656614


  170. Kraft M, Martin RJ, Lazarus SC, Fahy JV, Boushey HA, Lemanske RF, Szefler SJ. Airway tissue mast cells in persistent asthma: predictor of treatment failure when patients discontinue inhaled corticosteroids. Chest 2003. PMID: 12853500


  171. Hays SR, Fahy JV. The role of mucus in fatal asthma. The American journal of medicine 2003. PMID: 12867239


  172. Fahy JV. Goblet cell and mucin gene abnormalities in asthma. Chest 2002. PMID: 12475809


  173. Djukanovic R, Sterk PJ, Fahy JV, Hargreave FE. Standardised methodology of sputum induction and processing. The European respiratory journal. Supplement 2002. PMID: 12361359


  174. Woodruff PG, Fahy JV. Airway remodeling in asthma. Seminars in respiratory and critical care medicine 2002. PMID: 16088629


  175. Martin RJ, Szefler SJ, Chinchilli VM, Kraft M, Dolovich M, Boushey HA, Cherniack RM, Craig TJ, Drazen JM, Fagan JK, Fahy JV, Fish JE, Ford JG, Israel E, Kunselman SJ, Lazarus SC, Lemanske RF, Peters SP, Sorkness CA. Systemic effect comparisons of six inhaled corticosteroid preparations. American journal of respiratory and critical care medicine 2002. PMID: 12016099


  176. Woodruff PG, Fahy JV. A role for neutrophils in asthma? The American journal of medicine 2002. PMID: 11959064


  177. Szefler SJ, Martin RJ, King TS, Boushey HA, Cherniack RM, Chinchilli VM, Craig TJ, Dolovich M, Drazen JM, Fagan JK, Fahy JV, Fish JE, Ford JG, Israel E, Kiley J, Kraft M, Lazarus SC, Lemanske RF, Mauger E, Peters SP, Sorkness CA. Significant variability in response to inhaled corticosteroids for persistent asthma. The Journal of allergy and clinical immunology 2002. PMID: 11897984


  178. Hallstrand TS, Fahy JV. Practical management of acute asthma in adults. Respiratory care 2002. PMID: 11812274


  179. Martin RJ, Kephart DK, Dyer AM, Fahy J, Kraft M. Quality control within the Asthma Clinical Research Network. Controlled clinical trials 2001. PMID: 11728625


  180. Ordoñez CL, Fahy JV. Epithelial desquamation in asthma. American journal of respiratory and critical care medicine 2001. PMID: 11780603


  181. Fahy JV. Remodeling of the airway epithelium in asthma. American journal of respiratory and critical care medicine 2001. PMID: 11734466


  182. Hays SR, Woodruff PG, Khashayar R, Ferrando RE, Liu J, Fung P, Zhao CQ, Wong HH, Fahy JV. Allergen challenge causes inflammation but not goblet cell degranulation in asthmatic subjects. The Journal of allergy and clinical immunology 2001. PMID: 11692105


  183. Woodruff PG, Khashayar R, Lazarus SC, Janson S, Avila P, Boushey HA, Segal M, Fahy JV. Relationship between airway inflammation, hyperresponsiveness, and obstruction in asthma. The Journal of allergy and clinical immunology 2001. PMID: 11692100


  184. Dolganov GM, Woodruff PG, Novikov AA, Zhang Y, Ferrando RE, Szubin R, Fahy JV. A novel method of gene transcript profiling in airway biopsy homogenates reveals increased expression of a Na+-K+-Cl- cotransporter (NKCC1) in asthmatic subjects. Genome research 2001. PMID: 11544191


  185. Woodruff PG, Fahy JV. Asthma: prevalence, pathogenesis, and prospects for novel therapies. JAMA 2001. PMID: 11466111


  186. Lemanske RF, Sorkness CA, Mauger EA, Lazarus SC, Boushey HA, Fahy JV, Drazen JM, Chinchilli VM, Craig T, Fish JE, Ford JG, Israel E, Kraft M, Martin RJ, Nachman SA, Peters SP, Spahn JD, Szefler SJ. Inhaled corticosteroid reduction and elimination in patients with persistent asthma receiving salmeterol: a randomized controlled trial. JAMA 2001. PMID: 11368733


  187. Lazarus SC, Boushey HA, Fahy JV, Chinchilli VM, Lemanske RF, Sorkness CA, Kraft M, Fish JE, Peters SP, Craig T, Drazen JM, Ford JG, Israel E, Martin RJ, Mauger EA, Nachman SA, Spahn JD, Szefler SJ. Long-acting beta2-agonist monotherapy vs continued therapy with inhaled corticosteroids in patients with persistent asthma: a randomized controlled trial. JAMA 2001. PMID: 11368732


  188. Fahy JV, Boushey HA, Lazarus SC, Mauger EA, Cherniack RM, Chinchilli VM, Craig TJ, Drazen JM, Ford JG, Fish JE, Israel E, Kraft M, Lemanske RF, Martin RJ, McLean D, Peters SP, Sorkness C, Szefler SJ. Safety and reproducibility of sputum induction in asthmatic subjects in a multicenter study. American journal of respiratory and critical care medicine 2001. PMID: 11371420


  189. Leone FT, Mauger EA, Peters SP, Chinchilli VM, Fish JE, Boushey HA, Cherniack RM, Drazen JM, Fahy JV, Ford J, Israel E, Lazarus SC, Lemanske RF, Martin RJ, McGeady SJ, Sorkness C, Szefler SJ. The utility of peak flow, symptom scores, and beta-agonist use as outcome measures in asthma clinical research. Chest 2001. PMID: 11296165


  190. Fahy JV, O'Byrne PM. "Reactive airways disease". A lazy term of uncertain meaning that should be abandoned. American journal of respiratory and critical care medicine 2001. PMID: 11282751


  191. Ordoñez CL, Khashayar R, Wong HH, Ferrando R, Wu R, Hyde DM, Hotchkiss JA, Zhang Y, Novikov A, Dolganov G, Fahy JV. Mild and moderate asthma is associated with airway goblet cell hyperplasia and abnormalities in mucin gene expression. American journal of respiratory and critical care medicine 2001. PMID: 11179133


  192. Takeyama K, Fahy JV, Nadel JA. Relationship of epidermal growth factor receptors to goblet cell production in human bronchi. American journal of respiratory and critical care medicine 2001. PMID: 11179132


  193. Israel E, Drazen JM, Liggett SB, Boushey HA, Cherniack RM, Chinchilli VM, Cooper DM, Fahy JV, Fish JE, Ford JG, Kraft M, Kunselman S, Lazarus SC, Lemanske RF, Martin RJ, McLean DE, Peters SP, Silverman EK, Sorkness CA, Szefler SJ, Weiss ST, Yandava CN. Effect of polymorphism of the beta(2)-adrenergic receptor on response to regular use of albuterol in asthma. International archives of allergy and immunology 2001. PMID: 11306963


  194. Rubin BK, Tomkiewicz R, Fahy JV, Green FH. Histopathology of fatal asthma: drowning in mucus. Pediatric pulmonology 2001. PMID: 11886162


  195. Janson S, Hardie G, Fahy J, Boushey H. Use of biological markers of airway inflammation to detect the efficacy of nurse-delivered asthma education. Heart & lung : the journal of critical care 2001. PMID: 11174366


  196. Ordoñez C, Ferrando R, Hyde DM, Wong HH, Fahy JV. Epithelial desquamation in asthma: artifact or pathology? American journal of respiratory and critical care medicine 2000. PMID: 11112158


  197. Boushey HA, Fahy JV. Targeting cytokines in asthma therapy: round one. Lancet (London, England) 2000. PMID: 11191533


  198. Israel E, Drazen JM, Liggett SB, Boushey HA, Cherniack RM, Chinchilli VM, Cooper DM, Fahy JV, Fish JE, Ford JG, Kraft M, Kunselman S, Lazarus SC, Lemanske RF, Martin RJ, McLean DE, Peters SP, Silverman EK, Sorkness CA, Szefler SJ, Weiss ST, Yandava CN. The effect of polymorphisms of the beta(2)-adrenergic receptor on the response to regular use of albuterol in asthma. American journal of respiratory and critical care medicine 2000. PMID: 10903223


  199. Avila PC, Segal MR, Wong HH, Boushey HA, Fahy JV. Predictors of late asthmatic response. Logistic regression and classification tree analyses. American journal of respiratory and critical care medicine 2000. PMID: 10852792


  200. Fahy JV. Reducing IgE levels as a strategy for the treatment of asthma. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2000. PMID: 10849469


  201. Thoison O, Fahy J, Dumontet V, Chiaroni A, Riche C, Tri MV, Sévenet T. Cytotoxic prenylxanthones from Garcinia bracteata. Journal of natural products 2000. PMID: 10785410


  202. Ordoñez CL, Shaughnessy TE, Matthay MA, Fahy JV. Increased neutrophil numbers and IL-8 levels in airway secretions in acute severe asthma: Clinical and biologic significance. American journal of respiratory and critical care medicine 2000. PMID: 10764310


  203. Fahy JV, Corry DB, Boushey HA. Airway inflammation and remodeling in asthma. Current opinion in pulmonary medicine 2000. PMID: 10608420


  204. Gershman NH, Wong HH, Liu JT, Fahy JV. Low- and high-dose fluticasone propionate in asthma; effects during and after treatment. The European respiratory journal 2000. PMID: 10678614


  205. Longphre M, Li D, Gallup M, Drori E, Ordoñez CL, Redman T, Wenzel S, Bice DE, Fahy JV, Basbaum C. Allergen-induced IL-9 directly stimulates mucin transcription in respiratory epithelial cells. The Journal of clinical investigation 1999. PMID: 10562299


  206. Fahy JV, Cockcroft DW, Boulet LP, Wong HH, Deschesnes F, Davis EE, Ruppel J, Su JQ, Adelman DC. Effect of aerosolized anti-IgE (E25) on airway responses to inhaled allergen in asthmatic subjects. American journal of respiratory and critical care medicine 1999. PMID: 10471635


  207. Gershman NH, Liu H, Wong HH, Liu JT, Fahy JV. Fractional analysis of sequential induced sputum samples during sputum induction: evidence that different lung compartments are sampled at different time points. The Journal of allergy and clinical immunology 1999. PMID: 10452752


  208. Gershman NH, Fahy JV. The effect of methacholine challenge on the cellular composition of induced sputum. The Journal of allergy and clinical immunology 1999. PMID: 10329838


  209. Liu H, Lazarus SC, Caughey GH, Fahy JV. Neutrophil elastase and elastase-rich cystic fibrosis sputum degranulate human eosinophils in vitro. The American journal of physiology 1999. PMID: 9887052


  210. Fahy JV. A safe, simple, standardized method should be used for sputum induction for research purposes. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1998. PMID: 9761006


  211. Fahy JV, Boushey HA. Effect of low-dose beclomethasone dipropionate on asthma control and airway inflammation. The European respiratory journal 1998. PMID: 9657561


  212. Fahy JV, Boushey HA. Targeting IgE with monoclonal antibodies: the future is now. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1998. PMID: 9677128


  213. Kips JC, Fahy JV, Hargreave FE, Ind PW, in't Veen JC. Methods for sputum induction and analysis of induced sputum: a method for assessing airway inflammation in asthma. The European respiratory journal. Supplement 1998. PMID: 9585872


  214. Fish JE, Peters SP, Chambers CV, McGeady SJ, Epstein KR, Boushey HA, Cherniack RM, Chinchilli VM, Drazen JM, Fahy JV, Hurd SS, Israel E, Lazarus SC, Lemanske RF, Martin RJ, Mauger EA, Sorkness C, Szefler SJ. An evaluation of colchicine as an alternative to inhaled corticosteriods in moderate asthma. National Heart, Lung, and Blood Institute's Asthma Clinical Research Network. American journal of respiratory and critical care medicine 1997. PMID: 9351617


  215. Wong HH, Fahy JV. Safety of one method of sputum induction in asthmatic subjects. American journal of respiratory and critical care medicine 1997. PMID: 9230765


  216. Fahy JV, Fleming HE, Wong HH, Liu JT, Su JQ, Reimann J, Fick RB, Boushey HA. The effect of an anti-IgE monoclonal antibody on the early- and late-phase responses to allergen inhalation in asthmatic subjects. American journal of respiratory and critical care medicine 1997. PMID: 9196082


  217. Fahy JV, Figueroa DJ, Wong HH, Liu JT, Abrams JS. Similar RANTES levels in healthy and asthmatic airways by immunoassay and in situ hybridization. American journal of respiratory and critical care medicine 1997. PMID: 9116993


  218. Gershman NH, Wong HH, Liu JT, Mahlmeister MJ, Fahy JV. Comparison of two methods of collecting induced sputum in asthmatic subjects. The European respiratory journal 1996. PMID: 8980952


  219. Drazen JM, Israel E, Boushey HA, Chinchilli VM, Fahy JV, Fish JE, Lazarus SC, Lemanske RF, Martin RJ, Peters SP, Sorkness C, Szefler SJ. Comparison of regularly scheduled with as-needed use of albuterol in mild asthma. Asthma Clinical Research Network. The New England journal of medicine 1996. PMID: 8778601


  221. Fahy JV, Boushey HA. Controversies involving inhaled beta-agonists and inhaled corticosteroids in the treatment of asthma. Clinics in chest medicine 1995. PMID: 8565410


  222. Boushey HA, Fahy JV. Basic mechanisms of asthma. Environmental health perspectives 1995. PMID: 8549478


  223. Fahy JV, Wong HH, Geppetti P, Reis JM, Harris SC, Maclean DB, Nadel JA, Boushey HA. Effect of an NK1 receptor antagonist (CP-99,994) on hypertonic saline-induced bronchoconstriction and cough in male asthmatic subjects. American journal of respiratory and critical care medicine 1995. PMID: 7663799


  224. Fahy JV, Wong HH, Liu JT, Boushey HA. Analysis of induced sputum after air and ozone exposures in healthy subjects. Environmental research 1995. PMID: 8674483


  225. Fahy JV, Wong H, Liu J, Boushey HA. Comparison of samples collected by sputum induction and bronchoscopy from asthmatic and healthy subjects. American journal of respiratory and critical care medicine 1995. PMID: 7599862


  226. Fahy JV, Kim KW, Liu J, Boushey HA. Prominent neutrophilic inflammation in sputum from subjects with asthma exacerbation. The Journal of allergy and clinical immunology 1995. PMID: 7722165


  227. Schuster A, Fahy JV, Ueki I, Nadel JA. Cystic fibrosis sputum induces a secretory response from airway gland serous cells that can be prevented by neutrophil protease inhibitors. The European respiratory journal 1995. PMID: 7744174


  228. Aquino SL, Gamsu G, Fahy JV, Claster S, Embury SH, Mentzer WC, Vichinsky EP. Chronic pulmonary disorders in sickle cell disease: findings at thin-section CT. Radiology 1994. PMID: 7972829


  229. Claman DM, Boushey HA, Liu J, Wong H, Fahy JV. Analysis of induced sputum to examine the effects of prednisone on airway inflammation in asthmatic subjects. The Journal of allergy and clinical immunology 1994. PMID: 7963155


  230. Fahy JV, Liu J, Wong H, Boushey HA. Analysis of cellular and biochemical constituents of induced sputum after allergen challenge: a method for studying allergic airway inflammation. The Journal of allergy and clinical immunology 1994. PMID: 8006308


  231. Steiger D, Fahy J, Boushey H, Finkbeiner WE, Basbaum C. Use of mucin antibodies and cDNA probes to quantify hypersecretion in vivo in human airways. American journal of respiratory cell and molecular biology 1994. PMID: 8179917


  232. Fahy JV, Liu J, Wong H, Boushey HA. Cellular and biochemical analysis of induced sputum from asthmatic and from healthy subjects. The American review of respiratory disease 1993. PMID: 8484620


  233. Janson-Bjerklie S, Fahy J, Geaghan S, Golden J. Disappearance of eosinophils from bronchoalveolar lavage fluid after patient education and high-dose inhaled corticosteroids: a case report. Heart & lung : the journal of critical care 1993. PMID: 8491659


  234. Ng VL, Geaghan SM, Leoung G, Shiboski S, Fahy J, Schnapp L, Yajko DM, Hopewell PC, Hadley WK. Lack of effect of prophylactic aerosolized pentamidine on the detection of Pneumocystis carinii in induced sputum or bronchoalveolar lavage specimens. Archives of pathology & laboratory medicine 1993. PMID: 8489338


  235. Fahy JV, Steiger DJ, Liu J, Basbaum CB, Finkbeiner WE, Boushey HA. Markers of mucus secretion and DNA levels in induced sputum from asthmatic and from healthy subjects. The American review of respiratory disease 1993. PMID: 8484621


  236. Naughton M, Fahy J, FitzGerald MX. Chronic eosinophilic pneumonia. A long-term follow-up of 12 patients. Chest 1993. PMID: 8031327


  237. Fahy JV, Schuster A, Ueki I, Boushey HA, Nadel JA. Mucus hypersecretion in bronchiectasis. The role of neutrophil proteases. The American review of respiratory disease 1992. PMID: 1280928


  238. Fahy JV, Chin DP, Schnapp LM, Steiger DJ, Schaumberg TH, Geaghan SM, Klein JS, Hopewell PC. Effect of aerosolized pentamidine prophylaxis on the clinical severity and diagnosis of Pneumocystis carinii pneumonia. The American review of respiratory disease 1992. PMID: 1416408


  239. Schnapp LM, Geaghan SM, Campagna A, Fahy J, Steiger D, Ng V, Hadley WK, Hopewell PC, Stansell JD. Toxoplasma gondii pneumonitis in patients infected with the human immunodeficiency virus. Archives of internal medicine 1992. PMID: 1304722


  240. Mulherin D, Fahy J, Grant W, Keogan M, Kavanagh B, FitzGerald M. Aminoglycoside induced ototoxicity in patients with cystic fibrosis. Irish journal of medical science 1991. PMID: 1752740


  241. Fahy JV, Walley T, Gibney RT, McCabe M, FitzGerald MX. "Slurry lung": a report of three cases. Thorax 1991. PMID: 2068701


  242. O'Laoide RM, Fahy J, Coffey M, Ward K, Malone D, Fitzgerald MX, Masterson J. A chest radiograph scoring system in adult cystic fibrosis: correlation with pulmonary function. Clinical radiology 1991. PMID: 2036754


  243. Fahy JV, Keoghan MT, Crummy EJ, FitzGerald MX. Bacteraemia and fungaemia in adults with cystic fibrosis. The Journal of infection 1991. PMID: 1906505


  244. Fahy J, Toner M, O'Sullivan J, FitzGerald MX. Haemopericardium and cardiac tamponade complicating pulmonary lymphangioleiomyomatosis. Thorax 1991. PMID: 2028440