Kamran Atabai, MD

Education
Fellowship, - Pulmonary/Critical Care, Harvard University
Postdoctoral Studies, - Graduate Division, University of California, San Francisco
Residency, - School of Medicine - Internal Medicine, University of California, San Francisco
Publications

  1. Lin S, Wang J, Mukherjee PK, Mao R, West G, Czarnecki D, Zhao S, Nguyen QT, Elias M, Massey WJ, Liu W, Wang Y, Prasad A, Banerjee S, Goren I, Chandra J, Le HT, Dejanovic D, Li J, Chen M, Holubar S, Olman M, Southern B, Hu S, Gordon IO, Atabai K, Fiocchi C, Rieder F. Milk fat globule-epidermal growth factor 8 (MFGE8) prevents intestinal fibrosis. Gut 2024. PMID: 38378253


  2. Atabai K, Badr MS, Costello J, Ridge K, Rounds S, Turenne M, White ES, Roman J. The American Thoracic Society Research Program (ATSRP) - Twenty Years of Driving Discovery in Respiratory Medicine. American journal of respiratory and critical care medicine 2024. PMID: 38422387


  3. Podolsky MJ, Kheyfets B, Pandey M, Beigh AH, Yang CD, Lizama CO, Datta R, Lin LL, Wang Z, Wolters PJ, McManus MT, Qi L, Atabai K. Genome-wide screens identify SEL1L as an intracellular rheostat controlling collagen turnover. Nature communications 2024. PMID: 38378719


  4. Datta R, Mukherjee D, Podolsky MJ, Yang CD, Alba DL, Singh S, Arnold TD, Koliwad S, Lizama CO, Atabai K. PTP1B mediates the inhibitory effect of MFGE8 on insulin signaling through the β5 integrin. The Journal of biological chemistry 2024. PMID: 38199575


  5. Jourdan Le Saux C, Ho TC, Brumwell AM, Kathiriya JJ, Wei Y, Hughes JB, Garakani K, Atabai K, Auyeung VC, Papa FR, Chapman HA. BCL-2 Modulates IRE1α Activation to Attenuate ER Stress and Pulmonary Fibrosis. American journal of respiratory cell and molecular biology 2023. PMID: 38117250


  6. Podolsky MJ, Kheyfets B, Beigh AH, Yang CD, Valenzuela CL, Datta R, Wolters PJ, McManus MT, Qi L, Atabai K. Genome-wide screens identify SEL1L as an intracellular rheostat controlling collagen turnover. bioRxiv : the preprint server for biology 2023. PMID: 36711851


  7. McKinsey GL, Santander N, Zhang X, Kleemann K, Tran L, Katewa A, Conant K, Barraza M, Waddell K, Lizama C, La Russa M, Koo HJ, Lee H, Mukherjee D, Paidassi H, Anton ES, Atabai K, Sheppard D, Butovsky O, Arnold TD. Radial glia promote microglial development through integrin α V β 8 -TGFβ1 signaling. bioRxiv : the preprint server for biology 2023. PMID: 37790363


  8. Datta R, Podolsky MJ, Yang CD, Alba DL, Singh S, Koliwad S, Lizama CO, Atabai K. MFGE8 inhibits insulin signaling through PTP1B. bioRxiv : the preprint server for biology 2023. PMID: 37398282


  9. Sinan Lin, Jie Wang, Pranab Mukherjee, Ren Mao, Gail A. West, Doug Czarnecki, Shuai Zhao, Quang Tam Nguyen, Jyotsna Chandra, Thi Hong Nga Le, Dina Dejanovic, Minhu Chen, Stefan D. Holubar, Mitch Olman, Brian D. Southern, Shaomin Hu, Ilyssa O. Gordon, Kamran Atabai, Claudio Fiocchi, Florian Rieder. Tu1246 CROHN'S DISEASE STRICTURE MATRISOME ANALYSIS REVEALS THE ANTI-FIBROTIC ACTIVITY OF MILK-FAT GLOBULE-EPIDERMAL GROWTH FACTOR 8 (MFGE8). Gastroenterology 2023. PMID:


  10. Datta R, Gholampour MA, Yang CD, Volk R, Lin S, Podolsky MJ, Arnold T, Rieder F, Zaro BW, Verzi M, Lehner R, Abumrad N, Lizama CO, Atabai K. MFGE8 links absorption of dietary fatty acids with catabolism of enterocyte lipid stores through HNF4?-dependent transcription of CES enzymes. Cell reports 2023. PMID: 36924494


  11. S Lin, J Wang, P Mukherjee, R Mao, G West, D Czarnecki, S Zhao, M Elias, Q T Nguyen, J Chandra, T H N Le, M H Chen, D Dejanovic, S Holubar, M Olman, B Southern, S Hu, I O Gordon, K Atabai, C Fiocchi, F Rieder. DOP32 Crohn’s disease stricture matrisome analysis reveals the anti-fibrotic activity of milk-fat globule-epidermal growth factor 8 (MFGE8). Journal of Crohn's and Colitis 2023. PMID:


  12. Datta R, Lizama CO, Soltani AK, Mckleroy W, Podolsky MJ, Yang CD, Huynh TL, Cautivo KM, Wang B, Koliwad SK, Abumrad NA, Atabai K. Autoregulation of insulin receptor signaling through MFGE8 and the αvβ5 integrin. Proceedings of the National Academy of Sciences of the United States of America 2021. PMID: 33903257


  13. Atabai K, Yang CD, Podolsky MJ. You Say You Want a Resolution (of Fibrosis). American journal of respiratory cell and molecular biology 2020. PMID: 32640171


  14. Oguri Y, Shinoda K, Kim H, Alba DL, Bolus WR, Wang Q, Brown Z, Pradhan RN, Tajima K, Yoneshiro T, Ikeda K, Chen Y, Cheang RT, Tsujino K, Kim CR, Greiner VJ, Datta R, Yang CD, Atabai K, McManus MT, Koliwad SK, Spiegelman BM, Kajimura S. CD81 Controls Beige Fat Progenitor Cell Growth and Energy Balance via FAK Signaling. Cell 2020. PMID: 32615086


  15. Podolsky MJ, Yang CD, Lizama C, Datta R, Huang SK, Nishimura SL, Dallas SL, Wolters P, Jourdan Le Saux C, Atabai K. Age-dependent regulation of cell-mediated collagen turnover. JCI insight 2020. PMID: 32315288


  16. Datta R, Podolsky MJ, Atabai K. Fat fibrosis: friend or foe? JCI insight 2018. PMID: 30282827


  17. Zhou Y, Bond AM, Shade JE, Zhu Y, Davis CO, Wang X, Su Y, Yoon KJ, Phan AT, Chen WJ, Oh JH, Marsh-Armstrong N, Atabai K, Ming GL, Song H. Autocrine Mfge8 Signaling Prevents Developmental Exhaustion of the Adult Neural Stem Cell Pool. Cell stem cell 2018. PMID: 30174295


  18. Viola JR, Lemnitzer P, Paulin N, Drechsler M, Nazari-Jahantigh M, Maas S, De Jong RJ, Winter J, Schober A, Weber C, Atabai K, Soehnlein O. Deletion of MFGE8 Inhibits Neointima Formation upon Arterial Damage. 2018. PMID: 29864782


  19. Podolsky MJ, Gupta D, Ha A, Ta R, Khalifeh-Soltani A, McKleroy W, Datta R, Sheppard D, Atabai K. Cell Division Cycle 7-Kinase is a negative regulator of cell-mediated collagen degradation. American journal of physiology. Lung cellular and molecular physiology 2018. PMID: 29792348


  20. Khalifeh-Soltani A, Gupta D, Ha A, Podolsky MJ, Datta R, Atabai K. The Mfge8-a8ß1-PTEN pathway regulates airway smooth muscle contraction in allergic inflammation. 2018. PMID: 29763381


  21. RITWIK DATTA, AMIN KHALIFEH-SOLTANI, ARNOLD HA, KAMRAN ATABAI. Mfge8 Binding of the avß5 Integrin Promotes Insulin Resistance in Mice. Diabetes 2018. PMID:


  22. Zhou Y, Horowitz JC, Naba A, Ambalavanan N, Atabai K, Balestrini J, Bitterman PB, Corley RA, Ding BS, Engler AJ, Hansen KC, Hagood JS, Kheradmand F, Lin QS, Neptune E, Niklason L, Ortiz LA, Parks WC, Tschumperlin DJ, White ES, Chapman HA, Thannickal VJ. Extracellular matrix in lung development, homeostasis and disease. 2018. PMID: 29524630


  23. Michalski MN, Seydel AL, Siismets EM, Zweifler LE, Koh AJ, Sinder BP, Aguirre JI, Atabai K, Roca H, McCauley LK. Inflammatory bone loss associated with MFG-E8 deficiency is rescued by teriparatide. 2018. PMID: 29475373


  24. Long Z, Cao M, Su S, Wu G, Meng F, Wu H, Liu J, Yu W, Atabai K, Wang X. Inhibition of hepatocyte nuclear factor 1b induces hepatic steatosis through DPP4/NOX1-mediated regulation of superoxide. Volume 113. 2017. PMID: 28942246


  25. Xie Y, Cifarelli V, Pietka T, Newberry EP, Kennedy SM, Khalifeh-Soltani A, Clugston R, Atabai K, Abumrad NA, Davidson NO. Cd36 knockout mice are protected against lithogenic diet-induced gallstones. Volume 58 of Issue 8. Journal of lipid research 2017. PMID: 28634191


  26. Ting-Hein Lee, Shigekazu Nagata, Kamran Atabai, Hou-Yu Chiang. Abstract 210: Milk Fat Globule Epidermal Growth Factor VIII Mediates Vascular Remodeling by Increasing Inflammation and Smooth Muscle Activation. Arteriosclerosis Thrombosis and Vascular Biology 2017. PMID:


  27. Khalifeh-Soltani A, Gupta D, Ha A, Iqbal J, Hussain M, Podolsky MJ, Atabai K. Mfge8 regulates enterocyte lipid storage by promoting enterocyte triglyceride hydrolase activity. Volume 1 of Issue 18. 2016. PMID: 27812539


  28. Kamran Atabai, Michael Podolsky, Donald Mccarthy. Loss Of Fatty Acid Synthase Increases The Severity Of Lung Fibrosis By Preventing Collagen Resorption. QJM 2016. PMID:


  29. Khalifeh-Soltani A, Ha A, Podolsky MJ, McCarthy DA, McKleroy W, Azary S, Sakuma S, Tharp KM, Wu N, Yokosaki Y, Hart D, Stahl A, Atabai K. a8ß1 integrin regulates nutrient absorption through an Mfge8-PTEN dependent mechanism. Volume 5. 2016. PMID: 27092791


  30. Tharp KM, Khalifeh-Soltani A, Park HM, Yurek DA, Falcon A, Wong L, Feng R, Atabai K, Stahl A. Prevention of gallbladder hypomotility via FATP2 inhibition protects from lithogenic diet-induced cholelithiasis. Volume 310 of Issue 10. 2016. PMID: 27033116


  31. Bhattacharya M, Sundaram A, Kudo M, Farmer J, Ganesan P, Khalifeh-Soltani A, Arjomandi M, Atabai K, Huang X, Sheppard D. IQGAP1-dependent scaffold suppresses RhoA and inhibits airway smooth muscle contraction. Volume 124 of Issue 11. The Journal of clinical investigation 2014. PMID: 25271629


  32. Soki FN, Koh AJ, Jones JD, Kim YW, Dai J, Keller ET, Pienta KJ, Atabai K, Roca H, McCauley LK. Polarization of prostate cancer-associated macrophages is induced by milk fat globule-EGF factor 8 (MFG-E8)-mediated efferocytosis. Volume 289 of Issue 35. The Journal of biological chemistry 2014. PMID: 25006249


  33. Khalifeh-Soltani A, McKleroy W, Sakuma S, Cheung YY, Tharp K, Qiu Y, Turner SM, Chawla A, Stahl A, Atabai K. Mfge8 promotes obesity by mediating the uptake of dietary fats and serum fatty acids. Volume 20 of Issue 2. Nature medicine 2014. PMID: 24441829


  34. Lee TH, McKleroy W, Khalifeh-Soltani A, Sakuma S, Lazarev S, Riento K, Nishimura SL, Nichols BJ, Atabai K. Functional genomic screen identifies novel mediators of collagen uptake. Volume 25 of Issue 5. 2014. PMID: 24403604


  35. McKleroy W, Lee TH, Atabai K. Always cleave up your mess: targeting collagen degradation to treat tissue fibrosis. Volume 304 of Issue 11. American journal of physiology. Lung cellular and molecular physiology 2013. PMID: 23564511


  36. Kudo M, Khalifeh Soltani SM, Sakuma SA, McKleroy W, Lee TH, Woodruff PG, Lee JW, Huang K, Chen C, Arjomandi M, Huang X, Atabai K. Mfge8 suppresses airway hyperresponsiveness in asthma by regulating smooth muscle contraction. Volume 110 of Issue 2. Proceedings of the National Academy of Sciences of the United States of America 2012. PMID: 23269839


  37. Kudo M, Melton AC, Chen C, Engler MB, Huang KE, Ren X, Wang Y, Bernstein X, Li JT, Atabai K, Huang X, Sheppard D. IL-17A produced by aß T cells drives airway hyper-responsiveness in mice and enhances mouse and human airway smooth muscle contraction. Volume 18 of Issue 4. Nature medicine 2012. PMID: 22388091


  38. Atabai K, Jame S, Azhar N, Kuo A, Lam M, McKleroy W, Dehart G, Rahman S, Xia DD, Melton AC, Wolters P, Emson CL, Turner SM, Werb Z, Sheppard D. Mfge8 diminishes the severity of tissue fibrosis in mice by binding and targeting collagen for uptake by macrophages. Volume 119 of Issue 12. The Journal of clinical investigation 2009. PMID: 19884654


  39. Nandrot EF, Anand M, Almeida D, Atabai K, Sheppard D, Finnemann SC. Essential role for MFG-E8 as ligand for alphavbeta5 integrin in diurnal retinal phagocytosis. Volume 104 of Issue 29. Proceedings of the National Academy of Sciences of the United States of America 2007. PMID: 17620600


  40. Atabai K, Sheppard D, Werb Z. Roles of the innate immune system in mammary gland remodeling during involution. Volume 12 of Issue 1. 2007. PMID: 17286210


  41. Atabai K, Fernandez R, Huang X, Ueki I, Kline A, Li Y, Sadatmansoori S, Smith-Steinhart C, Zhu W, Pytela R, Werb Z, Sheppard D. Mfge8 is critical for mammary gland remodeling during involution. Volume 16 of Issue 12. 2005. PMID: 16195353


  42. Atabai K, Ishigaki M, Geiser T, Ueki I, Matthay MA, Ware LB. Keratinocyte growth factor can enhance alveolar epithelial repair by nonmitogenic mechanisms. Volume 283 of Issue 1. American journal of physiology. Lung cellular and molecular physiology 2002. PMID: 12060573


  43. Atabai K, Ware LB, Snider ME, Koch P, Daniel B, Nuckton TJ, Matthay MA. Aerosolized beta(2)-adrenergic agonists achieve therapeutic levels in the pulmonary edema fluid of ventilated patients with acute respiratory failure. Volume 28 of Issue 6. Intensive care medicine 2002. PMID: 12107675


  45. Burgel PR, Lazarus SC, Tam DC, Ueki IF, Atabai K, Birch M, Nadel JA. Human eosinophils induce mucin production in airway epithelial cells via epidermal growth factor receptor activation. Volume 167 of Issue 10. Journal of immunology (Baltimore, Md. : 1950) 2001. PMID: 11698473


  46. Geiser T, Atabai K, Jarreau PH, Ware LB, Pugin J, Matthay MA. Pulmonary edema fluid from patients with acute lung injury augments in vitro alveolar epithelial repair by an IL-1beta-dependent mechanism. Volume 163 of Issue 6. American journal of respiratory and critical care medicine 2001. PMID: 11371405


  47. Miller LS, Atabai K, Nowakowski M, Chan A, Bluth MH, Minkoff H, Durkin HG. Increased expression of CD23 (Fc(epsilon) receptor II) by peripheral blood monocytes of aids patients. AIDS research and human retroviruses 2001. PMID: 11282013


  48. Geiser T, Jarreau PH, Atabai K, Matthay MA. Interleukin-1beta augments in vitro alveolar epithelial repair. Volume 279 of Issue 6. American journal of physiology. Lung cellular and molecular physiology 2000. PMID: 11076808