John Greenland, MD, PhD

Education
MD, 6/2008 - Medicine, Harvard Medical School
PhD, 6/2006 - Virology, Harvard Medical School
BS, 6/2000 - Chemistry (minors in Computer Science and History), Stanford University
Websites
Publications

  1. Kulkarni HS, Tague LK, Calabrese DR, Liao F, Liu Z, Garnica L, Shankar N, Wu X, Kulkarni DH, Bernardt C, Byers D, Chen C, Huang HJ, Witt CA, Hachem RR, Kreisel D, Atkinson JP, Greenland JR, Gelman AE. Impaired complement regulation drives chronic lung allograft dysfunction after lung transplantation. bioRxiv : the preprint server for biology 2024. PMID: 39605452


  2. Halloran K, Vos R, Snell G, Greenland JR. The lung transplant endobronchial biopsy: a forgotten specimen comes of age. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2024. PMID: 39476939


  3. Hsu FM, Mohanty RP, Rubbi L, Thompson M, Pickering H, Reed EF, Greenland JR, Schaenman JM, Pellegrini M. An epigenetic human cytomegalovirus infection score predicts viremia risk in seropositive lung transplant recipients. Epigenetics 2024. PMID: 39360678


  4. Tsao T, Qiu L, Bharti R, Shemesh A, Hernandez AM, Cleary SJ, Greenland NY, Santos J, Shi R, Bai L, Richardson J, Dilley K, Will M, Tomasevic N, Sputova T, Salles A, Kang J, Zhang D, Hays SR, Kukreja J, Singer JP, Lanier LL, Looney MR, Greenland JR, Calabrese DR. CD94+ Natural Killer cells potentiate pulmonary ischemia-reperfusion injury. The European respiratory journal 2024. PMID: 39190789


  5. Seijo L, Gao Y, Betancourt L, Venado A, Hays SR, Kukreja J, Calabrese DR, Greenland JR, Singer JP. Improvements in Patient-Reported Functioning after Lung Transplant is Associated with Improved Quality of Life and Survival. medRxiv : the preprint server for health sciences 2024. PMID: 39211845


  6. Mohanty RP, Moghbeli K, Singer JP, Calabrese DR, Hays SR, Iasella C, Lieber S, Leard LE, Shah RJ, Venado A, Kleinhenz ME, Golden JA, Martinu T, Love C, Ward R, Langelier CR, McDyer J, Greenland JR. Small airway brush gene expression predicts chronic lung allograft dysfunction and mortality. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2024. PMID: 39115489


  7. Michon M, Müller-Schiffmann A, Lingappa AF, Yu SF, Du L, Deiter F, Broce S, Mallesh S, Crabtree J, Lingappa UF, Macieik A, Müller L, Ostermann PN, Andrée M, Adams O, Schaal H, Hogan RJ, Tripp RA, Appaiah U, Anand SK, Campi TW, Ford MJ, Reed JC, Lin J, Akintunde O, Copeland K, Nichols C, Petrouski E, Moreira AR, Jiang IT, DeYarman N, Brown I, Lau S, Segal I, Goldsmith D, Hong S, Asundi V, Briggs EM, Phyo NS, Froehlich M, Onisko B, Matlack K, Dey D, Lingappa JR, Prasad DM, Kitaygorodskyy A, Solas D, Boushey H, Greenland J, Pillai S, Lo MK, Montgomery JM, Spiropoulou CF, Korth C, Selvarajah S, Paulvannan K, Lingappa VR. A pan-respiratory antiviral chemotype targeting a transient host multi-protein complex. Open biology 2024. PMID: 38889796


  8. Kudryashova TV, Zaitsev SV, Jiang L, Buckley BJ, McGuckin JP, Goncharov D, Zhyvylo I, Lin D, Newcomb G, Piper B, Bogamuwa S, Saiyed A, Teos L, Pena A, Ranson M, Greenland JR, Wolters PJ, Kelso MJ, Poncz M, DeLisser HM, Cines DB, Goncharova EA, Farkas L, Stepanova V. PAI-1 Deficiency Drives Pulmonary Vascular Smooth Muscle Remodeling and Pulmonary Hypertension. American journal of physiology. Lung cellular and molecular physiology 2024. PMID: 38860847


  9. Du L, Deiter F, Bouzidi MS, Billaud JN, Simmons G, Dabral P, Selvarajah S, Lingappa AF, Michon M, Yu SF, Paulvannan K, Manicassamy B, Lingappa VR, Boushey H, Greenland JR, Pillai SK. A viral assembly inhibitor blocks SARS-CoV-2 replication in airway epithelial cells. Communications biology 2024. PMID: 38649430


  10. Calabrese DR, Yellamilli S, Ekstrand C, Singer JP, Hays SR, Leard LE, Shah RJ, Venado A, Kolaitis NA, Perez A, Combes A, Greenland JR. Macrophage and CD8 T Cell Discordance are Associated with Acute Lung Allograft Dysfunction Progression. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2024. PMID: 38367738


  11. Kapse B, Budev MM, Singer JP, Greenland JR. Immune aging: biological mechanisms, clinical symptoms, and management in lung transplant recipients. Frontiers in Transplantation 2024. PMID: 38993782


  12. Kapse B, Budev MM, Singer JP, Greenland JR. Immune aging: biological mechanisms, clinical symptoms, and management in lung transplant recipients Front Transplant 2024. PMID:


  13. Prather AA, Gao Y, Betancourt L, Kordahl RC, Sriram A, Huang CY, Hays SR, Kukreja J, Calabrese DR, Venado A, Greenland JR, Singer JP. Disturbed sleep is associated with worse patient-reported outcomes and chronic lung allograft dysfunction after lung transplantation. medRxiv : the preprint server for health sciences 2023. PMID: 37873197


  14. Aguilar OA, Qualls AE, Gonzalez-Hinojosa MDR, Obeidalla S, Kerchberger VE, Tsao T, Singer JP, Looney MR, Raymond W, Hays SR, Golden JA, Kukreja J, Shaver CM, Ware LB, Christie J, Diamond JM, Lanier LL, Greenland JR, Calabrese DR, LTOG Investigators. MICB Genomic Variant is Associated with NKG2D-mediated Acute Lung Injury and Death. American journal of respiratory and critical care medicine 2023. PMID: 37878820


  15. Selvarajah S, Lingappa AF, Michon M, Du L, Deiter F, Yu SF, Macieik A, Mallesh S, Appaiah U, Crabtree J, Copeland K, Müller-Schiffmann A, Müller L, Ostermann PN, Andrée M, Adams O, Schaal H, Hogan RJ, Tripp RA, Anand SK, Campi TW, Ford MJ, Reed JC, Lin J, Akintunde O, Nichols C, Petrouski E, Moreira AR, Jiang IT, DeYarman N, Broce S, Brown I, Lau S, Segal I, Goldsmith D, Hong S, Asundi V, Briggs EM, Phyo NS, Froehlich M, Onisko B, Matlack K, Dey D, Lingappa JR, Prasad MD, Korth C, Kitaygorodskyy A, Solas D, Boushey H, Greenland J, Pillai S, Paulvannan K, Lingappa VR. From COVID-19 to the Common Cold: Novel Host-Targeted, Pan-Respiratory Antiviral Small Molecule Therapeutics. 2015 Year Book of Pediatrics. Ed. Cabana MD. (Elsevier; Philadelphia, PA) 2021. PMID: 34931190


  16. Santos J, Wang P, Shemesh A, Liu F, Tsao T, Aguilar OA, Cleary SJ, Singer JP, Gao Y, Hays SR, Golden J, Leard LE, Kleinhenz ME, Kolaitis NA, Shah RJ, Venado A, Kukreja J, Weigt SS, Belperio JA, Lanier LL, Looney MR, Greenland JR, Calabrese DR. CCR5 drives NK cell-associated airway damage in pulmonary ischemia-reperfusion injury. JCI insight 2023. PMID: 37788115


  17. Pavlisko EN, Adam BA, Berry GJ, Calabrese F, Cortes-Santiago N, Glass CH, Goddard M, Greenland JR, Kreisel D, Levine DJ, Martinu T, Verleden SE, Sam WS, Roux A. The 2022 Banff Meeting Lung Report. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2023. PMID: 37931751


  18. Hackney JA, Shivram H, Vander Heiden J, Overall C, Orozco L, Gao X, Kim E, West N, Qamra A, Chang D, Chakrabarti A, Choy DF, Combes AJ, Courau T, Fragiadakis GK, Rao AA, Ray A, Tsui J, Hu K, Kuhn NF, Krummel MF, Erle DJ, Kangelaris K, Sarma A, Lyon Z, Calfee CS, Woodruff PG, Ghale R, Mick E, Byrne A, Zha BS, Langelier C, Hendrickson CM, van der Wijst MGP, Hartoularos GC, Grant T, Bueno R, Lee DS, Greenland JR, Sun Y, Perez R, Ogorodnikov A, Ward A, Ye CJ, UCSF COMET Consortium, Ramalingam T, McBride JM, Cai F, Teterina A, Bao M, Tsai L, Rosas IO, Regev A, Kapadia SB, Bauer RN, Rosenberger CM. A myeloid program associated with COVID-19 severity is decreased by therapeutic blockade of IL-6 signaling. iScience 2023. PMID: 37810211


  19. Greenland JR, Guo R, Lee S, Tran L, Kapse B, Kukreja J, Hays SR, Golden JA, Calabrese DR, Singer JP, Wolters PJ. Short Airway Telomeres are Associated with Primary Graft Dysfunction and Chronic Lung Allograft Dysfunction. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2023. PMID: 37648073


  20. Santos J, Hays SR, Golden JA, Calabrese DR, Kolaitis N, Kleinhenz ME, Shah R, Estrada AV, Leard LE, Kukreja J, Singer JP, Greenland JR. Decreased Lymphocytic Bronchitis Severity in the Era of Azithromycin Prophylaxis. Transplantation direct 2023. PMID: 37575951


  21. Calabrese DR, Greenland JR. Theseus and the search for an antibody-mediated rejection molecular state in lung transplant biopsies. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2023. PMID: 37562578


  22. Du L, Bouzidi MS, Gala A, Deiter F, Billaud JN, Yeung ST, Dabral P, Jin J, Simmons G, Dossani ZY, Niki T, Ndhlovu LC, Greenland JR, Pillai SK. Human galectin-9 potently enhances SARS-CoV-2 replication and inflammation in airway epithelial cells. Journal of molecular cell biology 2023. PMID: 37127426


  23. Nguyen A, Chen J, Isaza E, Panchal N, Deiter F, Hoover J, Trinh B, Hays SR, Golden JA, Singer JP, Brzezinski M, Greenland JR, Kukreja J. Biofire pneumonia panel in lung donors: faster detection but limited pathogens. Transplant infectious disease : an official journal of the Transplantation Society 2023. PMID: 37428868


  24. Singer JP, Gao Y, Huang CY, Kordahl RC, Sriram A, Hays SR, Kukreja J, Venado A, Calabrese DR, Greenland JR. The Association Between Frailty and Chronic Lung Allograft Dysfunction After Lung Transplantation. Transplantation 2023. PMID: 37287095


  25. Pillai S, Du L, Deiter F, Bouzidi M, Billaud JN, Graham S, Prerna D, Selvarajah S, Lingappa A, Michon M, Yu S, Paulvannan K, Lingappa V, Boushey H, Greenland J. A Novel Viral Assembly Inhibitor Blocks SARS-CoV-2 Replication in Airway Epithelial Cells. Research square 2023. PMID: 37292622


  26. Singer JP, Christie JD, Diamond JM, Anderson MA, Benvenuto LA, Gao Y, Arcasoy SM, Lederer DJ, Calabrese D, Wang P, Hays SR, Kukreja J, Venado A, Kolaitis NA, Leard LE, Shah RJ, Kleinhenz ME, Golden J, Betancourt L, Oyster M, Zaleski D, Adler J, Kalman L, Balar P, Patel S, Medikonda N, Koons B, Tevald M, Covinsky KE, Greenland JR, Katz PK. Development of the Lung Transplant Frailty Scale (LT-FS). The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2023. PMID: 36925382


  27. Singer JP, Calfee CS, Delucchi K, Diamond JM, Anderson MA, Benvenuto LA, Gao Y, Wang P, Arcasoy SM, Lederer DJ, Hays SR, Kukreja J, Venado A, Kolaitis NA, Leard L LE, Shah RJ, Kleinhenz ME, Golden J, Betancourt L, Oyster M, Brown M, Zaleski D, Medikonda N, Kalman L, Balar P, Patel S, Calabrese DR, Greenland JR, Christie JD. Subphenotypes of frailty in lung transplant candidates. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2023. PMID: 36740192


  28. Odisho AY, Liu AW, Maiorano AR, Bigazzi MOA, Medina E, Leard LE, Shah R, Venado A, Perez A, Golden J, Kleinhenz ME, Kolaitis NA, Maheshwari J, Trinh BN, Kukreja J, Greenland J, Calabrese D, Neinstein AB, Singer JP, Hays SR. Design and implementation of a digital health home spirometry intervention for remote monitoring of lung transplant function. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2023. PMID: 37031033


  29. Calabrese DR, Chong T, Singer JP, Rajalingam R, Hays SR, Kukreja J, Leard L, Golden JA, Lanier LL, Greenland JR. CD16+ natural killer cells in bronchoalveolar lavage are associated with antibody-mediated rejection and chronic lung allograft dysfunction. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2023. PMID: 36695619


  30. Macrae TA, Lazo J, Viduya J, Florez R, Dewey K, Gao Y, Singer JP, Hays SR, Golden JA, Kukreja J, Greenland JR, Calabrese DR. Frailty and genetic risk predict fracture after lung transplantation. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2023. PMID: 36695698


  31. Calabrese DR, Tsao T, Magnen M, Valet C, Gao Y, Mallavia B, Tian JJ, Aminian EA, Wang KM, Shemesh A, Punzalan EB, Sarma A, Calfee CS, Christenson SA, Langelier CR, Hays SR, Golden JA, Leard LE, Kleinhenz ME, Kolaitis NA, Shah RJ, Venado A, Lanier LL, Greenland JR, Sayah DM, Ardehali A, Kukreja J, Weigt SS, Belperio JA, Singer JP, Looney MR. NKG2D receptor activation drives primary graft dysfunction severity and poor lung transplantation outcomes. JCI insight 2022. PMID: 36346670


  32. Tang Q, Leung J, Peng Y, Sanchez-Fueyo A, Lozano JJ, Lam A, Lee K, Greenland JR, Hellerstein M, Fitch M, Li KW, Esensten JH, Putnam AL, Lares A, Nguyen V, Liu W, Bridges ND, Odim J, Demetris AJ, Levitsky J, Taner T, Feng S. Selective decrease of donor-reactive Tregs after liver transplantation limits Treg therapy for promoting allograft tolerance in humans. Science translational medicine 2022. PMID: 36322627


  33. Shemesh A, Su Y, Calabrese DR, Chen D, Arakawa-Hoyt J, Roybal KT, Heath JR, Greenland JR, Lanier LL. Diminished cell proliferation promotes natural killer cell adaptive-like phenotype by limiting FceRI? expression. The Journal of experimental medicine 2022. PMID: 36066491


  34. Cantu E, Diamond JM, Cevasco M, Suzuki Y, Crespo M, Clausen E, Dallara L, Ramon CV, Harmon MT, Bermudez C, Benvenuto L, Anderson M, Wille KM, Weinacker A, Dhillon GS, Orens J, Shah P, Merlo C, Lama V, McDyer J, Snyder L, Palmer S, Hartwig M, Hage CA, Singer J, Calfee C, Kukreja J, Greenland JR, Ware LB, Localio R, Hsu J, Gallop R, Christie JD. Contemporary trends in PGD incidence, outcomes, and therapies. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2022. PMID: 36216694


  35. Santos J, Calabrese DR, Greenland JR. Lymphocytic Airway Inflammation in Lung Allografts. Frontiers in immunology 2022. PMID: 35911676


  36. Greenland JR, Tullius SG, Schaenman J. Editorial: Immune Aging: Implications for Transplantation. Frontiers in immunology 2022. PMID: 35812424


  37. Du L, Bouzidi MS, Gala A, Deiter F, Billaud JN, Yeung ST, Dabral P, Jin J, Simmons G, Dossani Z, Niki T, Ndhlovu LC, Greenland JR, Pillai SK. Human Galectin-9 Potently Enhances SARS-CoV-2 Replication and Inflammation in Airway Epithelial Cells. 2015 Year Book of Pediatrics. Ed. Cabana MD. (Elsevier; Philadelphia, PA) 2022. PMID: 35378763


  38. Venado A, Kukreja J, Greenland JR. Chronic Lung Allograft Dysfunction. 2015 Year Book of Pediatrics. Ed. Cabana MD. (Elsevier; Philadelphia, PA) 2022. PMID: 35512941


  39. Koons B, Anderson MR, Smith PJ, Greenland JR, Singer JP. The Intersection of Aging and Lung Transplantation: its Impact on Transplant Evaluation, Outcomes, and Clinical Care. Current transplantation reports 2022. PMID: 36341000


  40. Valet C, Magnen M, Qiu L, Cleary SJ, Wang KM, Ranucci S, Grockowiak E, Boudra R, Conrad C, Seo Y, Calabrese DR, Greenland JR, Leavitt AD, Passegué E, Mendez-Ferrer S, Swirski FK, Looney MR. Sepsis promotes splenic production of a protective platelet pool with high CD40 ligand expression. 2015 Year Book of Pediatrics. Ed. Cabana MD. (Elsevier; Philadelphia, PA) 2022. PMID: 35192546


  41. Kolaitis NA, Gao Y, Soong A, Greenland JR, Hays SR, Golden JA, Venado A, Leard LE, Shah RJ, Kleinhenz ME, Katz PP, Kukreja J, Blanc PD, Smith PJ, Singer JP. Depressive symptoms in lung transplant recipients: trajectory and association with mortality and allograft dysfunction. 2015 Year Book of Pediatrics. Ed. Cabana MD. (Elsevier; Philadelphia, PA) 2022. PMID: 35354643


  42. Wang P, Greenland JR. HLA-G/ILT2 signaling on the path to tolerance. 2015 Year Book of Pediatrics. Ed. Cabana MD. (Elsevier; Philadelphia, PA) 2022. PMID: 35382979


  43. Greenland NY, Deiter F, Calabrese DR, Hays SR, Kukreja J, Leard LE, Kolaitis NA, Golden JA, Singer JP, Greenland JR. Inflammation on bronchoalveolar lavage cytology is associated with decreased chronic lung allograft dysfunction-free survival. 2015 Year Book of Pediatrics. Ed. Cabana MD. (Elsevier; Philadelphia, PA) 2022. PMID: 35246990


  44. Greenland JR, McDyer JF. Molecular diagnostics for CLAD: When and where? 2015 Year Book of Pediatrics. Ed. Cabana MD. (Elsevier; Philadelphia, PA) 2021. PMID: 34910363


  45. Wang P, Leung J, Lam A, Lee S, Calabrese DR, Hays SR, Golden JA, Kukreja J, Singer JP, Wolters PJ, Tang Q, Greenland JR. Lung transplant recipients with idiopathic pulmonary fibrosis have impaired alloreactive immune responses. 2015 Year Book of Pediatrics. Ed. Cabana MD. (Elsevier; Philadelphia, PA) 2021. PMID: 34924263


  46. Dugger DT, Calabrese DR, Gao Y, Deiter F, Tsao T, Maheshwari J, Hays SR, Leard L, Kleinhenz ME, Shah R, Golden J, Kukreja J, Gordon ED, Singer JP, Greenland JR. Lung Allograft Epithelium DNA Methylation Age Is Associated With Graft Chronologic Age and Primary Graft Dysfunction. 2015 Year Book of Pediatrics. Ed. Cabana MD. (Elsevier; Philadelphia, PA) 2021. PMID: 34691018


  47. Maheshwari JA, Kolaitis NA, Anderson MR, Benvenuto L, Gao Y, Katz PP, Greenland J, Wolters PJ, Covinsky K, Hays SR, Kukreja J, Calabrese DR, Venado A, Shah RJ, Leard LE, Trinh B, Huang CY, Glidden D, Kleinhenz ME, Golden JA, Sutter N, Tietje-Ulrich G, Criner RN, Arcasoy SM, Christie JD, Diamond J, Singer JP. Construct and Predictive Validity of Sarcopenia in Lung Transplant Candidates. Annals of the American Thoracic Society 2021. PMID: 33565917


  48. van der Wijst MGP, Vazquez SE, Hartoularos GC, Bastard P, Grant T, Bueno R, Lee DS, Greenland JR, Sun Y, Perez R, Ogorodnikov A, Ward A, Mann SA, Lynch KL, Yun C, Havlir DV, Chamie G, Marquez C, Greenhouse B, Lionakis MS, Norris PJ, Dumont LJ, Kelly K, Zhang P, Zhang Q, Gervais A, Le Voyer T, Whatley A, Si Y, Byrne A, Combes AJ, Rao AA, Song YS, Fragiadakis GK, Kangelaris K, Calfee CS, Erle DJ, Hendrickson C, Krummel MF, Woodruff PG, Langelier CR, Casanova JL, Derisi JL, Anderson MS, Ye CJ, UCSF COMET consortium. Type I interferon autoantibodies are associated with systemic immune alterations in patients with COVID-19. Science translational medicine 2021. PMID: 34429372


  50. van der Wijst MGP, Vazquez SE, Hartoularos GC, Bastard P, Grant T, Bueno R, Lee DS, Greenland JR, Sun Y, Perez R, Ogorodnikov A, Ward A, Mann SA, Lynch KL, Yun C, Havlir DV, Chamie G, Marquez C, Greenhouse B, Lionakis MS, Norris PJ, Dumont LJ, Kelly K, Zhang P, Zhang Q, Gervais A, Voyer TL, Whatley A, Si Y, Byrne A, Combes AJ, Rao AA, Song YS, UCSF COMET consortium , Fragiadakis GK, Kangelaris K, Calfee CS, Erle DJ, Hendrickson C, Krummel MF, Woodruff PG, Langelier CR, Casanova JL, Derisi JL, Anderson MS, Ye CJ. Longitudinal single-cell epitope and RNA-sequencing reveals the immunological impact of type 1 interferon autoantibodies in critical COVID-19. bioRxiv : the preprint server for biology 2021. PMID: 33758859


  51. Hoover J, Mintz MA, Deiter F, Aminian E, Chen J, Hays SR, Singer JP, Calabrese DR, Kukreja J, Greenland JR. Rapid Molecular Detection of Airway Pathogens in Lung Transplant Recipients. Transplant infectious disease : an official journal of the Transplantation Society 2021. PMID: 33523538


  52. Calabrese DR, Aminian E, Mallavia B, Liu F, Cleary SJ, Aguilar OA, Wang P, Hoover J, Singer JP, Hays SR, Golden JA, Kukreja J, Dugger DT, Nakamura M, Lanier LL, Looney MR, Greenland JR. Natural killer cells activated through NKG2D mediate lung ischemia-reperfusion injury. The Journal of clinical investigation 2020. PMID: 33290276


  53. Schaenman JM, Diamond JM, Greenland JR, Gries C, Kennedy CC, Parulekar AD, Rozenberg D, Singer JP, Singer LG, Snyder LD, Bhorade S. Frailty and Aging-Associated Syndromes in Lung Transplant Candidates and Recipients. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2020. PMID: 33296550


  54. Iasella CJ, Hoji A, Popescu I, Wei J, Snyder M, Zhang Y, Xu W, Iouchmanov V, Koshy R, Brown M, Fung M, Langelier C, Lendermon EA, Dugger D, Shah R, Lee J, Johnson B, Golden J, Leard LE, Kleinhenz ME, Kilaru S, Hays SR, Singer JP, Sanchez PG, Morrell MR, Pilewski JM, Greenland JR, Chen K, McDyer JF. Type-1 Immunity and Endogenous Immune Regulators Predominate in the Airway Transcriptome during Chronic Lung Allograft Dysfunction. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2020. PMID: 33078555


  55. Cleary SJ, Kwaan N, Tian JJ, Calabrese DR, Mallavia B, Magnen M, Greenland JR, Urisman A, Singer JP, Hays SR, Kukreja J, Hay AM, Howie HL, Toy P, Lowell CA, Morrell CN, Zimring JC, Looney MR. Complement activation on endothelium initiates antibody-mediated acute lung injury. The Journal of clinical investigation 2020. PMID: 32730229


  56. Greenland JR. Transcriptome-based diagnostics for chronic lung allograft dysfunction: A socratic question revisited. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2020. PMID: 33250117


  57. Dobi D, Vincenti F, Chandran S, Greenland JR, Bowman C, Chen A, Henrik J, Laszik ZG. The impact of belatacept on the phenotypic heterogeneity of renal T cell-mediated alloimmune response: the critical role of maintenance treatment and inflammatory load. Clinical transplantation 2020. PMID: 32939817


  58. Naikawadi RP, Green G, Jones KD, Achtar-Zadeh N, Mieleszko JE, Arnould I, Kukreja J, Greenland J, Wolters PJ. Airway Epithelial Telomere Dysfunction Drives Remodeling Similar to Chronic Lung Allograft Dysfunction. American journal of respiratory cell and molecular biology 2020. PMID: 32551854


  59. Dugger DT, Fung M, Hays SR, Singer JP, Ellen Kleinhenz M, Leard LE, Golden JA, Shah RJ, Lee JS, Deiter F, Greenland NY, Jones KD, Langelier CR, Greenland JR. Chronic Lung Allograft Dysfunction Small Airways Reveal A Lymphocytic Inflammation Gene Signature. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2020. PMID: 32885581


  60. Kolaitis NA, Gao Y, Soong A, Greenland JR, Hays SR, Golden J, Leard LE, Shah RJ, Kleinhenz ME, Katz PP, Venado A, Kukreja J, Blanc PD, Singer JP. Primary graft dysfunction attenuates improvements in health-related quality of life after lung transplantation, but not disability or depression. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2020. PMID: 32794295


  61. Greenland JR, Michelow MD, Wang L, London MJ. COVID-19 Infection: Perioperative Implications: Reply. Anesthesiology 2020. PMID: 32604140


  62. Dugger DT, Fung M, Zlock L, Caldera S, Sharp L, Hays SR, Singer JP, Leard LE, Golden JA, Shah RJ, Kukreja J, Gordon E, Finkbeiner W, Kleinhenz ME, Langelier C, Greenland JR. Cystic Fibrosis Lung Transplant Recipients Have Suppressed Airway Interferon Responses during Pseudomonas Infection. Cell reports. Medicine 2020. PMID: 32754722


  63. Martinu T, Koutsokera A, Benden C, Cantu E, Chambers D, Cypel M, Edelman J, Emtiazjoo A, Fisher AJ, Greenland JR, Hayes D, Hwang D, Keller BC, Lease ED, Perch M, Sato M, Todd JL, Verleden S, von der Thüsen J, Weigt SS, Keshavjee S. International Society for Heart and Lung Transplantation consensus statement for the standardization of bronchoalveolar lavage in lung transplantation. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2020. PMID: 32773322


  64. Greenland JR, Michelow MD, Wang L, London MJ. COVID-19 Infection: Implications for Perioperative and Critical Care Physicians. Anesthesiology 2020. PMID: 32195698


  65. Anderson MR, Easthausen I, Gallagher G, Udupa J, Tong Y, Torigian D, Diamond JM, Porteous MK, Palmer SM, Snyder LD, Benvenuto L, Aversa M, Arcasoy S, Greenland JR, Hays SR, Kukreja J, Cantu E, Kim JS, Gallagher D, Baldwin MR, Barr RG, Lederer DJ, Christie JD, Singer JP. Skeletal muscle adiposity and outcomes in candidates for lung transplantation: a lung transplant body composition cohort study. Thorax 2020. PMID: 32482837


  66. Venado A, Kolaitis NA, Huang CY, Gao Y, Glidden DV, Soong A, Sutter N, Katz PP, Greenland JR, Calabrese DR, Hays SR, Golden JA, Shah RJ, Leard LE, Kukreja J, Deuse T, Wolters PJ, Covinsky K, Blanc PD, Singer JP. Frailty after lung transplantation is associated with impaired health-related quality of life and mortality. Thorax 2020. PMID: 32376733


  67. Koons B, Greenland J, Diamond J, Singer J. Pathobiology of Frailty in Lung Disease. Translational research : the journal of laboratory and clinical medicine 2020. PMID: 32376405


  68. Perez AA, Hays SR, Soong A, Gao Y, Greenland JR, Leard LE, Shah RJ, Golden J, Kukreja J, Venado A, Kleinhenz ME, Singer JP. Improvements in frailty contribute to substantial improvements in quality of life after lung transplantation in patients with cystic fibrosis. Pediatric pulmonology 2020. PMID: 32237273


  69. Kolaitis NA, Calabrese DR, Ahearn P, Venado A, Florez R, Lei HL, Isaak K, Henricksen E, Martinez E, Chong T, Shah RJ, Leard LE, Kleinhenz ME, Golden J, De Marco T, Greenland JR, Kukreja J, Hays SR, Blanc PD, Singer JP. Tacrolimus trough monitoring guided by mass spectrometry without accounting for assay differences is associated with acute kidney injury in lung transplant recipients. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 2019. PMID: 31696925


  70. Calabrese DR, Wang P, Chong T, Hoover J, Singer JP, Torgerson D, Hays SR, Golden JA, Kukreja J, Dugger D, Christie JD, Investigators L, Greenland JR. Dectin-1 genetic deficiency predicts chronic lung allograft dysfunction and death. JCI insight 2019. PMID: 31613800


  71. Anderson MR, Udupa JK, Edwin E, Diamond JM, Singer JP, Kukreja J, Hays SR, Greenland JR, Ferrante A, Lippel M, Blue T, McBurnie A, Oyster M, Kalman L, Rushefski M, Wu C, Pednekar G, Liu W, Arcasoy S, Sonett J, D'Ovidio F, Bacchetta M, Newell JD, Torigian D, Cantu E, Farber DL, Giles JT, Tong Y, Palmer S, Ware LB, Hancock WW, Christie JD, Lederer DJ. Adipose tissue quantification and primary graft dysfunction after lung transplantation: The Lung Transplant Body Composition study. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2019. PMID: 31474492


  72. Anderson MR, Kolaitis N, Gao Y, Kukreja J, Greenland J, Hays S, Wolters P, Golden J, Diamond J, Palmer S, Arcasoy S, Udupa J, Christie JD, Lederer DJ, Singer JP. A non-linear relationship between visceral adipose tissue and frailty in adult lung transplant candidates. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2019. PMID: 31278829


  73. Perez AA, Singer JP, Schwartz BS, Chin-Hong P, Shah RJ, Kleinhenz ME, Gao Y, Venado A, Leard LE, Golden JA, Kukreja J, Greenland JR, Hays SR. Management and clinical outcomes after lung transplantation in patients with pre-transplant Mycobacterium abscessus infection: a single center experience. Transplant infectious disease : an official journal of the Transplantation Society 2019. PMID: 30924986


  74. Singer JP, Soong A, Chen J, Shrestha P, Zhuo H, Gao Y, Greenland JR, Hays SR, Kukreja J, Golden J, Gregorich SE, Stewart AL. Development and Preliminary Validation of the Lung Transplant Quality of Life (LT-QOL) Survey. American journal of respiratory and critical care medicine 2018. PMID: 30303408


  75. Greenland JR, Wang P, Brotman JJ, Ahuja R, Chong TA, Kleinhenz ME, Leard LE, Golden JA, Hays SR, Kukreja J, Singer JP, Rajalingam R, Jones K, Laszik ZG, Trivedi NN, Greenland NY, Blanc PD. Gene signatures common to allograft rejection are associated with lymphocytic bronchitis. Clinical transplantation 2019. PMID: 30849195


  76. Venado A, McCulloch C, Greenland JR, Katz P, Soong A, Shrestha P, Hays S, Golden J, Shah R, Leard LE, Kleinhenz ME, Kukreja J, Zablotska L, Allen IE, Covinsky K, Blanc P, Singer JP. Frailty trajectories in adult lung transplantation: A cohort study. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2019. PMID: 31005571


  77. Calabrese DR, Chong T, Wang A, Singer JP, Gottschall M, Hays SR, Golden JA, Kukreja J, Lanier LL, Tang Q, Greenland JR. NKG2C natural killer cells in bronchoalveolar lavage are associated with cytomegalovirus viremia and poor outcomes in lung allograft recipients. Volume 103 of Issue 3. 2018. PMID: 30211828


  78. Greenland JR. Where the Chromosome Ends: Telomeres and CMV Risk in Lung Transplant Recipients. American journal of respiratory and critical care medicine 2018. PMID: 30160976


  79. Calabrese DR, Lanier LL, Greenland JR. Natural killer cells in lung transplantation. Volume 74 of Issue 4. 2018. PMID: 30381399


  80. Calabrese DR, Florez R, Dewey K, Hui C, Torgerson D, Chong T, Faust H, Rajalingam R, Hays SR, Golden JA, Kukreja J, Singer JP, Greenland JR. Genotypes associated with tacrolimus pharmacokinetics impact clinical outcomes in lung transplant recipients. Volume 32 of Issue 8. 2018. PMID: 29920787


  81. Singer JP, Soong A, Bruun A, Bracha A, Chin G, Hays SR, Kukreja J, Rigler J, Golden JA, Greenland JR, Garvey C. A mobile health technology enabled home-based intervention to treat frailty in adult lung transplant candidates: A pilot study. Clinical transplantation 2018. PMID: 29742287


  82. Greenland JR, Chong T, Wang AS, Martinez E, Shrestha P, Kukreja J, Hays SR, Golden JA, Singer JP, Tang Q. Suppressed calcineurin-dependent gene expression identifies lung allograft recipients at increased risk of infection. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2018. PMID: 29673076


  83. Singer JP, Diamond JM, Anderson MR, Katz PP, Covinsky K, Oyster M, Blue T, Soong A, Kalman L, Shrestha P, Arcasoy SM, Greenland JR, Shah L, Kukreja J, Blumenthal NP, Easthausen I, Golden JA, McBurnie A, Cantu E, Sonett J, Hays S, Robbins H, Raza K, Bacchetta M, Shah RJ, D'Ovidio F, Venado A, Christie JD, Lederer DJ. Frailty phenotypes and mortality after lung transplantation: A prospective cohort study. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2018. PMID: 29667786


  84. Kolaitis NA, Soong A, Shrestha P, Zhuo H, Neuhaus J, Katz PP, Greenland JR, Golden J, Leard LE, Shah RJ, Hays SR, Kukreja J, Kleinhenz ME, Blanc PD, Singer JP. Improvement in patient-reported outcomes after lung transplantation is not impacted by the use of extracorporeal membrane oxygenation as a bridge to transplantation. 2018. PMID: 29550072


  85. Baldwin MR, Singer JP, Huang D, Sell J, Gonzalez WC, Pollack LR, Maurer MS, D'Ovidio FF, Bacchetta M, Sonett JR, Arcasoy SM, Shah L, Robbins H, Hays SR, Kukreja J, Greenland JR, Shah RJ, Leard L, Morrell M, Gries C, Katz PP, Christie JD, Diamond JM, Lederer DJ. Refining Low Physical Activity Measurement Improves Frailty Assessment in Advanced Lung Disease and Survivors of Critical Illness. Annals of the American Thoracic Society 2017. PMID: 28398076


  86. Greenland JR, Sun H, Calabrese D, Chong T, Singer JP, Kukreja J, Hays SR, Golden JA, Caughey GH, Venstrom JM, Rajalingam R. HLA Mismatching Favoring Host-Versus-Graft NK Cell Activity Via KIR3DL1 Is Associated With Improved Outcomes Following Lung Transplantation. Volume 17 of Issue 8. 2017. PMID: 28375571


  87. Faust HE, Golden JA, Rajalingam R, Wang AS, Green G, Hays SR, Kukreja J, Singer JP, Wolters PJ, Greenland JR. Short lung transplant donor telomere length is associated with decreased CLAD-free survival. Thorax 2017. PMID: 28446663


  88. Singer JP, Katz PP, Soong A, Shrestha P, Huang D, Ho J, Mindo M, Greenland JR, Hays SR, Golden J, Kukreja J, Kleinhenz ME, Shah RJ, Blanc PD. Effect of Lung Transplantation on Health-Related Quality of Life in the Era of the Lung Allocation Score: A U.S. Prospective Cohort Study. Volume 17 of Issue 5. 2017. PMID: 27743488


  89. Xu X, Greenland JR, Gotts JE, Matthay MA, Caughey GH. Cathepsin L Helps to Defend Mice from Infection with Influenza A. Volume 11 of Issue 10. PloS one 2016. PMID: 27716790


  90. Greenland JR, Wong CM, Ahuja R, Wang AS, Uchida C, Golden JA, Hays SR, Leard LE, Rajalingam R, Singer JP, Kukreja J, Wolters PJ, Caughey GH, Tang Q. Donor-Reactive Regulatory T Cell Frequency Increases During Acute Cellular Rejection of Lung Allografts. Volume 100 of Issue 10. 2016. PMID: 27077597


  91. Singer JP, Diamond JM, Gries CJ, McDonnough J, Blanc PD, Shah R, Dean MY, Hersh B, Wolters PJ, Tokman S, Arcasoy SM, Ramphal K, Greenland JR, Smith N, Heffernan P, Shah L, Shrestha P, Golden JA, Blumenthal NP, Huang D, Sonett J, Hays S, Oyster M, Katz PP, Robbins H, Brown M, Leard LE, Kukreja J, Bacchetta M, Bush E, D'Ovidio F, Rushefski M, Raza K, Christie JD, Lederer DJ. Frailty Phenotypes, Disability, and Outcomes in Adult Candidates for Lung Transplantation. Volume 192 of Issue 11. American journal of respiratory and critical care medicine 2015. PMID: 26258797


  92. Kern RM, Singer JP, Koth L, Mooney J, Golden J, Hays S, Greenland J, Wolters P, Ghio E, Jones KD, Leard L, Kukreja J, Blanc PD. Lung transplantation for hypersensitivity pneumonitis. Volume 147 of Issue 6. Chest 2015. PMID: 25412059


  93. Greenland JR, Xu X, Sayah DM, Liu FC, Jones KD, Looney MR, Caughey GH. Mast cells in a murine lung ischemia-reperfusion model of primary graft dysfunction. Volume 15. 2014. PMID: 25115556


  94. Greenland JR, Jewell NP, Gottschall M, Trivedi NN, Kukreja J, Hays SR, Singer JP, Golden JA, Caughey GH. Bronchoalveolar lavage cell immunophenotyping facilitates diagnosis of lung allograft rejection. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2014. PMID: 24512389


  95. Xu X, Greenland J, Baluk P, Adams A, Bose O, McDonald DM, Caughey GH. Cathepsin L protects mice from mycoplasmal infection and is essential for airway lymphangiogenesis. Volume 49 of Issue 3. 2013. PMID: 23600672


  96. Greenland JR, Jones KD, Hays SR, Golden JA, Urisman A, Jewell NP, Caughey GH, Trivedi NN. Association of large-airway lymphocytic bronchitis with bronchiolitis obliterans syndrome. Volume 187 of Issue 4. American journal of respiratory and critical care medicine 2012. PMID: 23239157


  98. Geiben-Lynn R, Greenland JR, Frimpong-Boateng K, van Rooijen N, Hovav AH, Letvin NL. CD4+ T lymphocytes mediate in vivo clearance of plasmid DNA vaccine antigen expression and potentiate CD8+ T-cell immune responses. Blood 2008. PMID: 18784371


  99. Geiben-Lynn R, Greenland JR, Frimpong-Boateng K, Letvin NL. Kinetics of recombinant adenovirus type 5, vaccinia virus, modified vaccinia ankara virus, and DNA antigen expression in vivo and the induction of memory T-lymphocyte responses. Clinical and vaccine immunology : CVI 2008. PMID: 18272665


  100. Qin L, Greenland JR, Moriya C, Cayabyab MJ, Letvin NL. Effects of type I interferons on the adjuvant properties of plasmid granulocyte-macrophage colony-stimulating factor in vivo. Journal of virology 2007. PMID: 17652387


  101. Greenland JR, Geiben R, Ghosh S, Pastor WA, Letvin NL. Plasmid DNA vaccine-elicited cellular immune responses limit in vivo vaccine antigen expression through Fas-mediated apoptosis. Journal of immunology (Baltimore, Md. : 1950) 2007. PMID: 17442948


  102. Greenland JR, Letvin NL. Chemical adjuvants for plasmid DNA vaccines. Vaccine 2007. PMID: 17350735


  103. Hovav AH, Cayabyab MJ, Panas MW, Santra S, Greenland J, Geiben R, Haynes BF, Jacobs WR, Letvin NL. Rapid memory CD8+ T-lymphocyte induction through priming with recombinant Mycobacterium smegmatis. Journal of virology 2006. PMID: 17050608


  104. Greenland JR, Liu H, Berry D, Anderson DG, Kim WK, Irvine DJ, Langer R, Letvin NL. Beta-amino ester polymers facilitate in vivo DNA transfection and adjuvant plasmid DNA immunization. Molecular therapy : the journal of the American Society of Gene Therapy 2005. PMID: 15963932


  105. Dominski Z, Erkmann JA, Greenland JA, Marzluff WF. Mutations in the RNA binding domain of stem-loop binding protein define separable requirements for RNA binding and for histone pre-mRNA processing. Molecular and cellular biology 2001. PMID: 11238936