Jonathan Budzik, MD, PhD

Education
2020 - Diversity, Equity, and Inclusion Champion Training, University of California
2017 - Pulmonary and Critical Care Medicine Fellowship, University of California
2014 - Internal Medicine Residency, University of California
MD, 2011 - Medicine, University of Chicago
PhD, 2009 - Microbiology, University of Chicago
Publications

  1. Golovkine GR, Roberts AW, Morrison HM, Rivera-Lugo R, McCall RM, Nilsson H, Garelis NE, Repasy T, Cronce M, Budzik J, Van Dis E, Popov LM, Mitchell G, Zalpuri R, Jorgens D, Cox JS. Author Correction: Autophagy restricts Mycobacterium tuberculosis during acute infection in mice. Nature microbiology 2024. PMID: 38308100


  2. Nieto-Caballero VE, Reijneveld JF, Ruvalcaba A, Innocenzi G, Abeydeera N, Asgari S, Lopez K, Iwany SK, Luo Y, Nathan A, Fernandez-Salinas D, Chiñas M, Huang CC, Zhang Z, León SR, Calderon RI, Lecca L, Budzik JM, Murray M, Van Rhijn I, Raychaudhuri S, Moody DB, Suliman S, Gutierrez-Arcelus M. History of tuberculosis disease is associated with genetic regulatory variation in Peruvians. PLoS genetics 2024. PMID: 38870230


  3. Zheng W, Chang IC, Limberis J, Budzik JM, Zha BS, Howard Z, Chen L, Ernst JD. Mycobacterium tuberculosis resides in lysosome-poor monocyte-derived lung cells during chronic infection. PLoS pathogens 2024. PMID: 38701094


  4. Zheng W, Chang IC, Limberis J, Budzik J, Zha BS, Howard Z, Chen L, Ernst J. Mycobacterium tuberculosis resides in lysosome-poor monocyte-derived lung cells during chronic infection. Research square 2023. PMID: 37398178


  5. Zheng W, Chang IC, Limberis J, Budzik JM, Zha BS, Howard Z, Ernst JD. Mycobacterium tuberculosis resides in lysosome-poor monocyte-derived lung cells during persistent infection. bioRxiv : the preprint server for biology 2023. PMID: 36711606


  6. Golovkine GR, Roberts AW, Morrison HM, Rivera-Lugo R, McCall RM, Nilsson H, Garelis NE, Repasy T, Cronce M, Budzik J, Van Dis E, Popov LM, Mitchell G, Zalpuri R, Jorgens D, Cox JS. Autophagy restricts Mycobacterium tuberculosis during acute infection in mice. Nature microbiology 2023. PMID: 37037941


  7. Mitchell G, Silvis MR, Talkington KC, Budzik JM, Dodd CE, Paluba JM, Oki EA, Trotta KL, Licht DJ, Jimenez-Morales D, Chou S, Savage PB, Gross CA, Marletta MA, Cox JS. Ceragenins and Antimicrobial Peptides Kill Bacteria through Distinct Mechanisms. 2015 Year Book of Pediatrics. Ed. Cabana MD. (Elsevier; Philadelphia, PA) 2022. PMID: 35073755


  8. Hiatt J, Cavero DA, McGregor MJ, Zheng W, Budzik JM, Roth TL, Haas KM, Wu D, Rathore U, Meyer-Franke A, Bouzidi MS, Shifrut E, Lee Y, Kumar VE, Dang EV, Gordon DE, Wojcechowskyj JA, Hultquist JF, Fontaine KA, Pillai SK, Cox JS, Ernst JD, Krogan NJ, Marson A. Efficient generation of isogenic primary human myeloid cells using CRISPR-Cas9 ribonucleoproteins. Cell reports 2021. PMID: 33979618


  9. Anstey KM, Lee M, Dawson D, Jue V, Budzik JM, Yu M, Kleinhenz ME, Otani IM. Antibiotic Adverse Reactions in Adult Cystic Fibrosis Patients. The journal of allergy and clinical immunology. In practice 2020. PMID: 32673878


  10. Budzik JM, Swaney DL, Jimenez-Morales D, Johnson JR, Garelis NE, Repasy T, Roberts AW, Popov LM, Parry TJ, Pratt D, Ideker T, Krogan NJ, Cox JS. Dynamic post-translational modification profiling of M. tuberculosis-infected primary macrophages. eLife 2020. PMID: 31951200


  11. Budzik JM, Jarlsberg LG, Higashi J, Grinsdale J, Hopewell PC, Kato-Maeda M, Nahid P. Pyrazinamide resistance, Mycobacterium tuberculosis lineage and treatment outcomes in San Francisco, California. PloS one 2014. PMID: 24759760


  12. Hendrickx AP, Poor CB, Jureller JE, Budzik JM, He C, Schneewind O. Isopeptide bonds of the major pilin protein BcpA influence pilus structure and bundle formation on the surface of Bacillus cereus. Molecular microbiology 2012. PMID: 22624947


  13. Budzik JM, Hosseini M, Mackinnon AC, Taxy JB. Disseminated Nocardia farcinica: literature review and fatal outcome in an immunocompetent patient. Surgical infections 2012. PMID: 22612440


  14. Oh SY, Budzik JM, Garufi G, Schneewind O. Two capsular polysaccharides enable Bacillus cereus G9241 to cause anthrax-like disease. Molecular microbiology 2011. PMID: 21371137


  15. Hendrickx AP, Budzik JM, Oh SY, Schneewind O. Architects at the bacterial surface - sortases and the assembly of pili with isopeptide bonds. Nature reviews. Microbiology 2011. PMID: 21326273


  16. Budzik JM, Poor CB, Faull KF, Whitelegge JP, He C, Schneewind O. Intramolecular amide bonds stabilize pili on the surface of bacilli. Proceedings of the National Academy of Sciences of the United States of America 2009. PMID: 19903875


  17. Budzik JM, Oh SY, Schneewind O. Sortase D forms the covalent bond that links BcpB to the tip of Bacillus cereus pili. The Journal of biological chemistry 2009. PMID: 19269972


  18. Richter S, Anderson VJ, Garufi G, Lu L, Budzik JM, Joachimiak A, He C, Schneewind O, Missiakas D. Capsule anchoring in Bacillus anthracis occurs by a transpeptidation reaction that is inhibited by capsidin. Molecular microbiology 2008. PMID: 19017271


  19. Budzik JM, Oh SY, Schneewind O. Cell wall anchor structure of BcpA pili in Bacillus anthracis. The Journal of biological chemistry 2008. PMID: 18940793


  20. Oh SY, Budzik JM, Schneewind O. Sortases make pili from three ingredients. Proceedings of the National Academy of Sciences of the United States of America 2008. PMID: 18784365


  21. Budzik JM, Marraffini LA, Souda P, Whitelegge JP, Faull KF, Schneewind O. Amide bonds assemble pili on the surface of bacilli. Proceedings of the National Academy of Sciences of the United States of America 2008. PMID: 18621716


  22. Budzik JM, Marraffini LA, Schneewind O. Assembly of pili on the surface of Bacillus cereus vegetative cells. Molecular microbiology 2007. PMID: 17897374


  23. Budzik JM, Schneewind O. Pili prove pertinent to enterococcal endocarditis. The Journal of clinical investigation 2006. PMID: 17016552


  24. Budzik JM, Rosche WA, Rietsch A, O'Toole GA. Isolation and characterization of a generalized transducing phage for Pseudomonas aeruginosa strains PAO1 and PA14. Journal of bacteriology 2004. PMID: 15126493


  25. Zegans ME, Becker HI, Budzik J, O'Toole G. The role of bacterial biofilms in ocular infections. DNA and cell biology 2002. PMID: 12167244